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The map label for this gene is lpxD [H]

Identifier: 126207893

GI number: 126207893

Start: 465680

End: 466705

Strand: Reverse

Name: lpxD [H]

Synonym: APL_0409

Alternate gene names: 126207893

Gene position: 466705-465680 (Counterclockwise)

Preceding gene: 126207894

Following gene: 126207892

Centisome position: 20.52

GC content: 43.47

Gene sequence:

>1026_bases
ATGGCTAATTTCCGTTTAATTGAACTTGCGGAGCAAATCGGCGGTACTCTAAGGGGTAACGCCGATTTGGCTATTTCTAG
CATTGCCGCATTAGATAAAGCAAATTCGTCACAAATTACTTTTATTTCTAACGCAAAATATCGCCCTCAATTAGCACAAT
CTCAAGCCGGTGCGATTATTGTCAGCGAAGCGGATATCGAGTTTTGTGCGGAATCACAAAATCTTATTATCGTAAAGAAT
CCGTATGTCGCTTACGCATTATTGGCACAGTATATGGATTCGACGCCTAAAGCCGCTAACAGTATTTCACCTAACGCCGT
TATTTCTTCGGAAGCAATTTTAGGCAATAATGTTTTCGTCGGTGCGAATGCGGTGATTGAAAGCGGTGTAGAATTGGGCG
ATGACGTTATCATCGGTGCCGGATGTTTTATCGGTAAAAATACTAAAATCGGCGCACGTACTCAATTGTGGGCAAACGTA
TCGGTTTACCATAACGTCCGAATCGGTTCGGATTGTTTAATCCAATCCTCTGCGGTAATCGGCAGTGACGGCTTCGGTTA
TGCCAATGATAAAGGTCAATGGATTAAAATTCCGCAAACGGGCGGCGTGATTATCGGTAATCGTGTGGAAATCGGCGCTT
GTACTTGTATTGACCGCGGTGCTTTGGATCCGACCGTTATCGAAGACAATGTAATTATCGACAATCTTTGTCAAATTGCG
CATAATGTTCATATTGGTTTCGGTACGGCCGTTGCCGGTGGAGTAATTATGGCGGGTAGCCTGAAAGTAGGCAGATTCTG
TCAAATCGGCGGTGCAAGCGTATTAAACGGTCATATGGAAATTTGTGACGGAGCCGTCATTACCGGTATGAGTATGGTGA
TGAAACCGATTACCGAAAAAGGAATCTACTCGTCCGGTATCCCTGCTCAAACCAATAAAGAATGGCGTAAAACCGCTGCG
CTAACAATGAATATCGATGAGATGAACAAACGTTTAAAAGCGATTGAAAAACGTTTAGCTGAATAA

Upstream 100 bases:

>100_bases
AACAACCGGTTGCAAATCCGGAGGTAAAAGCGGAAGAAGCTAAACCGGCAACCGACGCACCTCAAGCAGAAACAACCAAA
CCAGAAGAAGCGAAAAAATA

Downstream 100 bases:

>100_bases
GCATTTTTTATGGGCTTACCGCTGTAAGCCTTATTTTAGTTTATACATTTTATTATGAGGCCGAATTAATGACTATTGAA
GTACAAGAAAATAGAGAACC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MANFRLIELAEQIGGTLRGNADLAISSIAALDKANSSQITFISNAKYRPQLAQSQAGAIIVSEADIEFCAESQNLIIVKN
PYVAYALLAQYMDSTPKAANSISPNAVISSEAILGNNVFVGANAVIESGVELGDDVIIGAGCFIGKNTKIGARTQLWANV
SVYHNVRIGSDCLIQSSAVIGSDGFGYANDKGQWIKIPQTGGVIIGNRVEIGACTCIDRGALDPTVIEDNVIIDNLCQIA
HNVHIGFGTAVAGGVIMAGSLKVGRFCQIGGASVLNGHMEICDGAVITGMSMVMKPITEKGIYSSGIPAQTNKEWRKTAA
LTMNIDEMNKRLKAIEKRLAE

Sequences:

>Translated_341_residues
MANFRLIELAEQIGGTLRGNADLAISSIAALDKANSSQITFISNAKYRPQLAQSQAGAIIVSEADIEFCAESQNLIIVKN
PYVAYALLAQYMDSTPKAANSISPNAVISSEAILGNNVFVGANAVIESGVELGDDVIIGAGCFIGKNTKIGARTQLWANV
SVYHNVRIGSDCLIQSSAVIGSDGFGYANDKGQWIKIPQTGGVIIGNRVEIGACTCIDRGALDPTVIEDNVIIDNLCQIA
HNVHIGFGTAVAGGVIMAGSLKVGRFCQIGGASVLNGHMEICDGAVITGMSMVMKPITEKGIYSSGIPAQTNKEWRKTAA
LTMNIDEMNKRLKAIEKRLAE
>Mature_340_residues
ANFRLIELAEQIGGTLRGNADLAISSIAALDKANSSQITFISNAKYRPQLAQSQAGAIIVSEADIEFCAESQNLIIVKNP
YVAYALLAQYMDSTPKAANSISPNAVISSEAILGNNVFVGANAVIESGVELGDDVIIGAGCFIGKNTKIGARTQLWANVS
VYHNVRIGSDCLIQSSAVIGSDGFGYANDKGQWIKIPQTGGVIIGNRVEIGACTCIDRGALDPTVIEDNVIIDNLCQIAH
NVHIGFGTAVAGGVIMAGSLKVGRFCQIGGASVLNGHMEICDGAVITGMSMVMKPITEKGIYSSGIPAQTNKEWRKTAAL
TMNIDEMNKRLKAIEKRLAE

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=341, Percent_Identity=62.1700879765396, Blast_Score=455, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 35948; Mature: 35817

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANFRLIELAEQIGGTLRGNADLAISSIAALDKANSSQITFISNAKYRPQLAQSQAGAII
CCCCHHHHHHHHHCCEECCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCHHHHCCCCEEE
VSEADIEFCAESQNLIIVKNPYVAYALLAQYMDSTPKAANSISPNAVISSEAILGNNVFV
EEECCHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCEEECCCEEE
GANAVIESGVELGDDVIIGAGCFIGKNTKIGARTQLWANVSVYHNVRIGSDCLIQSSAVI
ECHHHHHCCCCCCCCEEEECCEEECCCCCCCCCEEEEEEEEEEEEEEECCHHEEECCEEE
GSDGFGYANDKGQWIKIPQTGGVIIGNRVEIGACTCIDRGALDPTVIEDNVIIDNLCQIA
CCCCCCCCCCCCCEEEECCCCCEEECCEEEEEEEEEECCCCCCCEEEECCCHHHHHHHHH
HNVHIGFGTAVAGGVIMAGSLKVGRFCQIGGASVLNGHMEICDGAVITGMSMVMKPITEK
HCEEEEECHHHHCCEEEECCCCCCCEEECCCCHHCCCCHHHHCCHHHHHHHHHHHHHHHC
GIYSSGIPAQTNKEWRKTAALTMNIDEMNKRLKAIEKRLAE
CCCCCCCCCCCCHHHHHEEEEEEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ANFRLIELAEQIGGTLRGNADLAISSIAALDKANSSQITFISNAKYRPQLAQSQAGAII
CCCHHHHHHHHHCCEECCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCHHHHCCCCEEE
VSEADIEFCAESQNLIIVKNPYVAYALLAQYMDSTPKAANSISPNAVISSEAILGNNVFV
EEECCHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCEEECCCEEE
GANAVIESGVELGDDVIIGAGCFIGKNTKIGARTQLWANVSVYHNVRIGSDCLIQSSAVI
ECHHHHHCCCCCCCCEEEECCEEECCCCCCCCCEEEEEEEEEEEEEEECCHHEEECCEEE
GSDGFGYANDKGQWIKIPQTGGVIIGNRVEIGACTCIDRGALDPTVIEDNVIIDNLCQIA
CCCCCCCCCCCCCEEEECCCCCEEECCEEEEEEEEEECCCCCCCEEEECCCHHHHHHHHH
HNVHIGFGTAVAGGVIMAGSLKVGRFCQIGGASVLNGHMEICDGAVITGMSMVMKPITEK
HCEEEEECHHHHCCEEEECCCCCCCEEECCCCHHCCCCHHHHCCHHHHHHHHHHHHHHHC
GIYSSGIPAQTNKEWRKTAALTMNIDEMNKRLKAIEKRLAE
CCCCCCCCCCCCHHHHHEEEEEEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA