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The map label for this gene is puuP [H]

Identifier: 126176000

GI number: 126176000

Start: 4473608

End: 4474939

Strand: Reverse

Name: puuP [H]

Synonym: Sbal_3809

Alternate gene names: 126176000

Gene position: 4474939-4473608 (Counterclockwise)

Preceding gene: 126176002

Following gene: 126175999

Centisome position: 87.28

GC content: 47.52

Gene sequence:

>1332_bases
ATGAGTCAACACAAACCGGGTTTGAAGCAGACCCTCAATTTATGGCAAGTGGTAGTGATGGGGCTCGCCTATCTCACACC
TATGGCTGTTTTTGACACCTTTGGTATTGTTTCTGAGATTACCTCTGGCCATGTGGCTACGTCCTATCTATTCGCACTGG
CGGGAATTTTGTTTACCGCATTCAGTTATGGCCACTTAGTGCGTAAATATCCCTACGCGGGATCAGCCTACACCTACGCC
CAGAAAACTTTTAGTCCGAATGTCGGTTTTATGGTGGGCTGGTCGTCGCTACTTGATTATATGTTTATGCCAATGATCAA
CATGTTGCTGGCAAAAATCTATTTAACCGCCATGTTTCCCACTGTCGAACCTTGGATCTTCATTTTCGCACTCGTGACCA
TAATGACCCAGCTCAATCTTAAAGGGATTGATCTGGTGGCTAACTTTAATGGGGTGATAGTGTTTGTGCAAATCGCCATT
ATCCTCGTGTTTATTGCATTAATGGCCTATAGCATTTCCCTTGGTGAAGGCGAAGGTGCGATTGCAAGCGTGCGACCATT
TTATGCCGAGAATATGGCGATTGTGCCGTTATTTACTGGCGCCACTATTCTGTGTTTTTCCTTCCTCGGCTTTGACGGTT
TGAGCTCGCTGACCGAAGAAACGAAGGATGCGCAGCGAGTTATTCCGCGCGCGATTGTGTTGACCGCCTTGATTGGTGGG
GTGATTTTTGTCGGCGTGTCTTATTTTCTTCAGCTTTATTTCCCCGATATTTCCCGCTTCCAGGAGCTTGATGCTGTATT
GCCCGAAATCGCACTCTATGTTGGAGGAAACTTATTCCAGTCCATCGTATTAGTGGCGACTACAGTGGCGGTGTTGGCAT
CCGGTATGGCTGCCCACGCTGGCGTTGCACGGATTTTGTATGTGATGGGGCGAGATAACATGCTGCCACGTAAAGGGTTT
GCTTATATCCACCCTAAGTGGCGCACCCCTGCATTTAATGTGCTGCTGGTGGGGGCACTGGCGCTGTCTGCCGTATCATT
TGATTTGGAAATGGCCTTAGCCTTAGTGAATTTTGGCGCTTTAGTGGCATTCACCTTCGTGAACTTAGCCGTCATAGTGC
AGTTTTATGTGAGGGAGCGACGTAATCAATCCTTTAAGGATCACCTGCAATACTTAGTCTTGCCCCTGTGTGGTGCTGGC
ACTATTGGCATGCTTTGGGCAAACTTAGAGCCACAGTCTTTAGAATTGGGATTAATTTGGGCTGCCGTGGGAGCTTTATA
TTTAACCCTGCGTAGCATACGTTTACGCCGAGCAGTAGAGTTACACAATTAG

Upstream 100 bases:

>100_bases
AGTTAGCCATTAAGCCTAAAGTGCTGATGGTGAGTCACATGCCAAAACCAATTGCAGATGCATGATTAGCTGTTCACCCC
TGTGCAATGGGGGCTTGCTC

Downstream 100 bases:

>100_bases
TTGCAGCATAGGATTGTAGAGTCGCAGCTATTGCTAACAACTGACAACGGTTTGATTGAGGCATCATAGTCTTCTAATAA
AACGTCCAACTAAAAAGACC

Product: amino acid permease-associated protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSQHKPGLKQTLNLWQVVVMGLAYLTPMAVFDTFGIVSEITSGHVATSYLFALAGILFTAFSYGHLVRKYPYAGSAYTYA
QKTFSPNVGFMVGWSSLLDYMFMPMINMLLAKIYLTAMFPTVEPWIFIFALVTIMTQLNLKGIDLVANFNGVIVFVQIAI
ILVFIALMAYSISLGEGEGAIASVRPFYAENMAIVPLFTGATILCFSFLGFDGLSSLTEETKDAQRVIPRAIVLTALIGG
VIFVGVSYFLQLYFPDISRFQELDAVLPEIALYVGGNLFQSIVLVATTVAVLASGMAAHAGVARILYVMGRDNMLPRKGF
AYIHPKWRTPAFNVLLVGALALSAVSFDLEMALALVNFGALVAFTFVNLAVIVQFYVRERRNQSFKDHLQYLVLPLCGAG
TIGMLWANLEPQSLELGLIWAAVGALYLTLRSIRLRRAVELHN

Sequences:

>Translated_443_residues
MSQHKPGLKQTLNLWQVVVMGLAYLTPMAVFDTFGIVSEITSGHVATSYLFALAGILFTAFSYGHLVRKYPYAGSAYTYA
QKTFSPNVGFMVGWSSLLDYMFMPMINMLLAKIYLTAMFPTVEPWIFIFALVTIMTQLNLKGIDLVANFNGVIVFVQIAI
ILVFIALMAYSISLGEGEGAIASVRPFYAENMAIVPLFTGATILCFSFLGFDGLSSLTEETKDAQRVIPRAIVLTALIGG
VIFVGVSYFLQLYFPDISRFQELDAVLPEIALYVGGNLFQSIVLVATTVAVLASGMAAHAGVARILYVMGRDNMLPRKGF
AYIHPKWRTPAFNVLLVGALALSAVSFDLEMALALVNFGALVAFTFVNLAVIVQFYVRERRNQSFKDHLQYLVLPLCGAG
TIGMLWANLEPQSLELGLIWAAVGALYLTLRSIRLRRAVELHN
>Mature_442_residues
SQHKPGLKQTLNLWQVVVMGLAYLTPMAVFDTFGIVSEITSGHVATSYLFALAGILFTAFSYGHLVRKYPYAGSAYTYAQ
KTFSPNVGFMVGWSSLLDYMFMPMINMLLAKIYLTAMFPTVEPWIFIFALVTIMTQLNLKGIDLVANFNGVIVFVQIAII
LVFIALMAYSISLGEGEGAIASVRPFYAENMAIVPLFTGATILCFSFLGFDGLSSLTEETKDAQRVIPRAIVLTALIGGV
IFVGVSYFLQLYFPDISRFQELDAVLPEIALYVGGNLFQSIVLVATTVAVLASGMAAHAGVARILYVMGRDNMLPRKGFA
YIHPKWRTPAFNVLLVGALALSAVSFDLEMALALVNFGALVAFTFVNLAVIVQFYVRERRNQSFKDHLQYLVLPLCGAGT
IGMLWANLEPQSLELGLIWAAVGALYLTLRSIRLRRAVELHN

Specific function: Imports putrescine [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=426, Percent_Identity=24.8826291079812, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI258614003, Length=410, Percent_Identity=25.3658536585366, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI258614005, Length=416, Percent_Identity=25.2403846153846, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI114326544, Length=193, Percent_Identity=27.979274611399, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI114326550, Length=193, Percent_Identity=27.979274611399, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI258645169, Length=410, Percent_Identity=25.1219512195122, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI186910308, Length=344, Percent_Identity=23.2558139534884, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI186910306, Length=344, Percent_Identity=23.2558139534884, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI186910304, Length=344, Percent_Identity=23.2558139534884, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI87081869, Length=439, Percent_Identity=62.870159453303, Blast_Score=572, Evalue=1e-164,
Organism=Escherichia coli, GI87082023, Length=436, Percent_Identity=62.8440366972477, Blast_Score=563, Evalue=1e-162,
Organism=Escherichia coli, GI87082250, Length=348, Percent_Identity=22.4137931034483, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786789, Length=474, Percent_Identity=22.1518987341772, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=421, Percent_Identity=24.4655581947743, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17533459, Length=423, Percent_Identity=25.531914893617, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17531343, Length=402, Percent_Identity=24.8756218905473, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24668806, Length=413, Percent_Identity=25.90799031477, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21356285, Length=413, Percent_Identity=25.90799031477, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24668802, Length=413, Percent_Identity=25.90799031477, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI221512776, Length=408, Percent_Identity=23.2843137254902, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24666159, Length=408, Percent_Identity=23.2843137254902, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24667468, Length=400, Percent_Identity=24, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281366235, Length=403, Percent_Identity=24.8138957816377, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI116007820, Length=403, Percent_Identity=24.8138957816377, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI116007818, Length=403, Percent_Identity=25.5583126550869, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI85725152, Length=403, Percent_Identity=25.5583126550869, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI161077963, Length=402, Percent_Identity=22.8855721393035, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48692; Mature: 48561

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQHKPGLKQTLNLWQVVVMGLAYLTPMAVFDTFGIVSEITSGHVATSYLFALAGILFTA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
FSYGHLVRKYPYAGSAYTYAQKTFSPNVGFMVGWSSLLDYMFMPMINMLLAKIYLTAMFP
HHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCC
TVEPWIFIFALVTIMTQLNLKGIDLVANFNGVIVFVQIAIILVFIALMAYSISLGEGEGA
CHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IASVRPFYAENMAIVPLFTGATILCFSFLGFDGLSSLTEETKDAQRVIPRAIVLTALIGG
EECCCCHHHCCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIFVGVSYFLQLYFPDISRFQELDAVLPEIALYVGGNLFQSIVLVATTVAVLASGMAAHA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
GVARILYVMGRDNMLPRKGFAYIHPKWRTPAFNVLLVGALALSAVSFDLEMALALVNFGA
HHHHHHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVAFTFVNLAVIVQFYVRERRNQSFKDHLQYLVLPLCGAGTIGMLWANLEPQSLELGLIW
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHEECCCCCHHHHHHHH
AAVGALYLTLRSIRLRRAVELHN
HHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SQHKPGLKQTLNLWQVVVMGLAYLTPMAVFDTFGIVSEITSGHVATSYLFALAGILFTA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
FSYGHLVRKYPYAGSAYTYAQKTFSPNVGFMVGWSSLLDYMFMPMINMLLAKIYLTAMFP
HHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCC
TVEPWIFIFALVTIMTQLNLKGIDLVANFNGVIVFVQIAIILVFIALMAYSISLGEGEGA
CHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IASVRPFYAENMAIVPLFTGATILCFSFLGFDGLSSLTEETKDAQRVIPRAIVLTALIGG
EECCCCHHHCCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIFVGVSYFLQLYFPDISRFQELDAVLPEIALYVGGNLFQSIVLVATTVAVLASGMAAHA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
GVARILYVMGRDNMLPRKGFAYIHPKWRTPAFNVLLVGALALSAVSFDLEMALALVNFGA
HHHHHHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVAFTFVNLAVIVQFYVRERRNQSFKDHLQYLVLPLCGAGTIGMLWANLEPQSLELGLIW
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHEECCCCCHHHHHHHH
AAVGALYLTLRSIRLRRAVELHN
HHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]