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The map label for this gene is degS [H]

Identifier: 126175850

GI number: 126175850

Start: 4277942

End: 4279024

Strand: Direct

Name: degS [H]

Synonym: Sbal_3655

Alternate gene names: 126175850

Gene position: 4277942-4279024 (Clockwise)

Preceding gene: 126175849

Following gene: 126175858

Centisome position: 83.43

GC content: 48.2

Gene sequence:

>1083_bases
ATGACGATAAAAGACACACTATTATATCTCGGTAAAGCCACCCTTTTCGGTCTTATCATGGCGGCCATGTTTTTATTGGT
AACCCGTTATTTCGATAACCAATCCCTCGGTAATAGCCTGCTACAAACCCGAGCCAACAACACAGTCGAGCTCTCCTTTG
CCAAGGCGGTCCGCCGCGCAGCCCCTGCCGTTGTTAACATTTATAGCCTCAGCATAGATCAGAACCGCCCACTTAACTCG
GGTTCGCTACAGGGCCTAGGTTCTGGGGTGATAATGAGCAAAGAAGGCTATATTCTTACGAATTATCATGTCATTAAAAA
GGCCGACGAAATTGTTGTCGCCCTGCAAGATGGACGCAAATTTACCTCTGAAGTGGTTGGCTTCGATCCAGAAACCGATT
TATCGGTACTCAAGATTGAAGGCGATAACTTACCGATTGTCCCCGTTAACCTCGACAGTCCACCTCAAGTCGGTGATGTC
GTGCTCGCCATTGGTAATCCCTACAATTTAGGCCAAACCATTACCCAAGGCATCATCAGTGCCACAGGTCGTAACGGTTT
AAGTTCTGGTTACTTAGACTTTTTGCAAACCGATGCGGCGATTAATGCCGGTAACTCTGGCGGCGCCCTCATTGACACTA
ACGGCAGCCTTATCGGTATTAATACCGCAGCATTCCAAGTGGGTGAAGAAGGCGGCGGCCATGGGATTAACTTCGCTATC
CCGATTAAATTGGCCCACAGCATTATGGGTAAGTTGATTAAGAATGGCCGCGTGATCCGTGGTGCCTTAGGGATTTCTGG
CGAGCCAATTAACCCTGTGGTGGCGCAGATCCTTAATCTACCCGACCTAAAAGGTGTGCTCGTTACAGGTGTCGATCCTA
ATGGCCCTGCGGCGCGAGCCCTCTTAATGCCAAGGGATGTGATTATTAAATACGATGGTGAAGATGTGCCAGGTGTTGAA
ATGCTGATGGATCGCATAGCTGAAACCACACCGGGTAAGAAAGTAATGATGACTGTGATACGCCAAGGTAAACAACAGGA
GTTACCTGTGATTATCGATGAGAAGGTTGTGGTCGATAACTAG

Upstream 100 bases:

>100_bases
ATTTTTTCTGCCACACATAAGCATAGGGAGCTTAGGTTCCCTATACTTACATAGATTAAACATGTTAATCTAACTCACCT
TTTTCAAGATCCATCCTGCC

Downstream 100 bases:

>100_bases
AGTGGCACTCCTCATTGCGTAGCACACTAAAACGCAGACAACAAAAAACCAGCTTTTAAGCTGGTTTTTTAATGGGTCGA
GATTTTAATCTCTCAGGCCT

Product: periplasmic serine protease DegS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MTIKDTLLYLGKATLFGLIMAAMFLLVTRYFDNQSLGNSLLQTRANNTVELSFAKAVRRAAPAVVNIYSLSIDQNRPLNS
GSLQGLGSGVIMSKEGYILTNYHVIKKADEIVVALQDGRKFTSEVVGFDPETDLSVLKIEGDNLPIVPVNLDSPPQVGDV
VLAIGNPYNLGQTITQGIISATGRNGLSSGYLDFLQTDAAINAGNSGGALIDTNGSLIGINTAAFQVGEEGGGHGINFAI
PIKLAHSIMGKLIKNGRVIRGALGISGEPINPVVAQILNLPDLKGVLVTGVDPNGPAARALLMPRDVIIKYDGEDVPGVE
MLMDRIAETTPGKKVMMTVIRQGKQQELPVIIDEKVVVDN

Sequences:

>Translated_360_residues
MTIKDTLLYLGKATLFGLIMAAMFLLVTRYFDNQSLGNSLLQTRANNTVELSFAKAVRRAAPAVVNIYSLSIDQNRPLNS
GSLQGLGSGVIMSKEGYILTNYHVIKKADEIVVALQDGRKFTSEVVGFDPETDLSVLKIEGDNLPIVPVNLDSPPQVGDV
VLAIGNPYNLGQTITQGIISATGRNGLSSGYLDFLQTDAAINAGNSGGALIDTNGSLIGINTAAFQVGEEGGGHGINFAI
PIKLAHSIMGKLIKNGRVIRGALGISGEPINPVVAQILNLPDLKGVLVTGVDPNGPAARALLMPRDVIIKYDGEDVPGVE
MLMDRIAETTPGKKVMMTVIRQGKQQELPVIIDEKVVVDN
>Mature_359_residues
TIKDTLLYLGKATLFGLIMAAMFLLVTRYFDNQSLGNSLLQTRANNTVELSFAKAVRRAAPAVVNIYSLSIDQNRPLNSG
SLQGLGSGVIMSKEGYILTNYHVIKKADEIVVALQDGRKFTSEVVGFDPETDLSVLKIEGDNLPIVPVNLDSPPQVGDVV
LAIGNPYNLGQTITQGIISATGRNGLSSGYLDFLQTDAAINAGNSGGALIDTNGSLIGINTAAFQVGEEGGGHGINFAIP
IKLAHSIMGKLIKNGRVIRGALGISGEPINPVVAQILNLPDLKGVLVTGVDPNGPAARALLMPRDVIIKYDGEDVPGVEM
LMDRIAETTPGKKVMMTVIRQGKQQELPVIIDEKVVVDN

Specific function: Senses the OMP signal triggered by the accumulation of unassembled porins in the envelope and then initiates rseA degradation by cleaving it in its periplasmic domain, making it an attractive substrate for subsequent cleavage by rseP [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=330, Percent_Identity=31.5151515151515, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI4506141, Length=321, Percent_Identity=30.2180685358255, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI24308541, Length=286, Percent_Identity=32.1678321678322, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI7019477, Length=314, Percent_Identity=31.5286624203822, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1789630, Length=353, Percent_Identity=49.5750708215297, Blast_Score=285, Evalue=4e-78,
Organism=Escherichia coli, GI1789629, Length=274, Percent_Identity=43.0656934306569, Blast_Score=204, Evalue=6e-54,
Organism=Escherichia coli, GI1786356, Length=263, Percent_Identity=42.2053231939163, Blast_Score=197, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24646839, Length=286, Percent_Identity=31.1188811188811, Blast_Score=121, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011783
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 38168; Mature: 38037

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKDTLLYLGKATLFGLIMAAMFLLVTRYFDNQSLGNSLLQTRANNTVELSFAKAVRRA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEHHHHHHHHH
APAVVNIYSLSIDQNRPLNSGSLQGLGSGVIMSKEGYILTNYHVIKKADEIVVALQDGRK
CCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEECCCEEEEEEHEEECCCEEEEEEECCCH
FTSEVVGFDPETDLSVLKIEGDNLPIVPVNLDSPPQVGDVVLAIGNPYNLGQTITQGIIS
HHHHHCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHH
ATGRNGLSSGYLDFLQTDAAINAGNSGGALIDTNGSLIGINTAAFQVGEEGGGHGINFAI
HCCCCCCCHHHHHHHHCCCEEECCCCCCEEEECCCCEEEEEHHEEEECCCCCCCCEEEEE
PIKLAHSIMGKLIKNGRVIRGALGISGEPINPVVAQILNLPDLKGVLVTGVDPNGPAARA
HHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCCCHHEE
LLMPRDVIIKYDGEDVPGVEMLMDRIAETTPGKKVMMTVIRQGKQQELPVIIDEKVVVDN
EECCCEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEECCEEEECC
>Mature Secondary Structure 
TIKDTLLYLGKATLFGLIMAAMFLLVTRYFDNQSLGNSLLQTRANNTVELSFAKAVRRA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEHHHHHHHHH
APAVVNIYSLSIDQNRPLNSGSLQGLGSGVIMSKEGYILTNYHVIKKADEIVVALQDGRK
CCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEECCCEEEEEEHEEECCCEEEEEEECCCH
FTSEVVGFDPETDLSVLKIEGDNLPIVPVNLDSPPQVGDVVLAIGNPYNLGQTITQGIIS
HHHHHCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHH
ATGRNGLSSGYLDFLQTDAAINAGNSGGALIDTNGSLIGINTAAFQVGEEGGGHGINFAI
HCCCCCCCHHHHHHHHCCCEEECCCCCCEEEECCCCEEEEEHHEEEECCCCCCCCEEEEE
PIKLAHSIMGKLIKNGRVIRGALGISGEPINPVVAQILNLPDLKGVLVTGVDPNGPAARA
HHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCCCHHEE
LLMPRDVIIKYDGEDVPGVEMLMDRIAETTPGKKVMMTVIRQGKQQELPVIIDEKVVVDN
EECCCEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]