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The map label for this gene is thrC [H]

Identifier: 126173467

GI number: 126173467

Start: 1413249

End: 1414532

Strand: Direct

Name: thrC [H]

Synonym: Sbal_1229

Alternate gene names: 126173467

Gene position: 1413249-1414532 (Clockwise)

Preceding gene: 126173466

Following gene: 126173468

Centisome position: 27.56

GC content: 48.05

Gene sequence:

>1284_bases
ATGGAACTATATAATTTAAAACACCCTTCGCAGAAAGTGAGCTTTAAAGAGGCAGTGCAATTAGGTTTAGGTCAGGATAG
AGGTTTGTTCTTCCCCACCCAAATTCCGGTCTTAGACGATATTGAAGGACTGCTGGCATTGCCATTTGTTGAGCGCAGTA
AAAAAGTGCTCGGTGCATGGCTTGCCTCTGAACTAGGGCAAGATGCAGTTGATGAACTGGTTGAACGTGCCTTTAACTTC
GATTTACCTTTGGTTGCCGTCGATGAGCAGCGCGCTTGCCTCGAATTGTTCCACGGTCCTACTCTGGCATTTAAAGATTT
TGGTGCGCGTTTTATGGCGCAATGCGTCAATGCCTTTGTCGGCGACACACGCTTAACCATTCTGACTGCGACTTCGGGTG
ACACTGGCGCCGCGGTTGCCGATGCCTTTTATGGGCTTGAAAAAGTCAATGTAGTGGTGCTCTATCCTAAGGGCAAGATC
AGTGAGCTACAGGAAAAGATGTTCACGACTTTGGGCAAGAATATCCATACAGTTGCCGTATCGTCCGATTTTGATGCCTG
CCAAGATCTGGTTAAACGCGCCTTTGATGATCCAGAAGTCCGCGAGGGTTTGAGCTTAAACTCGGCGAACTCTATCAACA
TCAGCCGCTTACTTGCGCAAATTTGTTATTACTTTGAAGCCGTTGCCCAGTCTAAACAACGCCACGACGCCGATCCTGTG
ATTTCAGTGCCAAGTGGTAACTTTGGTAACCTGACGGCGGGTTTATTCGCCAAAGCCATGGGGTTACCGGTTAAACGCTT
TATCGCCGCAACCAATGCGAATGATACTGTGCCGCGCTATTTAGAAAACGGCCAATGGCAGCCCAATCAAACCCAAGCGA
CCATGTCTAATGCGATGGATGTGAGTGAGCCAAGTAACTGGCCGCGAGTGGAAGCCATTTGTGAGAAATTAGCTTGGCCG
CTGAGTAACTTAGTGGGCATGCGTTTATCTGAAGAGCAAACTTCACTGGCATTAGCTGAGTTGCATGCACAGGGTTATGT
GTCTGAGCCCCATGCAGCGATTGCAGCTAAAGCTTTGTCTTTAACCTTAGTGCCCGATGAAGTGGGTATATTCTTAGGTA
CAGCGCATCCCGCTAAATTTAAGGATGTGGTCGATAGAGAGCTAAATCTTAACTTACCACTGCCGGTTGAACTTGAGGCC
GTTGCCCACAAACCTATCTTGTCGGCTGACTTACCCGCCGATTTTGCGGCACTGAAAGCGCACTTATTCAAGATCTTAAC
CTAA

Upstream 100 bases:

>100_bases
GTATCAAGACTAAGCATTAAGGCTAAATATCCATCTTATGCATAAAGAGCATGCATCAAGAATTAGCATTCAAGGCTTAG
CATCAAAAGGTCGAGTGAGC

Downstream 100 bases:

>100_bases
GCTGCTTGTACTTAAGGTATTGGCCTAGCGGTGAGATAACATAGCGTTACAGAAGAGAAGGGAGCTTAGCTCCCTTTTTT
ATCAGCACAATTTTGATAAA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MELYNLKHPSQKVSFKEAVQLGLGQDRGLFFPTQIPVLDDIEGLLALPFVERSKKVLGAWLASELGQDAVDELVERAFNF
DLPLVAVDEQRACLELFHGPTLAFKDFGARFMAQCVNAFVGDTRLTILTATSGDTGAAVADAFYGLEKVNVVVLYPKGKI
SELQEKMFTTLGKNIHTVAVSSDFDACQDLVKRAFDDPEVREGLSLNSANSINISRLLAQICYYFEAVAQSKQRHDADPV
ISVPSGNFGNLTAGLFAKAMGLPVKRFIAATNANDTVPRYLENGQWQPNQTQATMSNAMDVSEPSNWPRVEAICEKLAWP
LSNLVGMRLSEEQTSLALAELHAQGYVSEPHAAIAAKALSLTLVPDEVGIFLGTAHPAKFKDVVDRELNLNLPLPVELEA
VAHKPILSADLPADFAALKAHLFKILT

Sequences:

>Translated_427_residues
MELYNLKHPSQKVSFKEAVQLGLGQDRGLFFPTQIPVLDDIEGLLALPFVERSKKVLGAWLASELGQDAVDELVERAFNF
DLPLVAVDEQRACLELFHGPTLAFKDFGARFMAQCVNAFVGDTRLTILTATSGDTGAAVADAFYGLEKVNVVVLYPKGKI
SELQEKMFTTLGKNIHTVAVSSDFDACQDLVKRAFDDPEVREGLSLNSANSINISRLLAQICYYFEAVAQSKQRHDADPV
ISVPSGNFGNLTAGLFAKAMGLPVKRFIAATNANDTVPRYLENGQWQPNQTQATMSNAMDVSEPSNWPRVEAICEKLAWP
LSNLVGMRLSEEQTSLALAELHAQGYVSEPHAAIAAKALSLTLVPDEVGIFLGTAHPAKFKDVVDRELNLNLPLPVELEA
VAHKPILSADLPADFAALKAHLFKILT
>Mature_427_residues
MELYNLKHPSQKVSFKEAVQLGLGQDRGLFFPTQIPVLDDIEGLLALPFVERSKKVLGAWLASELGQDAVDELVERAFNF
DLPLVAVDEQRACLELFHGPTLAFKDFGARFMAQCVNAFVGDTRLTILTATSGDTGAAVADAFYGLEKVNVVVLYPKGKI
SELQEKMFTTLGKNIHTVAVSSDFDACQDLVKRAFDDPEVREGLSLNSANSINISRLLAQICYYFEAVAQSKQRHDADPV
ISVPSGNFGNLTAGLFAKAMGLPVKRFIAATNANDTVPRYLENGQWQPNQTQATMSNAMDVSEPSNWPRVEAICEKLAWP
LSNLVGMRLSEEQTSLALAELHAQGYVSEPHAAIAAKALSLTLVPDEVGIFLGTAHPAKFKDVVDRELNLNLPLPVELEA
VAHKPILSADLPADFAALKAHLFKILT

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=450, Percent_Identity=30.8888888888889, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI149193323, Length=347, Percent_Identity=32.5648414985591, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1786185, Length=421, Percent_Identity=60.8076009501188, Blast_Score=494, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6319901, Length=455, Percent_Identity=33.1868131868132, Blast_Score=217, Evalue=3e-57,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 46547; Mature: 46547

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELYNLKHPSQKVSFKEAVQLGLGQDRGLFFPTQIPVLDDIEGLLALPFVERSKKVLGAW
CCCCCCCCCCHHCCHHHHHHHCCCCCCCEECCCCCCCHHCCHHHHHHHHHHHHHHHHHHH
LASELGQDAVDELVERAFNFDLPLVAVDEQRACLELFHGPTLAFKDFGARFMAQCVNAFV
HHHHHCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
GDTRLTILTATSGDTGAAVADAFYGLEKVNVVVLYPKGKISELQEKMFTTLGKNIHTVAV
CCCEEEEEEECCCCCCHHHHHHHHCHHHEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEE
SSDFDACQDLVKRAFDDPEVREGLSLNSANSINISRLLAQICYYFEAVAQSKQRHDADPV
CCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
ISVPSGNFGNLTAGLFAKAMGLPVKRFIAATNANDTVPRYLENGQWQPNQTQATMSNAMD
EECCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHCCCCCCCCHHHHHHHCCC
VSEPSNWPRVEAICEKLAWPLSNLVGMRLSEEQTSLALAELHAQGYVSEPHAAIAAKALS
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHE
LTLVPDEVGIFLGTAHPAKFKDVVDRELNLNLPLPVELEAVAHKPILSADLPADFAALKA
EEECCCCCCEEEECCCCHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHH
HLFKILT
HHHHHCC
>Mature Secondary Structure
MELYNLKHPSQKVSFKEAVQLGLGQDRGLFFPTQIPVLDDIEGLLALPFVERSKKVLGAW
CCCCCCCCCCHHCCHHHHHHHCCCCCCCEECCCCCCCHHCCHHHHHHHHHHHHHHHHHHH
LASELGQDAVDELVERAFNFDLPLVAVDEQRACLELFHGPTLAFKDFGARFMAQCVNAFV
HHHHHCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
GDTRLTILTATSGDTGAAVADAFYGLEKVNVVVLYPKGKISELQEKMFTTLGKNIHTVAV
CCCEEEEEEECCCCCCHHHHHHHHCHHHEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEE
SSDFDACQDLVKRAFDDPEVREGLSLNSANSINISRLLAQICYYFEAVAQSKQRHDADPV
CCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
ISVPSGNFGNLTAGLFAKAMGLPVKRFIAATNANDTVPRYLENGQWQPNQTQATMSNAMD
EECCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHCCCCCCCCHHHHHHHCCC
VSEPSNWPRVEAICEKLAWPLSNLVGMRLSEEQTSLALAELHAQGYVSEPHAAIAAKALS
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHE
LTLVPDEVGIFLGTAHPAKFKDVVDRELNLNLPLPVELEAVAHKPILSADLPADFAALKA
EEECCCCCCEEEECCCCHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHH
HLFKILT
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]