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The map label for this gene is glmS [H]

Identifier: 126176542

GI number: 126176542

Start: 5103611

End: 5105440

Strand: Reverse

Name: glmS [H]

Synonym: Sbal_4361

Alternate gene names: 126176542

Gene position: 5105440-5103611 (Counterclockwise)

Preceding gene: 126176543

Following gene: 126176541

Centisome position: 99.57

GC content: 48.74

Gene sequence:

>1830_bases
ATGTGTGGAATCGTAGGCGCCGTGGCGCAAAGGGATGTGGCTGAAATTCTGGTAGAAGGCTTACGCCGCTTAGAATATCG
CGGATATGACTCCGCAGGCGTTGCCGTTATTCACAATGGTGAACTCAATCGCACGCGCCGCGTTGGTAAAGTACAAGAGC
TGTCTGCTGCGCTTGAAACCGATCCATTAGCGGGCGGAACCGGTATCGCGCACACTCGCTGGGCGACCCACGGTGAACCG
AGTGAGCGTAATGCTCACCCGCATTTATCGGAAGGTGATATCGCGGTGGTGCACAACGGCATTATTGAAAACCACAATAA
ACTGCGCGAGATGCTAAAAGGTTTAGGCTATAAATTTAGCTCAGATACCGATACCGAAGTGATTTGTCACTTAGTACACC
ATGAGCTGAAAACTAACAGCACTTTGCTTTCTGCCGTGCAAGCCACAGTTAAACAACTCGAAGGCGCCTATGGCACAGTG
GTAATCGATCGCCGCGACAGCGAGCGCTTGGTTGTGGCTCGATCTGGTAGTCCTTTAGTGATTGGTTTTGGTCTAGGTGA
AAACTTTGTCGCCTCGGATCAACTGGCACTCTTACCTGTGACTCGTTCATTCGCCTTCTTAGAAGAAGGTGATGTGGCCG
AAGTAACCCGTCGCAGCGTGAGTATTTTCGACTTAAACGGTAATGCCGTTGAGCGTGAAGTCAAAGAATCTGAAATTACT
CACGATGCTGGTGATAAGGGCGAATATCGCCACTACATGCTTAAAGAGATTTACGAGCAGCCATTGGCACTGACGCGCAC
TATCGAAGGCCGTATTGCTAACAAGCAAGTGCTAGACACGGCTTTTGGTGATAACGCTGCTGAGTTCTTAAAAGATATCA
AACACGTGCAAATCATCGCTTGTGGCACTAGCTACCATGCGGGCATGGCGGCGCGTTACTGGTTGGAAGATTGGGCTGGC
GTATCGTGTAACGTCGAAATTGCCTCTGAGTTCCGTTACCGCAAGTCGCACTTATTCCCAAATAGCCTGTTGGTGACGAT
TTCACAATCTGGTGAAACTGCAGATACTTTAGCGGCCATGCGCTTAGCGAAAGAAATGGGTTACAAAGCCACATTGACGA
TTTGTAATGCGCCAGGTTCGTCACTGGTTCGCGAATCTGACATGGCTTACATGATGAAAGCGGGCGCCGAGATTGGTGTG
GCATCCACTAAAGCCTTCACAGTACAGCTTGCTGGCTTGTTAATGTTGACTGCGGTGATCGGTCGCCACAATGGTATGTC
TGATCAAATGCAGGCCCAAATCACTCAAAGCCTACAATCTATGCCAGCTAAAGTGGAACAAGCTTTAGGGCTAGATGCTG
CGATTGCTGAATTGGCTGAAGATTTTGCCGATAAACACCATGCTTTATTCCTTGGCCGTGGCGATCAATACCCGATTGCG
ATGGAAGGCGCGTTAAAGCTGAAAGAGATTTCTTACATTCATGCTGAAGCGTATGCCTCTGGCGAATTAAAACACGGCCC
ATTAGCGCTTATCGATGCCGATATGCCTGTGATTGTCGTTGCGCCAAACAATGAATTGCTCGAAAAACTGAAATCGAATG
TTGAAGAAGTGCGTGCCCGTGGCGGCTTAATGTATGTGTTTGCCGATGTGGATGCCGAGTTCGAGTCGGATGACACGATG
AAAGTGATTCCAGTGCCACACTGCGATATATTTATGGCGCCGCTGATTTACACTATTCCGCTACAGCTATTGTCGTACCA
TGTTGCGTTGATCAAAGGTACCGACGTGGATCAACCACGCAACCTAGCAAAATCTGTAACAGTAGAATAA

Upstream 100 bases:

>100_bases
AAATTTCAGATCAGGGCGTGCGAGTTATGCTAGCGCCCTACGCTCATGAGTGAGTGCAAAATAACTTAACAACTTCATTT
TTAATTTATAGGTAAAGACT

Downstream 100 bases:

>100_bases
ATATAAGCATTTAAATAAAAACCGCTGTGGGTTAACAATAAAGTTGTTACCTACACAATATAGTTGTTAACTTTACAATT
TAGTTGTTAATTATTGCCAT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVIHNGELNRTRRVGKVQELSAALETDPLAGGTGIAHTRWATHGEP
SERNAHPHLSEGDIAVVHNGIIENHNKLREMLKGLGYKFSSDTDTEVICHLVHHELKTNSTLLSAVQATVKQLEGAYGTV
VIDRRDSERLVVARSGSPLVIGFGLGENFVASDQLALLPVTRSFAFLEEGDVAEVTRRSVSIFDLNGNAVEREVKESEIT
HDAGDKGEYRHYMLKEIYEQPLALTRTIEGRIANKQVLDTAFGDNAAEFLKDIKHVQIIACGTSYHAGMAARYWLEDWAG
VSCNVEIASEFRYRKSHLFPNSLLVTISQSGETADTLAAMRLAKEMGYKATLTICNAPGSSLVRESDMAYMMKAGAEIGV
ASTKAFTVQLAGLLMLTAVIGRHNGMSDQMQAQITQSLQSMPAKVEQALGLDAAIAELAEDFADKHHALFLGRGDQYPIA
MEGALKLKEISYIHAEAYASGELKHGPLALIDADMPVIVVAPNNELLEKLKSNVEEVRARGGLMYVFADVDAEFESDDTM
KVIPVPHCDIFMAPLIYTIPLQLLSYHVALIKGTDVDQPRNLAKSVTVE

Sequences:

>Translated_609_residues
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVIHNGELNRTRRVGKVQELSAALETDPLAGGTGIAHTRWATHGEP
SERNAHPHLSEGDIAVVHNGIIENHNKLREMLKGLGYKFSSDTDTEVICHLVHHELKTNSTLLSAVQATVKQLEGAYGTV
VIDRRDSERLVVARSGSPLVIGFGLGENFVASDQLALLPVTRSFAFLEEGDVAEVTRRSVSIFDLNGNAVEREVKESEIT
HDAGDKGEYRHYMLKEIYEQPLALTRTIEGRIANKQVLDTAFGDNAAEFLKDIKHVQIIACGTSYHAGMAARYWLEDWAG
VSCNVEIASEFRYRKSHLFPNSLLVTISQSGETADTLAAMRLAKEMGYKATLTICNAPGSSLVRESDMAYMMKAGAEIGV
ASTKAFTVQLAGLLMLTAVIGRHNGMSDQMQAQITQSLQSMPAKVEQALGLDAAIAELAEDFADKHHALFLGRGDQYPIA
MEGALKLKEISYIHAEAYASGELKHGPLALIDADMPVIVVAPNNELLEKLKSNVEEVRARGGLMYVFADVDAEFESDDTM
KVIPVPHCDIFMAPLIYTIPLQLLSYHVALIKGTDVDQPRNLAKSVTVE
>Mature_609_residues
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVIHNGELNRTRRVGKVQELSAALETDPLAGGTGIAHTRWATHGEP
SERNAHPHLSEGDIAVVHNGIIENHNKLREMLKGLGYKFSSDTDTEVICHLVHHELKTNSTLLSAVQATVKQLEGAYGTV
VIDRRDSERLVVARSGSPLVIGFGLGENFVASDQLALLPVTRSFAFLEEGDVAEVTRRSVSIFDLNGNAVEREVKESEIT
HDAGDKGEYRHYMLKEIYEQPLALTRTIEGRIANKQVLDTAFGDNAAEFLKDIKHVQIIACGTSYHAGMAARYWLEDWAG
VSCNVEIASEFRYRKSHLFPNSLLVTISQSGETADTLAAMRLAKEMGYKATLTICNAPGSSLVRESDMAYMMKAGAEIGV
ASTKAFTVQLAGLLMLTAVIGRHNGMSDQMQAQITQSLQSMPAKVEQALGLDAAIAELAEDFADKHHALFLGRGDQYPIA
MEGALKLKEISYIHAEAYASGELKHGPLALIDADMPVIVVAPNNELLEKLKSNVEEVRARGGLMYVFADVDAEFESDDTM
KVIPVPHCDIFMAPLIYTIPLQLLSYHVALIKGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=684, Percent_Identity=36.5497076023392, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI205277386, Length=693, Percent_Identity=36.3636363636364, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI29570798, Length=267, Percent_Identity=26.2172284644195, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1790167, Length=610, Percent_Identity=69.344262295082, Blast_Score=865, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=232, Percent_Identity=28.8793103448276, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17539970, Length=432, Percent_Identity=39.5833333333333, Blast_Score=281, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17532897, Length=432, Percent_Identity=39.3518518518519, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17532899, Length=432, Percent_Identity=39.3518518518519, Blast_Score=280, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6322745, Length=722, Percent_Identity=36.1495844875346, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6323731, Length=432, Percent_Identity=30.5555555555556, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6323730, Length=204, Percent_Identity=37.7450980392157, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323958, Length=174, Percent_Identity=28.735632183908, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21357745, Length=687, Percent_Identity=36.098981077147, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI28573187, Length=140, Percent_Identity=33.5714285714286, Blast_Score=71, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66448; Mature: 66448

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVIHNGELNRTRRVGKVQELSAALET
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHCHHHHHHHHHCC
DPLAGGTGIAHTRWATHGEPSERNAHPHLSEGDIAVVHNGIIENHNKLREMLKGLGYKFS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHCHHHHHHHHHHCCCCCC
SDTDTEVICHLVHHELKTNSTLLSAVQATVKQLEGAYGTVVIDRRDSERLVVARSGSPLV
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCEE
IGFGLGENFVASDQLALLPVTRSFAFLEEGDVAEVTRRSVSIFDLNGNAVEREVKESEIT
EEECCCCCCCCCCCEEEEEEHHHHHHHCCCCHHHHHHCEEEEEECCCCHHHHHHHHHHCC
HDAGDKGEYRHYMLKEIYEQPLALTRTIEGRIANKQVLDTAFGDNAAEFLKDIKHVQIIA
CCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHCCEEEEEE
CGTSYHAGMAARYWLEDWAGVSCNVEIASEFRYRKSHLFPNSLLVTISQSGETADTLAAM
ECCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHH
RLAKEMGYKATLTICNAPGSSLVRESDMAYMMKAGAEIGVASTKAFTVQLAGLLMLTAVI
HHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
GRHNGMSDQMQAQITQSLQSMPAKVEQALGLDAAIAELAEDFADKHHALFLGRGDQYPIA
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCEE
MEGALKLKEISYIHAEAYASGELKHGPLALIDADMPVIVVAPNNELLEKLKSNVEEVRAR
ECCCEEEHHHHEEEHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
GGLMYVFADVDAEFESDDTMKVIPVPHCDIFMAPLIYTIPLQLLSYHVALIKGTDVDQPR
CCEEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCH
NLAKSVTVE
HHHHHCCCC
>Mature Secondary Structure
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVIHNGELNRTRRVGKVQELSAALET
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHCHHHHHHHHHCC
DPLAGGTGIAHTRWATHGEPSERNAHPHLSEGDIAVVHNGIIENHNKLREMLKGLGYKFS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHCHHHHHHHHHHCCCCCC
SDTDTEVICHLVHHELKTNSTLLSAVQATVKQLEGAYGTVVIDRRDSERLVVARSGSPLV
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCEE
IGFGLGENFVASDQLALLPVTRSFAFLEEGDVAEVTRRSVSIFDLNGNAVEREVKESEIT
EEECCCCCCCCCCCEEEEEEHHHHHHHCCCCHHHHHHCEEEEEECCCCHHHHHHHHHHCC
HDAGDKGEYRHYMLKEIYEQPLALTRTIEGRIANKQVLDTAFGDNAAEFLKDIKHVQIIA
CCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHCCEEEEEE
CGTSYHAGMAARYWLEDWAGVSCNVEIASEFRYRKSHLFPNSLLVTISQSGETADTLAAM
ECCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHH
RLAKEMGYKATLTICNAPGSSLVRESDMAYMMKAGAEIGVASTKAFTVQLAGLLMLTAVI
HHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
GRHNGMSDQMQAQITQSLQSMPAKVEQALGLDAAIAELAEDFADKHHALFLGRGDQYPIA
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCEE
MEGALKLKEISYIHAEAYASGELKHGPLALIDADMPVIVVAPNNELLEKLKSNVEEVRAR
ECCCEEEHHHHEEEHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
GGLMYVFADVDAEFESDDTMKVIPVPHCDIFMAPLIYTIPLQLLSYHVALIKGTDVDQPR
CCEEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCH
NLAKSVTVE
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]