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The map label for this gene is bioF [H]

Identifier: 126173986

GI number: 126173986

Start: 2049293

End: 2050513

Strand: Direct

Name: bioF [H]

Synonym: Sbal_1759

Alternate gene names: 126173986

Gene position: 2049293-2050513 (Clockwise)

Preceding gene: 126173985

Following gene: 126173987

Centisome position: 39.97

GC content: 51.11

Gene sequence:

>1221_bases
ATGAGTTCTCTGCTTGAGACTAAAATTGCCGCCCGTCAGCATGCTTTGCGTGAGCAAGGATTACTGCGACAACGTAAAGT
GCTGAGTGTCGATCATGCCCTTAACACCAACGCATCCACTTCGAGCCCACGTTTTGTGTTCGAAGGTCGCGCCTATGTCA
ATTTCAGCAGTAATGATTATTTAGGTTTATCCCGCGTACCACAACTCGCTGAGGCCTTGCACCTTGGCGCGCAAACCTAC
GGTGTGGGTAGCGGCGCATCGCCCTTAGTGACAGGATACAGTGACGCACATTTGGCGCTGGAGCGTGAGCTTTGCGCCTT
AACGGGACATGAAGCGGCATTGTTATTTTGCTCGGGCTTTAGTGCTAATACGGCGCTGATGAAAACCCTGTTTGATCAGC
ACGATATTGTAGTTGCCGACAAACTCGTACATGCCTCCATTATTGATGGTTTGCAAGATAGTGGCGCGCAGCTGAAACGT
TTTTTACACAATTCCTTAGAAAGCGCTGAGCGGTTACTTGCTCGAAATCAAACATCGGCGTTAATCACTGAAAGCGTGTT
TAGCATGGACGGAGATTGTGCGCCAATTGCCCAGTTATCGGCGCTTTGTCGCCAACATCATACTTGGTTGGTTGTCGATG
ATGCCCATGGTTTTGCGGTGCTCGATGGTTATCACAATGCAGAGGCCGCCAAGCTTATCGATGTGCAAGTGGTGACCTTT
GGTAAAGCCTTAGGTTGCCAAGGCGCGGCCGTGTTGGGGAGTCAGGCGCTGATCGATTTTTTGGTCAGTAACGCCCGCGA
ATATATTTACTCGACTGCTTTATCGCCCGCCAATGCGGCGCTAGCCTTAGCCGCGACTCAGTACAGCACAGCACATCCCG
AGTTACAGCAACAACTGCTTGAGAATATTAAGCTATTCAAACGGTTATGCCGAGAGGCTAATGTGCCCCTTTTAGGTTCA
GATACCGCGATTCAGCCGCTGATCATTGGGGATGCGTTGCAAACCTTGCAAGTAGCCGAGGAGCTAAGGGCTGCAGGAAT
TTGGGTTGGCGCGATTCGCCCGCCGACCGTGCCTGTAAGCTCTGCGCGTTTACGTATTACTTTAACGGCAGCTCACGCCG
CGGAAGATATCGCAACGTGTGTTGCGCAATTAGCTCAAGTGCTCAGTCGCGTCGGTGTGCCGCTTGTGACTGAACGAAAA
GCTGCGGATTATAACAGATAA

Upstream 100 bases:

>100_bases
CTAAGGCAACCGTCTTAAACCGAACACTCATAGGGTAATCATTGTTGAGACCATTGTTGAAACAGTCATTTTTGAGTCAG
TCATGCTTGAGGCTACATCG

Downstream 100 bases:

>100_bases
ATGTACGCTATAGAACGCGTTATTCTATTGAAATTTAAGTTTTTATGGTTGAGTGTTAACTGCAATGCCAAGCCCGATTA
AATCCAGCAAGCCCAACGCG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSSLLETKIAARQHALREQGLLRQRKVLSVDHALNTNASTSSPRFVFEGRAYVNFSSNDYLGLSRVPQLAEALHLGAQTY
GVGSGASPLVTGYSDAHLALERELCALTGHEAALLFCSGFSANTALMKTLFDQHDIVVADKLVHASIIDGLQDSGAQLKR
FLHNSLESAERLLARNQTSALITESVFSMDGDCAPIAQLSALCRQHHTWLVVDDAHGFAVLDGYHNAEAAKLIDVQVVTF
GKALGCQGAAVLGSQALIDFLVSNAREYIYSTALSPANAALALAATQYSTAHPELQQQLLENIKLFKRLCREANVPLLGS
DTAIQPLIIGDALQTLQVAEELRAAGIWVGAIRPPTVPVSSARLRITLTAAHAAEDIATCVAQLAQVLSRVGVPLVTERK
AADYNR

Sequences:

>Translated_406_residues
MSSLLETKIAARQHALREQGLLRQRKVLSVDHALNTNASTSSPRFVFEGRAYVNFSSNDYLGLSRVPQLAEALHLGAQTY
GVGSGASPLVTGYSDAHLALERELCALTGHEAALLFCSGFSANTALMKTLFDQHDIVVADKLVHASIIDGLQDSGAQLKR
FLHNSLESAERLLARNQTSALITESVFSMDGDCAPIAQLSALCRQHHTWLVVDDAHGFAVLDGYHNAEAAKLIDVQVVTF
GKALGCQGAAVLGSQALIDFLVSNAREYIYSTALSPANAALALAATQYSTAHPELQQQLLENIKLFKRLCREANVPLLGS
DTAIQPLIIGDALQTLQVAEELRAAGIWVGAIRPPTVPVSSARLRITLTAAHAAEDIATCVAQLAQVLSRVGVPLVTERK
AADYNR
>Mature_405_residues
SSLLETKIAARQHALREQGLLRQRKVLSVDHALNTNASTSSPRFVFEGRAYVNFSSNDYLGLSRVPQLAEALHLGAQTYG
VGSGASPLVTGYSDAHLALERELCALTGHEAALLFCSGFSANTALMKTLFDQHDIVVADKLVHASIIDGLQDSGAQLKRF
LHNSLESAERLLARNQTSALITESVFSMDGDCAPIAQLSALCRQHHTWLVVDDAHGFAVLDGYHNAEAAKLIDVQVVTFG
KALGCQGAAVLGSQALIDFLVSNAREYIYSTALSPANAALALAATQYSTAHPELQQQLLENIKLFKRLCREANVPLLGSD
TAIQPLIIGDALQTLQVAEELRAAGIWVGAIRPPTVPVSSARLRITLTAAHAAEDIATCVAQLAQVLSRVGVPLVTERKA
ADYNR

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=344, Percent_Identity=30.8139534883721, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI284448556, Length=344, Percent_Identity=30.8139534883721, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI4502025, Length=354, Percent_Identity=31.3559322033898, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI40316939, Length=354, Percent_Identity=31.3559322033898, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI83977444, Length=361, Percent_Identity=30.4709141274238, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI83977442, Length=361, Percent_Identity=30.4709141274238, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI83977440, Length=361, Percent_Identity=30.4709141274238, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI4758668, Length=364, Percent_Identity=27.7472527472527, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI119220554, Length=372, Percent_Identity=26.3440860215054, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI5454084, Length=268, Percent_Identity=26.865671641791, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1786993, Length=344, Percent_Identity=46.2209302325581, Blast_Score=252, Evalue=2e-68,
Organism=Escherichia coli, GI1790046, Length=388, Percent_Identity=31.4432989690722, Blast_Score=196, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI71994529, Length=353, Percent_Identity=31.4447592067989, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI32566772, Length=366, Percent_Identity=25.4098360655738, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17560912, Length=368, Percent_Identity=25.2717391304348, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17560914, Length=368, Percent_Identity=25.2717391304348, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71982625, Length=273, Percent_Identity=23.4432234432234, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71982617, Length=273, Percent_Identity=23.4432234432234, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320438, Length=378, Percent_Identity=30.1587301587302, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320267, Length=391, Percent_Identity=24.5524296675192, Blast_Score=109, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6323954, Length=225, Percent_Identity=28, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24662918, Length=397, Percent_Identity=30.2267002518892, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI17137420, Length=406, Percent_Identity=29.5566502463054, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI17136286, Length=388, Percent_Identity=27.319587628866, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24653280, Length=305, Percent_Identity=25.2459016393443, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24653276, Length=305, Percent_Identity=25.2459016393443, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24653278, Length=305, Percent_Identity=25.2459016393443, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 43492; Mature: 43361

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLLETKIAARQHALREQGLLRQRKVLSVDHALNTNASTSSPRFVFEGRAYVNFSSNDY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECEEEEEECCCCC
LGLSRVPQLAEALHLGAQTYGVGSGASPLVTGYSDAHLALERELCALTGHEAALLFCSGF
CCHHHHHHHHHHHHHCCHHCCCCCCCCCCEECCCCHHHHHHHHHHHHCCCCEEEEEEECC
SANTALMKTLFDQHDIVVADKLVHASIIDGLQDSGAQLKRFLHNSLESAERLLARNQTSA
CCHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHH
LITESVFSMDGDCAPIAQLSALCRQHHTWLVVDDAHGFAVLDGYHNAEAAKLIDVQVVTF
HHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEECCCCEEEEECCCCCCHHHEEEEEEEEH
GKALGCQGAAVLGSQALIDFLVSNAREYIYSTALSPANAALALAATQYSTAHPELQQQLL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEHHCCCCCHHHHHHHH
ENIKLFKRLCREANVPLLGSDTAIQPLIIGDALQTLQVAEELRAAGIWVGAIRPPTVPVS
HHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCC
SARLRITLTAAHAAEDIATCVAQLAQVLSRVGVPLVTERKAADYNR
CCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCC
>Mature Secondary Structure 
SSLLETKIAARQHALREQGLLRQRKVLSVDHALNTNASTSSPRFVFEGRAYVNFSSNDY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECEEEEEECCCCC
LGLSRVPQLAEALHLGAQTYGVGSGASPLVTGYSDAHLALERELCALTGHEAALLFCSGF
CCHHHHHHHHHHHHHCCHHCCCCCCCCCCEECCCCHHHHHHHHHHHHCCCCEEEEEEECC
SANTALMKTLFDQHDIVVADKLVHASIIDGLQDSGAQLKRFLHNSLESAERLLARNQTSA
CCHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHH
LITESVFSMDGDCAPIAQLSALCRQHHTWLVVDDAHGFAVLDGYHNAEAAKLIDVQVVTF
HHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEECCCCEEEEECCCCCCHHHEEEEEEEEH
GKALGCQGAAVLGSQALIDFLVSNAREYIYSTALSPANAALALAATQYSTAHPELQQQLL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEHHCCCCCHHHHHHHH
ENIKLFKRLCREANVPLLGSDTAIQPLIIGDALQTLQVAEELRAAGIWVGAIRPPTVPVS
HHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCC
SARLRITLTAAHAAEDIATCVAQLAQVLSRVGVPLVTERKAADYNR
CCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA