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The map label for this gene is holA [H]

Identifier: 126175471

GI number: 126175471

Start: 3833891

End: 3834922

Strand: Direct

Name: holA [H]

Synonym: Sbal_3271

Alternate gene names: 126175471

Gene position: 3833891-3834922 (Clockwise)

Preceding gene: 126175470

Following gene: 126175472

Centisome position: 74.77

GC content: 49.71

Gene sequence:

>1032_bases
ATGAGAGTCTATCCCGATCAACTCTCCCGCCACCTCAACCAGTTATTTCCTTGTTATCTGATTTTTGGGGATGATCCTTG
GTTGATTGAAACCACCAAAGATCAGATCCGCCAATTCGCCAAGCGTCAGGGTTTCGATGAAAAAGTCCAACTCATTCAAG
AGACGGGCTTTAATTGGAACGACTTGACTCAGGAATGGCAGGCCATGAGCCTGTTTTCCAGTAAGCGTCTGATTGAGTTA
ACCCTTCCACAATCTAAGCCCGGTGCCGAAGGCTCAAGCACACTGCAAGCCCTATTGCAGACGCCCAATCCCGATATGCT
GTTGATTATCGAAGGGCCAAAGCTCGCCAACGAGCAAACCAACAGCAAATGGTTTAAGACCTTAGATGCCCATGGCATGT
ATCTGCCCTGCGCTACGCCAGAGGGCGATCAGTTTATGCGCTGGCTCGATGGCCGCATCAAGCACTTTAAGCTCAATCTG
CAGCCGGATGCCCGCGCTATGTTGCATTCGCTATATGAAGGCAATTTACTGGCTGCCGATCAAGCCATGCAGTTGCTGCA
ACTCCTGAGTCCAACAAATCCCGTCAGTGCCGATGAACTGAGCCACTATTTTGAGGATCAGTCACGCTTCACCGTATTCC
AACTCACGGATGCATTACTGAATAATAAACAAGATAGCGCGCAGCACATGCTGGCCCAGCTCAATGGCGAAGGCACAGCC
TTACCTATCCTGCTGTGGGCCTTGTTTAAAGAGCTCGGCTTGTTATTCAATTTGAAATGCGAGCAAGCCCAAGGCGTCGC
GCTGAGTGCGCTCTGGAGTAAACATCGAATTTGGGATAAACGTAAACCTCTGTATCAAGCGGCGCTGCAACGACTTAGCC
TCGAACAGTTAGAACACATGCTCGCCCTTGCCTCGAAACTTGAGCTCAACTTAAAGCAGCAGGGTAAAGAGGATTGGACT
GGTCTTACCCACCTGTGTCTGTTATTTGATCCTAGAGCCCATCGGCATCTGGCACATATAGCCATAGACTAA

Upstream 100 bases:

>100_bases
CTGCGGATCGTATTCTGCAAGCGATGGCCAGTACTGAGGTGAATTAATGCGGGTCATCAATTAAATGCGGATAATCTACT
AAATGCGGATAATCAACTAA

Downstream 100 bases:

>100_bases
TCATAGGTTAACCAAAGAGTTGATATGCGCATTGGTATTTTAGGCGGCACCTTCGACCCGATACACTATGGTCATATCCG
TCCGGCGATTGAAGTAAAAC

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MRVYPDQLSRHLNQLFPCYLIFGDDPWLIETTKDQIRQFAKRQGFDEKVQLIQETGFNWNDLTQEWQAMSLFSSKRLIEL
TLPQSKPGAEGSSTLQALLQTPNPDMLLIIEGPKLANEQTNSKWFKTLDAHGMYLPCATPEGDQFMRWLDGRIKHFKLNL
QPDARAMLHSLYEGNLLAADQAMQLLQLLSPTNPVSADELSHYFEDQSRFTVFQLTDALLNNKQDSAQHMLAQLNGEGTA
LPILLWALFKELGLLFNLKCEQAQGVALSALWSKHRIWDKRKPLYQAALQRLSLEQLEHMLALASKLELNLKQQGKEDWT
GLTHLCLLFDPRAHRHLAHIAID

Sequences:

>Translated_343_residues
MRVYPDQLSRHLNQLFPCYLIFGDDPWLIETTKDQIRQFAKRQGFDEKVQLIQETGFNWNDLTQEWQAMSLFSSKRLIEL
TLPQSKPGAEGSSTLQALLQTPNPDMLLIIEGPKLANEQTNSKWFKTLDAHGMYLPCATPEGDQFMRWLDGRIKHFKLNL
QPDARAMLHSLYEGNLLAADQAMQLLQLLSPTNPVSADELSHYFEDQSRFTVFQLTDALLNNKQDSAQHMLAQLNGEGTA
LPILLWALFKELGLLFNLKCEQAQGVALSALWSKHRIWDKRKPLYQAALQRLSLEQLEHMLALASKLELNLKQQGKEDWT
GLTHLCLLFDPRAHRHLAHIAID
>Mature_343_residues
MRVYPDQLSRHLNQLFPCYLIFGDDPWLIETTKDQIRQFAKRQGFDEKVQLIQETGFNWNDLTQEWQAMSLFSSKRLIEL
TLPQSKPGAEGSSTLQALLQTPNPDMLLIIEGPKLANEQTNSKWFKTLDAHGMYLPCATPEGDQFMRWLDGRIKHFKLNL
QPDARAMLHSLYEGNLLAADQAMQLLQLLSPTNPVSADELSHYFEDQSRFTVFQLTDALLNNKQDSAQHMLAQLNGEGTA
LPILLWALFKELGLLFNLKCEQAQGVALSALWSKHRIWDKRKPLYQAALQRLSLEQLEHMLALASKLELNLKQQGKEDWT
GLTHLCLLFDPRAHRHLAHIAID

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=345, Percent_Identity=39.4202898550725, Blast_Score=197, Evalue=8e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 39337; Mature: 39337

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVYPDQLSRHLNQLFPCYLIFGDDPWLIETTKDQIRQFAKRQGFDEKVQLIQETGFNWN
CCCCHHHHHHHHHHHCCEEEEECCCCEEEECCHHHHHHHHHHCCCHHHHHHHHHCCCCHH
DLTQEWQAMSLFSSKRLIELTLPQSKPGAEGSSTLQALLQTPNPDMLLIIEGPKLANEQT
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCC
NSKWFKTLDAHGMYLPCATPEGDQFMRWLDGRIKHFKLNLQPDARAMLHSLYEGNLLAAD
CHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCEEEHH
QAMQLLQLLSPTNPVSADELSHYFEDQSRFTVFQLTDALLNNKQDSAQHMLAQLNGEGTA
HHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHCCCCHHHHHHHHHHCCCCCH
LPILLWALFKELGLLFNLKCEQAQGVALSALWSKHRIWDKRKPLYQAALQRLSLEQLEHM
HHHHHHHHHHHHCCEEECEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LALASKLELNLKQQGKEDWTGLTHLCLLFDPRAHRHLAHIAID
HHHHHHHHHHHHHCCCHHHHHHHHHHHEECCHHHHHHEEEECC
>Mature Secondary Structure
MRVYPDQLSRHLNQLFPCYLIFGDDPWLIETTKDQIRQFAKRQGFDEKVQLIQETGFNWN
CCCCHHHHHHHHHHHCCEEEEECCCCEEEECCHHHHHHHHHHCCCHHHHHHHHHCCCCHH
DLTQEWQAMSLFSSKRLIELTLPQSKPGAEGSSTLQALLQTPNPDMLLIIEGPKLANEQT
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCC
NSKWFKTLDAHGMYLPCATPEGDQFMRWLDGRIKHFKLNLQPDARAMLHSLYEGNLLAAD
CHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCEEEHH
QAMQLLQLLSPTNPVSADELSHYFEDQSRFTVFQLTDALLNNKQDSAQHMLAQLNGEGTA
HHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHCCCCHHHHHHHHHHCCCCCH
LPILLWALFKELGLLFNLKCEQAQGVALSALWSKHRIWDKRKPLYQAALQRLSLEQLEHM
HHHHHHHHHHHHCCEEECEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LALASKLELNLKQQGKEDWTGLTHLCLLFDPRAHRHLAHIAID
HHHHHHHHHHHHHCCCHHHHHHHHHHHEECCHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]