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The map label for this gene is fadD [C]

Identifier: 126176459

GI number: 126176459

Start: 5001788

End: 5003593

Strand: Reverse

Name: fadD [C]

Synonym: Sbal_4274

Alternate gene names: 126176459

Gene position: 5003593-5001788 (Counterclockwise)

Preceding gene: 126176460

Following gene: 126176458

Centisome position: 97.59

GC content: 49.45

Gene sequence:

>1806_bases
ATGTCTCTCGATCAATATCATGTTATTCGACTATTACAGCAGCAGAGCGAGTCTTTAAAAGACGCGATAGCGCTGGAAGG
TTTTGAAATGGCCGCTCCTTGGTATCAGGTGAGCTGGCAAGCCTTTGACCAAATTAGCAGTAAAATTGCACAAGTGTTGA
TCGAACTTGGCGTACAAGTGCAAGACCGTTGCGTTATTTTGGCGCAAAACTGCCCACAGTGGACCTGTGCCGATGTCGGT
ACACTTAAAAGTCGCGCCGTTGTGGTGCCGATTTACCCCACCAGTACCCTCGAACAGGCGAGCTTTATCGTTAACGATGC
GGCGGCGAAAGTCATTTTTGTCGACGATGCTAAGCAATACGCTATGGCCTGCGAGCTTCAAAGCTTATGCCCAAGCCTAG
AGCATGTGATTGTTTTTGATGCCAGCGTGGCACTTGCCGCTGACAAAGCTGAGCAGCATTGGCATTTAGATGCGCTGCTA
GCGGGTGATGCTAAAGCGATTAAGCAAGAAGTTGAGCTTAACCAGCGTTTACAAGCGGCTAATCTCGATGATTTACTGAC
CCTCATTTATACCTCTGGCACGACTGGCGATCCTAAAGGCGTGATGCTGGATTACCGCAATATGGCCTCGACCATACGTC
AACACGATCAAAAACTGGCTTTCCATTCTGGCGATGTGTCTTTGGCATTCTTGCCCTTGAGCCATGTCTTTGAGCGCAGT
TGGAGTTTTTACGTTCTGTGCCGTGGCGGTCATAACGTCTATTTGCAAAATACCCAAAGAGTGAAAGAGGCGATTAGCGC
CGTGCGTCCGCACACCTTGTGTGTGGTGCCGCGTTTCCTCGAAAAAGTGTACAGCGCCGTACAAGATAAAGTCGCCAAGT
CAGCCGATGGCCGTAAGAAGTTGTTTGCTTGGGCGATGCGTGTTGGTCAACGTCAGTTCGAAGTCGGTCAAGGTCGTGCT
AAGGGCGGATTATGGTTGTCGCTGCAATGGCGTTTGGCCCACAAACTTGTGTATAGCAAGCTGCAAGCCGTGCTTGGCGG
GCGGTTGAAGTTTATGCCCTGCGGTGGCGCGGCGTTAGATGTGAATGTCGGTAGCTTCTTCCATGCGATTAATATTCCTG
TGCTGTGTGGTTACGGTATGACGGAAACCAACGCGACCGTGACCTGCAATACCTTAGGTAATCGAGTGCCAGGTTCTAAT
GGTCAACCTCTGCTGGAAACCGAAATCAAGCTAGGCAAGGACGATGAGATTTTAGTCCGCGGCGCGACTGTGATGCGTGG
CTATTACAATCGACCAGAAGATACCGCCGCCGCCTTCGAAGACGGTTGGTTAAAAACCGGCGATGCAGGGCGTTTCGATG
CGAACGGTAACTTATTTATTACCGACCGTATCAAAGAGTTAATGAAAACCTCTAACGGCAAATATATCGCGCCGCAACGG
GTTGAGGGTGCAGTGGGCTGTTGTCCTTTTATCGAACAAGTGGCGATTATTGCCGATGCGCGTAATTATGTGACCGCTTT
AATTGTGCCAGCGTTTGAATCACTGGAAGCGTGGGCGAAGGACAAAGGGCTGAAGTATGAGTCGCCTTTAGAATTGCTAC
GCCATAGTCATGTGGTTGAGCATTTTGAACAACGTCTCAAGCAGTTGCAGCATGAATTGGCGGGTTTTGAACAGATCAAA
AAGTTCACGCTGTTGCCAGAAGTCTTCTCGATGGAAGCGGGTTTAATCACCCCAACGCTCAAGCTGCGCCGTAAGATGAT
TTATCATAAATACGCCCACGAAATTAATGCTATGTACAACAGCTGA

