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The map label for this gene is folB [H]

Identifier: 126173389

GI number: 126173389

Start: 1327654

End: 1328004

Strand: Direct

Name: folB [H]

Synonym: Sbal_1150

Alternate gene names: 126173389

Gene position: 1327654-1328004 (Clockwise)

Preceding gene: 126173387

Following gene: 126173390

Centisome position: 25.89

GC content: 47.01

Gene sequence:

>351_bases
ATGGATAAGGTACTTATACGGCAATTGCGCATTGATACTGTGATTGGTGTCTATGAGTGGGAAAAGACAATCCATCAGAG
CCTGTTATTAGACTTAGACATGGCGTGGGATAACAAACCTGCCGCAGCGACGGATGATTATCAATATGCGCTGTGCTATG
AGACAGTTTCCAATCGATTAACCCAACTTGTTACTGAGCATCCAATCGAGTTAATCGAAACGGTTGCCGAGCGAGTGGCC
GATTGCCTACTTCAAGAATTTAACGTGACTTGGGTGAAAGTTGTCGTGATGAAGCCAGGCGCGGTAGCGACTGCAGCTTC
GGTTGGCGTCGAGATTGAACGTTCACGTTAG

Upstream 100 bases:

>100_bases
TAGAAAGTAAATTAGTTATCTGTCAGAAGATTGCGGATTATACAGCTAGGATCGCTTTTAGCTTATCAGACCTCATAGTA
GTCAGTTAGTTGGAGAAAGC

Downstream 100 bases:

>100_bases
ATGAGTACTTGATCAACTGCGCTGTTGATTGAGAAATAGTGTTTATCTTCAGATAAATCGGACATTAGCATGGCACGTAT
TTATATCAGTCTGGGTAGCA

Product: dihydroneopterin aldolase

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 116; Mature: 116

Protein sequence:

>116_residues
MDKVLIRQLRIDTVIGVYEWEKTIHQSLLLDLDMAWDNKPAAATDDYQYALCYETVSNRLTQLVTEHPIELIETVAERVA
DCLLQEFNVTWVKVVVMKPGAVATAASVGVEIERSR

Sequences:

>Translated_116_residues
MDKVLIRQLRIDTVIGVYEWEKTIHQSLLLDLDMAWDNKPAAATDDYQYALCYETVSNRLTQLVTEHPIELIETVAERVA
DCLLQEFNVTWVKVVVMKPGAVATAASVGVEIERSR
>Mature_116_residues
MDKVLIRQLRIDTVIGVYEWEKTIHQSLLLDLDMAWDNKPAAATDDYQYALCYETVSNRLTQLVTEHPIELIETVAERVA
DCLLQEFNVTWVKVVVMKPGAVATAASVGVEIERSR

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimeriza

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI87082204, Length=115, Percent_Identity=49.5652173913044, Blast_Score=113, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 13163; Mature: 13163

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKVLIRQLRIDTVIGVYEWEKTIHQSLLLDLDMAWDNKPAAATDDYQYALCYETVSNRL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
TQLVTEHPIELIETVAERVADCLLQEFNVTWVKVVVMKPGAVATAASVGVEIERSR
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHCEEEECCC
>Mature Secondary Structure
MDKVLIRQLRIDTVIGVYEWEKTIHQSLLLDLDMAWDNKPAAATDDYQYALCYETVSNRL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
TQLVTEHPIELIETVAERVADCLLQEFNVTWVKVVVMKPGAVATAASVGVEIERSR
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]