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The map label for this gene is hap [H]

Identifier: 126176065

GI number: 126176065

Start: 4550058

End: 4552394

Strand: Direct

Name: hap [H]

Synonym: Sbal_3874

Alternate gene names: 126176065

Gene position: 4550058-4552394 (Clockwise)

Preceding gene: 126176064

Following gene: 126176069

Centisome position: 88.74

GC content: 48.4

Gene sequence:

>2337_bases
ATGATGCTAAACAAAAAACTGTCGCTACTCTTCATTGCTGTGTCGGCCACGTTAGGCACATCAGCATTTGCTGCTGATGT
TGTCGATGTCGGCACACTTAGAAGCGCGTCTTCAAGCAATAACTTAGTGTCTCAGTTCAACTTAGACGCAGGTAGCCAAC
TCAAAGTCGAGAAAAAACTCGACCTAGGTCAAGGCAAGCAGAAACAACGTTTACAACAATATTTCCATGACGTGCCTGTT
TATGGTTTCTCTGTTGCAACGTCACAATCGAGCATGGGCTTCTACAGCGACATGTCTGGCCGCGTATTAAAAAATATTGA
AAAGTCGGCTGATTTTGTCAAACCCACTTTAACGGCTAACAAAGCCTTAGACATTGCCATTCGTGGCAAGTCAGAGAAAG
CTGTTGCCGGCCTAAAAGCTGAAAACAAACAAGCTAAATTATGGCTTTACCTTGATGATGCGGCTAAAACTCGCCTCGTT
TATGTGACGTCTTTTGTGGTATATGGCGATGAGCCAAGCCGTCCATTCACTATGATTGACGCGCACTCAGGTGAAGTGCT
CAAGCGTTGGGAAGGGATTAACCACGCCGCGAGCGGTACAGGTCCTGGCGGTAACATCAAGACTGGCCAATACGAATACG
GTACGGATTTTTCTTACTTAGACGTTGAAGTGAGCGGTGACACCTGCACCATGAACTCACCTAACGTGAAAACCGTTAAC
TTAAACGGTGCCACATCAGGCGCAACAGCCTTCTCTTATACTTGCCCACGCAATACAGTTAAAGAGATCAACGGTGCTTA
CTCGCCATTAAACGATGCGCACTATTTTGGTAACGTGATCTACAACATGTATAGCGAGTGGTACAACACTGCGCCGTTAA
CTTTCCAGTTAACCATGCGGGTTCACTACAGCAGCAACTACGAAAATGCCTTCTGGGACGGCAGTGCTATGACCTTCGGT
GATGGCGCAACGACCTTCTACCCATTAGTGAGCTTAGATGTCTCGGCACACGAAGTGAGCCATGGTTTCACTGAGCAAAA
CTCAGGCCTGATTTACGATGCTCAATCTGGTGGCATGAACGAAGCCTTCTCAGATATGGCGGGTGAAGCTGCTGAATTTT
ACATGCACGGCACGAACGACTGGTTAGTCGGCGCTGATATCTTTAAAGGCAATGGCGCACTGCGTTACATGGCAGATCCA
ACCTTAGACGGAATCTCAATCGGCCATATCGACGATTACTATGATGGCATCGACGTACACCACAGTTCAGGTGTCTTCAA
CAAAGCCTTCTACACACTCGCAAACTTACCGGGCTGGGATACACGCACTGCATTCCAAACATTTGTGGTCGCTAACCAAT
TATATTGGACAGCTGACAGCTTGTTCTGGCAAGGCGCTTGTGGCGTTAAATCTGCGGCGACTGACTTAGGCTTAAGTGCT
GATGATGTGGTTACTGCGTTTGCTGCAGTAGGTATCACACCTTGTGAAACGCCACCACCACCGCCACCACCAGAAGCCAC
TGAGCTCGCGAACGGTGTCGCTGTGACGGATTTAGCGGGCGCATCTGGTAGCAAACAATACTACAAACTCGACGTAGCAA
GCGGTGCAACCAACCTGAGCTTTAATATGTCAGGCGGCACGGGTGATGCGGACATGTATGTTAAATTCGGCCAAGCTCCT
ACCTCTAGTAGCTATGATTGCCGTCCATACAAAGCCGGTAATGCCGAAAGCTGCCCTATCGATCCAGCCCAAACAGGAAC
TTATTGGGTCATGGTCAGTGGCTATAGCAGCTACACAGGTGTGAGCCTAGTGGGTGCTTATGACGGTGGCGATGAGATAC
CAAACCAAGATCCTACAGCGGGCTTTACGGCAAGCTTTGCCAACGGTAACGGTAGCTTCACTAGCACCAGTACTGACAGC
GATGGTGATGTCGTTGCATGGAGCTGGAGTTTCGGTGATGGCACGACTGCTTCAGGTGCAAGTGTAAATCATCAGTATGC
TCAGTCAGGCAACTACACAGTGACATTGACAGTGACTGACAACGATGGCGCAACAGCAAGCACTTCTGAAGAATTTGCAG
TTGAAGTGCCAGAAGTGGCGTTAGAAATGACAGTGAAAAACGCTAACAAATCTCGTCGCGGCAGCATTCGTGTTGCACTC
GCATGGGAAGGTCATAACGCTGATGAGTACACTATCTTCCGTAACGGCGTTGCGGTAGGTACTTCAAGCAATTCGTCGTT
TATTGACCGTTTCACTGACCTAGCTGGCACTAGCTTCAGCTATAAAGTGTGTGAAACTAACGGCCCTTGCTCAAACGAAG
AAACCGTTAACTTTTAA

Upstream 100 bases:

>100_bases
CGACGACCCTGTAGAAATTACAATAAAAAAACGCTCGCCCGAGCCAGTTAAGCAGTATGGCATTCCAACGTTAATGACAA
ACGGAAAAAGGATTTTAAGC

Downstream 100 bases:

>100_bases
TCGCATAAGATAATCGTATCGTGGTGCTAGCGTAAAATCCTAGCGCCAATTTATCGATAAACTTCTCGTTTCTTGTTAAT
GCCACTCAGCCTTTTTTGAG

Product: peptidase M4 thermolysin

Products: NA

Alternate protein names: HA/protease; Vibriolysin [H]

Number of amino acids: Translated: 778; Mature: 778

Protein sequence:

>778_residues
MMLNKKLSLLFIAVSATLGTSAFAADVVDVGTLRSASSSNNLVSQFNLDAGSQLKVEKKLDLGQGKQKQRLQQYFHDVPV
YGFSVATSQSSMGFYSDMSGRVLKNIEKSADFVKPTLTANKALDIAIRGKSEKAVAGLKAENKQAKLWLYLDDAAKTRLV
YVTSFVVYGDEPSRPFTMIDAHSGEVLKRWEGINHAASGTGPGGNIKTGQYEYGTDFSYLDVEVSGDTCTMNSPNVKTVN
LNGATSGATAFSYTCPRNTVKEINGAYSPLNDAHYFGNVIYNMYSEWYNTAPLTFQLTMRVHYSSNYENAFWDGSAMTFG
DGATTFYPLVSLDVSAHEVSHGFTEQNSGLIYDAQSGGMNEAFSDMAGEAAEFYMHGTNDWLVGADIFKGNGALRYMADP
TLDGISIGHIDDYYDGIDVHHSSGVFNKAFYTLANLPGWDTRTAFQTFVVANQLYWTADSLFWQGACGVKSAATDLGLSA
DDVVTAFAAVGITPCETPPPPPPPEATELANGVAVTDLAGASGSKQYYKLDVASGATNLSFNMSGGTGDADMYVKFGQAP
TSSSYDCRPYKAGNAESCPIDPAQTGTYWVMVSGYSSYTGVSLVGAYDGGDEIPNQDPTAGFTASFANGNGSFTSTSTDS
DGDVVAWSWSFGDGTTASGASVNHQYAQSGNYTVTLTVTDNDGATASTSEEFAVEVPEVALEMTVKNANKSRRGSIRVAL
AWEGHNADEYTIFRNGVAVGTSSNSSFIDRFTDLAGTSFSYKVCETNGPCSNEETVNF

Sequences:

>Translated_778_residues
MMLNKKLSLLFIAVSATLGTSAFAADVVDVGTLRSASSSNNLVSQFNLDAGSQLKVEKKLDLGQGKQKQRLQQYFHDVPV
YGFSVATSQSSMGFYSDMSGRVLKNIEKSADFVKPTLTANKALDIAIRGKSEKAVAGLKAENKQAKLWLYLDDAAKTRLV
YVTSFVVYGDEPSRPFTMIDAHSGEVLKRWEGINHAASGTGPGGNIKTGQYEYGTDFSYLDVEVSGDTCTMNSPNVKTVN
LNGATSGATAFSYTCPRNTVKEINGAYSPLNDAHYFGNVIYNMYSEWYNTAPLTFQLTMRVHYSSNYENAFWDGSAMTFG
DGATTFYPLVSLDVSAHEVSHGFTEQNSGLIYDAQSGGMNEAFSDMAGEAAEFYMHGTNDWLVGADIFKGNGALRYMADP
TLDGISIGHIDDYYDGIDVHHSSGVFNKAFYTLANLPGWDTRTAFQTFVVANQLYWTADSLFWQGACGVKSAATDLGLSA
DDVVTAFAAVGITPCETPPPPPPPEATELANGVAVTDLAGASGSKQYYKLDVASGATNLSFNMSGGTGDADMYVKFGQAP
TSSSYDCRPYKAGNAESCPIDPAQTGTYWVMVSGYSSYTGVSLVGAYDGGDEIPNQDPTAGFTASFANGNGSFTSTSTDS
DGDVVAWSWSFGDGTTASGASVNHQYAQSGNYTVTLTVTDNDGATASTSEEFAVEVPEVALEMTVKNANKSRRGSIRVAL
AWEGHNADEYTIFRNGVAVGTSSNSSFIDRFTDLAGTSFSYKVCETNGPCSNEETVNF
>Mature_778_residues
MMLNKKLSLLFIAVSATLGTSAFAADVVDVGTLRSASSSNNLVSQFNLDAGSQLKVEKKLDLGQGKQKQRLQQYFHDVPV
YGFSVATSQSSMGFYSDMSGRVLKNIEKSADFVKPTLTANKALDIAIRGKSEKAVAGLKAENKQAKLWLYLDDAAKTRLV
YVTSFVVYGDEPSRPFTMIDAHSGEVLKRWEGINHAASGTGPGGNIKTGQYEYGTDFSYLDVEVSGDTCTMNSPNVKTVN
LNGATSGATAFSYTCPRNTVKEINGAYSPLNDAHYFGNVIYNMYSEWYNTAPLTFQLTMRVHYSSNYENAFWDGSAMTFG
DGATTFYPLVSLDVSAHEVSHGFTEQNSGLIYDAQSGGMNEAFSDMAGEAAEFYMHGTNDWLVGADIFKGNGALRYMADP
TLDGISIGHIDDYYDGIDVHHSSGVFNKAFYTLANLPGWDTRTAFQTFVVANQLYWTADSLFWQGACGVKSAATDLGLSA
DDVVTAFAAVGITPCETPPPPPPPEATELANGVAVTDLAGASGSKQYYKLDVASGATNLSFNMSGGTGDADMYVKFGQAP
TSSSYDCRPYKAGNAESCPIDPAQTGTYWVMVSGYSSYTGVSLVGAYDGGDEIPNQDPTAGFTASFANGNGSFTSTSTDS
DGDVVAWSWSFGDGTTASGASVNHQYAQSGNYTVTLTVTDNDGATASTSEEFAVEVPEVALEMTVKNANKSRRGSIRVAL
AWEGHNADEYTIFRNGVAVGTSSNSSFIDRFTDLAGTSFSYKVCETNGPCSNEETVNF

Specific function: May play a role in the pathogenesis of cholera. Hap nicks and activates the A subunit of cholera enterotoxin and related enterotoxins [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR007280
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C; PF04151 PPC [H]

