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The map label for this gene is pheA

Identifier: 125624706

GI number: 125624706

Start: 1904864

End: 1905703

Strand: Reverse

Name: pheA

Synonym: llmg_1924

Alternate gene names: 125624706

Gene position: 1905703-1904864 (Counterclockwise)

Preceding gene: 125624707

Following gene: 125624705

Centisome position: 75.34

GC content: 37.38

Gene sequence:

>840_bases
ATGAAAATTGCATATTTAGGTCCACGAGGTTCTTTTTGCTCAGTCGTAGCCGAAGCAGCTTTTAAATCTGAGGAGTTGTA
CTCTTATGCAACTATTTTGGATGTCATTGAAGCCTATAATGAGGGCGAATGTGATTTTGCACTAGTTCCTATTGAAAATT
CGACTGAAGGAACGGTCAATATGAGCATTGATAAAATTTTTCATGATTCAAATGCCAAGGTTGTGGCCGAGTTTGTTCTT
CCAATTTCTCAAAATTTATTGGCAGTTTCTAAAGAACAAAAAATTGAGCATATTTACTCTCATCCTCAAGCTTTGGCTCA
AACGAGAGTTTATTTGAGAAAATTTTATCCTCAGGCGCAGGTGGAAATTACTGAGTCCACTTCGGCAGCGGCTGAGTTTG
TGAAAAATAATCCGGACTTGCCCGCAGCAGCGGTGGCAAATTCTTTTGCAGCTAAAATGTATGATTTGGAATTCATTGCT
GAAAATATTCAAGATTTGGCGGGGAATTCGACTCGTTTTTGGTTACTAGGAAAAGAAAAGCAATCCTTTGATTTAAATCA
AACAAAGGATAAGGTGACTTTGGCTTTGACGCTACCTGACAATTTGCCAGGAGCATTGCACAAAGCAATTTCTGTTTTTG
CTTGGCGTGATATTGACATGACTAAAATTGAGTCACGTCCTTTAAGGACACGTTTGGGACAGTACTTTTTTATTATTGAT
TTAGAAAATAATGCAACGAACAGTTTAAAGATTCCTTATGCTCTTGAAGAATTGGCAGGTTTGGGAGTAAATGTTCGATT
GTTAGGAAATTATTCAGTATATTCATTAGGTGAGGTGTAA

Upstream 100 bases:

>100_bases
AAAGACTATTCATTGGTTGCGGATTTAACAATTGATGTGACCGATAAAAGTCCAGAGCAGATTGCAGAGCAGATTAGAGA
AAAGTGGGAGATAGAGTAGG

Downstream 100 bases:

>100_bases
AGGTGAGAATTTATTTTGTACGACATGGTAAAACGGAGTGGAATTTGGCACGGCGTTTGCAGGGACAAAAGGGAGACTCA
CCTTTATTGCCAGAATCTTA

Product: prephenate dehydratase

Products: NA

Alternate protein names: PDT

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MKIAYLGPRGSFCSVVAEAAFKSEELYSYATILDVIEAYNEGECDFALVPIENSTEGTVNMSIDKIFHDSNAKVVAEFVL
PISQNLLAVSKEQKIEHIYSHPQALAQTRVYLRKFYPQAQVEITESTSAAAEFVKNNPDLPAAAVANSFAAKMYDLEFIA
ENIQDLAGNSTRFWLLGKEKQSFDLNQTKDKVTLALTLPDNLPGALHKAISVFAWRDIDMTKIESRPLRTRLGQYFFIID
LENNATNSLKIPYALEELAGLGVNVRLLGNYSVYSLGEV

Sequences:

