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The map label for this gene is rmlA1 [H]

Identifier: 126175070

GI number: 126175070

Start: 3375426

End: 3376313

Strand: Reverse

Name: rmlA1 [H]

Synonym: Sbal_2866

Alternate gene names: 126175070

Gene position: 3376313-3375426 (Counterclockwise)

Preceding gene: 126175071

Following gene: 126175069

Centisome position: 65.85

GC content: 48.2

Gene sequence:

>888_bases
ATGAGAAAAGGCATTTTACTGGCGGGCGGTACGGGCTCGCGTCTTTATCCTATGACGCTGGTTGTCTGTAAGCAATTACT
GCCCATTTACGATAAACCTATGATTTATTATCCACTTGTCACCCTGATGCAGGCTGGTATTCGAGACATCTTGATTATTT
GCACTCCCCACGATTTGCCGCTATTCAAGGCATTACTCGGTGATGGCTGTCATTGGGGACTTAAGCTGCAATATGCCGTG
CAAGCCTCTCCGAAGGGATTGGCGCAAGCGCTCATCATTGCTGAGCCATTTTTAGCGGGTGAGGCCTGTGCGCTTATTCT
TGGGGATAATCTATTCTATGGTCAGCACTTAGCGGCAAATTTGCAATATGCTTGGCAAGCCCAAGCTGGGGCGACCGTTT
TTGGTTACCATGTGGCGAATCCTAACGCTTATGGTGTCGTTGAGTTTGATGGTGCAGGTAAGGTGCTTTCTATTGAAGAA
AAACCTCAACATCCACGCTCTCGTTACGCTATGCCTGGGTTGTACTTTTTTGACGGCCGCGCGGCCGCATTTGCAAAAAC
GGTTTTACCTTCGGCAAGGGGCGAGTTAGAGATTGTCGATGTTATCACTCGTTACTTAGCCTTGGGAGAATTGCGCGTCG
ATATTCTTGGGCGGGGGACAGCTTGGTTAGATACTGGCACGCCGGATGCGATGGCCGAGGCGACACAATTTGTTGCTGCC
ATTGAGAAACGACAAGGTCTAAAGATCAATTGCCCAGAAGAGACTGCATTTCGCAGCGGTTGGATCAATGCGCAGCAATT
AGTTGAATTAGCTCAGCCTTTACTCAAAAGTGGTTATGGTGAGTATTTGCTCGGCTTACTCGATAAGCAGGTATTTGATG
AAATGTAG

Upstream 100 bases:

>100_bases
ATCGACGGACTCATCTCCTGTCATCCGTTCTTCCGGCTCGTCGTCTTTTATATGCTACAATCTGGACACTTCACCTAGCT
TATCAATCTTAAATATTTCA

Downstream 100 bases:

>100_bases
CGAAACTGAGTTAGCCGAAGTGTTGGTGTTTGAACCGCAAGTCTTTGGGGATGAACGCGGTTTCTTTATGGAGACGTTTA
GGCAATCCTATTTTGATGCC

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MRKGILLAGGTGSRLYPMTLVVCKQLLPIYDKPMIYYPLVTLMQAGIRDILIICTPHDLPLFKALLGDGCHWGLKLQYAV
QASPKGLAQALIIAEPFLAGEACALILGDNLFYGQHLAANLQYAWQAQAGATVFGYHVANPNAYGVVEFDGAGKVLSIEE
KPQHPRSRYAMPGLYFFDGRAAAFAKTVLPSARGELEIVDVITRYLALGELRVDILGRGTAWLDTGTPDAMAEATQFVAA
IEKRQGLKINCPEETAFRSGWINAQQLVELAQPLLKSGYGEYLLGLLDKQVFDEM

Sequences:

>Translated_295_residues
MRKGILLAGGTGSRLYPMTLVVCKQLLPIYDKPMIYYPLVTLMQAGIRDILIICTPHDLPLFKALLGDGCHWGLKLQYAV
QASPKGLAQALIIAEPFLAGEACALILGDNLFYGQHLAANLQYAWQAQAGATVFGYHVANPNAYGVVEFDGAGKVLSIEE
KPQHPRSRYAMPGLYFFDGRAAAFAKTVLPSARGELEIVDVITRYLALGELRVDILGRGTAWLDTGTPDAMAEATQFVAA
IEKRQGLKINCPEETAFRSGWINAQQLVELAQPLLKSGYGEYLLGLLDKQVFDEM
>Mature_295_residues
MRKGILLAGGTGSRLYPMTLVVCKQLLPIYDKPMIYYPLVTLMQAGIRDILIICTPHDLPLFKALLGDGCHWGLKLQYAV
QASPKGLAQALIIAEPFLAGEACALILGDNLFYGQHLAANLQYAWQAQAGATVFGYHVANPNAYGVVEFDGAGKVLSIEE
KPQHPRSRYAMPGLYFFDGRAAAFAKTVLPSARGELEIVDVITRYLALGELRVDILGRGTAWLDTGTPDAMAEATQFVAA
IEKRQGLKINCPEETAFRSGWINAQQLVELAQPLLKSGYGEYLLGLLDKQVFDEM

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788351, Length=283, Percent_Identity=61.4840989399293, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=56.4912280701754, Blast_Score=333, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI133931050, Length=179, Percent_Identity=27.3743016759777, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=251, Percent_Identity=25.8964143426295, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355443, Length=249, Percent_Identity=24.4979919678715, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24644084, Length=249, Percent_Identity=24.4979919678715, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32234; Mature: 32234

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKGILLAGGTGSRLYPMTLVVCKQLLPIYDKPMIYYPLVTLMQAGIRDILIICTPHDLP
CCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCH
LFKALLGDGCHWGLKLQYAVQASPKGLAQALIIAEPFLAGEACALILGDNLFYGQHLAAN
HHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEEEECCEEECCHHHHC
LQYAWQAQAGATVFGYHVANPNAYGVVEFDGAGKVLSIEEKPQHPRSRYAMPGLYFFDGR
CEEEEECCCCCEEEEEEECCCCEEEEEEECCCCCEEEECCCCCCCHHHCCCCCEEEECCC
AAAFAKTVLPSARGELEIVDVITRYLALGELRVDILGRGTAWLDTGTPDAMAEATQFVAA
HHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEEECCEEEECCCCCHHHHHHHHHHHH
IEKRQGLKINCPEETAFRSGWINAQQLVELAQPLLKSGYGEYLLGLLDKQVFDEM
HHHCCCCEEECCHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKGILLAGGTGSRLYPMTLVVCKQLLPIYDKPMIYYPLVTLMQAGIRDILIICTPHDLP
CCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCH
LFKALLGDGCHWGLKLQYAVQASPKGLAQALIIAEPFLAGEACALILGDNLFYGQHLAAN
HHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEEEECCEEECCHHHHC
LQYAWQAQAGATVFGYHVANPNAYGVVEFDGAGKVLSIEEKPQHPRSRYAMPGLYFFDGR
CEEEEECCCCCEEEEEEECCCCEEEEEEECCCCCEEEECCCCCCCHHHCCCCCEEEECCC
AAAFAKTVLPSARGELEIVDVITRYLALGELRVDILGRGTAWLDTGTPDAMAEATQFVAA
HHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEEECCEEEECCCCCHHHHHHHHHHHH
IEKRQGLKINCPEETAFRSGWINAQQLVELAQPLLKSGYGEYLLGLLDKQVFDEM
HHHCCCCEEECCHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]