EC number: NA

Molecular weight: Translated: 83174; Mature: 83174

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS50093 PKD ; PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLNKKLSLLFIAVSATLGTSAFAADVVDVGTLRSASSSNNLVSQFNLDAGSQLKVEKKL
CCCCCCEEEEEEEEEHHCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCEEEEEECC
DLGQGKQKQRLQQYFHDVPVYGFSVATSQSSMGFYSDMSGRVLKNIEKSADFVKPTLTAN
CCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCEECCC
KALDIAIRGKSEKAVAGLKAENKQAKLWLYLDDAAKTRLVYVTSFVVYGDEPSRPFTMID
CEEEEEEECCCCCEEECCCCCCCCEEEEEEECCCCCEEEEEEEEEEEECCCCCCCEEEEE
AHSGEVLKRWEGINHAASGTGPGGNIKTGQYEYGTDFSYLDVEVSGDTCTMNSPNVKTVN
CCCCHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEECCCEEECCCCCEEEEE
LNGATSGATAFSYTCPRNTVKEINGAYSPLNDAHYFGNVIYNMYSEWYNTAPLTFQLTMR
ECCCCCCCEEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEE
VHYSSNYENAFWDGSAMTFGDGATTFYPLVSLDVSAHEVSHGFTEQNSGLIYDAQSGGMN
EEECCCCCCEEECCCEEEECCCCCEEEEEEEECCCHHHHHCCCCCCCCCEEEECCCCCCH
EAFSDMAGEAAEFYMHGTNDWLVGADIFKGNGALRYMADPTLDGISIGHIDDYYDGIDVH
HHHHHHCCCCEEEEEECCCCEEEEEEEEECCCEEEEEECCCCCCEEECCCHHHCCCEEEE
HSSGVFNKAFYTLANLPGWDTRTAFQTFVVANQLYWTADSLFWQGACGVKSAATDLGLSA
CCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEEECHHEECCCCCCCHHHHHCCCCH
DDVVTAFAAVGITPCETPPPPPPPEATELANGVAVTDLAGASGSKQYYKLDVASGATNLS
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCEEEEEECCCCCCCEEEEEEECCCCCEEE
FNMSGGTGDADMYVKFGQAPTSSSYDCRPYKAGNAESCPIDPAQTGTYWVMVSGYSSYTG
EEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCC
VSLVGAYDGGDEIPNQDPTAGFTASFANGNGSFTSTSTDSDGDVVAWSWSFGDGTTASGA
EEEEEECCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCCCEEEEEEECCCCCCCCCC
SVNHQYAQSGNYTVTLTVTDNDGATASTSEEFAVEVPEVALEMTVKNANKSRRGSIRVAL
CCCCHHHCCCCEEEEEEEECCCCCCCCCCCCEEEECCCEEEEEEEECCCCCCCCEEEEEE
AWEGHNADEYTIFRNGVAVGTSSNSSFIDRFTDLAGTSFSYKVCETNGPCSNEETVNF
EECCCCCCEEEEEECCEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MMLNKKLSLLFIAVSATLGTSAFAADVVDVGTLRSASSSNNLVSQFNLDAGSQLKVEKKL
CCCCCCEEEEEEEEEHHCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCEEEEEECC
DLGQGKQKQRLQQYFHDVPVYGFSVATSQSSMGFYSDMSGRVLKNIEKSADFVKPTLTAN
CCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCEECCC
KALDIAIRGKSEKAVAGLKAENKQAKLWLYLDDAAKTRLVYVTSFVVYGDEPSRPFTMID
CEEEEEEECCCCCEEECCCCCCCCEEEEEEECCCCCEEEEEEEEEEEECCCCCCCEEEEE
AHSGEVLKRWEGINHAASGTGPGGNIKTGQYEYGTDFSYLDVEVSGDTCTMNSPNVKTVN
CCCCHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEECCCEEECCCCCEEEEE
LNGATSGATAFSYTCPRNTVKEINGAYSPLNDAHYFGNVIYNMYSEWYNTAPLTFQLTMR
ECCCCCCCEEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEE
VHYSSNYENAFWDGSAMTFGDGATTFYPLVSLDVSAHEVSHGFTEQNSGLIYDAQSGGMN
EEECCCCCCEEECCCEEEECCCCCEEEEEEEECCCHHHHHCCCCCCCCCEEEECCCCCCH
EAFSDMAGEAAEFYMHGTNDWLVGADIFKGNGALRYMADPTLDGISIGHIDDYYDGIDVH
HHHHHHCCCCEEEEEECCCCEEEEEEEEECCCEEEEEECCCCCCEEECCCHHHCCCEEEE
HSSGVFNKAFYTLANLPGWDTRTAFQTFVVANQLYWTADSLFWQGACGVKSAATDLGLSA
CCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEEECHHEECCCCCCCHHHHHCCCCH
DDVVTAFAAVGITPCETPPPPPPPEATELANGVAVTDLAGASGSKQYYKLDVASGATNLS
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCEEEEEECCCCCCCEEEEEEECCCCCEEE
FNMSGGTGDADMYVKFGQAPTSSSYDCRPYKAGNAESCPIDPAQTGTYWVMVSGYSSYTG
EEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCC
VSLVGAYDGGDEIPNQDPTAGFTASFANGNGSFTSTSTDSDGDVVAWSWSFGDGTTASGA
EEEEEECCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCCCEEEEEEECCCCCCCCCC
SVNHQYAQSGNYTVTLTVTDNDGATASTSEEFAVEVPEVALEMTVKNANKSRRGSIRVAL
CCCCHHHCCCCEEEEEEEECCCCCCCCCCCCEEEECCCEEEEEEEECCCCCCCCEEEEEE
AWEGHNADEYTIFRNGVAVGTSSNSSFIDRFTDLAGTSFSYKVCETNGPCSNEETVNF
EECCCCCCEEEEEECCEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2045361; 10952301; 2123831 [H]