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The map label for this gene is tyrP [H]

Identifier: 126174646

GI number: 126174646

Start: 2834692

End: 2835879

Strand: Direct

Name: tyrP [H]

Synonym: Sbal_2433

Alternate gene names: 126174646

Gene position: 2834692-2835879 (Clockwise)

Preceding gene: 126174645

Following gene: 126174647

Centisome position: 55.29

GC content: 51.18

Gene sequence:

>1188_bases
ATGACACAGAATAAAATTTTCGGCAGTTTGCTGCTTATCGCAGGCACCACAATTGGCGCGGGTATGCTGGCTTTGCCTAT
CGCATCGGCGGGACTTGGTTTTGGCACGTCCTCCGCCATCATGTTGATCCTGTGGGCGCTAATGGCCTACACGGCACTGC
TTATGGTGGAAATCCATCAATTCGCCCCCAGCGATGCCAGCCTTAATCACTTGGCGCAACGCTTATTGGGTCGTAAGGGC
CAGTTGATCGCCAATAGCGCCTTGATGTTTTTACTTTACGCCCTTTGCGCCGCCTACATTGCCGGTGGCGGTGAGCAAGT
GAACCAAAAGCTGAGCACTTGGCTAGGGCTAAGTTTGCCACCACAGGCTGGCGCCATCCTGTTTACCCTGCTGATTGGGG
CGATTGTGGGCATGGGAACTCACTGTGTGGACCTTATCAACCGCGGTTTGTTTGCCCTTAAGCTATTGGCATTACTGCTT
ATGTTGGCCTTGTTACTGCCGCAGGTAGAAAGCCCACATTTGCTCGAACTCCCACTCAACCAAGGTTTAATTATCACGGC
TATTCCGGTGATTTTTACTTCCTTTGGTTTCCACGGTTCGATTCCATCAGTGGTGCGCTACTTAGGGGTTGAGGTCAAAG
CCCTGCGCAGGATCATGCTACTCGGCTCCGCTTTACCACTGGTCATTTATCTTTTGTGGCAAGTAGGTAGCCAAGGTGTA
CTGAGCCAAAGCCAATTGCTCGAAAATCAGAGCTTATCGAGCTTTATCAATCAACTGGCGAGCGTACTACACAGCGAATA
CTTAAGCAGTGCGATCAGTTTGTTTGCCGATCTCGCCCTTGCGACTTCGTTTTTAGGGGTGAGTTTAGGCTTGTTTGATT
TTATGGCCTCAACCTTAAGACGTGAGGATAATTTTTCTGGTCGTAGTTTGACCGCTGCCATCACCTTTTTACCGCCCTTA
GGTTTTGCCCTCTTCTACCCCCAAGGTTTTATCACAGCCCTGGGTTATGCGGCGATTGCGCTGGTGATCCTCGCCATCTT
TTTACCTGTAGCCATGGTGTGGACACAGCGCCAGACGCGAGATGCGGCCAATATGCCGACGGGATATCGGGTCGCGGGCG
GTAAGTTTACCTTAATGCTCGCCACACTTTGCGGAATAGTGGTTATCGCCGCGCAGATGTTTAGCTAG

Upstream 100 bases:

>100_bases
AATCGTTTCATAATTGAATCGCAGCAAAATATTTTATGACAGTTGCTTTCGGATCAAGTCTTTAGCTCTTTTTCATCCGA
CACGCTTTTGAGATTATGTT

Downstream 100 bases:

>100_bases
TCGCAATTCACTCACCAAGAGTTATTTAATCAAAAGTTAGCTAGCCCCAATTCACTAGCCTTATTCGCTAGCTCGAATAA
AAGATTAGGTACAAGAGTCT

Product: aromatic amino acid transporter

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MTQNKIFGSLLLIAGTTIGAGMLALPIASAGLGFGTSSAIMLILWALMAYTALLMVEIHQFAPSDASLNHLAQRLLGRKG
QLIANSALMFLLYALCAAYIAGGGEQVNQKLSTWLGLSLPPQAGAILFTLLIGAIVGMGTHCVDLINRGLFALKLLALLL
MLALLLPQVESPHLLELPLNQGLIITAIPVIFTSFGFHGSIPSVVRYLGVEVKALRRIMLLGSALPLVIYLLWQVGSQGV
LSQSQLLENQSLSSFINQLASVLHSEYLSSAISLFADLALATSFLGVSLGLFDFMASTLRREDNFSGRSLTAAITFLPPL
GFALFYPQGFITALGYAAIALVILAIFLPVAMVWTQRQTRDAANMPTGYRVAGGKFTLMLATLCGIVVIAAQMFS