Upstream 100 bases:

>100_bases
AGCTTGCACAAGATTAGAGCAAAAACTCTTAGTTTTTGACTGGCCTTCAGGTAGAATGGCCAAAAAGCGGTACACTTGTA
AGCTAAAAGGTGAGTCTCTT

Downstream 100 bases:

>100_bases
TTGTTAAGCCGTTGTTACTAAAGGCCGCTGTTGCGGCCTTTTTTGTTTCTGCTACTTCCTGAAGCGCTTAACTTAGCTTA
AAATTCGCTCCGTTTACTGG

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 601; Mature: 600

Protein sequence:

>601_residues
MSLDQYHVIRLLQQQSESLKDAIALEGFEMAAPWYQVSWQAFDQISSKIAQVLIELGVQVQDRCVILAQNCPQWTCADVG
TLKSRAVVVPIYPTSTLEQASFIVNDAAAKVIFVDDAKQYAMACELQSLCPSLEHVIVFDASVALAADKAEQHWHLDALL
AGDAKAIKQEVELNQRLQAANLDDLLTLIYTSGTTGDPKGVMLDYRNMASTIRQHDQKLAFHSGDVSLAFLPLSHVFERS
WSFYVLCRGGHNVYLQNTQRVKEAISAVRPHTLCVVPRFLEKVYSAVQDKVAKSADGRKKLFAWAMRVGQRQFEVGQGRA
KGGLWLSLQWRLAHKLVYSKLQAVLGGRLKFMPCGGAALDVNVGSFFHAINIPVLCGYGMTETNATVTCNTLGNRVPGSN
GQPLLETEIKLGKDDEILVRGATVMRGYYNRPEDTAAAFEDGWLKTGDAGRFDANGNLFITDRIKELMKTSNGKYIAPQR
VEGAVGCCPFIEQVAIIADARNYVTALIVPAFESLEAWAKDKGLKYESPLELLRHSHVVEHFEQRLKQLQHELAGFEQIK
KFTLLPEVFSMEAGLITPTLKLRRKMIYHKYAHEINAMYNS

Sequences:

>Translated_601_residues
MSLDQYHVIRLLQQQSESLKDAIALEGFEMAAPWYQVSWQAFDQISSKIAQVLIELGVQVQDRCVILAQNCPQWTCADVG
TLKSRAVVVPIYPTSTLEQASFIVNDAAAKVIFVDDAKQYAMACELQSLCPSLEHVIVFDASVALAADKAEQHWHLDALL
AGDAKAIKQEVELNQRLQAANLDDLLTLIYTSGTTGDPKGVMLDYRNMASTIRQHDQKLAFHSGDVSLAFLPLSHVFERS
WSFYVLCRGGHNVYLQNTQRVKEAISAVRPHTLCVVPRFLEKVYSAVQDKVAKSADGRKKLFAWAMRVGQRQFEVGQGRA
KGGLWLSLQWRLAHKLVYSKLQAVLGGRLKFMPCGGAALDVNVGSFFHAINIPVLCGYGMTETNATVTCNTLGNRVPGSN
GQPLLETEIKLGKDDEILVRGATVMRGYYNRPEDTAAAFEDGWLKTGDAGRFDANGNLFITDRIKELMKTSNGKYIAPQR
VEGAVGCCPFIEQVAIIADARNYVTALIVPAFESLEAWAKDKGLKYESPLELLRHSHVVEHFEQRLKQLQHELAGFEQIK
KFTLLPEVFSMEAGLITPTLKLRRKMIYHKYAHEINAMYNS
>Mature_600_residues
SLDQYHVIRLLQQQSESLKDAIALEGFEMAAPWYQVSWQAFDQISSKIAQVLIELGVQVQDRCVILAQNCPQWTCADVGT
LKSRAVVVPIYPTSTLEQASFIVNDAAAKVIFVDDAKQYAMACELQSLCPSLEHVIVFDASVALAADKAEQHWHLDALLA
GDAKAIKQEVELNQRLQAANLDDLLTLIYTSGTTGDPKGVMLDYRNMASTIRQHDQKLAFHSGDVSLAFLPLSHVFERSW
SFYVLCRGGHNVYLQNTQRVKEAISAVRPHTLCVVPRFLEKVYSAVQDKVAKSADGRKKLFAWAMRVGQRQFEVGQGRAK
GGLWLSLQWRLAHKLVYSKLQAVLGGRLKFMPCGGAALDVNVGSFFHAINIPVLCGYGMTETNATVTCNTLGNRVPGSNG
QPLLETEIKLGKDDEILVRGATVMRGYYNRPEDTAAAFEDGWLKTGDAGRFDANGNLFITDRIKELMKTSNGKYIAPQRV
EGAVGCCPFIEQVAIIADARNYVTALIVPAFESLEAWAKDKGLKYESPLELLRHSHVVEHFEQRLKQLQHELAGFEQIKK
FTLLPEVFSMEAGLITPTLKLRRKMIYHKYAHEINAMYNS

