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The map label for this gene is upp [H]

Identifier: 125624946

GI number: 125624946

Start: 2144746

End: 2145381

Strand: Reverse

Name: upp [H]

Synonym: llmg_2176

Alternate gene names: 125624946

Gene position: 2145381-2144746 (Counterclockwise)

Preceding gene: 125624947

Following gene: 125624945

Centisome position: 84.82

GC content: 39.31

Gene sequence:

>636_bases
ATGTCAAAATTTCAAGTCGTAGAACATCCATTGATTCAACACAAACTCTCAATCTTGCGTCGTAAAGAGGCGTCAACAAA
AGAATTCCGTGAGCTTGTTGACGAAATCGGAATGCTTATGGCCTACGAAGTATCAAGAGATTTACCTCTCGAAGATGTCG
AAATTGAAACACCTGTTCAAAAAACGACAGTTAAACAAATCGCGGGTAAAAAATTAGCGATTGTGCCAATCTTACGTGCA
GGTATCGGGATGGTTGATGGAATTTTGAAATTAATTCCAGCTGCTCGTGTGGGACATATCGGAATGTACCGTGATGAAGA
AACACTTAAACCAGTTGAGTATTTAGTAAAACTTCCAGCAGATATTGCTGACCGTCAAATTTTCCTTGTTGACCCAATGC
TTGCAACAGGTGGTTCAGCAATTTTGGCAGTTGATTCTCTTAAAAAACGTAATGCTAAAGCAGAAAATATTAAATTCGTT
TGTCTTGTTGCCGCACCAGAAGGTGTAAAAGCCCTTCAAGAAGCACATCCAGATATCGAAATTTATACAGCAGCTTTGGA
TGAAAAACTTAATGAACATGGTTATATCGTTCCAGGTCTTGGTGACGCTGGTGACCGTTTGTTCGGTACAAAATAA

Upstream 100 bases:

>100_bases
TCTAAAAAATTTTGCCTAAAATTAGCAAAATTGCCATATAATGGCAGTTTACAAATCTGAACTTTGCTTAGCAAAGGGAT
CTAGCGAAAGGAAAATCAAA

Downstream 100 bases:

>100_bases
GAAAAATTCCCTTATTTTTGATATGACCCCCATAAGTTAGACTAAAAAGTCTAGTTAATGGAGGTCAATTTTTTTATGAC
AAAATATACATTTGAATTTA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MSKFQVVEHPLIQHKLSILRRKEASTKEFRELVDEIGMLMAYEVSRDLPLEDVEIETPVQKTTVKQIAGKKLAIVPILRA
GIGMVDGILKLIPAARVGHIGMYRDEETLKPVEYLVKLPADIADRQIFLVDPMLATGGSAILAVDSLKKRNAKAENIKFV
CLVAAPEGVKALQEAHPDIEIYTAALDEKLNEHGYIVPGLGDAGDRLFGTK

Sequences:

>Translated_211_residues
MSKFQVVEHPLIQHKLSILRRKEASTKEFRELVDEIGMLMAYEVSRDLPLEDVEIETPVQKTTVKQIAGKKLAIVPILRA
GIGMVDGILKLIPAARVGHIGMYRDEETLKPVEYLVKLPADIADRQIFLVDPMLATGGSAILAVDSLKKRNAKAENIKFV
CLVAAPEGVKALQEAHPDIEIYTAALDEKLNEHGYIVPGLGDAGDRLFGTK
>Mature_210_residues
SKFQVVEHPLIQHKLSILRRKEASTKEFRELVDEIGMLMAYEVSRDLPLEDVEIETPVQKTTVKQIAGKKLAIVPILRAG
IGMVDGILKLIPAARVGHIGMYRDEETLKPVEYLVKLPADIADRQIFLVDPMLATGGSAILAVDSLKKRNAKAENIKFVC
LVAAPEGVKALQEAHPDIEIYTAALDEKLNEHGYIVPGLGDAGDRLFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=32.6732673267327, Blast_Score=107, Evalue=7e-24,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=32.6732673267327, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI21450816, Length=194, Percent_Identity=28.8659793814433, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI87082118, Length=205, Percent_Identity=56.5853658536585, Blast_Score=247, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI17539892, Length=207, Percent_Identity=27.536231884058, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17539894, Length=207, Percent_Identity=27.536231884058, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=40.625, Blast_Score=140, Evalue=1e-34,
Organism=Drosophila melanogaster, GI45550449, Length=205, Percent_Identity=32.1951219512195, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI28573516, Length=205, Percent_Identity=32.1951219512195, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI28573514, Length=205, Percent_Identity=32.1951219512195, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI28573512, Length=205, Percent_Identity=32.1951219512195, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI21358379, Length=197, Percent_Identity=26.3959390862944, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23232; Mature: 23100

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKFQVVEHPLIQHKLSILRRKEASTKEFRELVDEIGMLMAYEVSRDLPLEDVEIETPVQ
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHH
KTTVKQIAGKKLAIVPILRAGIGMVDGILKLIPAARVGHIGMYRDEETLKPVEYLVKLPA
HHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHCCC
DIADRQIFLVDPMLATGGSAILAVDSLKKRNAKAENIKFVCLVAAPEGVKALQEAHPDIE
CCCCCEEEEECCHHHCCCCEEEEEHHHHHCCCCCCCEEEEEEEECCHHHHHHHHCCCCCE
IYTAALDEKLNEHGYIVPGLGDAGDRLFGTK
EEHHHHHHHHCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SKFQVVEHPLIQHKLSILRRKEASTKEFRELVDEIGMLMAYEVSRDLPLEDVEIETPVQ
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHH
KTTVKQIAGKKLAIVPILRAGIGMVDGILKLIPAARVGHIGMYRDEETLKPVEYLVKLPA
HHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHCCC
DIADRQIFLVDPMLATGGSAILAVDSLKKRNAKAENIKFVCLVAAPEGVKALQEAHPDIE
CCCCCEEEEECCHHHCCCCEEEEEHHHHHCCCCCCCEEEEEEEECCHHHHHHHHCCCCCE
IYTAALDEKLNEHGYIVPGLGDAGDRLFGTK
EEHHHHHHHHCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]