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The map label for this gene is umuC [H]

Identifier: 126175749

GI number: 126175749

Start: 4175354

End: 4176610

Strand: Reverse

Name: umuC [H]

Synonym: Sbal_3553

Alternate gene names: 126175749

Gene position: 4176610-4175354 (Counterclockwise)

Preceding gene: 126175750

Following gene: 126175748

Centisome position: 81.46

GC content: 46.62

Gene sequence:

>1257_bases
ATGTTTGCGCTAGTCGATGCCAATAGCTTCTACTGTAGCGCGGAACAGGTGTTCCGGCCTGATTGGCGTGGTAAGCCTGT
TGTTGTACTCAGTAATAACGATGGGATGATTGTTGCTGCTAATAGACAGGCTAAAGAAGCGGGTATTCAGAAGTTTGTGC
CTTACTTTCAAGTCAAAGCACTCTGTGCAGAGCGTGGTGTTATTGCCTGTTCGTCTAACAATGAACTGTATGCTGATTTG
TCTAGCAAGATGATGGATATCATTGGCCGATTTGCGCCTGAGCAACATGTCTACAGTATCGATGAAACCTTCCTGTCGTT
TAAGAACTGCTACCCTGCCATAAAGTGCCTACATACCCAAGGGCAATTGATAAGACGCGCTGTATGGAAAGAAGCCCGTT
TACCTGTTTGTGTGGGGATTGCTAAAACCCTGACGCTGGCGAAACTAGCTAACCATGCTGCTAAGAAGATAGAGGGCTAT
AAAGGTGTCTGTGTTATCGACAATGACCAAGACCGAATCGCTATTTTAAAACAGCTTGCAGTGGGTGATGTTTGGGGGAT
TGGACGCAGGCTTAGTACGAAGCTCGAACTGATGAATATCCGTACTGCGTTTGACCTCGCTAACATGCCAGCAGGATTAG
CCCGTAAACAGTTCAGCATTGAAGTCGAGCGCACAGTACGCGAGCTTAACGGCCAAGTATGCAAGGTGTGGGATGAAGCG
AGGGCTGATAAGAAGCAGATATTCTCGACAAGAAGCATGGGTGAGCGCATCACAGATTTTGAGTCATTATTGCAAGCATT
GAGTAAGCACGTGGGGATTGCGGCGGCTAAAGCGCGTAAGCAAGGCTCAGTCTGCAAGACTATGCTGTTATTTGCCACTA
ACTCTCCCCATGATGAGCGCCCTGTAAACTATAAAACAGTGGTGCACTTTCTTTGTCCAACTAACTGTACGGTCGAGCTG
ACTAAGGCCATATGTGAAGCCGCACCTAAGCTATTTCGTGAAGATGTACGCTATTACAAGATAGGCGTAGGTTTGATTGA
CTTAGCGAGCGAGAAACATAGCCAACTAGACCTGTTCAATCCACCGACAGCAAAACCAGCGCTAATGCTTACACTCGATC
ACATTAACCAACGATATGGTAGTGATACTCTGTTTATTGCTGCTCAAGGCATAGAGCATAAATGGGCAATGCGGAGGGAC
TTATTGACTCCTCAATATACGACTAAGTGGCGAAGTGTACCGCGTATCAAGTGCTAA

Upstream 100 bases:

>100_bases
GCCTGTCATCATTCACGAATATGATGAATTTAGTATTGAAGGGGTTATTACTCGTTCTATCCGTTGCCACCGTAAAAGTC
CCTTATTGAGTGAAAAGTAG

Downstream 100 bases:

>100_bases
CTTGACTATGCCCCAAAATGAGTTTAAATCATTTAAGTGTAAACTCTACCAATCAATCCTTTGCCTTACATTTACTCATG
CAGCACATGAGAATTTTAAG

Product: DNA-directed DNA polymerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MFALVDANSFYCSAEQVFRPDWRGKPVVVLSNNDGMIVAANRQAKEAGIQKFVPYFQVKALCAERGVIACSSNNELYADL
SSKMMDIIGRFAPEQHVYSIDETFLSFKNCYPAIKCLHTQGQLIRRAVWKEARLPVCVGIAKTLTLAKLANHAAKKIEGY
KGVCVIDNDQDRIAILKQLAVGDVWGIGRRLSTKLELMNIRTAFDLANMPAGLARKQFSIEVERTVRELNGQVCKVWDEA
RADKKQIFSTRSMGERITDFESLLQALSKHVGIAAAKARKQGSVCKTMLLFATNSPHDERPVNYKTVVHFLCPTNCTVEL
TKAICEAAPKLFREDVRYYKIGVGLIDLASEKHSQLDLFNPPTAKPALMLTLDHINQRYGSDTLFIAAQGIEHKWAMRRD
LLTPQYTTKWRSVPRIKC

Sequences:

>Translated_418_residues
MFALVDANSFYCSAEQVFRPDWRGKPVVVLSNNDGMIVAANRQAKEAGIQKFVPYFQVKALCAERGVIACSSNNELYADL
SSKMMDIIGRFAPEQHVYSIDETFLSFKNCYPAIKCLHTQGQLIRRAVWKEARLPVCVGIAKTLTLAKLANHAAKKIEGY
KGVCVIDNDQDRIAILKQLAVGDVWGIGRRLSTKLELMNIRTAFDLANMPAGLARKQFSIEVERTVRELNGQVCKVWDEA
RADKKQIFSTRSMGERITDFESLLQALSKHVGIAAAKARKQGSVCKTMLLFATNSPHDERPVNYKTVVHFLCPTNCTVEL
TKAICEAAPKLFREDVRYYKIGVGLIDLASEKHSQLDLFNPPTAKPALMLTLDHINQRYGSDTLFIAAQGIEHKWAMRRD
LLTPQYTTKWRSVPRIKC
>Mature_418_residues
MFALVDANSFYCSAEQVFRPDWRGKPVVVLSNNDGMIVAANRQAKEAGIQKFVPYFQVKALCAERGVIACSSNNELYADL
SSKMMDIIGRFAPEQHVYSIDETFLSFKNCYPAIKCLHTQGQLIRRAVWKEARLPVCVGIAKTLTLAKLANHAAKKIEGY
KGVCVIDNDQDRIAILKQLAVGDVWGIGRRLSTKLELMNIRTAFDLANMPAGLARKQFSIEVERTVRELNGQVCKVWDEA
RADKKQIFSTRSMGERITDFESLLQALSKHVGIAAAKARKQGSVCKTMLLFATNSPHDERPVNYKTVVHFLCPTNCTVEL
TKAICEAAPKLFREDVRYYKIGVGLIDLASEKHSQLDLFNPPTAKPALMLTLDHINQRYGSDTLFIAAQGIEHKWAMRRD
LLTPQYTTKWRSVPRIKC

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=426, Percent_Identity=41.5492957746479, Blast_Score=310, Evalue=8e-86,
Organism=Escherichia coli, GI1786425, Length=217, Percent_Identity=24.4239631336406, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 46989; Mature: 46989

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFALVDANSFYCSAEQVFRPDWRGKPVVVLSNNDGMIVAANRQAKEAGIQKFVPYFQVKA
CEEEEECCCCEECHHHHCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHH
LCAERGVIACSSNNELYADLSSKMMDIIGRFAPEQHVYSIDETFLSFKNCYPAIKCLHTQ
HHHHCCEEEECCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
GQLIRRAVWKEARLPVCVGIAKTLTLAKLANHAAKKIEGYKGVCVIDNDQDRIAILKQLA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHH
VGDVWGIGRRLSTKLELMNIRTAFDLANMPAGLARKQFSIEVERTVRELNGQVCKVWDEA
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEHHHHHHHHHCCCCEEHHHHH
RADKKQIFSTRSMGERITDFESLLQALSKHVGIAAAKARKQGSVCKTMLLFATNSPHDER
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHEEEECCCCCCCC
PVNYKTVVHFLCPTNCTVELTKAICEAAPKLFREDVRYYKIGVGLIDLASEKHSQLDLFN
CCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCEECCCCCCCCCCCCC
PPTAKPALMLTLDHINQRYGSDTLFIAAQGIEHKWAMRRDLLTPQYTTKWRSVPRIKC
CCCCCCEEEEEHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCHHHHHCCCCCCCC
>Mature Secondary Structure
MFALVDANSFYCSAEQVFRPDWRGKPVVVLSNNDGMIVAANRQAKEAGIQKFVPYFQVKA
CEEEEECCCCEECHHHHCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHH
LCAERGVIACSSNNELYADLSSKMMDIIGRFAPEQHVYSIDETFLSFKNCYPAIKCLHTQ
HHHHCCEEEECCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
GQLIRRAVWKEARLPVCVGIAKTLTLAKLANHAAKKIEGYKGVCVIDNDQDRIAILKQLA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHH
VGDVWGIGRRLSTKLELMNIRTAFDLANMPAGLARKQFSIEVERTVRELNGQVCKVWDEA
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEHHHHHHHHHCCCCEEHHHHH
RADKKQIFSTRSMGERITDFESLLQALSKHVGIAAAKARKQGSVCKTMLLFATNSPHDER
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHEEEECCCCCCCC
PVNYKTVVHFLCPTNCTVELTKAICEAAPKLFREDVRYYKIGVGLIDLASEKHSQLDLFN
CCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCEECCCCCCCCCCCCC
PPTAKPALMLTLDHINQRYGSDTLFIAAQGIEHKWAMRRDLLTPQYTTKWRSVPRIKC
CCCCCCEEEEEHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2144275; 2203737; 11677609 [H]