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The map label for this gene is relA [H]

Identifier: 126175347

GI number: 126175347

Start: 3682592

End: 3684802

Strand: Reverse

Name: relA [H]

Synonym: Sbal_3146

Alternate gene names: 126175347

Gene position: 3684802-3682592 (Counterclockwise)

Preceding gene: 126175348

Following gene: 126175346

Centisome position: 71.87

GC content: 50.07

Gene sequence:

>2211_bases
ATGGTCTCTGTTCGCGAAGCGCACTTTAATGATCCCGATTTTCACTTAGAAGATTGGGTGGCTCGCTATGTCGGTCATGC
CGATGAAGCGCAGATGCTGCTCTCCTTGATAGGGCAGATTGACGCCTTACCCGCCAAGAGTCCTGCGGCGAAGAGAGAAC
TGCTCGAACGTGCTCGAGAGATGATCGAAATCCTCGCACCGCTGAACATGGACATTGAAACCCTGCAAGCGGCGATTCTG
TTTGTGGTGTTCGATGCTGGCTTACTGACCGAAGACGCCATCAAAGAAAAATTTGGTGAGCCGCTGGCGCGTTTAGTGGC
GAGTGTCGTGACCATGAATGCTATCGGTGCCTTAAAAATCAATCCCAACAGCCGCTCAACCGAGCCACAAATCGACAACA
TCCGCCGCATGTTACTGGCGATGGTTGAAGATGTGCGTGCAGTTGTCATCAAACTTGCCGAGCGTGTGTGTTTGCTGCGG
GCAGTGAAAAATGCCGACGAAGAAACTCGCGTGCTGCTGGCCCGCGAAATTGCCGATATTTATGCGCCGCTGGCCAACCG
TTTAGGGATTGGACAATTGAAGTGGGAGCTGGAAGATATTTCTTTTCGCTACCTGCATCCAGATACCTATAAAGACATTG
CTAAGCAATTAGATGGCAAACGACTGGATCGTGAAGTCTTTATCGACAAGTTTGTCAGCCAGTTACAACAAAGACTAGAT
GAAGACCAAATTCGCGCTAAGGTCTACGGTCGGCCGAAACATATCTACAGTATCTGGCGCAAGATGAAGGGCAAACACCT
CAAATTTGATGAGTTGTTTGACGTGCGCGCCGTGCGTATCGTGACCGATCGTCTGCAGGATTGTTATGGTGCATTAGGCG
TAGTGCATACGCTTTGGCACCATATTCCGCGGGAATTTGACGACTATGTCGCCAACCCTAAACCTAACGGTTATCAATCG
ATTCATACCGTAGTGGTGGGGCCTGAGGGCAAAACCGTTGAAATTCAAATTCGTACCCAAGACATGCATGAAGATGCAGA
GCTGGGTGTGGCCGCGCATTGGAAATACAAAGAAGGTAATAATCATTCCGGTAAGCAAAGCGGCTACGAAGAAAAAATTA
ACTGGCTGCGTAAAATTCTGCAATGGCAGGAAGACGTGGTCGAAAGTGGCAACTTGGTCGAAGAAGTGCGCAGCCAAGTG
TTTGAAGACAGAGTCTATGTGTTCACCCCAAGCGGTGAAGTCGTCGACTTGCCACTGGGCTCAACCGTGCTCGACTTTGC
CTATTACATTCACTCCCAAGTAGGGCATAAATGTATTGGCGCTAAGGTCGATGGCCGTATTGTACCGTTTACTTATCAGG
TCGAAACGGGCGAGCGTATCGAGATCATCACCTCGAAACAGCCCAATCCCAAGCGCGACTGGCTTAACCCTAACTTAGGT
TATATCCGTACCTCGCGGGCGCGTTCGAAAATCCAGCATTGGTTTAAGCAGCAGGACAGAGACAAGAATATTGTCGCCGG
CAAAGAAATGCTCGAATCCGAATTGGCGCGGGTGAGCCTTAAAATTAAAGACGCGGCCATCGCGGTCGAGCGCTTTAATA
TGGCGAGCATGGATGACTTACTGGCGGCGATTGGCGGCGGTGATGTGCGTCTGCATCAAGTGGTTAACCATATTCAGAGT
CGTCTGCGACTCGACGAAGTGTCAGAAGAAGATGCCGTCGAAGAATTAGTTAAGAAAGGCCAACATAAGCCGACTTCCAG
TGGCCGTGGTCAGGTTGAAGTCAACGGTGTGGGAAACTTGCTTAACCATATCGCCCGTTGTTGCCAGCCCGTTCCCGGTG
ATGAAATCTTAGGTTTTATCACTAAAGGCCGCGGCATTTCTGTACATCGCGCTGATTGTGAACAAGTTAAAGAGTTAATG
CGGGTTCACCCAGAGCGCGGTGTCGATGTGGTCTGGGGCGAAAATTACTCCGGCGGTTATCGCATGCGTCTGCGGGTATT
AGCCCACGATCGCAGCGGTTTATTGCGTGACTTAACCTCAGTGTTGGCTGCCGAAAAATCCAATGTATTGGCCATGAGTT
CGTCATCGGATACTAAAAACCAGACCGCCGCGATTGAGTTGGAACTAGAGCTTTATAACCTTGATGGTTTATCGCGGGTG
TTATCGAAGCTGACCCAGGTCGATAGCGTGATCGAGGCAAGACGGCTTTAA