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI40807491, Length=596, Percent_Identity=29.3624161073826, Blast_Score=250, Evalue=3e-66,
Organism=Homo sapiens, GI42794760, Length=590, Percent_Identity=29.3220338983051, Blast_Score=228, Evalue=2e-59,
Organism=Homo sapiens, GI42794758, Length=590, Percent_Identity=29.3220338983051, Blast_Score=228, Evalue=2e-59,
Organism=Homo sapiens, GI42794756, Length=590, Percent_Identity=29.3220338983051, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI27477105, Length=631, Percent_Identity=28.2091917591125, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI57165412, Length=560, Percent_Identity=29.1071428571429, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI57165410, Length=560, Percent_Identity=28.5714285714286, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI42794754, Length=604, Percent_Identity=27.4834437086093, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI42794752, Length=604, Percent_Identity=27.4834437086093, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI83745141, Length=599, Percent_Identity=26.0434056761269, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI12669909, Length=603, Percent_Identity=25.8706467661692, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI4758332, Length=603, Percent_Identity=25.8706467661692, Blast_Score=177, Evalue=2e-44,
Organism=Escherichia coli, GI1788107, Length=516, Percent_Identity=25.1937984496124, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI1788595, Length=210, Percent_Identity=30, Blast_Score=76, Evalue=8e-15,
Organism=Escherichia coli, GI145693145, Length=163, Percent_Identity=30.6748466257669, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI221142682, Length=200, Percent_Identity=25, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17556552, Length=561, Percent_Identity=29.9465240641711, Blast_Score=233, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17510401, Length=590, Percent_Identity=30.5084745762712, Blast_Score=224, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI17541856, Length=596, Percent_Identity=29.0268456375839, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI25147511, Length=597, Percent_Identity=26.465661641541, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI17564090, Length=539, Percent_Identity=28.3858998144712, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17553312, Length=606, Percent_Identity=24.9174917491749, Blast_Score=197, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI193204819, Length=630, Percent_Identity=27.4603174603175, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI32563687, Length=335, Percent_Identity=25.0746268656716, Blast_Score=96, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17531443, Length=473, Percent_Identity=23.8900634249471, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17559526, Length=134, Percent_Identity=40.2985074626866, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17558820, Length=213, Percent_Identity=30.0469483568075, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI133901848, Length=212, Percent_Identity=28.3018867924528, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17560140, Length=132, Percent_Identity=32.5757575757576, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6324893, Length=652, Percent_Identity=25.1533742331288, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6320852, Length=590, Percent_Identity=24.0677966101695, Blast_Score=161, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6322182, Length=452, Percent_Identity=28.0973451327434, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323903, Length=623, Percent_Identity=25.2006420545746, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319699, Length=144, Percent_Identity=36.1111111111111, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281366413, Length=595, Percent_Identity=29.7478991596639, Blast_Score=248, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24666501, Length=589, Percent_Identity=30.2207130730051, Blast_Score=248, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24666497, Length=589, Percent_Identity=30.2207130730051, Blast_Score=248, Evalue=1e-65,
Organism=Drosophila melanogaster, GI17933690, Length=624, Percent_Identity=24.3589743589744, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI62471681, Length=623, Percent_Identity=27.76886035313, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI62471687, Length=623, Percent_Identity=27.76886035313, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24586634, Length=623, Percent_Identity=27.76886035313, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI22026970, Length=623, Percent_Identity=27.76886035313, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI62471689, Length=623, Percent_Identity=27.76886035313, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI62471679, Length=623, Percent_Identity=27.76886035313, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI62471683, Length=623, Percent_Identity=27.76886035313, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI62471685, Length=623, Percent_Identity=27.76886035313, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24586636, Length=623, Percent_Identity=27.76886035313, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI19921316, Length=627, Percent_Identity=26.4752791068581, Blast_Score=193, Evalue=3e-49,
Organism=Drosophila melanogaster, GI18859661, Length=464, Percent_Identity=25, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI20130357, Length=139, Percent_Identity=34.5323741007194, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 66997; Mature: 66866

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDQYHVIRLLQQQSESLKDAIALEGFEMAAPWYQVSWQAFDQISSKIAQVLIELGVQV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
QDRCVILAQNCPQWTCADVGTLKSRAVVVPIYPTSTLEQASFIVNDAAAKVIFVDDAKQY
CCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHEECCCEEEEEEECCHHH
AMACELQSLCPSLEHVIVFDASVALAADKAEQHWHLDALLAGDAKAIKQEVELNQRLQAA
HHHHHHHHHCCCCCEEEEEECHHEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHC
NLDDLLTLIYTSGTTGDPKGVMLDYRNMASTIRQHDQKLAFHSGDVSLAFLPLSHVFERS
CHHHHHHHHEECCCCCCCCCEEEEHHHHHHHHHHHHHHHEEECCCCEEEEECHHHHHHCC
WSFYVLCRGGHNVYLQNTQRVKEAISAVRPHTLCVVPRFLEKVYSAVQDKVAKSADGRKK
CCEEEEEECCCEEEECCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHH
LFAWAMRVGQRQFEVGQGRAKGGLWLSLQWRLAHKLVYSKLQAVLGGRLKFMPCGGAALD
HHHHHHHHCCHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEE
VNVGSFFHAINIPVLCGYGMTETNATVTCNTLGNRVPGSNGQPLLETEIKLGKDDEILVR
ECHHHHHHHCCCCEEECCCCCCCCCEEEEECCCCCCCCCCCCCEEEHHCCCCCCCCEEEE
GATVMRGYYNRPEDTAAAFEDGWLKTGDAGRFDANGNLFITDRIKELMKTSNGKYIAPQR
CHHHHHCCCCCCCHHHHHHHCCCEECCCCCCCCCCCCEEEHHHHHHHHHCCCCCEECCHH
VEGAVGCCPFIEQVAIIADARNYVTALIVPAFESLEAWAKDKGLKYESPLELLRHSHVVE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
HFEQRLKQLQHELAGFEQIKKFTLLPEVFSMEAGLITPTLKLRRKMIYHKYAHEINAMYN
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
S
C
>Mature Secondary Structure 
SLDQYHVIRLLQQQSESLKDAIALEGFEMAAPWYQVSWQAFDQISSKIAQVLIELGVQV
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
QDRCVILAQNCPQWTCADVGTLKSRAVVVPIYPTSTLEQASFIVNDAAAKVIFVDDAKQY
CCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHEECCCEEEEEEECCHHH
AMACELQSLCPSLEHVIVFDASVALAADKAEQHWHLDALLAGDAKAIKQEVELNQRLQAA
HHHHHHHHHCCCCCEEEEEECHHEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHC
NLDDLLTLIYTSGTTGDPKGVMLDYRNMASTIRQHDQKLAFHSGDVSLAFLPLSHVFERS
CHHHHHHHHEECCCCCCCCCEEEEHHHHHHHHHHHHHHHEEECCCCEEEEECHHHHHHCC
WSFYVLCRGGHNVYLQNTQRVKEAISAVRPHTLCVVPRFLEKVYSAVQDKVAKSADGRKK
CCEEEEEECCCEEEECCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHH
LFAWAMRVGQRQFEVGQGRAKGGLWLSLQWRLAHKLVYSKLQAVLGGRLKFMPCGGAALD
HHHHHHHHCCHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEE
VNVGSFFHAINIPVLCGYGMTETNATVTCNTLGNRVPGSNGQPLLETEIKLGKDDEILVR
ECHHHHHHHCCCCEEECCCCCCCCCEEEEECCCCCCCCCCCCCEEEHHCCCCCCCCEEEE
GATVMRGYYNRPEDTAAAFEDGWLKTGDAGRFDANGNLFITDRIKELMKTSNGKYIAPQR
CHHHHHCCCCCCCHHHHHHHCCCEECCCCCCCCCCCCEEEHHHHHHHHHCCCCCEECCHH
VEGAVGCCPFIEQVAIIADARNYVTALIVPAFESLEAWAKDKGLKYESPLELLRHSHVVE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
HFEQRLKQLQHELAGFEQIKKFTLLPEVFSMEAGLITPTLKLRRKMIYHKYAHEINAMYN
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]