>Translated_279_residues
MKIAYLGPRGSFCSVVAEAAFKSEELYSYATILDVIEAYNEGECDFALVPIENSTEGTVNMSIDKIFHDSNAKVVAEFVL
PISQNLLAVSKEQKIEHIYSHPQALAQTRVYLRKFYPQAQVEITESTSAAAEFVKNNPDLPAAAVANSFAAKMYDLEFIA
ENIQDLAGNSTRFWLLGKEKQSFDLNQTKDKVTLALTLPDNLPGALHKAISVFAWRDIDMTKIESRPLRTRLGQYFFIID
LENNATNSLKIPYALEELAGLGVNVRLLGNYSVYSLGEV
>Mature_279_residues
MKIAYLGPRGSFCSVVAEAAFKSEELYSYATILDVIEAYNEGECDFALVPIENSTEGTVNMSIDKIFHDSNAKVVAEFVL
PISQNLLAVSKEQKIEHIYSHPQALAQTRVYLRKFYPQAQVEITESTSAAAEFVKNNPDLPAAAVANSFAAKMYDLEFIA
ENIQDLAGNSTRFWLLGKEKQSFDLNQTKDKVTLALTLPDNLPGALHKAISVFAWRDIDMTKIESRPLRTRLGQYFFIID
LENNATNSLKIPYALEELAGLGVNVRLLGNYSVYSLGEV

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain

Homologues:

Organism=Escherichia coli, GI1788951, Length=276, Percent_Identity=31.8840579710145, Blast_Score=117, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6324013, Length=290, Percent_Identity=24.8275862068966, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PHEA_LACLM (P43909)

Other databases:

- EMBL:   X78413
- EMBL:   AM406671
- PIR:   S52582
- RefSeq:   YP_001033189.1
- ProteinModelPortal:   P43909
- SMR:   P43909
- STRING:   P43909
- GeneID:   4798602
- GenomeReviews:   AM406671_GR
- KEGG:   llm:llmg_1924
- eggNOG:   COG0077
- HOGENOM:   HBG693866
- OMA:   CRKWLDA
- ProtClustDB:   PRK11898
- InterPro:   IPR001086
- InterPro:   IPR018528

Pfam domain/function: PF00800 PDT

EC number: =4.2.1.51

Molecular weight: Translated: 31031; Mature: 31031

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00857 PREPHENATE_DEHYDR_1; PS00858 PREPHENATE_DEHYDR_2; PS51171 PREPHENATE_DEHYDR_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAYLGPRGSFCSVVAEAAFKSEELYSYATILDVIEAYNEGECDFALVPIENSTEGTVN
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEE
MSIDKIFHDSNAKVVAEFVLPISQNLLAVSKEQKIEHIYSHPQALAQTRVYLRKFYPQAQ
EEEEHEEECCCCCEEEEEHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCE
VEITESTSAAAEFVKNNPDLPAAAVANSFAAKMYDLEFIAENIQDLAGNSTRFWLLGKEK
EEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
QSFDLNQTKDKVTLALTLPDNLPGALHKAISVFAWRDIDMTKIESRPLRTRLGQYFFIID
CCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHEECCCCHHHCCCCCHHHHCCCEEEEEE
LENNATNSLKIPYALEELAGLGVNVRLLGNYSVYSLGEV
ECCCCCCCEECCHHHHHHHCCCEEEEEEECCCEEEECCC
>Mature Secondary Structure
MKIAYLGPRGSFCSVVAEAAFKSEELYSYATILDVIEAYNEGECDFALVPIENSTEGTVN
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEE
MSIDKIFHDSNAKVVAEFVLPISQNLLAVSKEQKIEHIYSHPQALAQTRVYLRKFYPQAQ
EEEEHEEECCCCCEEEEEHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCE
VEITESTSAAAEFVKNNPDLPAAAVANSFAAKMYDLEFIAENIQDLAGNSTRFWLLGKEK
EEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
QSFDLNQTKDKVTLALTLPDNLPGALHKAISVFAWRDIDMTKIESRPLRTRLGQYFFIID
CCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHEECCCCHHHCCCCCHHHHCCCEEEEEE
LENNATNSLKIPYALEELAGLGVNVRLLGNYSVYSLGEV
ECCCCCCCEECCHHHHHHHCCCEEEEEEECCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7823907