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The map label for this gene is uvrB [H]

Identifier: 126174473

GI number: 126174473

Start: 2610631

End: 2612637

Strand: Reverse

Name: uvrB [H]

Synonym: Sbal_2257

Alternate gene names: 126174473

Gene position: 2612637-2610631 (Counterclockwise)

Preceding gene: 126174482

Following gene: 126174470

Centisome position: 50.95

GC content: 49.98

Gene sequence:

>2007_bases
GTGTCAGAATCTGTTTTTCAGCTTGAATCGCAATTCGCCCCCGCAGGCGACCAACCTACAGCGATAGCCAAATTAGTCGA
TGGACTCGAAGCGGGTTTAGCTTGCCAAACCTTACTCGGGGTGACGGGCTCAGGTAAAACCTTCACGATTGCCAATGTAA
TCCAAAAATTAGGTCGCCCCACGATTATCATGGCGCCTAATAAAACCTTGGCAGCGCAGCTTTATGGCGAGATGAAAGAG
TTCTTTCCCCATAATGCGGTCGAGTATTTTGTTTCTTACTACGATTACTATCAGCCAGAAGCCTATGTGCCTGCATCAAA
TACCTTTATCGAGAAAGACGCGTCGGTTAATGCCCACATAGAGCAAATGCGCCTGTCGGCGACAAAGGCGCTGTTAGAGC
GTAAAGATGTGGTGCTCATCGCCTCTGTGTCGGCCATTTATGGTTTGGGCGATCCCGACTCCTATTTAAAAATGTTGCTG
CATCTACGCCAAGGCGATGTGATGGGGCAGCGTGATATCTTAATTCGTCTCAGTGAATTGCAGTATAAACGCAATGATAT
CGAGCTACAGCGTGGTACCTATCGCGTGCGTGGTGAAGTGATTGATGTTTTCCCTGCCGATTCTGAGCGTAATGCCATTC
GTGTTGAGTTGTTCGACGATGAGATTGAGCGTTTAAGCGAGTTTGATCCGTTAACCGGTCATATCATTAAGCGCATCGCC
CGTACAACGGTTTACCCTAAGACTCACTATGTGACGCCGCGGGAAAAAATCATCGCCGCCACTGAGTTCATTAAAGAAGA
GCTGCGTGAGCGTAAGCAATATCTACTCGATAATAACAAGTTAATTGAAGCCCAGCGTATCCATGAGCGAGTGCAATACG
ATGTGGAAATGATGGTGGAGTTAGGTTACTGCTCTGGCATCGAAAACTACTCGCGCTATTTGTCAGGCCGCGCACCGGGG
GAAGGGCCGCCAACCCTACTCGACTATTTGCCCGCTGACGGTCTATTAATTATCGACGAATCCCATGTGACTGTGCCGCA
AATCGGCGCCATGTACAAAGGTGACCGTTCCCGTAAAACCACATTGGTGGAATACGGTTTCCGCTTACCGTCAGCCTTGG
ATAACCGACCGCTCAAGTTCGAAGAGTTTGAGCAATTGATGCCTCAAACCATTTATGTGTCGGCGACACCGAGTGTCTAC
GAGCTGGAAAAGAGCGAAGGCGAGATTGCCGAGCAGGTCGTGCGGCCAACGGGTTTACTCGATCCTGAATTAGAAGTGCG
TCCTGTTGGGACTCAAGTGGACGATTTATTGTCTGAGATCGCCAAGCGCGTTGCTGTTAACGAGCGGGTGTTAGTGACGA
CGCTGACCAAGCGTATGTCGGAGGATTTGACCGAATACCTCGACGAACATGGTGTAAAAGTGCGTTATTTGCACTCGGAT
ATCGACACGGTTGAACGGGTGGAGATCATCCGCGATCTGCGTTTAGGTAAGTTTGATGTGTTGGTTGGGATCAACTTATT
GCGCGAAGGCTTAGACATGCCTGAAGTGTCATTGGTGTGTATTTTAGATGCGGATAAAGAGGGCTTCCTGCGCTCAGAAC
GCTCGCTCATCCAAACCATTGGCCGCGCCGCGCGTAACGTTAATGGCAAAGTAATCCTCTATGCCGATCGCATTACCAAT
TCGATGGCGAAGGCCATTGGTGAAACTGACCGCCGACGTGAACGCCAGCGCGCGCACAACTTAAAGCACGGCATCACACC
TAAGGGCGTGGTTAAACGGATCACCGATGTGATGGATGTGGATGACGGCCGCGACAGTAAAGCTGTGTATGGTAAAGTGG
CTGAACCTAAGTCCCATTACCATAAAGCCGATGCGACTGAGTTGAGCCATCAAATCGATCAGCTTGAGAAGAAGATGCAC
GAACATGCGCGCAACTTAGAGTTCGAACAAGCGGCGGCGATGCGTGATGAAGTCAAGCATCTGCGGGACTTGTTGATCAA
GGCCTAG