Sequences:

>Translated_395_residues
MTQNKIFGSLLLIAGTTIGAGMLALPIASAGLGFGTSSAIMLILWALMAYTALLMVEIHQFAPSDASLNHLAQRLLGRKG
QLIANSALMFLLYALCAAYIAGGGEQVNQKLSTWLGLSLPPQAGAILFTLLIGAIVGMGTHCVDLINRGLFALKLLALLL
MLALLLPQVESPHLLELPLNQGLIITAIPVIFTSFGFHGSIPSVVRYLGVEVKALRRIMLLGSALPLVIYLLWQVGSQGV
LSQSQLLENQSLSSFINQLASVLHSEYLSSAISLFADLALATSFLGVSLGLFDFMASTLRREDNFSGRSLTAAITFLPPL
GFALFYPQGFITALGYAAIALVILAIFLPVAMVWTQRQTRDAANMPTGYRVAGGKFTLMLATLCGIVVIAAQMFS
>Mature_394_residues
TQNKIFGSLLLIAGTTIGAGMLALPIASAGLGFGTSSAIMLILWALMAYTALLMVEIHQFAPSDASLNHLAQRLLGRKGQ
LIANSALMFLLYALCAAYIAGGGEQVNQKLSTWLGLSLPPQAGAILFTLLIGAIVGMGTHCVDLINRGLFALKLLALLLM
LALLLPQVESPHLLELPLNQGLIITAIPVIFTSFGFHGSIPSVVRYLGVEVKALRRIMLLGSALPLVIYLLWQVGSQGVL
SQSQLLENQSLSSFINQLASVLHSEYLSSAISLFADLALATSFLGVSLGLFDFMASTLRREDNFSGRSLTAAITFLPPLG
FALFYPQGFITALGYAAIALVILAIFLPVAMVWTQRQTRDAANMPTGYRVAGGKFTLMLATLCGIVVIAAQMFS

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=394, Percent_Identity=50, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI1790145, Length=398, Percent_Identity=28.894472361809, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1789552, Length=362, Percent_Identity=28.1767955801105, Blast_Score=166, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 42045; Mature: 41914

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQNKIFGSLLLIAGTTIGAGMLALPIASAGLGFGTSSAIMLILWALMAYTALLMVEIHQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FAPSDASLNHLAQRLLGRKGQLIANSALMFLLYALCAAYIAGGGEQVNQKLSTWLGLSLP
HCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
PQAGAILFTLLIGAIVGMGTHCVDLINRGLFALKLLALLLMLALLLPQVESPHLLELPLN
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCC
QGLIITAIPVIFTSFGFHGSIPSVVRYLGVEVKALRRIMLLGSALPLVIYLLWQVGSQGV
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LSQSQLLENQSLSSFINQLASVLHSEYLSSAISLFADLALATSFLGVSLGLFDFMASTLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REDNFSGRSLTAAITFLPPLGFALFYPQGFITALGYAAIALVILAIFLPVAMVWTQRQTR
HCCCCCCCHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAANMPTGYRVAGGKFTLMLATLCGIVVIAAQMFS
HHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQNKIFGSLLLIAGTTIGAGMLALPIASAGLGFGTSSAIMLILWALMAYTALLMVEIHQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FAPSDASLNHLAQRLLGRKGQLIANSALMFLLYALCAAYIAGGGEQVNQKLSTWLGLSLP
HCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
PQAGAILFTLLIGAIVGMGTHCVDLINRGLFALKLLALLLMLALLLPQVESPHLLELPLN
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCC
QGLIITAIPVIFTSFGFHGSIPSVVRYLGVEVKALRRIMLLGSALPLVIYLLWQVGSQGV
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LSQSQLLENQSLSSFINQLASVLHSEYLSSAISLFADLALATSFLGVSLGLFDFMASTLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REDNFSGRSLTAAITFLPPLGFALFYPQGFITALGYAAIALVILAIFLPVAMVWTQRQTR
HCCCCCCCHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAANMPTGYRVAGGKFTLMLATLCGIVVIAAQMFS
HHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]