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The map label for this gene is hisI [H]

Identifier: 126174645

GI number: 126174645

Start: 2833439

End: 2834080

Strand: Direct

Name: hisI [H]

Synonym: Sbal_2432

Alternate gene names: 126174645

Gene position: 2833439-2834080 (Clockwise)

Preceding gene: 126174644

Following gene: 126174646

Centisome position: 55.26

GC content: 47.51

Gene sequence:

>642_bases
ATGTTAACGCAAACAAACACTAAAGCGGATTTTAGCGAGCTGGATTGGGACAAACAGGATGGACTTATTCCTGCCGTTAT
CCAAAATCACTTATCGGGCAAGGTATTAATGCTCGGTTACATGGATAAGGCCGCGCTGGAAAAAACCTTGAGCACAGGTG
ATGTGACGTTTTTCAGCCGCTCAAAACAGCGCTTGTGGACCAAGGGTGAAACCTCGGGCAATACCCTAAAGTTGGTGGCT
ATCGATAAGGACTGCGATAACGACAGCCTGTTAGTGCAAGTTATTCCCAATGGCCCAACCTGCCACAAAGGCACCGAAAG
TTGCTGGTTAGATGACAATGCGCACCCCTTTTTGAATAATCTCGCCAGCTTAATCACCTCGCGTAAAGGGCAAAGTGCCG
ATTCAAGCTATACAGCGTCTTTATTTGCGCGCGGCACTAAACGTATCGCCCAAAAGGTCGGGGAAGAAGGTCTTGAAACC
GCCCTTGCCGCTGCGACACACGATAAAGAAGAGCTGGTTAACGAAGCCTCAGATCTTATCTATCACTTGCTGGTATTGCT
TGAAGATCAAAACTTAAGCCTCAGTGATATCACAGCAAACTTGCTGGCAAGACATGAAAAGGCGCTGCAGAGCAAAGCAT
AA

Upstream 100 bases:

>100_bases
TAGCGAGCTAATGCCACCTCTAGATACCGCGACAGTAAGAGCATGAGCAAGCAACCTGAATATGTCGCTAAAAAGCATCA
ACAAATTAAGAGTGAACACT

Downstream 100 bases:

>100_bases
ACGGCTTACTGACTCTGATTTCATGCTAGTCGCTTACATCTAGAAATGCCGCACACTTAAGCCAAGTCTGCGGCATTTTT
TATCTTGCCATAAATCTAGC

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MLTQTNTKADFSELDWDKQDGLIPAVIQNHLSGKVLMLGYMDKAALEKTLSTGDVTFFSRSKQRLWTKGETSGNTLKLVA
IDKDCDNDSLLVQVIPNGPTCHKGTESCWLDDNAHPFLNNLASLITSRKGQSADSSYTASLFARGTKRIAQKVGEEGLET
ALAAATHDKEELVNEASDLIYHLLVLLEDQNLSLSDITANLLARHEKALQSKA

Sequences:

>Translated_213_residues
MLTQTNTKADFSELDWDKQDGLIPAVIQNHLSGKVLMLGYMDKAALEKTLSTGDVTFFSRSKQRLWTKGETSGNTLKLVA
IDKDCDNDSLLVQVIPNGPTCHKGTESCWLDDNAHPFLNNLASLITSRKGQSADSSYTASLFARGTKRIAQKVGEEGLET
ALAAATHDKEELVNEASDLIYHLLVLLEDQNLSLSDITANLLARHEKALQSKA
>Mature_213_residues
MLTQTNTKADFSELDWDKQDGLIPAVIQNHLSGKVLMLGYMDKAALEKTLSTGDVTFFSRSKQRLWTKGETSGNTLKLVA
IDKDCDNDSLLVQVIPNGPTCHKGTESCWLDDNAHPFLNNLASLITSRKGQSADSSYTASLFARGTKRIAQKVGEEGLET
ALAAATHDKEELVNEASDLIYHLLVLLEDQNLSLSDITANLLARHEKALQSKA

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=208, Percent_Identity=61.5384615384615, Blast_Score=257, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6319819, Length=208, Percent_Identity=34.1346153846154, Blast_Score=95, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 23316; Mature: 23316

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTQTNTKADFSELDWDKQDGLIPAVIQNHLSGKVLMLGYMDKAALEKTLSTGDVTFFSR
CCCCCCCCCCHHHCCCCCCCCEEHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCCEECC
SKQRLWTKGETSGNTLKLVAIDKDCDNDSLLVQVIPNGPTCHKGTESCWLDDNAHPFLNN
CHHHHCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCEEECCCCCHHHHH
LASLITSRKGQSADSSYTASLFARGTKRIAQKVGEEGLETALAAATHDKEELVNEASDLI
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
YHLLVLLEDQNLSLSDITANLLARHEKALQSKA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLTQTNTKADFSELDWDKQDGLIPAVIQNHLSGKVLMLGYMDKAALEKTLSTGDVTFFSR
CCCCCCCCCCHHHCCCCCCCCEEHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCCEECC
SKQRLWTKGETSGNTLKLVAIDKDCDNDSLLVQVIPNGPTCHKGTESCWLDDNAHPFLNN
CHHHHCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCEEECCCCCHHHHH
LASLITSRKGQSADSSYTASLFARGTKRIAQKVGEEGLETALAAATHDKEELVNEASDLI
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
YHLLVLLEDQNLSLSDITANLLARHEKALQSKA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]