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The map label for this gene is ykgC [H]

Identifier: 125625092

GI number: 125625092

Start: 2289174

End: 2290496

Strand: Reverse

Name: ykgC [H]

Synonym: llmg_2331

Alternate gene names: 125625092

Gene position: 2290496-2289174 (Counterclockwise)

Preceding gene: 125625093

Following gene: 125625088

Centisome position: 90.55

GC content: 37.26

Gene sequence:

>1323_bases
ATGGAAACAAGACATTTTAAAAATATAATCATTGGATTTGGGAAAGCCGGACGTGCTTTGGCGAAATCATTATCGAAAAA
TGGAGAAGAAGCTTTAATTATTGAGCGTGACCAAGCAATGTATGGTGGGACTTGTCCGAATGTTGGTTGTGCTCCGTCTA
AAACTTTGATTGTTGCTGGTCAAAAAAACATGAATTTTTCAGAAGCAATGACAACAAAATATAAGGTTCGTGAGATTCTA
CATAATGCTGCTTATCATGGAGTAGCAGATGAAGCCCTTGTTTATGTTATGGATGGCCTAGCTCGTTTTATTAATTCTAA
AACTGTTGAGGTGGTCAATGGTGAGAATGTCACTCAGGTCATTGGAGAGAGAATCTTCATAAATACTGGAGCGACACCGA
TTATCCCAGAAATTGAAGGAATTCATGAAGCTAAAAATATTGTCACTTCTGAGGGAGCGATGGAACTTTCTGAGCTTCCT
AAGAAATTAGTCATCATCGGGGCCGGTTATATCGGATTAGAATTTGCTGGAATGTTTAACAAATTTGGATCTGAAGTGAC
TATTTTAGAGCCACATGCTACTTTTTTACCTAAAGAAGATGAAGATATCTCAAATGAGATTTACAAAGATTTAGTTGCTG
CTGGAGTTGAAATTCAACTTGGAGTAGAAATTGAAAGAATTACTGACAGTGAGGTTTTCGCAGGAGGGAAGGTTTATCCA
GCTGATAAAATATTAATAGCTACTGGACGTCGGCCGAATATTAAAGACCTTGACTTGGAGAAAGCCGATGTTGAACTTTC
AGAAAATGGTTATATTAAAGTCGATGATGATTTAAAAACTACTGCTCAAAATATCTGGGCACTGGGTGATGTTCGGGGTG
GAGGACAATTCTACTATCTTTCGACAGATGATTTTCGGATTGTCAATAATCAATTATTTGGCGACCATTCACGTAAGTTA
AGTGACAGGAAACTTGTGCCTTATTCAGTTTTTATCAGCCCAACCTTATCTCGGATTGGCTTAGATGAAAAACAAGCAAA
AGAAGCTGGAGTTAATTATCGTTTATTTAAGATGGCTGCGGCACCAATTGTTAAAGCCAAAGTTGTTCAAGATACTCGAG
GATTACTTAAAGCATTAGTTGACCCTAACACGGATGAAATTCTTGGCGCAACTTTATATCATGAAGATTCTCATGAAGTC
ATCAATCTTGTAAGTTTGGCGATGAAAATGCACACTCCTTATCAAGTTTTACGTGACCAAATTTTTACTCACCCCACTAT
GGGCGAAGGTTTGAATGATTTATTTCAAAATGAAGTGAAATAA

Upstream 100 bases:

>100_bases
GACGCCTTGTGGCGTTTTTTTATTAAGTCATGATGAACCACACAGACCTTCAAAAGTTATAGAATAGAAGCATAAAGAAA
AGGGAGGCAGAGAGAAGAAG

Downstream 100 bases:

>100_bases
AAGTTACTGACAGTTTTGTTTTATGAGTGAATGTCACACAAAAATTTTCTGTCAGTAAAATAAAAAAACTCGTCAATGAC
GAGTTTTTGTTTATTTGAAT

Product: pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
METRHFKNIIIGFGKAGRALAKSLSKNGEEALIIERDQAMYGGTCPNVGCAPSKTLIVAGQKNMNFSEAMTTKYKVREIL
HNAAYHGVADEALVYVMDGLARFINSKTVEVVNGENVTQVIGERIFINTGATPIIPEIEGIHEAKNIVTSEGAMELSELP
KKLVIIGAGYIGLEFAGMFNKFGSEVTILEPHATFLPKEDEDISNEIYKDLVAAGVEIQLGVEIERITDSEVFAGGKVYP
ADKILIATGRRPNIKDLDLEKADVELSENGYIKVDDDLKTTAQNIWALGDVRGGGQFYYLSTDDFRIVNNQLFGDHSRKL
SDRKLVPYSVFISPTLSRIGLDEKQAKEAGVNYRLFKMAAAPIVKAKVVQDTRGLLKALVDPNTDEILGATLYHEDSHEV
INLVSLAMKMHTPYQVLRDQIFTHPTMGEGLNDLFQNEVK

Sequences:

>Translated_440_residues
METRHFKNIIIGFGKAGRALAKSLSKNGEEALIIERDQAMYGGTCPNVGCAPSKTLIVAGQKNMNFSEAMTTKYKVREIL
HNAAYHGVADEALVYVMDGLARFINSKTVEVVNGENVTQVIGERIFINTGATPIIPEIEGIHEAKNIVTSEGAMELSELP
KKLVIIGAGYIGLEFAGMFNKFGSEVTILEPHATFLPKEDEDISNEIYKDLVAAGVEIQLGVEIERITDSEVFAGGKVYP
ADKILIATGRRPNIKDLDLEKADVELSENGYIKVDDDLKTTAQNIWALGDVRGGGQFYYLSTDDFRIVNNQLFGDHSRKL
SDRKLVPYSVFISPTLSRIGLDEKQAKEAGVNYRLFKMAAAPIVKAKVVQDTRGLLKALVDPNTDEILGATLYHEDSHEV
INLVSLAMKMHTPYQVLRDQIFTHPTMGEGLNDLFQNEVK
>Mature_440_residues
METRHFKNIIIGFGKAGRALAKSLSKNGEEALIIERDQAMYGGTCPNVGCAPSKTLIVAGQKNMNFSEAMTTKYKVREIL
HNAAYHGVADEALVYVMDGLARFINSKTVEVVNGENVTQVIGERIFINTGATPIIPEIEGIHEAKNIVTSEGAMELSELP
KKLVIIGAGYIGLEFAGMFNKFGSEVTILEPHATFLPKEDEDISNEIYKDLVAAGVEIQLGVEIERITDSEVFAGGKVYP
ADKILIATGRRPNIKDLDLEKADVELSENGYIKVDDDLKTTAQNIWALGDVRGGGQFYYLSTDDFRIVNNQLFGDHSRKL
SDRKLVPYSVFISPTLSRIGLDEKQAKEAGVNYRLFKMAAAPIVKAKVVQDTRGLLKALVDPNTDEILGATLYHEDSHEV
INLVSLAMKMHTPYQVLRDQIFTHPTMGEGLNDLFQNEVK

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=462, Percent_Identity=29.6536796536797, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI50301238, Length=453, Percent_Identity=27.1523178807947, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI22035672, Length=426, Percent_Identity=25.8215962441315, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI291045266, Length=435, Percent_Identity=24.1379310344828, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI148277065, Length=434, Percent_Identity=23.0414746543779, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI33519430, Length=434, Percent_Identity=23.0414746543779, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI33519428, Length=434, Percent_Identity=23.0414746543779, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI33519426, Length=434, Percent_Identity=23.0414746543779, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI148277071, Length=434, Percent_Identity=23.0414746543779, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI291045268, Length=431, Percent_Identity=23.4338747099768, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI87081717, Length=434, Percent_Identity=47.926267281106, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1786307, Length=452, Percent_Identity=29.646017699115, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1789915, Length=428, Percent_Identity=26.4018691588785, Blast_Score=141, Evalue=8e-35,
Organism=Escherichia coli, GI87082354, Length=465, Percent_Identity=26.4516129032258, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI32565766, Length=462, Percent_Identity=26.4069264069264, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI71983429, Length=421, Percent_Identity=25.6532066508314, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=24.7881355932203, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71983419, Length=421, Percent_Identity=25.6532066508314, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71982272, Length=439, Percent_Identity=24.8291571753986, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321091, Length=468, Percent_Identity=28.6324786324786, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6325166, Length=467, Percent_Identity=27.8372591006424, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6325240, Length=474, Percent_Identity=23.2067510548523, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21358499, Length=461, Percent_Identity=29.9349240780911, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=26.7368421052632, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24640551, Length=474, Percent_Identity=25.9493670886076, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24640549, Length=474, Percent_Identity=25.9493670886076, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24640553, Length=474, Percent_Identity=25.9493670886076, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: NA

Molecular weight: Translated: 48508; Mature: 48508

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METRHFKNIIIGFGKAGRALAKSLSKNGEEALIIERDQAMYGGTCPNVGCAPSKTLIVAG
CCCCCCCCEEEECCCCHHHHHHHHHCCCCEEEEEECCCCEECCCCCCCCCCCCCEEEEEC
QKNMNFSEAMTTKYKVREILHNAAYHGVADEALVYVMDGLARFINSKTVEVVNGENVTQV
CCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHH
IGERIFINTGATPIIPEIEGIHEAKNIVTSEGAMELSELPKKLVIIGAGYIGLEFAGMFN
HCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCEEEEEECCHHHHHHHHHHH
KFGSEVTILEPHATFLPKEDEDISNEIYKDLVAAGVEIQLGVEIERITDSEVFAGGKVYP
HHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEECCCCEECCCEECC
ADKILIATGRRPNIKDLDLEKADVELSENGYIKVDDDLKTTAQNIWALGDVRGGGQFYYL
CCEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCHHHHHHHHEEEEEECCCCEEEEE
STDDFRIVNNQLFGDHSRKLSDRKLVPYSVFISPTLSRIGLDEKQAKEAGVNYRLFKMAA
ECCCEEEECCCCCCCHHHCCCCCCCCEEEEEECCHHHHCCCCHHHHHHCCCCEEEEHHHH
APIVKAKVVQDTRGLLKALVDPNTDEILGATLYHEDSHEVINLVSLAMKMHTPYQVLRDQ
CCHHHHHHHHHHHHHHHHHCCCCCHHHEEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHH
IFTHPTMGEGLNDLFQNEVK
HHCCCCCCCCHHHHHHHCCC
>Mature Secondary Structure
METRHFKNIIIGFGKAGRALAKSLSKNGEEALIIERDQAMYGGTCPNVGCAPSKTLIVAG
CCCCCCCCEEEECCCCHHHHHHHHHCCCCEEEEEECCCCEECCCCCCCCCCCCCEEEEEC
QKNMNFSEAMTTKYKVREILHNAAYHGVADEALVYVMDGLARFINSKTVEVVNGENVTQV
CCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHH
IGERIFINTGATPIIPEIEGIHEAKNIVTSEGAMELSELPKKLVIIGAGYIGLEFAGMFN
HCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCEEEEEECCHHHHHHHHHHH
KFGSEVTILEPHATFLPKEDEDISNEIYKDLVAAGVEIQLGVEIERITDSEVFAGGKVYP
HHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEECCCCEECCCEECC
ADKILIATGRRPNIKDLDLEKADVELSENGYIKVDDDLKTTAQNIWALGDVRGGGQFYYL
CCEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCHHHHHHHHEEEEEECCCCEEEEE
STDDFRIVNNQLFGDHSRKLSDRKLVPYSVFISPTLSRIGLDEKQAKEAGVNYRLFKMAA
ECCCEEEECCCCCCCHHHCCCCCCCCEEEEEECCHHHHCCCCHHHHHHCCCCEEEEHHHH
APIVKAKVVQDTRGLLKALVDPNTDEILGATLYHEDSHEVINLVSLAMKMHTPYQVLRDQ
CCHHHHHHHHHHHHHHHHHCCCCCHHHEEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHH
IFTHPTMGEGLNDLFQNEVK
HHCCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]