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The map label for this gene is ilvC [H]

Identifier: 126176218

GI number: 126176218

Start: 4733544

End: 4735022

Strand: Reverse

Name: ilvC [H]

Synonym: Sbal_4032

Alternate gene names: 126176218

Gene position: 4735022-4733544 (Counterclockwise)

Preceding gene: 126176220

Following gene: 126176217

Centisome position: 92.35

GC content: 48.55

Gene sequence:

>1479_bases
ATGGCTAACTATTTTAACTCTCTGAATTTACGTCAACAATTAGCACAGCTTGGCCAATGTCGTTTCATGGATCGTTCTGA
GTTTAGCGACGGCTGTAACTACATCAAAGATTGGAATATTGTTATTTTAGGTTGTGGTGCTCAAGGTCTGAACCAAGGCT
TGAACATGCGTGATTCGGGCTTGAATATCTCTTTTGCCCTGCGCCCTGAAGCAATTGAACAGAAACGTGCCTCATGGCAA
AAAGCGACCGACAATGGTTTCCGTGTCGGTACGTTTGAAGAATTAATACCCGCGGCGGATCTGGTGCTTAACCTGACGCC
GGACAAACAGCATTCCAACGTGGTTAACGCGGTTATGCCATTGATGAAGCAAGGTTCTACCTTGTCTTACTCACACGGCT
TCAACATCGTTGAAGAGGGCATGCAAGTTCGTCCCGATATCACTGTGGTGATGGTTGCCCCTAAGTGCCCTGGCACTGAA
GTGCGTGAAGAATACAAACGTGGTTTTGGTGTACCAACCCTTATTGCGGTTCACCCAGAAAACGATCCAGACGGTGACGG
CTTAGAGATTGCGAAAGCCTACGCTAGCGCAACGGGTGGCGACAGAGCCGGTGTTCTACTGTCGTCTTTCATCGCCGAAG
TAAAGTCAGATCTAATGGGCGAGCAGACCATTCTGTGCGGTATGTTGCAGACGGGCGCCATCTTAGGTTACGAGAAAATG
ATCGCCGATGGCGTTGAGCCAGGTTATGCGGCCAAGCTTATCCAGCAAGGTTGGGAAACGGTCACTGAAGCGCTGAAACA
CGGCGGCATCACTAACATGATGGACCGTTTGTCTAATCCAGCCAAGATTAAAGCATTTGAAATTGCAGAAGATTTAAAAG
AAATCCTCCAGCCATTATTTGAAAAGCACATGGATGACATCATCAGCGGCGAATTCTCTCGCACTATGATGGAAGACTGG
GCGAACGATGATGCGAACTTACTGCGTTGGAGAGCGGAAACTGGCGAAACAGGTTTCGAAAATGCACCCGTATCGAGCGA
GCATATCGACGAACAGACTTATTTCGACAAAGGTATTTTCCTTGTCGCTATGATCAAAGCGGGTGTGGAACTGGCGTTCG
ACACTATGGTGTCTGCGGGTATCGTGGAAGAGTCGGCTTATTACGAGTCACTGCACGAAACCCCACTTATCGCTAATACG
ATTGCCCGTAAGCGTTTGTATGAGATGAACGTGGTGATTTCAGACACGGCCGAATACGGTTGCTACCTGTTCAATCACGC
CGCCGTACCTATGCTGCGCGACTACGTTAATGCCATGTCATCTGAGTATTTAGGTGCTGGCCTGAAAGACAGCGCAACCG
GTGTCGACAATCTAACGCTCATCGCAGTTAACGAAGCGATTCGTGAAACGGCGGTGGAATATGTTGGCGCTGAACTTCGC
GGTTACATGACTGATATGAAGAGCATTGTTGAGGCTTAA

Upstream 100 bases:

>100_bases
ATGATAAGCATGGGTTATAGTGATTTCAATCACAACCAAGCCGTAACATTATGTTAGTTTGGTTGCGTCCAAAATTTCTG
ACTTATAGGTGGTATATCAG

Downstream 100 bases:

>100_bases
TTGATAGTTAATTAAGCCCAACATTGGGGGAGAGGGTTGAGACTCAAAGGACTTGGGTCTCAACTCAGTTCCCAAGCAAC
CTCAGAGACTGAAACGCGCA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MANYFNSLNLRQQLAQLGQCRFMDRSEFSDGCNYIKDWNIVILGCGAQGLNQGLNMRDSGLNISFALRPEAIEQKRASWQ
KATDNGFRVGTFEELIPAADLVLNLTPDKQHSNVVNAVMPLMKQGSTLSYSHGFNIVEEGMQVRPDITVVMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPDGDGLEIAKAYASATGGDRAGVLLSSFIAEVKSDLMGEQTILCGMLQTGAILGYEKM
IADGVEPGYAAKLIQQGWETVTEALKHGGITNMMDRLSNPAKIKAFEIAEDLKEILQPLFEKHMDDIISGEFSRTMMEDW
ANDDANLLRWRAETGETGFENAPVSSEHIDEQTYFDKGIFLVAMIKAGVELAFDTMVSAGIVEESAYYESLHETPLIANT
IARKRLYEMNVVISDTAEYGCYLFNHAAVPMLRDYVNAMSSEYLGAGLKDSATGVDNLTLIAVNEAIRETAVEYVGAELR
GYMTDMKSIVEA

Sequences:

>Translated_492_residues
MANYFNSLNLRQQLAQLGQCRFMDRSEFSDGCNYIKDWNIVILGCGAQGLNQGLNMRDSGLNISFALRPEAIEQKRASWQ
KATDNGFRVGTFEELIPAADLVLNLTPDKQHSNVVNAVMPLMKQGSTLSYSHGFNIVEEGMQVRPDITVVMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPDGDGLEIAKAYASATGGDRAGVLLSSFIAEVKSDLMGEQTILCGMLQTGAILGYEKM
IADGVEPGYAAKLIQQGWETVTEALKHGGITNMMDRLSNPAKIKAFEIAEDLKEILQPLFEKHMDDIISGEFSRTMMEDW
ANDDANLLRWRAETGETGFENAPVSSEHIDEQTYFDKGIFLVAMIKAGVELAFDTMVSAGIVEESAYYESLHETPLIANT
IARKRLYEMNVVISDTAEYGCYLFNHAAVPMLRDYVNAMSSEYLGAGLKDSATGVDNLTLIAVNEAIRETAVEYVGAELR
GYMTDMKSIVEA
>Mature_491_residues
ANYFNSLNLRQQLAQLGQCRFMDRSEFSDGCNYIKDWNIVILGCGAQGLNQGLNMRDSGLNISFALRPEAIEQKRASWQK
ATDNGFRVGTFEELIPAADLVLNLTPDKQHSNVVNAVMPLMKQGSTLSYSHGFNIVEEGMQVRPDITVVMVAPKCPGTEV
REEYKRGFGVPTLIAVHPENDPDGDGLEIAKAYASATGGDRAGVLLSSFIAEVKSDLMGEQTILCGMLQTGAILGYEKMI
ADGVEPGYAAKLIQQGWETVTEALKHGGITNMMDRLSNPAKIKAFEIAEDLKEILQPLFEKHMDDIISGEFSRTMMEDWA
NDDANLLRWRAETGETGFENAPVSSEHIDEQTYFDKGIFLVAMIKAGVELAFDTMVSAGIVEESAYYESLHETPLIANTI
ARKRLYEMNVVISDTAEYGCYLFNHAAVPMLRDYVNAMSSEYLGAGLKDSATGVDNLTLIAVNEAIRETAVEYVGAELRG
YMTDMKSIVEA

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=492, Percent_Identity=71.9512195121951, Blast_Score=733, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323387, Length=294, Percent_Identity=31.2925170068027, Blast_Score=114, Evalue=4e-26,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 54164; Mature: 54033

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANYFNSLNLRQQLAQLGQCRFMDRSEFSDGCNYIKDWNIVILGCGAQGLNQGLNMRDSG
CCCCHHCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCEEEEECCCHHHHCCCCCCCCC
LNISFALRPEAIEQKRASWQKATDNGFRVGTFEELIPAADLVLNLTPDKQHSNVVNAVMP
CEEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHCHHHHEEECCCCHHHHHHHHHHHH
LMKQGSTLSYSHGFNIVEEGMQVRPDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCEEEECCCCHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCC
NDPDGDGLEIAKAYASATGGDRAGVLLSSFIAEVKSDLMGEQTILCGMLQTGAILGYEKM
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHH
IADGVEPGYAAKLIQQGWETVTEALKHGGITNMMDRLSNPAKIKAFEIAEDLKEILQPLF
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
EKHMDDIISGEFSRTMMEDWANDDANLLRWRAETGETGFENAPVSSEHIDEQTYFDKGIF
HHHHHHHHCCHHHHHHHHHHCCCCCHHEEEECCCCCCCCCCCCCCHHHCCHHHHHHCHHH
LVAMIKAGVELAFDTMVSAGIVEESAYYESLHETPLIANTIARKRLYEMNVVISDTAEYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEECCHHHC
CYLFNHAAVPMLRDYVNAMSSEYLGAGLKDSATGVDNLTLIAVNEAIRETAVEYVGAELR
EEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHH
GYMTDMKSIVEA
HHHHHHHHHHCC
>Mature Secondary Structure 
ANYFNSLNLRQQLAQLGQCRFMDRSEFSDGCNYIKDWNIVILGCGAQGLNQGLNMRDSG
CCCHHCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCEEEEECCCHHHHCCCCCCCCC
LNISFALRPEAIEQKRASWQKATDNGFRVGTFEELIPAADLVLNLTPDKQHSNVVNAVMP
CEEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHCHHHHEEECCCCHHHHHHHHHHHH
LMKQGSTLSYSHGFNIVEEGMQVRPDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCEEEECCCCHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCC
NDPDGDGLEIAKAYASATGGDRAGVLLSSFIAEVKSDLMGEQTILCGMLQTGAILGYEKM
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHH
IADGVEPGYAAKLIQQGWETVTEALKHGGITNMMDRLSNPAKIKAFEIAEDLKEILQPLF
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
EKHMDDIISGEFSRTMMEDWANDDANLLRWRAETGETGFENAPVSSEHIDEQTYFDKGIF
HHHHHHHHCCHHHHHHHHHHCCCCCHHEEEECCCCCCCCCCCCCCHHHCCHHHHHHCHHH
LVAMIKAGVELAFDTMVSAGIVEESAYYESLHETPLIANTIARKRLYEMNVVISDTAEYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEECCHHHC
CYLFNHAAVPMLRDYVNAMSSEYLGAGLKDSATGVDNLTLIAVNEAIRETAVEYVGAELR
EEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHH
GYMTDMKSIVEA
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]