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The map label for this gene is thrS [H]

Identifier: 125624939

GI number: 125624939

Start: 2136874

End: 2138814

Strand: Reverse

Name: thrS [H]

Synonym: llmg_2169

Alternate gene names: 125624939

Gene position: 2138814-2136874 (Counterclockwise)

Preceding gene: 125624940

Following gene: 125624938

Centisome position: 84.56

GC content: 40.03

Gene sequence:

>1941_bases
ATGATTAAAATAACATTTCCAGATGGCAACATAAAAGAATTTGAGTCAGGTGTAACAACATTTGAAATCGCCAAATCAAT
CTCACCAAGTCTTGCCAAAAAAACACTTGCAGGTAAGGTCAACGGAAAGTTGATTGATGCAACACGTGCAATCAATGAAG
ATAGCAACTTTGAAATTGTAACACCAGACCATGAAGATGCGCTTGGAATTCTACGCCATTCAGCCGCTCACCTTTTTGCT
CAAGCAGCAAAACGTCACTTCCCGAATATTCATTTGGGTGTTGGACCAGCTATTCAAGATGGATTCTATTATGATACAGA
TAATGAAGCAGGCCAAATTTCAAATGACGACTTAGCAACAATTGAAGCTGAAATGAAGAAAATTGTCAAAGAAAACTTCA
AATCAGAGCGTAAAGAGGTCAGCAAAGAAGAAGCAAAAGAAATTTTTGCAAGTGACCCTTACAAACTTGAACTCATTGAA
GAACATAACGAAGATGAAGGTGGACTCACTATCTACACTCAAGGGGAATACACTGACCTTTGTCGTGGCCCACATGTTCC
GTCAACTGGTGTCATCAAATTTTTCCACCTTCTCAACGTTGCAGGCGCTTACTGGCGCGGAAATTCGGATAACAAGATGA
TGCAACGTATTTACGGTACAGCATGGTTTTCAAAAGAAGAATTAGAAGCAAATCTTAAACTTCGTGAAGAAGCAAAAGAA
CGTGATCACCGTAAACTCGGTCGTGAACTTGATTTGTTCTTTAACGACGCAGAACTTGGTGCAGGTACAGCTTACTGGCT
CCCAGCTGGTGCTACTATTCGTCGAATCATTGAACGTTTTGTCGTTGACCAAGAAGTGAAAAATGGTTATCAACATGTTA
TCACACCAGTCATGATGAACCTTAATACTTACAAACAATCAGGTCACTGGCAACATTACCATGAAGATATGTACCCACCA
ATGGATATGGGAGACGGCGAAGAAATGGAACTTCGTCCAATGAACTGCCCAAGCCATATTGCCATCTATAAACACCATGT
CCACTCTTATCGTGAACTCCCAATTCGTATCGCCGAATTTGGAATGATGCATCGTTATGAAAAATCAGGTGCACTCTCAG
GACTTCAACGTGTGCGTGAAATGACTCTGAATGATGGCCATACATTCGTGATGTTAGAACAAGTCCAAGAAGAATTTAGT
AAAATTCTTCAATTGATTATGGACATGTACCGTGACTTTGGAATCAATGATTACAGTTTCCGTCTCAGCTATCGTGACCC
TAAAGATACAGTTAAATACTTCCCAGATGATGAAATGTGGGAAAAATCTCAAGCGATGCTTAAAGCAACAATGGACGACA
TGAAACTTGACTATGTTGAAGCAGAAGGGGAAGCTGCATTTTACGGTCCCAAACTTGACATTCAAGTTAAAACAGCCCTC
GGAAATGAAGAAACGCTCTCAACTATTCAGTTAGACTTCCTCAATCCAGAAAACTTTGACATCTCATACGTTGGTGCTGA
TGGAGAAAAACATCGTCCAGTGATGATTCACCGTGGTGTAATTTCAACACTTGAACGTTTCATTGCCTACCTTATCGAAG
TTTACAAAGGTGCTTTCCCAACATGGCTTGCTCCAACTCAAGCAACGATTATTCCAGTAAATAATGAAATTCATGCCGAT
TATGCTTGGAAAATTCAACGTGAACTTCAAGATAAAGGCTTCCGTGTCGTTGTTGATGAAGCCAACGAAAAAATGGGTTG
GAAAATTCGCCAATCACAAACTCACAAAATTCCTTACCAAATCGTTATTGGTGACCAAGAACAGGCCGATGGTACAGTAA
ATATTCGTCGTTATGGCTCAAAAGAAACAGAAGTCATTCCGTTTGAAGATTTTATTGAGAAAATCAGTGCCGATGTAGCT
AATTTTAGCCGAGTTGACTAA

Upstream 100 bases:

>100_bases
GATTTGCGTTTTTTTATTTCCATAAATTACTGACAGCACTACTAATAGATAAAAAAGTTTTGTCAGTAAACTAAAAACGA
TAAAAAGAAAGGCACATAAA

Downstream 100 bases:

>100_bases
ATTAAAAAAGACTGTTGAAAAATAGTCTTTTTTTATACTGTTGTATCAATATAAGGTATAATAAATGGTATTAAAATGAC
AATAAGGATAGAATAAAGAG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 646; Mature: 646

Protein sequence:

>646_residues
MIKITFPDGNIKEFESGVTTFEIAKSISPSLAKKTLAGKVNGKLIDATRAINEDSNFEIVTPDHEDALGILRHSAAHLFA
QAAKRHFPNIHLGVGPAIQDGFYYDTDNEAGQISNDDLATIEAEMKKIVKENFKSERKEVSKEEAKEIFASDPYKLELIE
EHNEDEGGLTIYTQGEYTDLCRGPHVPSTGVIKFFHLLNVAGAYWRGNSDNKMMQRIYGTAWFSKEELEANLKLREEAKE
RDHRKLGRELDLFFNDAELGAGTAYWLPAGATIRRIIERFVVDQEVKNGYQHVITPVMMNLNTYKQSGHWQHYHEDMYPP
MDMGDGEEMELRPMNCPSHIAIYKHHVHSYRELPIRIAEFGMMHRYEKSGALSGLQRVREMTLNDGHTFVMLEQVQEEFS
KILQLIMDMYRDFGINDYSFRLSYRDPKDTVKYFPDDEMWEKSQAMLKATMDDMKLDYVEAEGEAAFYGPKLDIQVKTAL
GNEETLSTIQLDFLNPENFDISYVGADGEKHRPVMIHRGVISTLERFIAYLIEVYKGAFPTWLAPTQATIIPVNNEIHAD
YAWKIQRELQDKGFRVVVDEANEKMGWKIRQSQTHKIPYQIVIGDQEQADGTVNIRRYGSKETEVIPFEDFIEKISADVA
NFSRVD

Sequences:

>Translated_646_residues
MIKITFPDGNIKEFESGVTTFEIAKSISPSLAKKTLAGKVNGKLIDATRAINEDSNFEIVTPDHEDALGILRHSAAHLFA
QAAKRHFPNIHLGVGPAIQDGFYYDTDNEAGQISNDDLATIEAEMKKIVKENFKSERKEVSKEEAKEIFASDPYKLELIE
EHNEDEGGLTIYTQGEYTDLCRGPHVPSTGVIKFFHLLNVAGAYWRGNSDNKMMQRIYGTAWFSKEELEANLKLREEAKE
RDHRKLGRELDLFFNDAELGAGTAYWLPAGATIRRIIERFVVDQEVKNGYQHVITPVMMNLNTYKQSGHWQHYHEDMYPP
MDMGDGEEMELRPMNCPSHIAIYKHHVHSYRELPIRIAEFGMMHRYEKSGALSGLQRVREMTLNDGHTFVMLEQVQEEFS
KILQLIMDMYRDFGINDYSFRLSYRDPKDTVKYFPDDEMWEKSQAMLKATMDDMKLDYVEAEGEAAFYGPKLDIQVKTAL
GNEETLSTIQLDFLNPENFDISYVGADGEKHRPVMIHRGVISTLERFIAYLIEVYKGAFPTWLAPTQATIIPVNNEIHAD
YAWKIQRELQDKGFRVVVDEANEKMGWKIRQSQTHKIPYQIVIGDQEQADGTVNIRRYGSKETEVIPFEDFIEKISADVA
NFSRVD
>Mature_646_residues
MIKITFPDGNIKEFESGVTTFEIAKSISPSLAKKTLAGKVNGKLIDATRAINEDSNFEIVTPDHEDALGILRHSAAHLFA
QAAKRHFPNIHLGVGPAIQDGFYYDTDNEAGQISNDDLATIEAEMKKIVKENFKSERKEVSKEEAKEIFASDPYKLELIE
EHNEDEGGLTIYTQGEYTDLCRGPHVPSTGVIKFFHLLNVAGAYWRGNSDNKMMQRIYGTAWFSKEELEANLKLREEAKE
RDHRKLGRELDLFFNDAELGAGTAYWLPAGATIRRIIERFVVDQEVKNGYQHVITPVMMNLNTYKQSGHWQHYHEDMYPP
MDMGDGEEMELRPMNCPSHIAIYKHHVHSYRELPIRIAEFGMMHRYEKSGALSGLQRVREMTLNDGHTFVMLEQVQEEFS
KILQLIMDMYRDFGINDYSFRLSYRDPKDTVKYFPDDEMWEKSQAMLKATMDDMKLDYVEAEGEAAFYGPKLDIQVKTAL
GNEETLSTIQLDFLNPENFDISYVGADGEKHRPVMIHRGVISTLERFIAYLIEVYKGAFPTWLAPTQATIIPVNNEIHAD
YAWKIQRELQDKGFRVVVDEANEKMGWKIRQSQTHKIPYQIVIGDQEQADGTVNIRRYGSKETEVIPFEDFIEKISADVA
NFSRVD

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=623, Percent_Identity=38.5232744783307, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI38570111, Length=624, Percent_Identity=37.9807692307692, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI20070344, Length=633, Percent_Identity=33.6492890995261, Blast_Score=374, Evalue=1e-103,
Organism=Escherichia coli, GI1788013, Length=647, Percent_Identity=39.5672333848532, Blast_Score=502, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI71984184, Length=618, Percent_Identity=39.9676375404531, Blast_Score=448, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI71984192, Length=618, Percent_Identity=39.9676375404531, Blast_Score=447, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6322112, Length=634, Percent_Identity=36.1198738170347, Blast_Score=406, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6322654, Length=401, Percent_Identity=35.1620947630923, Blast_Score=238, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24583839, Length=636, Percent_Identity=37.5786163522013, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24583842, Length=636, Percent_Identity=37.5786163522013, Blast_Score=445, Evalue=1e-125,
Organism=Drosophila melanogaster, GI28574141, Length=636, Percent_Identity=37.5786163522013, Blast_Score=445, Evalue=1e-125,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 74162; Mature: 74162

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKITFPDGNIKEFESGVTTFEIAKSISPSLAKKTLAGKVNGKLIDATRAINEDSNFEIV
CEEEECCCCCHHHHHCCCHHHHHHHHCCHHHHHHHHHCCCCCEEEEHHHHCCCCCCEEEE
TPDHEDALGILRHSAAHLFAQAAKRHFPNIHLGVGPAIQDGFYYDTDNEAGQISNDDLAT
CCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEECCCCCCCCCCCCCHHH
IEAEMKKIVKENFKSERKEVSKEEAKEIFASDPYKLELIEEHNEDEGGLTIYTQGEYTDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEECCCCHHH
CRGPHVPSTGVIKFFHLLNVAGAYWRGNSDNKMMQRIYGTAWFSKEELEANLKLREEAKE
HCCCCCCCHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHCCCHHHHHCCCHHHHHHHH
RDHRKLGRELDLFFNDAELGAGTAYWLPAGATIRRIIERFVVDQEVKNGYQHVITPVMMN
HHHHHHCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHC
LNTYKQSGHWQHYHEDMYPPMDMGDGEEMELRPMNCPSHIAIYKHHVHSYRELPIRIAEF
CHHHHCCCCCCHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHH
GMMHRYEKSGALSGLQRVREMTLNDGHTFVMLEQVQEEFSKILQLIMDMYRDFGINDYSF
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
RLSYRDPKDTVKYFPDDEMWEKSQAMLKATMDDMKLDYVEAEGEAAFYGPKLDIQVKTAL
EEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEECCEEEEEEEECC
GNEETLSTIQLDFLNPENFDISYVGADGEKHRPVMIHRGVISTLERFIAYLIEVYKGAFP
CCCCCEEEEEEEECCCCCCEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCC
TWLAPTQATIIPVNNEIHADYAWKIQRELQDKGFRVVVDEANEKMGWKIRQSQTHKIPYQ
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCCCCEE
IVIGDQEQADGTVNIRRYGSKETEVIPFEDFIEKISADVANFSRVD
EEECCCCCCCCEEEEEECCCCCCEEECHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIKITFPDGNIKEFESGVTTFEIAKSISPSLAKKTLAGKVNGKLIDATRAINEDSNFEIV
CEEEECCCCCHHHHHCCCHHHHHHHHCCHHHHHHHHHCCCCCEEEEHHHHCCCCCCEEEE
TPDHEDALGILRHSAAHLFAQAAKRHFPNIHLGVGPAIQDGFYYDTDNEAGQISNDDLAT
CCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEECCCCCCCCCCCCCHHH
IEAEMKKIVKENFKSERKEVSKEEAKEIFASDPYKLELIEEHNEDEGGLTIYTQGEYTDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEECCCCHHH
CRGPHVPSTGVIKFFHLLNVAGAYWRGNSDNKMMQRIYGTAWFSKEELEANLKLREEAKE
HCCCCCCCHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHCCCHHHHHCCCHHHHHHHH
RDHRKLGRELDLFFNDAELGAGTAYWLPAGATIRRIIERFVVDQEVKNGYQHVITPVMMN
HHHHHHCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHC
LNTYKQSGHWQHYHEDMYPPMDMGDGEEMELRPMNCPSHIAIYKHHVHSYRELPIRIAEF
CHHHHCCCCCCHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHH
GMMHRYEKSGALSGLQRVREMTLNDGHTFVMLEQVQEEFSKILQLIMDMYRDFGINDYSF
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
RLSYRDPKDTVKYFPDDEMWEKSQAMLKATMDDMKLDYVEAEGEAAFYGPKLDIQVKTAL
EEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEECCEEEEEEEECC
GNEETLSTIQLDFLNPENFDISYVGADGEKHRPVMIHRGVISTLERFIAYLIEVYKGAFP
CCCCCEEEEEEEECCCCCCEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCC
TWLAPTQATIIPVNNEIHADYAWKIQRELQDKGFRVVVDEANEKMGWKIRQSQTHKIPYQ
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCCCCEE
IVIGDQEQADGTVNIRRYGSKETEVIPFEDFIEKISADVANFSRVD
EEECCCCCCCCEEEEEECCCCCCEEECHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]