Upstream 100 bases:

>100_bases
CGGTGTTAATGCGTATTGAATTGACGACAGGAAGGATAACTGTGGAGCTTAGTCGGTGACTTGATTAGAATGGGGCGACT
CATTAAAAGGATATGTGCGC

Downstream 100 bases:

>100_bases
ATTTACCTTAACGCTAAAGATAAAAAAGCCGTCCAGCAATGATGCTGCGACGGCTTTTTTATGTCTGTCAGAGAATTACG
CAGAGACTTTTACGTGGCGA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 668; Mature: 667

Protein sequence:

>668_residues
MSESVFQLESQFAPAGDQPTAIAKLVDGLEAGLACQTLLGVTGSGKTFTIANVIQKLGRPTIIMAPNKTLAAQLYGEMKE
FFPHNAVEYFVSYYDYYQPEAYVPASNTFIEKDASVNAHIEQMRLSATKALLERKDVVLIASVSAIYGLGDPDSYLKMLL
HLRQGDVMGQRDILIRLSELQYKRNDIELQRGTYRVRGEVIDVFPADSERNAIRVELFDDEIERLSEFDPLTGHIIKRIA
RTTVYPKTHYVTPREKIIAATEFIKEELRERKQYLLDNNKLIEAQRIHERVQYDVEMMVELGYCSGIENYSRYLSGRAPG
EGPPTLLDYLPADGLLIIDESHVTVPQIGAMYKGDRSRKTTLVEYGFRLPSALDNRPLKFEEFEQLMPQTIYVSATPSVY
ELEKSEGEIAEQVVRPTGLLDPELEVRPVGTQVDDLLSEIAKRVAVNERVLVTTLTKRMSEDLTEYLDEHGVKVRYLHSD
IDTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTIGRAARNVNGKVILYADRITN
SMAKAIGETDRRRERQRAHNLKHGITPKGVVKRITDVMDVDDGRDSKAVYGKVAEPKSHYHKADATELSHQIDQLEKKMH
EHARNLEFEQAAAMRDEVKHLRDLLIKA

Sequences:

>Translated_668_residues
MSESVFQLESQFAPAGDQPTAIAKLVDGLEAGLACQTLLGVTGSGKTFTIANVIQKLGRPTIIMAPNKTLAAQLYGEMKE
FFPHNAVEYFVSYYDYYQPEAYVPASNTFIEKDASVNAHIEQMRLSATKALLERKDVVLIASVSAIYGLGDPDSYLKMLL
HLRQGDVMGQRDILIRLSELQYKRNDIELQRGTYRVRGEVIDVFPADSERNAIRVELFDDEIERLSEFDPLTGHIIKRIA
RTTVYPKTHYVTPREKIIAATEFIKEELRERKQYLLDNNKLIEAQRIHERVQYDVEMMVELGYCSGIENYSRYLSGRAPG
EGPPTLLDYLPADGLLIIDESHVTVPQIGAMYKGDRSRKTTLVEYGFRLPSALDNRPLKFEEFEQLMPQTIYVSATPSVY
ELEKSEGEIAEQVVRPTGLLDPELEVRPVGTQVDDLLSEIAKRVAVNERVLVTTLTKRMSEDLTEYLDEHGVKVRYLHSD
IDTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTIGRAARNVNGKVILYADRITN
SMAKAIGETDRRRERQRAHNLKHGITPKGVVKRITDVMDVDDGRDSKAVYGKVAEPKSHYHKADATELSHQIDQLEKKMH
EHARNLEFEQAAAMRDEVKHLRDLLIKA
>Mature_667_residues
SESVFQLESQFAPAGDQPTAIAKLVDGLEAGLACQTLLGVTGSGKTFTIANVIQKLGRPTIIMAPNKTLAAQLYGEMKEF
FPHNAVEYFVSYYDYYQPEAYVPASNTFIEKDASVNAHIEQMRLSATKALLERKDVVLIASVSAIYGLGDPDSYLKMLLH
LRQGDVMGQRDILIRLSELQYKRNDIELQRGTYRVRGEVIDVFPADSERNAIRVELFDDEIERLSEFDPLTGHIIKRIAR
TTVYPKTHYVTPREKIIAATEFIKEELRERKQYLLDNNKLIEAQRIHERVQYDVEMMVELGYCSGIENYSRYLSGRAPGE
GPPTLLDYLPADGLLIIDESHVTVPQIGAMYKGDRSRKTTLVEYGFRLPSALDNRPLKFEEFEQLMPQTIYVSATPSVYE
LEKSEGEIAEQVVRPTGLLDPELEVRPVGTQVDDLLSEIAKRVAVNERVLVTTLTKRMSEDLTEYLDEHGVKVRYLHSDI
DTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTIGRAARNVNGKVILYADRITNS
MAKAIGETDRRRERQRAHNLKHGITPKGVVKRITDVMDVDDGRDSKAVYGKVAEPKSHYHKADATELSHQIDQLEKKMHE
HARNLEFEQAAAMRDEVKHLRDLLIKA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=668, Percent_Identity=72.7544910179641, Blast_Score=982, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=307, Percent_Identity=24.1042345276873, Blast_Score=73, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 75776; Mature: 75644

