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The map label for this gene is pdhR [H]

Identifier: 126176104

GI number: 126176104

Start: 4608293

End: 4609045

Strand: Reverse

Name: pdhR [H]

Synonym: Sbal_3914

Alternate gene names: 126176104

Gene position: 4609045-4608293 (Counterclockwise)

Preceding gene: 126176105

Following gene: 126176103

Centisome position: 89.89

GC content: 49.54

Gene sequence:

>753_bases
ATGGCCTATAGTAAAATTAATCAGCCAAAAATTTCTGATGTGATCATGGCTCAATTAGAGCAGATGATCTTAGAGGGCAG
TTTGCAGCCCGGTCAGAAGTTACCGCCTGAACGCGAACTGGCGATCCAGTTTGAAGTGTCTCGACCTTCTTTGCGTGAAG
CTATCCAAAAGCTTGAGGCAAAAGGACTGTTAATGCGCCGCCAAGGCGGTGGTACTTATGTCAAAGAGCAACTCTGGCAG
AGCCTTGCCGATCCTATCGTTGAACTTATGAATTCTGATCCAGAGAGTCAATACGACTTGCTGGAGTTCCGTCATGCTAC
CGAAGGCATGATGGCTTATTTTGCGGCGCTGCGTGGTACTGACGCCGACATGCAAAATATCAAACGTATGATCCTCGATG
TGGAAGCCGCCACCGATATCGAAAAACAAGCCGCCGCCATTGTGCGCTTTTATCGTGCCGTTGCCGAAGCGTCACATAAC
GTGGCTATGTTACATCTCGTTCTCAGTTTAACCCCTGTGCTGCATCAAAATGTGGCGCAAAACTTGGAGCTTTTAAGCCG
CCGCGAAGAAGCTTCTACTATGGCTAACGATCACAGACGGGCCTTGCTCGCTGCCATCGTTCGTCGTGATCCCGAAGCCG
CCAGAGAAGCCTCGAATGAACACTTAAGTTACATCGAAGAGGTGATGTTATCTGTGCGGGAAGAAGATAGCCGGTTGCAG
CGAAGCTTGCGCCGTTTAAAGAGTGGCGCTTAA

Upstream 100 bases:

>100_bases
AAGGAGTGATCTTCAATCTGGACATCAAAACGCTGATTTGATAAAGTGCGCTCACTCAAAAAAATTGGTAAGACCAATTT
ACAACGGAGCTGAGCGCCTG

Downstream 100 bases:

>100_bases
GTTCTGTAGTTTAGCTGTCTGCTAAATCGGAATATGCCGCAAACACCATTCATTATCATGTATATAGAGAAGGACAGTGT
CATGTCTGAAGATATGCTAC

Product: transcriptional regulator PdhR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MAYSKINQPKISDVIMAQLEQMILEGSLQPGQKLPPERELAIQFEVSRPSLREAIQKLEAKGLLMRRQGGGTYVKEQLWQ
SLADPIVELMNSDPESQYDLLEFRHATEGMMAYFAALRGTDADMQNIKRMILDVEAATDIEKQAAAIVRFYRAVAEASHN
VAMLHLVLSLTPVLHQNVAQNLELLSRREEASTMANDHRRALLAAIVRRDPEAAREASNEHLSYIEEVMLSVREEDSRLQ
RSLRRLKSGA

Sequences:

>Translated_250_residues
MAYSKINQPKISDVIMAQLEQMILEGSLQPGQKLPPERELAIQFEVSRPSLREAIQKLEAKGLLMRRQGGGTYVKEQLWQ
SLADPIVELMNSDPESQYDLLEFRHATEGMMAYFAALRGTDADMQNIKRMILDVEAATDIEKQAAAIVRFYRAVAEASHN
VAMLHLVLSLTPVLHQNVAQNLELLSRREEASTMANDHRRALLAAIVRRDPEAAREASNEHLSYIEEVMLSVREEDSRLQ
RSLRRLKSGA
>Mature_249_residues
AYSKINQPKISDVIMAQLEQMILEGSLQPGQKLPPERELAIQFEVSRPSLREAIQKLEAKGLLMRRQGGGTYVKEQLWQS
LADPIVELMNSDPESQYDLLEFRHATEGMMAYFAALRGTDADMQNIKRMILDVEAATDIEKQAAAIVRFYRAVAEASHNV
AMLHLVLSLTPVLHQNVAQNLELLSRREEASTMANDHRRALLAAIVRRDPEAAREASNEHLSYIEEVMLSVREEDSRLQR
SLRRLKSGA

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=233, Percent_Identity=58.3690987124464, Blast_Score=276, Evalue=9e-76,
Organism=Escherichia coli, GI1790032, Length=239, Percent_Identity=34.3096234309623, Blast_Score=140, Evalue=5e-35,
Organism=Escherichia coli, GI1789353, Length=238, Percent_Identity=28.5714285714286, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790780, Length=230, Percent_Identity=30, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI87082208, Length=237, Percent_Identity=29.1139240506329, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI48994955, Length=212, Percent_Identity=27.8301886792453, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789621, Length=233, Percent_Identity=27.4678111587983, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 28277; Mature: 28146

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYSKINQPKISDVIMAQLEQMILEGSLQPGQKLPPERELAIQFEVSRPSLREAIQKLEA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
KGLLMRRQGGGTYVKEQLWQSLADPIVELMNSDPESQYDLLEFRHATEGMMAYFAALRGT
HHHHHEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DADMQNIKRMILDVEAATDIEKQAAAIVRFYRAVAEASHNVAMLHLVLSLTPVLHQNVAQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
NLELLSRREEASTMANDHRRALLAAIVRRDPEAAREASNEHLSYIEEVMLSVREEDSRLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
RSLRRLKSGA
HHHHHHHCCC
>Mature Secondary Structure 
AYSKINQPKISDVIMAQLEQMILEGSLQPGQKLPPERELAIQFEVSRPSLREAIQKLEA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
KGLLMRRQGGGTYVKEQLWQSLADPIVELMNSDPESQYDLLEFRHATEGMMAYFAALRGT
HHHHHEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DADMQNIKRMILDVEAATDIEKQAAAIVRFYRAVAEASHNVAMLHLVLSLTPVLHQNVAQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
NLELLSRREEASTMANDHRRALLAAIVRRDPEAAREASNEHLSYIEEVMLSVREEDSRLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
RSLRRLKSGA
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]