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The map label for this gene is thrB [H]

Identifier: 126173466

GI number: 126173466

Start: 1412174

End: 1413136

Strand: Direct

Name: thrB [H]

Synonym: Sbal_1228

Alternate gene names: 126173466

Gene position: 1412174-1413136 (Clockwise)

Preceding gene: 126173465

Following gene: 126173467

Centisome position: 27.54

GC content: 50.26

Gene sequence:

>963_bases
ATGAGTTTGACCGTTTACGCTCCAGCCTCTATGGGTAACGTGGGAGTCGGATTTGATTTACTGGGCGCCGCTTTGGCGCC
TATCGATGGCAGTTTACTGGGCGACAGAGTGACTATCGCGGCGGCAGCGTCGGGTGTGAGTCTGGCGCAAACCGGTGCTT
GGGCCCATAAACTGCCTGAAAATCCGCAAGACAATATAGTGTACCAATGTGCCGAATTCTTCTTAACCGCCCTGAGTAAG
GAGTATTTAGAAGCGCTTGGAAAAGCAGAGGAAGGCGTAGCGCTGACACTGGAAAAGAACCTGCCCGTCGGCAGTGGTTT
AGGTTCGAGTGCAAGCTCAGTCGTGGCGGCGTTATATGCACTGAATGAACATTTTGACAGACCTTATAACGAGCAAGCCC
TGCTGGAACTGATGGGCGAGTTTGAAGGTAAGATCAGCGGCAGTGTGCACTATGACAACGTCGCCCCCTGTTATTTGGGT
GGCATGCAATTGATGCTCAATGTGCCGGGCACTGTATGTGAAGCGATACCGAGTTTTAAAGAATGGTATTGGGTTGTGGC
CTATCCAGGCATTTCACTCTCAACGGCGATGATGCGTAAACTTATGCCCGACCAATACGATAAAAGTGTCACTATCGATT
TTGGTCGTTATTTAAGTGCCTTTGTACATGCCTCTTATCAGCAGAATGCCAAGCTTGCGATCAGCGTATTAAAAGATGTG
TTAGCCGAGCCTTATCGCGCAGCTGCGATTCCGGGTTACGACAATGCCAGAGTTGCTTTAGCCGATTTAGGCATGTTGAC
TACGGGGATTTCCGGCAGTGGTCCAACGCTGTTTTCGATTACCGATGATTTAGCCACGGCAAATGCGGCTAAAACCTGGT
TAGAACAGCATTATTTAACCGAGGTGGGTGGCTTTGCCCACGTGTGTCGCCTCGATGAGCAAGGCACGCGTAGAGTCGAT
TAA

Upstream 100 bases:

>100_bases
CGTTTGTGCTGCGCGGTTATGGCGCGGGAACGGAAGTGACTGCCGCTGGCGCTTTTGCCGATGTATTAAGAACCTTGAAT
TGGACTCGTGAGGTGAGTGT

Downstream 100 bases:

>100_bases
TTCTTATTTTTAGTATCAAGACTAAGCATTAAGGCTAAATATCCATCTTATGCATAAAGAGCATGCATCAAGAATTAGCA
TTCAAGGCTTAGCATCAAAA

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MSLTVYAPASMGNVGVGFDLLGAALAPIDGSLLGDRVTIAAAASGVSLAQTGAWAHKLPENPQDNIVYQCAEFFLTALSK
EYLEALGKAEEGVALTLEKNLPVGSGLGSSASSVVAALYALNEHFDRPYNEQALLELMGEFEGKISGSVHYDNVAPCYLG
GMQLMLNVPGTVCEAIPSFKEWYWVVAYPGISLSTAMMRKLMPDQYDKSVTIDFGRYLSAFVHASYQQNAKLAISVLKDV
LAEPYRAAAIPGYDNARVALADLGMLTTGISGSGPTLFSITDDLATANAAKTWLEQHYLTEVGGFAHVCRLDEQGTRRVD

Sequences:

>Translated_320_residues
MSLTVYAPASMGNVGVGFDLLGAALAPIDGSLLGDRVTIAAAASGVSLAQTGAWAHKLPENPQDNIVYQCAEFFLTALSK
EYLEALGKAEEGVALTLEKNLPVGSGLGSSASSVVAALYALNEHFDRPYNEQALLELMGEFEGKISGSVHYDNVAPCYLG
GMQLMLNVPGTVCEAIPSFKEWYWVVAYPGISLSTAMMRKLMPDQYDKSVTIDFGRYLSAFVHASYQQNAKLAISVLKDV
LAEPYRAAAIPGYDNARVALADLGMLTTGISGSGPTLFSITDDLATANAAKTWLEQHYLTEVGGFAHVCRLDEQGTRRVD
>Mature_319_residues
SLTVYAPASMGNVGVGFDLLGAALAPIDGSLLGDRVTIAAAASGVSLAQTGAWAHKLPENPQDNIVYQCAEFFLTALSKE
YLEALGKAEEGVALTLEKNLPVGSGLGSSASSVVAALYALNEHFDRPYNEQALLELMGEFEGKISGSVHYDNVAPCYLGG
MQLMLNVPGTVCEAIPSFKEWYWVVAYPGISLSTAMMRKLMPDQYDKSVTIDFGRYLSAFVHASYQQNAKLAISVLKDVL
AEPYRAAAIPGYDNARVALADLGMLTTGISGSGPTLFSITDDLATANAAKTWLEQHYLTEVGGFAHVCRLDEQGTRRVD

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=315, Percent_Identity=53.3333333333333, Blast_Score=349, Evalue=2e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 34160; Mature: 34029

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTVYAPASMGNVGVGFDLLGAALAPIDGSLLGDRVTIAAAASGVSLAQTGAWAHKLPE
CCEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHCCCHHHCCCC
NPQDNIVYQCAEFFLTALSKEYLEALGKAEEGVALTLEKNLPVGSGLGSSASSVVAALYA
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHH
LNEHFDRPYNEQALLELMGEFEGKISGSVHYDNVAPCYLGGMQLMLNVPGTVCEAIPSFK
HHHHHCCCCCHHHHHHHHHHHCCCCCCCEECCCCCHHHHCCCHHEEECCHHHHHHCCCHH
EWYWVVAYPGISLSTAMMRKLMPDQYDKSVTIDFGRYLSAFVHASYQQNAKLAISVLKDV
HCEEEEEECCCCHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHH
LAEPYRAAAIPGYDNARVALADLGMLTTGISGSGPTLFSITDDLATANAAKTWLEQHYLT
HCCCHHHCCCCCCCCCEEEHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHH
EVGGFAHVCRLDEQGTRRVD
HHCCHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SLTVYAPASMGNVGVGFDLLGAALAPIDGSLLGDRVTIAAAASGVSLAQTGAWAHKLPE
CEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHCCCHHHCCCC
NPQDNIVYQCAEFFLTALSKEYLEALGKAEEGVALTLEKNLPVGSGLGSSASSVVAALYA
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHH
LNEHFDRPYNEQALLELMGEFEGKISGSVHYDNVAPCYLGGMQLMLNVPGTVCEAIPSFK
HHHHHCCCCCHHHHHHHHHHHCCCCCCCEECCCCCHHHHCCCHHEEECCHHHHHHCCCHH
EWYWVVAYPGISLSTAMMRKLMPDQYDKSVTIDFGRYLSAFVHASYQQNAKLAISVLKDV
HCEEEEEECCCCHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHH
LAEPYRAAAIPGYDNARVALADLGMLTTGISGSGPTLFSITDDLATANAAKTWLEQHYLT
HCCCHHHCCCCCCCCCEEEHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHH
EVGGFAHVCRLDEQGTRRVD
HHCCHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]