Upstream 100 bases:

>100_bases
TTACGTCGGTTGGGTTTGACAAGTTCGCGCCAATGCTGAAGATAGGAGAGCTGAAGTGGTGCCCACTTTCTCTCTGAGCA
CGGATAAGGAAATAAATTAG

Downstream 100 bases:

>100_bases
GTTTCGCAATGCCGTTCGAAGTGAATAGCCTTGAAATCACTAGCAATATAAAAGATACAGAGAAGCCATCTAGAGGCCTT
GTTTCCTAAATAGGTTGAAC

Product: (p)ppGpp synthetase I, SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 736; Mature: 736

Protein sequence:

>736_residues
MVSVREAHFNDPDFHLEDWVARYVGHADEAQMLLSLIGQIDALPAKSPAAKRELLERAREMIEILAPLNMDIETLQAAIL
FVVFDAGLLTEDAIKEKFGEPLARLVASVVTMNAIGALKINPNSRSTEPQIDNIRRMLLAMVEDVRAVVIKLAERVCLLR
AVKNADEETRVLLAREIADIYAPLANRLGIGQLKWELEDISFRYLHPDTYKDIAKQLDGKRLDREVFIDKFVSQLQQRLD
EDQIRAKVYGRPKHIYSIWRKMKGKHLKFDELFDVRAVRIVTDRLQDCYGALGVVHTLWHHIPREFDDYVANPKPNGYQS
IHTVVVGPEGKTVEIQIRTQDMHEDAELGVAAHWKYKEGNNHSGKQSGYEEKINWLRKILQWQEDVVESGNLVEEVRSQV
FEDRVYVFTPSGEVVDLPLGSTVLDFAYYIHSQVGHKCIGAKVDGRIVPFTYQVETGERIEIITSKQPNPKRDWLNPNLG
YIRTSRARSKIQHWFKQQDRDKNIVAGKEMLESELARVSLKIKDAAIAVERFNMASMDDLLAAIGGGDVRLHQVVNHIQS
RLRLDEVSEEDAVEELVKKGQHKPTSSGRGQVEVNGVGNLLNHIARCCQPVPGDEILGFITKGRGISVHRADCEQVKELM
RVHPERGVDVVWGENYSGGYRMRLRVLAHDRSGLLRDLTSVLAAEKSNVLAMSSSSDTKNQTAAIELELELYNLDGLSRV
LSKLTQVDSVIEARRL

Sequences:

>Translated_736_residues
MVSVREAHFNDPDFHLEDWVARYVGHADEAQMLLSLIGQIDALPAKSPAAKRELLERAREMIEILAPLNMDIETLQAAIL
FVVFDAGLLTEDAIKEKFGEPLARLVASVVTMNAIGALKINPNSRSTEPQIDNIRRMLLAMVEDVRAVVIKLAERVCLLR
AVKNADEETRVLLAREIADIYAPLANRLGIGQLKWELEDISFRYLHPDTYKDIAKQLDGKRLDREVFIDKFVSQLQQRLD
EDQIRAKVYGRPKHIYSIWRKMKGKHLKFDELFDVRAVRIVTDRLQDCYGALGVVHTLWHHIPREFDDYVANPKPNGYQS
IHTVVVGPEGKTVEIQIRTQDMHEDAELGVAAHWKYKEGNNHSGKQSGYEEKINWLRKILQWQEDVVESGNLVEEVRSQV
FEDRVYVFTPSGEVVDLPLGSTVLDFAYYIHSQVGHKCIGAKVDGRIVPFTYQVETGERIEIITSKQPNPKRDWLNPNLG
YIRTSRARSKIQHWFKQQDRDKNIVAGKEMLESELARVSLKIKDAAIAVERFNMASMDDLLAAIGGGDVRLHQVVNHIQS
RLRLDEVSEEDAVEELVKKGQHKPTSSGRGQVEVNGVGNLLNHIARCCQPVPGDEILGFITKGRGISVHRADCEQVKELM
RVHPERGVDVVWGENYSGGYRMRLRVLAHDRSGLLRDLTSVLAAEKSNVLAMSSSSDTKNQTAAIELELELYNLDGLSRV
LSKLTQVDSVIEARRL
>Mature_736_residues
MVSVREAHFNDPDFHLEDWVARYVGHADEAQMLLSLIGQIDALPAKSPAAKRELLERAREMIEILAPLNMDIETLQAAIL
FVVFDAGLLTEDAIKEKFGEPLARLVASVVTMNAIGALKINPNSRSTEPQIDNIRRMLLAMVEDVRAVVIKLAERVCLLR
AVKNADEETRVLLAREIADIYAPLANRLGIGQLKWELEDISFRYLHPDTYKDIAKQLDGKRLDREVFIDKFVSQLQQRLD
EDQIRAKVYGRPKHIYSIWRKMKGKHLKFDELFDVRAVRIVTDRLQDCYGALGVVHTLWHHIPREFDDYVANPKPNGYQS
IHTVVVGPEGKTVEIQIRTQDMHEDAELGVAAHWKYKEGNNHSGKQSGYEEKINWLRKILQWQEDVVESGNLVEEVRSQV
FEDRVYVFTPSGEVVDLPLGSTVLDFAYYIHSQVGHKCIGAKVDGRIVPFTYQVETGERIEIITSKQPNPKRDWLNPNLG
YIRTSRARSKIQHWFKQQDRDKNIVAGKEMLESELARVSLKIKDAAIAVERFNMASMDDLLAAIGGGDVRLHQVVNHIQS
RLRLDEVSEEDAVEELVKKGQHKPTSSGRGQVEVNGVGNLLNHIARCCQPVPGDEILGFITKGRGISVHRADCEQVKELM
RVHPERGVDVVWGENYSGGYRMRLRVLAHDRSGLLRDLTSVLAAEKSNVLAMSSSSDTKNQTAAIELELELYNLDGLSRV
LSKLTQVDSVIEARRL

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=746, Percent_Identity=59.5174262734584, Blast_Score=894, Evalue=0.0,
Organism=Escherichia coli, GI1790082, Length=676, Percent_Identity=33.4319526627219, Blast_Score=409, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 83373; Mature: 83373

