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The map label for this gene is mutH

Identifier: 126173421

GI number: 126173421

Start: 1365775

End: 1366446

Strand: Reverse

Name: mutH

Synonym: Sbal_1183

Alternate gene names: 126173421

Gene position: 1366446-1365775 (Counterclockwise)

Preceding gene: 126173432

Following gene: 126173420

Centisome position: 26.65

GC content: 50.45

Gene sequence:

>672_bases
ATGAATCGAATTATTCCCCCCGAAAATCTCCCTGAGCTACTCGAGCGCGCCCATATGATGGCTGGCGTGAGTTTGGCGCA
AATTGCCGCCCAAAGAGGCCTAAGTGTCCCCAAGGATCTTAAGCGGGATAAAGGCTGGGTCGGCCAGTTAATCGAAATGG
AACTGGGCGCGACGGCTGGCTCTAAACCTGAGCAAGATTTTCTGCATTTAGGTGTCGAGCTTAAAACTATCCCCATCGAT
TCACAGGGACGACCATTGGAGACCACTTATGTTTGCGTGGCGCCGCTGTCGAATATCCAAGGGTTAACCTGGCAAAACAG
CTTAGTCAGCCATAAGTTACAGCGAGTCCTTTGGGTACCCGTTGAAGGTGAGCGGCATATTCCTGTGGGAGAGCGCCGTA
TTGGCACCCCGATATTGTGGGAGCCTGATCCACAGGAGTTGCAATTACTGCAACAGGATTGGGAAGAGATCATGGAGCTT
ATCGCCCTCGGCAAAGTCGAAAAACTCACCGCACGCCACGGCGAAGTACTGCAATTACGTCCCAAAGCCGCCAACAGTAA
AGCATTAACGCAAAGCATTGCCGAAGATGGCAGCCTCAAAATGACCAACCCTAGGGGCTTTTATTTAAAGACCAGTTTCA
CCGCCATGATACTTAATAAGGTTTTTGGTTAA

Upstream 100 bases:

>100_bases
GTTACTTAGAATAAAAACATTCGGTACAAGTTTACTTAAATCACTGAGTTCATTTTTTAACCACCATTGCTAAGCGGTTA
TTTTTAAGTAAAATCCAGCC

Downstream 100 bases:

>100_bases
TATTTAGTGACGATATAGACTTAGATTGATCCAGATCACAAATTTCACTGGCACTAAGGTGACTCTTTTCTATAAACTAC
GGCATTCTGAAATCACAGCC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: Methyl-directed mismatch repair protein

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MNRIIPPENLPELLERAHMMAGVSLAQIAAQRGLSVPKDLKRDKGWVGQLIEMELGATAGSKPEQDFLHLGVELKTIPID
SQGRPLETTYVCVAPLSNIQGLTWQNSLVSHKLQRVLWVPVEGERHIPVGERRIGTPILWEPDPQELQLLQQDWEEIMEL
IALGKVEKLTARHGEVLQLRPKAANSKALTQSIAEDGSLKMTNPRGFYLKTSFTAMILNKVFG

Sequences:

>Translated_223_residues
MNRIIPPENLPELLERAHMMAGVSLAQIAAQRGLSVPKDLKRDKGWVGQLIEMELGATAGSKPEQDFLHLGVELKTIPID
SQGRPLETTYVCVAPLSNIQGLTWQNSLVSHKLQRVLWVPVEGERHIPVGERRIGTPILWEPDPQELQLLQQDWEEIMEL
IALGKVEKLTARHGEVLQLRPKAANSKALTQSIAEDGSLKMTNPRGFYLKTSFTAMILNKVFG
>Mature_223_residues
MNRIIPPENLPELLERAHMMAGVSLAQIAAQRGLSVPKDLKRDKGWVGQLIEMELGATAGSKPEQDFLHLGVELKTIPID
SQGRPLETTYVCVAPLSNIQGLTWQNSLVSHKLQRVLWVPVEGERHIPVGERRIGTPILWEPDPQELQLLQQDWEEIMEL
IALGKVEKLTARHGEVLQLRPKAANSKALTQSIAEDGSLKMTNPRGFYLKTSFTAMILNKVFG

Specific function: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair

COG id: COG3066

COG function: function code L; DNA mismatch repair protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mutH family

Homologues:

Organism=Escherichia coli, GI1789196, Length=217, Percent_Identity=59.9078341013825, Blast_Score=281, Evalue=3e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTH_SHEB2 (B8EBS0)

Other databases:

- EMBL:   CP001252
- RefSeq:   YP_002359038.1
- ProteinModelPortal:   B8EBS0
- SMR:   B8EBS0
- GeneID:   7087908
- GenomeReviews:   CP001252_GR
- KEGG:   sbp:Sbal223_3130
- HOGENOM:   HBG296591
- OMA:   QDWEELM
- ProtClustDB:   PRK05070
- GO:   GO:0005737
- HAMAP:   MF_00759
- InterPro:   IPR004230
- InterPro:   IPR011337
- InterPro:   IPR011335
- Gene3D:   G3DSA:3.40.600.10
- SMART:   SM00927
- TIGRFAMs:   TIGR02248

Pfam domain/function: PF02976 MutH; SSF52980 Restrict_endonuc_II-like_core

EC number: NA

Molecular weight: Translated: 24893; Mature: 24893

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRIIPPENLPELLERAHMMAGVSLAQIAAQRGLSVPKDLKRDKGWVGQLIEMELGATAG
CCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHCCCCC
SKPEQDFLHLGVELKTIPIDSQGRPLETTYVCVAPLSNIQGLTWQNSLVSHKLQRVLWVP
CCCCHHHHHCCEEEEEEEECCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHEEEEE
VEGERHIPVGERRIGTPILWEPDPQELQLLQQDWEEIMELIALGKVEKLTARHGEVLQLR
CCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEC
PKAANSKALTQSIAEDGSLKMTNPRGFYLKTSFTAMILNKVFG
CCCCCHHHHHHHHHCCCCEEEECCCCEEEEHHHHHHHHHHHCC
>Mature Secondary Structure
MNRIIPPENLPELLERAHMMAGVSLAQIAAQRGLSVPKDLKRDKGWVGQLIEMELGATAG
CCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHCCCCC
SKPEQDFLHLGVELKTIPIDSQGRPLETTYVCVAPLSNIQGLTWQNSLVSHKLQRVLWVP
CCCCHHHHHCCEEEEEEEECCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHEEEEE
VEGERHIPVGERRIGTPILWEPDPQELQLLQQDWEEIMELIALGKVEKLTARHGEVLQLR
CCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEC
PKAANSKALTQSIAEDGSLKMTNPRGFYLKTSFTAMILNKVFG
CCCCCHHHHHHHHHCCCCEEEECCCCEEEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA