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The map label for this gene is hutH [H]

Identifier: 126176436

GI number: 126176436

Start: 4976867

End: 4978408

Strand: Reverse

Name: hutH [H]

Synonym: Sbal_4251

Alternate gene names: 126176436

Gene position: 4978408-4976867 (Counterclockwise)

Preceding gene: 126176437

Following gene: 126176435

Centisome position: 97.09

GC content: 52.01

Gene sequence:

>1542_bases
ATGAAATCTGTGAATCACTTAGTGTTAACGCCGGGCAGCTTGAGCCTAGCGCAATTGCGCGAAATCAGCCGCCATAAGCT
AACACTCGAACTCGCGCCAGAGGCCATTACCGACATCAACACCAGTGCGCAAATCGTGCAAAAAGTGCTGGATGAAGGCC
GTACCGTTTACGGCATCAACACGGGTTTTGGCTTGTTGGCCAATACCAAGATAGCGCCCGAAGATCTGCAATTGCTGCAA
CGCTCAATCGTGTTGTCGCACGCCGCTGGCACGGGCCAATACATGCAAGACGCCACAGTGCGCTTGATGATGGTGTTAAA
AATCAATTCATTAAGCCGTGGCTTCTCGGGCATTCGTTTAGAAGTGATTAACTTCTTAATCAGTTTAGTGAACGCCGAAG
TCTATCCCTGCGTGCCAGAAAAAGGCTCAGTGGGCGCATCGGGCGATTTAGCGCCACTGGCGCACATGTGTCTGCCTATG
CTGGGCGAAGGCGAGATGAGCTATCGAGGTGAGTTAATTTCTGCCGCCGAAGGTTTAGAAATCGCCGGCCTTAAGCCAAT
CGATTTAGCGGCTAAAGAAGGGCTCGCTTTGCTTAACGGCACACAAGCCTCGACTGCGCTAGCGCTGGAAGGGTTATTCC
ACGCCGAAGACTTGTTCGCAGCAAGTTCAGTGATCGGCGCCATGAGCGTCGAAGCGGCGATGGGCAGTCGTAGCCCGTTC
GATCCACGTATCCATGCGGCCCGTGGTCAGAAAGGTCAAATCGATTCGGCCATGATTTTCCGTCATCTATTGGGCGAAGA
GTCTGAGATCAGCGTGAGCCATGCAAACTGTGAAAAGGTGCAAGATCCTTACTCACTGCGCTGTCAGCCACAGGTGTTGG
GTGCTTGTTTAACGCAAATTCGCCATGCGGCCGATGTGTTAGGCACTGAAGCTAATGGCGTAACCGATAACCCACTGGTG
TTCCAAGACACTGGCGATATCATTTCAGGCGGTAACTTCCACGCTGAACCTGTGGCTATGGCGGCGGATAATCTGGCGAT
TGCGATTGCCGAGCTGGGTTCTATTGCCGAGCGTCGTATTGCACTGTTAATCGATTCTAGCCTGTCGAAACTGCCGCCTT
TCCTAGTGAAAAACGGCGGCGTGAACTCAGGCTTTATGATCGCTCAAGTAACAGCGGCGGCATTGGCGTCTGAGAACAAA
ACCTACGCCCATCCAGCGTCGGTAGACAGTTTACCAACATCGGCTAACCAAGAAGATCACGTCTCTATGGCGACTTTTGC
GGCCCGTCGTTTACGCGATATGAGTGAAAACACTCGTGGTGTACTGGCAATTGAATTGTTAGCGGCGGCGCAGGGTTTAG
ATTTTCGCGCACCTTTAGCGCCAAGTACTGCGGTGGCTAAGGCCAAAACTGAATTGCGTGAAGTCGTCGCCTATTACGAT
AAAGACAGGTACTTCGCACCAGATATCGAAGCCGCGACAGACCTGTTATATACAGCGAGTTTTAACGCTTACCTGCCAGC
AGGAACGCTAGTGAGCTTTTAA

Upstream 100 bases:

>100_bases
AAACTGCGCCAAAGAGCAGGGGCTCGACTTACCTATGCAAGAGTAGCCGATGCTAACTTCTTAAAATAACAATAATAACT
AAAAGCTTGGAGCTAAAAAT

Downstream 100 bases:

>100_bases
GGAGCATTATTTTAAACTCGCTTAAGCACTGACTGTGTAAAAAAAGGCACAAATCCTTGGTTTTGTGCCTTTTTTAATAC
CTAATTTTTGAGTTGAGCCT

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MKSVNHLVLTPGSLSLAQLREISRHKLTLELAPEAITDINTSAQIVQKVLDEGRTVYGINTGFGLLANTKIAPEDLQLLQ
RSIVLSHAAGTGQYMQDATVRLMMVLKINSLSRGFSGIRLEVINFLISLVNAEVYPCVPEKGSVGASGDLAPLAHMCLPM
LGEGEMSYRGELISAAEGLEIAGLKPIDLAAKEGLALLNGTQASTALALEGLFHAEDLFAASSVIGAMSVEAAMGSRSPF
DPRIHAARGQKGQIDSAMIFRHLLGEESEISVSHANCEKVQDPYSLRCQPQVLGACLTQIRHAADVLGTEANGVTDNPLV
FQDTGDIISGGNFHAEPVAMAADNLAIAIAELGSIAERRIALLIDSSLSKLPPFLVKNGGVNSGFMIAQVTAAALASENK
TYAHPASVDSLPTSANQEDHVSMATFAARRLRDMSENTRGVLAIELLAAAQGLDFRAPLAPSTAVAKAKTELREVVAYYD
KDRYFAPDIEAATDLLYTASFNAYLPAGTLVSF

Sequences:

>Translated_513_residues
MKSVNHLVLTPGSLSLAQLREISRHKLTLELAPEAITDINTSAQIVQKVLDEGRTVYGINTGFGLLANTKIAPEDLQLLQ
RSIVLSHAAGTGQYMQDATVRLMMVLKINSLSRGFSGIRLEVINFLISLVNAEVYPCVPEKGSVGASGDLAPLAHMCLPM
LGEGEMSYRGELISAAEGLEIAGLKPIDLAAKEGLALLNGTQASTALALEGLFHAEDLFAASSVIGAMSVEAAMGSRSPF
DPRIHAARGQKGQIDSAMIFRHLLGEESEISVSHANCEKVQDPYSLRCQPQVLGACLTQIRHAADVLGTEANGVTDNPLV
FQDTGDIISGGNFHAEPVAMAADNLAIAIAELGSIAERRIALLIDSSLSKLPPFLVKNGGVNSGFMIAQVTAAALASENK
TYAHPASVDSLPTSANQEDHVSMATFAARRLRDMSENTRGVLAIELLAAAQGLDFRAPLAPSTAVAKAKTELREVVAYYD
KDRYFAPDIEAATDLLYTASFNAYLPAGTLVSF
>Mature_513_residues
MKSVNHLVLTPGSLSLAQLREISRHKLTLELAPEAITDINTSAQIVQKVLDEGRTVYGINTGFGLLANTKIAPEDLQLLQ
RSIVLSHAAGTGQYMQDATVRLMMVLKINSLSRGFSGIRLEVINFLISLVNAEVYPCVPEKGSVGASGDLAPLAHMCLPM
LGEGEMSYRGELISAAEGLEIAGLKPIDLAAKEGLALLNGTQASTALALEGLFHAEDLFAASSVIGAMSVEAAMGSRSPF
DPRIHAARGQKGQIDSAMIFRHLLGEESEISVSHANCEKVQDPYSLRCQPQVLGACLTQIRHAADVLGTEANGVTDNPLV
FQDTGDIISGGNFHAEPVAMAADNLAIAIAELGSIAERRIALLIDSSLSKLPPFLVKNGGVNSGFMIAQVTAAALASENK
TYAHPASVDSLPTSANQEDHVSMATFAARRLRDMSENTRGVLAIELLAAAQGLDFRAPLAPSTAVAKAKTELREVVAYYD
KDRYFAPDIEAATDLLYTASFNAYLPAGTLVSF

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=487, Percent_Identity=47.2279260780287, Blast_Score=427, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17567831, Length=505, Percent_Identity=42.970297029703, Blast_Score=377, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 54394; Mature: 54394

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVNHLVLTPGSLSLAQLREISRHKLTLELAPEAITDINTSAQIVQKVLDEGRTVYGIN
CCCCCEEEECCCCCCHHHHHHHHHHEEEEEECCHHHHCCCCHHHHHHHHHHCCCEEEEEC
TGFGLLANTKIAPEDLQLLQRSIVLSHAAGTGQYMQDATVRLMMVLKINSLSRGFSGIRL
CCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEEEEEHHHHHCCCCCHHH
EVINFLISLVNAEVYPCVPEKGSVGASGDLAPLAHMCLPMLGEGEMSYRGELISAAEGLE
HHHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCE
IAGLKPIDLAAKEGLALLNGTQASTALALEGLFHAEDLFAASSVIGAMSVEAAMGSRSPF
ECCCCCHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DPRIHAARGQKGQIDSAMIFRHLLGEESEISVSHANCEKVQDPYSLRCQPQVLGACLTQI
CCCEECCCCCCCCCHHHHHHHHHHCCCCCEEEECCCHHHCCCCCCCCCCHHHHHHHHHHH
RHAADVLGTEANGVTDNPLVFQDTGDIISGGNFHAEPVAMAADNLAIAIAELGSIAERRI
HHHHHHHCCCCCCCCCCCEEEECCCCEECCCCCCCCCHHEECCCCEEEHHHHHHHHHHHE
ALLIDSSLSKLPPFLVKNGGVNSGFMIAQVTAAALASENKTYAHPASVDSLPTSANQEDH
EEEEECHHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHH
VSMATFAARRLRDMSENTRGVLAIELLAAAQGLDFRAPLAPSTAVAKAKTELREVVAYYD
HHHHHHHHHHHHHHCCCCCCEEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
KDRYFAPDIEAATDLLYTASFNAYLPAGTLVSF
CCCCCCCCHHHHHHHHEEECCCCCCCCCHHCCC
>Mature Secondary Structure
MKSVNHLVLTPGSLSLAQLREISRHKLTLELAPEAITDINTSAQIVQKVLDEGRTVYGIN
CCCCCEEEECCCCCCHHHHHHHHHHEEEEEECCHHHHCCCCHHHHHHHHHHCCCEEEEEC
TGFGLLANTKIAPEDLQLLQRSIVLSHAAGTGQYMQDATVRLMMVLKINSLSRGFSGIRL
CCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEEEEEHHHHHCCCCCHHH
EVINFLISLVNAEVYPCVPEKGSVGASGDLAPLAHMCLPMLGEGEMSYRGELISAAEGLE
HHHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCE
IAGLKPIDLAAKEGLALLNGTQASTALALEGLFHAEDLFAASSVIGAMSVEAAMGSRSPF
ECCCCCHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DPRIHAARGQKGQIDSAMIFRHLLGEESEISVSHANCEKVQDPYSLRCQPQVLGACLTQI
CCCEECCCCCCCCCHHHHHHHHHHCCCCCEEEECCCHHHCCCCCCCCCCHHHHHHHHHHH
RHAADVLGTEANGVTDNPLVFQDTGDIISGGNFHAEPVAMAADNLAIAIAELGSIAERRI
HHHHHHHCCCCCCCCCCCEEEECCCCEECCCCCCCCCHHEECCCCEEEHHHHHHHHHHHE
ALLIDSSLSKLPPFLVKNGGVNSGFMIAQVTAAALASENKTYAHPASVDSLPTSANQEDH
EEEEECHHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHH
VSMATFAARRLRDMSENTRGVLAIELLAAAQGLDFRAPLAPSTAVAKAKTELREVVAYYD
HHHHHHHHHHHHHHCCCCCCEEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
KDRYFAPDIEAATDLLYTASFNAYLPAGTLVSF
CCCCCCCCHHHHHHHHEEECCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]