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The map label for this gene is dsbC [H]

Identifier: 126173089

GI number: 126173089

Start: 954115

End: 954840

Strand: Direct

Name: dsbC [H]

Synonym: Sbal_0844

Alternate gene names: 126173089

Gene position: 954115-954840 (Clockwise)

Preceding gene: 126173088

Following gene: 126173090

Centisome position: 18.61

GC content: 46.56

Gene sequence:

>726_bases
ATGAAGTTAACCCGAGCATTATCTTTAATTTTTGCCCTTGTTGTAGCTCCTCTTGCTAACGCCGCAACAGCGACCTCGCC
AGATACAGCTGCTATTAAGCAAAAACTGACTGAGATGTTGGATGTTGAAGTCATTTCTATGCAGGATTCGCCGATTGAGG
GTTTGTATCAAGCCATGACCAACCGCGGCGTGCTCTATATTAGTCGTGATGGTTCAAAACTGTTCCACGGCAGTTTGTAT
GACCTAGATAAAGGCATGAAAAACTTAACTGAAGCGGCATTAGCTGGCCCACGTTTAGAAATGATGAAGCCGCTTGAAGA
CCATATGTTGGTTTACAAAGCTAAAAATGAAAAACATGTGGTCACTGTATTTACTGACGTCAGCTGTGGTTATTGCCGTA
AATTGCACAGCCAAATGGCCGATTACAACAAGCTTGGCATTACCGTGCGTTACTTAGCCTTTCCGCGTGCGGGCGTGCCG
TCAGCCAACGCCGACGAAATGCAAGCCATCTGGTGTGCTAAAGATCCATTAAAAGCCATGACAGACGCTAAAGCGGGCAG
CAAAGTTGCCGCAGCAACATGCGATGCTAAAATTGCCGAGCAATATGCTTTAGGCACCACCTTTGGTGTGAATGGTACGC
CTGCAATCGTGTTAGAAGATGGCAATATGATCCCAGGTTATCAACCCCCTGCGGACTTATTACGCACCTTAGAAGCGCGT
CAGTAA

Upstream 100 bases:

>100_bases
CTTGTCTGTAACTTTTTGCCACCATACGGGGTCTATTAAGTATATCGCGTTTGAACGACCCCAAAATCTCCTCGTCGAGA
CCCAATTTATAGGATGTCAC

Downstream 100 bases:

>100_bases
CAGTCAAAATAGTAAAATTTATCCCACTAAAGGTGAGCTTAAGGCTCACCTTTTTGTTATCTTATCGCCACGATTTCATG
AGAGTTTGAGTCCCTTGATC

Product: thiol:disulfide interchange protein DsbC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MKLTRALSLIFALVVAPLANAATATSPDTAAIKQKLTEMLDVEVISMQDSPIEGLYQAMTNRGVLYISRDGSKLFHGSLY
DLDKGMKNLTEAALAGPRLEMMKPLEDHMLVYKAKNEKHVVTVFTDVSCGYCRKLHSQMADYNKLGITVRYLAFPRAGVP
SANADEMQAIWCAKDPLKAMTDAKAGSKVAAATCDAKIAEQYALGTTFGVNGTPAIVLEDGNMIPGYQPPADLLRTLEAR
Q

Sequences:

>Translated_241_residues
MKLTRALSLIFALVVAPLANAATATSPDTAAIKQKLTEMLDVEVISMQDSPIEGLYQAMTNRGVLYISRDGSKLFHGSLY
DLDKGMKNLTEAALAGPRLEMMKPLEDHMLVYKAKNEKHVVTVFTDVSCGYCRKLHSQMADYNKLGITVRYLAFPRAGVP
SANADEMQAIWCAKDPLKAMTDAKAGSKVAAATCDAKIAEQYALGTTFGVNGTPAIVLEDGNMIPGYQPPADLLRTLEAR
Q
>Mature_241_residues
MKLTRALSLIFALVVAPLANAATATSPDTAAIKQKLTEMLDVEVISMQDSPIEGLYQAMTNRGVLYISRDGSKLFHGSLY
DLDKGMKNLTEAALAGPRLEMMKPLEDHMLVYKAKNEKHVVTVFTDVSCGYCRKLHSQMADYNKLGITVRYLAFPRAGVP
SANADEMQAIWCAKDPLKAMTDAKAGSKVAAATCDAKIAEQYALGTTFGVNGTPAIVLEDGNMIPGYQPPADLLRTLEAR
Q

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase [H]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1789260, Length=215, Percent_Identity=51.6279069767442, Blast_Score=227, Evalue=5e-61,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018950
- InterPro:   IPR009094
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10411 DsbC_N [H]

EC number: 5.3.4.1

Molecular weight: Translated: 26117; Mature: 26117

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTRALSLIFALVVAPLANAATATSPDTAAIKQKLTEMLDVEVISMQDSPIEGLYQAMT
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHH
NRGVLYISRDGSKLFHGSLYDLDKGMKNLTEAALAGPRLEMMKPLEDHMLVYKAKNEKHV
CCCEEEEECCCCEECCCHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHCEEEEEECCCCEE
VTVFTDVSCGYCRKLHSQMADYNKLGITVRYLAFPRAGVPSANADEMQAIWCAKDPLKAM
EEEEECCCHHHHHHHHHHHHCCHHHCEEEEEEECCCCCCCCCCHHHHHEEEECCCHHHHH
TDAKAGSKVAAATCDAKIAEQYALGTTFGVNGTPAIVLEDGNMIPGYQPPADLLRTLEAR
HHCCCCCCEEHHHHHHHHHHHHHCCCEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHCC
Q
C
>Mature Secondary Structure
MKLTRALSLIFALVVAPLANAATATSPDTAAIKQKLTEMLDVEVISMQDSPIEGLYQAMT
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHH
NRGVLYISRDGSKLFHGSLYDLDKGMKNLTEAALAGPRLEMMKPLEDHMLVYKAKNEKHV
CCCEEEEECCCCEECCCHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHCEEEEEECCCCEE
VTVFTDVSCGYCRKLHSQMADYNKLGITVRYLAFPRAGVPSANADEMQAIWCAKDPLKAM
EEEEECCCHHHHHHHHHHHHCCHHHCEEEEEEECCCCCCCCCCHHHHHEEEECCCHHHHH
TDAKAGSKVAAATCDAKIAEQYALGTTFGVNGTPAIVLEDGNMIPGYQPPADLLRTLEAR
HHCCCCCCEEHHHHHHHHHHHHHCCCEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHCC
Q
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]