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSVREAHFNDPDFHLEDWVARYVGHADEAQMLLSLIGQIDALPAKSPAAKRELLERARE
CCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
MIEILAPLNMDIETLQAAILFVVFDAGLLTEDAIKEKFGEPLARLVASVVTMNAIGALKI
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCEEEEE
NPNSRSTEPQIDNIRRMLLAMVEDVRAVVIKLAERVCLLRAVKNADEETRVLLAREIADI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YAPLANRLGIGQLKWELEDISFRYLHPDTYKDIAKQLDGKRLDREVFIDKFVSQLQQRLD
HHHHHHCCCCCCEEEEEECCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
EDQIRAKVYGRPKHIYSIWRKMKGKHLKFDELFDVRAVRIVTDRLQDCYGALGVVHTLWH
HHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HIPREFDDYVANPKPNGYQSIHTVVVGPEGKTVEIQIRTQDMHEDAELGVAAHWKYKEGN
HHCHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCCCHHCCEEEEEEECCCC
NHSGKQSGYEEKINWLRKILQWQEDVVESGNLVEEVRSQVFEDRVYVFTPSGEVVDLPLG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEECCCCCEEECCCC
STVLDFAYYIHSQVGHKCIGAKVDGRIVPFTYQVETGERIEIITSKQPNPKRDWLNPNLG
HHHHHHHHHHHHHHCCHHCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCC
YIRTSRARSKIQHWFKQQDRDKNIVAGKEMLESELARVSLKIKDAAIAVERFNMASMDDL
CEECHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEEHHHHHHHHHCCCCCHHHH
LAAIGGGDVRLHQVVNHIQSRLRLDEVSEEDAVEELVKKGQHKPTSSGRGQVEVNGVGNL
HHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHH
LNHIARCCQPVPGDEILGFITKGRGISVHRADCEQVKELMRVHPERGVDVVWGENYSGGY
HHHHHHHCCCCCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCCCCEEEECCCCCCCE
RMRLRVLAHDRSGLLRDLTSVLAAEKSNVLAMSSSSDTKNQTAAIELELELYNLDGLSRV
EEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEEEEECCCHHHHH
LSKLTQVDSVIEARRL
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVSVREAHFNDPDFHLEDWVARYVGHADEAQMLLSLIGQIDALPAKSPAAKRELLERARE
CCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
MIEILAPLNMDIETLQAAILFVVFDAGLLTEDAIKEKFGEPLARLVASVVTMNAIGALKI
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCEEEEE
NPNSRSTEPQIDNIRRMLLAMVEDVRAVVIKLAERVCLLRAVKNADEETRVLLAREIADI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YAPLANRLGIGQLKWELEDISFRYLHPDTYKDIAKQLDGKRLDREVFIDKFVSQLQQRLD
HHHHHHCCCCCCEEEEEECCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
EDQIRAKVYGRPKHIYSIWRKMKGKHLKFDELFDVRAVRIVTDRLQDCYGALGVVHTLWH
HHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HIPREFDDYVANPKPNGYQSIHTVVVGPEGKTVEIQIRTQDMHEDAELGVAAHWKYKEGN
HHCHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCCCHHCCEEEEEEECCCC
NHSGKQSGYEEKINWLRKILQWQEDVVESGNLVEEVRSQVFEDRVYVFTPSGEVVDLPLG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEECCCCCEEECCCC
STVLDFAYYIHSQVGHKCIGAKVDGRIVPFTYQVETGERIEIITSKQPNPKRDWLNPNLG
HHHHHHHHHHHHHHCCHHCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCC
YIRTSRARSKIQHWFKQQDRDKNIVAGKEMLESELARVSLKIKDAAIAVERFNMASMDDL
CEECHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEEHHHHHHHHHCCCCCHHHH
LAAIGGGDVRLHQVVNHIQSRLRLDEVSEEDAVEELVKKGQHKPTSSGRGQVEVNGVGNL
HHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHH
LNHIARCCQPVPGDEILGFITKGRGISVHRADCEQVKELMRVHPERGVDVVWGENYSGGY
HHHHHHHCCCCCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCCCCEEEECCCCCCCE
RMRLRVLAHDRSGLLRDLTSVLAAEKSNVLAMSSSSDTKNQTAAIELELELYNLDGLSRV
EEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEEEEECCCHHHHH
LSKLTQVDSVIEARRL
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]