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The map label for this gene is hemH [H]

Identifier: 126174758

GI number: 126174758

Start: 2978176

End: 2979195

Strand: Reverse

Name: hemH [H]

Synonym: Sbal_2545

Alternate gene names: 126174758

Gene position: 2979195-2978176 (Counterclockwise)

Preceding gene: 126174759

Following gene: 126174757

Centisome position: 58.1

GC content: 49.22

Gene sequence:

>1020_bases
ATGAGCCTAACGTTGAATCCTTCCCCTGCTTTTGGTGTGTTATTGGTTAACCTCGGCACGCCTGATGAACCTAGCCCTAA
GGCCGTAAAACGATTTTTAAGGCAGTTTTTAAGTGATCCGCGTGTCGTCGATTTATCACCGTGGATTTGGCAACCGCTGC
TGAATGGCATTATCCTCAACACCCGTCCGGCGAAAGTCGCCAAACTCTACCAAAGCGTGTGGACGCCAGAAGGCTCGCCC
TTGATGGTGATAAGTGCACGCCAAGCACAAAAGCTGGCGGTGGACTTAAGCGCTACGTTTAACCAGACCATTCCGGTTGA
ACTGGGTATGAGTTACGGCAATCCCTCCATCGATGCGGGATTTGAACGCTTGAAAGACCAAGGGGCAGAGCGCATTATTG
TGCTGCCTTTGTATCCCCAATATTCCTGCTCGACGGTGGCAAGTGTGTTCGATGCCGTTGCCAGTTATCTTAAAACCGTG
CGTGACATACCTCAGGTTCGCTTTAATAAAGACTATTTTGATTATGATGCTTATATAGCGGCGCTGGCGCATTCAGTGAC
ACGTCACTGGAAAACCCATGGGCAGGCCGCTAAGTTGCTCTTGTCATTTCACGGTATTCCGCTGCGTTATGTGAAAGAGG
GCGATCCATACCGCGAGCAGTGTTTTGTCACGGCGAAACTGTTAGCGCAAAAACTTGAGCTTAGCGAGTCGCAATGGCAA
GTGTGTTTCCAATCGCGCTTTGGCCGCGAAGAGTGGCTTACGCCTTACGCTGATGAATTATTGGCCGAGTTACCTGCACA
AGGAATCAAAAGTGTCGATGTGATTTGCCCTGCGTTTGCGACAGACTGCCTCGAAACCTTAGAAGAAATCTCCATTGGCG
CTAAGGAAACCTTTTTAGATGCAGGTGGCTGCGACTATCGGTTTATCCCTTGTTTGAACGACGATGAGTTACACATTGAA
TTATTACGGCAATTAATCCAAGAACAAGCGGTATCTTGGGCCCATACCCAAGCCACCTGA

Upstream 100 bases:

>100_bases
TAATTTACGAGAACGAGTTCTCATATTAGAAAAAAGCCTGCCGATGCAGGCTTTTTTTATGGGTATCGCAATGTTAGCCT
CCAAGTGAACTTCATTAACC

Downstream 100 bases:

>100_bases
AGAGTCGAGTTTCAGAGCGCCTAGGGTGATTCAATTCAAGGCGCATCAATGACAGAATGTCGGCCACCTTTTGAATTGAT
GCAACACGGAAGTGAAGTGC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 1; Protoheme ferro-lyase 1 [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MSLTLNPSPAFGVLLVNLGTPDEPSPKAVKRFLRQFLSDPRVVDLSPWIWQPLLNGIILNTRPAKVAKLYQSVWTPEGSP
LMVISARQAQKLAVDLSATFNQTIPVELGMSYGNPSIDAGFERLKDQGAERIIVLPLYPQYSCSTVASVFDAVASYLKTV
RDIPQVRFNKDYFDYDAYIAALAHSVTRHWKTHGQAAKLLLSFHGIPLRYVKEGDPYREQCFVTAKLLAQKLELSESQWQ
VCFQSRFGREEWLTPYADELLAELPAQGIKSVDVICPAFATDCLETLEEISIGAKETFLDAGGCDYRFIPCLNDDELHIE
LLRQLIQEQAVSWAHTQAT

Sequences:

>Translated_339_residues
MSLTLNPSPAFGVLLVNLGTPDEPSPKAVKRFLRQFLSDPRVVDLSPWIWQPLLNGIILNTRPAKVAKLYQSVWTPEGSP
LMVISARQAQKLAVDLSATFNQTIPVELGMSYGNPSIDAGFERLKDQGAERIIVLPLYPQYSCSTVASVFDAVASYLKTV
RDIPQVRFNKDYFDYDAYIAALAHSVTRHWKTHGQAAKLLLSFHGIPLRYVKEGDPYREQCFVTAKLLAQKLELSESQWQ
VCFQSRFGREEWLTPYADELLAELPAQGIKSVDVICPAFATDCLETLEEISIGAKETFLDAGGCDYRFIPCLNDDELHIE
LLRQLIQEQAVSWAHTQAT
>Mature_338_residues
SLTLNPSPAFGVLLVNLGTPDEPSPKAVKRFLRQFLSDPRVVDLSPWIWQPLLNGIILNTRPAKVAKLYQSVWTPEGSPL
MVISARQAQKLAVDLSATFNQTIPVELGMSYGNPSIDAGFERLKDQGAERIIVLPLYPQYSCSTVASVFDAVASYLKTVR
DIPQVRFNKDYFDYDAYIAALAHSVTRHWKTHGQAAKLLLSFHGIPLRYVKEGDPYREQCFVTAKLLAQKLELSESQWQV
CFQSRFGREEWLTPYADELLAELPAQGIKSVDVICPAFATDCLETLEEISIGAKETFLDAGGCDYRFIPCLNDDELHIEL
LRQLIQEQAVSWAHTQAT

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=337, Percent_Identity=25.2225519287834, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI60499021, Length=337, Percent_Identity=25.2225519287834, Blast_Score=105, Evalue=8e-23,
Organism=Escherichia coli, GI1786681, Length=315, Percent_Identity=51.1111111111111, Blast_Score=314, Evalue=6e-87,
Organism=Saccharomyces cerevisiae, GI6324750, Length=330, Percent_Identity=24.2424242424242, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17864156, Length=340, Percent_Identity=23.2352941176471, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24651774, Length=268, Percent_Identity=22.3880597014925, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 38023; Mature: 37892

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTLNPSPAFGVLLVNLGTPDEPSPKAVKRFLRQFLSDPRVVDLSPWIWQPLLNGIILN
CEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHCCEEEC
TRPAKVAKLYQSVWTPEGSPLMVISARQAQKLAVDLSATFNQTIPVELGMSYGNPSIDAG
CCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHEEEHHHCCCCCCCEEECCCCCCCCHHHH
FERLKDQGAERIIVLPLYPQYSCSTVASVFDAVASYLKTVRDIPQVRFNKDYFDYDAYIA
HHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHH
ALAHSVTRHWKTHGQAAKLLLSFHGIPLRYVKEGDPYREQCFVTAKLLAQKLELSESQWQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHH
VCFQSRFGREEWLTPYADELLAELPAQGIKSVDVICPAFATDCLETLEEISIGAKETFLD
HHHHHHCCHHHCCCHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHEEC
AGGCDYRFIPCLNDDELHIELLRQLIQEQAVSWAHTQAT
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLTLNPSPAFGVLLVNLGTPDEPSPKAVKRFLRQFLSDPRVVDLSPWIWQPLLNGIILN
EEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHCCEEEC
TRPAKVAKLYQSVWTPEGSPLMVISARQAQKLAVDLSATFNQTIPVELGMSYGNPSIDAG
CCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHEEEHHHCCCCCCCEEECCCCCCCCHHHH
FERLKDQGAERIIVLPLYPQYSCSTVASVFDAVASYLKTVRDIPQVRFNKDYFDYDAYIA
HHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHH
ALAHSVTRHWKTHGQAAKLLLSFHGIPLRYVKEGDPYREQCFVTAKLLAQKLELSESQWQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHH
VCFQSRFGREEWLTPYADELLAELPAQGIKSVDVICPAFATDCLETLEEISIGAKETFLD
HHHHHHCCHHHCCCHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHEEC
AGGCDYRFIPCLNDDELHIELLRQLIQEQAVSWAHTQAT
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]