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESVFQLESQFAPAGDQPTAIAKLVDGLEAGLACQTLLGVTGSGKTFTIANVIQKLGRP
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHCCC
TIIMAPNKTLAAQLYGEMKEFFPHNAVEYFVSYYDYYQPEAYVPASNTFIEKDASVNAHI
EEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCCCCEECCCCCCHHHH
EQMRLSATKALLERKDVVLIASVSAIYGLGDPDSYLKMLLHLRQGDVMGQRDILIRLSEL
HHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHEEHHHH
QYKRNDIELQRGTYRVRGEVIDVFPADSERNAIRVELFDDEIERLSEFDPLTGHIIKRIA
HHHHCCEEEECCEEEEECEEEEEECCCCCCCEEEEEECHHHHHHHHHCCCHHHHHHHHHH
RTTVYPKTHYVTPREKIIAATEFIKEELRERKQYLLDNNKLIEAQRIHERVQYDVEMMVE
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHH
LGYCSGIENYSRYLSGRAPGEGPPTLLDYLPADGLLIIDESHVTVPQIGAMYKGDRSRKT
HHHHCCHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCCCH
TLVEYGFRLPSALDNRPLKFEEFEQLMPQTIYVSATPSVYELEKSEGEIAEQVVRPTGLL
HHHHHCCCCCHHCCCCCCCHHHHHHHCCCEEEEECCCCCEEECCCCHHHHHHHHCCCCCC
DPELEVRPVGTQVDDLLSEIAKRVAVNERVLVTTLTKRMSEDLTEYLDEHGVKVRYLHSD
CCCCEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
IDTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNVNGKVILYADRITNSMAKAIGETDRRRERQRAHNLKHGITPKGVVKRITDVMDV
HHHHHCCCCEEEEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
DDGRDSKAVYGKVAEPKSHYHKADATELSHQIDQLEKKMHEHARNLEFEQAAAMRDEVKH
CCCCCCCHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LRDLLIKA
HHHHHHCC
>Mature Secondary Structure 
SESVFQLESQFAPAGDQPTAIAKLVDGLEAGLACQTLLGVTGSGKTFTIANVIQKLGRP
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHCCC
TIIMAPNKTLAAQLYGEMKEFFPHNAVEYFVSYYDYYQPEAYVPASNTFIEKDASVNAHI
EEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCCCCEECCCCCCHHHH
EQMRLSATKALLERKDVVLIASVSAIYGLGDPDSYLKMLLHLRQGDVMGQRDILIRLSEL
HHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHEEHHHH
QYKRNDIELQRGTYRVRGEVIDVFPADSERNAIRVELFDDEIERLSEFDPLTGHIIKRIA
HHHHCCEEEECCEEEEECEEEEEECCCCCCCEEEEEECHHHHHHHHHCCCHHHHHHHHHH
RTTVYPKTHYVTPREKIIAATEFIKEELRERKQYLLDNNKLIEAQRIHERVQYDVEMMVE
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHH
LGYCSGIENYSRYLSGRAPGEGPPTLLDYLPADGLLIIDESHVTVPQIGAMYKGDRSRKT
HHHHCCHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCCCH
TLVEYGFRLPSALDNRPLKFEEFEQLMPQTIYVSATPSVYELEKSEGEIAEQVVRPTGLL
HHHHHCCCCCHHCCCCCCCHHHHHHHCCCEEEEECCCCCEEECCCCHHHHHHHHCCCCCC
DPELEVRPVGTQVDDLLSEIAKRVAVNERVLVTTLTKRMSEDLTEYLDEHGVKVRYLHSD
CCCCEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
IDTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNVNGKVILYADRITNSMAKAIGETDRRRERQRAHNLKHGITPKGVVKRITDVMDV
HHHHHCCCCEEEEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
DDGRDSKAVYGKVAEPKSHYHKADATELSHQIDQLEKKMHEHARNLEFEQAAAMRDEVKH
CCCCCCCHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LRDLLIKA
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA