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The map label for this gene is aroE

Identifier: 125624719

GI number: 125624719

Start: 1919813

End: 1920673

Strand: Reverse

Name: aroE

Synonym: llmg_1939

Alternate gene names: 125624719

Gene position: 1920673-1919813 (Counterclockwise)

Preceding gene: 125624720

Following gene: 125624718

Centisome position: 75.93

GC content: 38.21

Gene sequence:

>861_bases
ATGAAAATTGACGGTTACACGCGGATGGCTGCTGTGGTGGCAAACCCTATTAAACACAGCTTATCTCCTTTTATTCATAA
TTTGGCCTTTGATTTAACTGATGAAAATGGCGTTTATTTAGCTTGGGAAGTTGAGTCTAAAAAATTAGCGGCTATTGTTG
AAAATGTTCGTAATTTGGACATGTATGGTCTGAATATCTCTATGCCTTATAAAGGTGAAATTATTAAATTTATGGATGAA
TTGAGCCCAGCGGCCGAACTAATCGGAGCGGTCAATACGGTAGTTAATCATTCAGGAAAATTAATCGGACATAATACTGA
TGGAATCGGATTTTTCAACAGTTTAAAAAAATATGATTTTAAGATAGAAAATAAACAAATACTTGTTCTTGGCGGCGGTG
GAGCAGCGATTGCCCTTATTGCTCAAGCAGCTTTATCAGGAGCTAAAAAAATAGTAGTGGCGGCGAGAAAATCTGCTTCT
TATGACCCTTTAAATGAAAAACTGGCAAAGCTGTCAGCAAAAACAGGAGTAGAAATTTTACTGACAGACTTATCTGGAGC
TGATAGATTACAAAAAGAGTTAAATCAGACAGATTTATTAGTGAATGCAACTTCTGTCGGAATGGACGGAGCGTCTTTTC
CTCTAGAAAAAAGCTTGCTTCTTCCTGACAAACTCTTGGTGGTGGATGCTATTTATAAAGTAAGAGAAACACCGTTTTTA
CACTGGGCCAAAGAGCAAGGAGCTCAAACTGAAAATGGGCTCGGTATGCTCATTGGACAGGCGGCGGAAAGCTTTTATTT
ATGGACAGGCAAAGAAATGCCTGTGGACAAAATTACATTAGAAATGGAGAGAGAAGTATGA

Upstream 100 bases:

>100_bases
CTGACAAAACCATCAGCAACTGCTGGAAGAACAATCAAGTTCTTTGAGCGGGAGCTTAGGACATGATCAAAATGTTTGTC
AGTAATTTTGGAGAATCTTT

Downstream 100 bases:

>100_bases
AATTAAATGTAAATCTACCAGACCATCCCTATGATGTCATCATTGAAAATGGGGCTTTGGCTAATATAGGAAATTGGGTT
TCATCATTGTGGAAAAAGCA

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MKIDGYTRMAAVVANPIKHSLSPFIHNLAFDLTDENGVYLAWEVESKKLAAIVENVRNLDMYGLNISMPYKGEIIKFMDE
LSPAAELIGAVNTVVNHSGKLIGHNTDGIGFFNSLKKYDFKIENKQILVLGGGGAAIALIAQAALSGAKKIVVAARKSAS
YDPLNEKLAKLSAKTGVEILLTDLSGADRLQKELNQTDLLVNATSVGMDGASFPLEKSLLLPDKLLVVDAIYKVRETPFL
HWAKEQGAQTENGLGMLIGQAAESFYLWTGKEMPVDKITLEMEREV

Sequences:

>Translated_286_residues
MKIDGYTRMAAVVANPIKHSLSPFIHNLAFDLTDENGVYLAWEVESKKLAAIVENVRNLDMYGLNISMPYKGEIIKFMDE
LSPAAELIGAVNTVVNHSGKLIGHNTDGIGFFNSLKKYDFKIENKQILVLGGGGAAIALIAQAALSGAKKIVVAARKSAS
YDPLNEKLAKLSAKTGVEILLTDLSGADRLQKELNQTDLLVNATSVGMDGASFPLEKSLLLPDKLLVVDAIYKVRETPFL
HWAKEQGAQTENGLGMLIGQAAESFYLWTGKEMPVDKITLEMEREV
>Mature_286_residues
MKIDGYTRMAAVVANPIKHSLSPFIHNLAFDLTDENGVYLAWEVESKKLAAIVENVRNLDMYGLNISMPYKGEIIKFMDE
LSPAAELIGAVNTVVNHSGKLIGHNTDGIGFFNSLKKYDFKIENKQILVLGGGGAAIALIAQAALSGAKKIVVAARKSAS
YDPLNEKLAKLSAKTGVEILLTDLSGADRLQKELNQTDLLVNATSVGMDGASFPLEKSLLLPDKLLVVDAIYKVRETPFL
HWAKEQGAQTENGLGMLIGQAAESFYLWTGKEMPVDKITLEMEREV

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=284, Percent_Identity=35.9154929577465, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI1789675, Length=286, Percent_Identity=33.9160839160839, Blast_Score=134, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6320332, Length=289, Percent_Identity=28.3737024221453, Blast_Score=86, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_LACLM (A2RMH6)

Other databases:

- EMBL:   AM406671
- RefSeq:   YP_001033202.1
- ProteinModelPortal:   A2RMH6
- SMR:   A2RMH6
- STRING:   A2RMH6
- GeneID:   4798936
- GenomeReviews:   AM406671_GR
- KEGG:   llm:llmg_1939
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   SIYIDAT
- ProtClustDB:   PRK00258
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 31135; Mature: 31135

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: ACT_SITE 71-71

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIDGYTRMAAVVANPIKHSLSPFIHNLAFDLTDENGVYLAWEVESKKLAAIVENVRNLD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEEECCHHHHHHHHHHHCCE
MYGLNISMPYKGEIIKFMDELSPAAELIGAVNTVVNHSGKLIGHNTDGIGFFNSLKKYDF
EEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHCCE
KIENKQILVLGGGGAAIALIAQAALSGAKKIVVAARKSASYDPLNEKLAKLSAKTGVEIL
EECCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEE
LTDLSGADRLQKELNQTDLLVNATSVGMDGASFPLEKSLLLPDKLLVVDAIYKVRETPFL
EECCCCHHHHHHHCCHHHEEEEEHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCE
HWAKEQGAQTENGLGMLIGQAAESFYLWTGKEMPVDKITLEMEREV
EEHHHCCCCCCCCCEEEEECCCCEEEEEECCCCCHHHEEEEEECCC
>Mature Secondary Structure
MKIDGYTRMAAVVANPIKHSLSPFIHNLAFDLTDENGVYLAWEVESKKLAAIVENVRNLD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEEECCHHHHHHHHHHHCCE
MYGLNISMPYKGEIIKFMDELSPAAELIGAVNTVVNHSGKLIGHNTDGIGFFNSLKKYDF
EEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHCCE
KIENKQILVLGGGGAAIALIAQAALSGAKKIVVAARKSASYDPLNEKLAKLSAKTGVEIL
EECCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEE
LTDLSGADRLQKELNQTDLLVNATSVGMDGASFPLEKSLLLPDKLLVVDAIYKVRETPFL
EECCCCHHHHHHHCCHHHEEEEEHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCE
HWAKEQGAQTENGLGMLIGQAAESFYLWTGKEMPVDKITLEMEREV
EEHHHCCCCCCCCCEEEEECCCCEEEEEECCCCCHHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA