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The map label for this gene is hemN [H]

Identifier: 125624230

GI number: 125624230

Start: 1385668

End: 1386807

Strand: Reverse

Name: hemN [H]

Synonym: llmg_1418

Alternate gene names: 125624230

Gene position: 1386807-1385668 (Counterclockwise)

Preceding gene: 125624231

Following gene: 125624229

Centisome position: 54.83

GC content: 34.47

Gene sequence:

>1140_bases
ATGTTTCAAAAACCGAACTCAGCATATTTTCATATTCCTTTTTGTTCTCATATCTGTTATTATTGCGACTTTGCCAAGGT
TTTGATGACAGGGCAACCTGTTGATGCTTATATTGAGGCAATCATTGAAGAATTCCAAAGTCTTAAAATAAAAAAATTGA
AAACGGTCTATATCGGTGGAGGAACACCGAGTGTTTTGTCAGCTCAACAGCTCGAGCGTTTGTTAACTGCTATAGCTGAC
CAATTGGATTTAGATTTTTTAGAAGAATTTACTGTGGAGGCAAATCCGGGAGATTTATCAGACGATGTGATTAAAGTTTT
AGCTCATTCTGCTGTCAATCGAATTTCGCTTGGTGTTCAAACTTTTAATAATACTTTATTAAAAAAAATTGGGCGAACTC
ATAATGAAGCTCAAGTCTATGATTCAATCGAACGCTTGAAAAGAGCTGGTTTTGAAAATATCACCATCGATTTAATTTAT
GCACTCCCTGGACAGACGATGGAAATGGTCAAATCAGATGTTGATAAATTTTTGGCTCTTGATCTTCCGCATGTTGCTTT
ATATAGTTTGATTTTAGAAGACCATACCGTTTTTATGAATCGTCAACGCCGTGGCCTTTTACGCTTGCCAAGCGAAGATA
AGAATGCAGATATGTATGAATATATCATGGATATCTTAGCTCAACATGGTTACCAGCATTATGAAGTTTCAAATTTTGGT
CGCCCTGGTTTTGAAAGTAAGCATAATATAACTTATTGGGATAATGAAGAGTATTATGGAATTGGTGCTGGAGCATCAGG
TTATTTATCTGGTGTTCGATATAAGAATTATGGACCAGTGCATCATTATCTTAAAGCAGCGGCAAATGATAAAAGAGTGA
ATGAAGAAGTCTTAAGCAAAAAATCTCAAATTGAAGAAGAGATGTTCCTAGGTCTGCGCAAAAAATCAGGAGTTCTGGTT
GAAAAATTTGAAGCAAAATTTAATTGTTCTTTTGATAAACTATATGGAGAACAAATTACAGAGCTCATCAAACAGAAGTT
ATTATATGATGACCGAGAAAGAATTCATATGACTGACAAAGGGTTTGAACTAGGAAATAACGTCTTTGAAAAATTTTTAC
TCGATGATGTTAATTTTTAA

Upstream 100 bases:

>100_bases
CAGGTGTGATATAATAGGGCAAGTATTTATGATTTACATTGGAGAAATTATTTTCCATTATATTTCATTGAGTAGGAAAA
AACTTTGAAGGGAAGTATTA

Downstream 100 bases:

>100_bases
TGCTATAGTGATGAATTTTTGTGAAAAAATGTTACAATATAATTAATGAAACCTAAAATGAGACGTAAACTTAAAAAAAT
GGGAGCTTTTATCTTTACAG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MFQKPNSAYFHIPFCSHICYYCDFAKVLMTGQPVDAYIEAIIEEFQSLKIKKLKTVYIGGGTPSVLSAQQLERLLTAIAD
QLDLDFLEEFTVEANPGDLSDDVIKVLAHSAVNRISLGVQTFNNTLLKKIGRTHNEAQVYDSIERLKRAGFENITIDLIY
ALPGQTMEMVKSDVDKFLALDLPHVALYSLILEDHTVFMNRQRRGLLRLPSEDKNADMYEYIMDILAQHGYQHYEVSNFG
RPGFESKHNITYWDNEEYYGIGAGASGYLSGVRYKNYGPVHHYLKAAANDKRVNEEVLSKKSQIEEEMFLGLRKKSGVLV
EKFEAKFNCSFDKLYGEQITELIKQKLLYDDRERIHMTDKGFELGNNVFEKFLLDDVNF

Sequences:

>Translated_379_residues
MFQKPNSAYFHIPFCSHICYYCDFAKVLMTGQPVDAYIEAIIEEFQSLKIKKLKTVYIGGGTPSVLSAQQLERLLTAIAD
QLDLDFLEEFTVEANPGDLSDDVIKVLAHSAVNRISLGVQTFNNTLLKKIGRTHNEAQVYDSIERLKRAGFENITIDLIY
ALPGQTMEMVKSDVDKFLALDLPHVALYSLILEDHTVFMNRQRRGLLRLPSEDKNADMYEYIMDILAQHGYQHYEVSNFG
RPGFESKHNITYWDNEEYYGIGAGASGYLSGVRYKNYGPVHHYLKAAANDKRVNEEVLSKKSQIEEEMFLGLRKKSGVLV
EKFEAKFNCSFDKLYGEQITELIKQKLLYDDRERIHMTDKGFELGNNVFEKFLLDDVNF
>Mature_379_residues
MFQKPNSAYFHIPFCSHICYYCDFAKVLMTGQPVDAYIEAIIEEFQSLKIKKLKTVYIGGGTPSVLSAQQLERLLTAIAD
QLDLDFLEEFTVEANPGDLSDDVIKVLAHSAVNRISLGVQTFNNTLLKKIGRTHNEAQVYDSIERLKRAGFENITIDLIY
ALPGQTMEMVKSDVDKFLALDLPHVALYSLILEDHTVFMNRQRRGLLRLPSEDKNADMYEYIMDILAQHGYQHYEVSNFG
RPGFESKHNITYWDNEEYYGIGAGASGYLSGVRYKNYGPVHHYLKAAANDKRVNEEVLSKKSQIEEEMFLGLRKKSGVLV
EKFEAKFNCSFDKLYGEQITELIKQKLLYDDRERIHMTDKGFELGNNVFEKFLLDDVNF

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=307, Percent_Identity=30.2931596091205, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1789325, Length=272, Percent_Identity=34.9264705882353, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI87082341, Length=245, Percent_Identity=28.1632653061224, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 43501; Mature: 43501

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQKPNSAYFHIPFCSHICYYCDFAKVLMTGQPVDAYIEAIIEEFQSLKIKKLKTVYIGG
CCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHEEEEEECC
GTPSVLSAQQLERLLTAIADQLDLDFLEEFTVEANPGDLSDDVIKVLAHSAVNRISLGVQ
CCCHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TFNNTLLKKIGRTHNEAQVYDSIERLKRAGFENITIDLIYALPGQTMEMVKSDVDKFLAL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHH
DLPHVALYSLILEDHTVFMNRQRRGLLRLPSEDKNADMYEYIMDILAQHGYQHYEVSNFG
CCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHCCCCEEECCCCC
RPGFESKHNITYWDNEEYYGIGAGASGYLSGVRYKNYGPVHHYLKAAANDKRVNEEVLSK
CCCCCCCCCEEEECCCCEEEECCCCHHHHCCCCCCCCCHHHHHHHHHCCCHHCCHHHHHH
KSQIEEEMFLGLRKKSGVLVEKFEAKFNCSFDKLYGEQITELIKQKLLYDDRERIHMTDK
HHHHHHHHHHHHHHCCCCHHEEHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHEEECCC
GFELGNNVFEKFLLDDVNF
CHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFQKPNSAYFHIPFCSHICYYCDFAKVLMTGQPVDAYIEAIIEEFQSLKIKKLKTVYIGG
CCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHEEEEEECC
GTPSVLSAQQLERLLTAIADQLDLDFLEEFTVEANPGDLSDDVIKVLAHSAVNRISLGVQ
CCCHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TFNNTLLKKIGRTHNEAQVYDSIERLKRAGFENITIDLIYALPGQTMEMVKSDVDKFLAL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHH
DLPHVALYSLILEDHTVFMNRQRRGLLRLPSEDKNADMYEYIMDILAQHGYQHYEVSNFG
CCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHCCCCEEECCCCC
RPGFESKHNITYWDNEEYYGIGAGASGYLSGVRYKNYGPVHHYLKAAANDKRVNEEVLSK
CCCCCCCCCEEEECCCCEEEECCCCHHHHCCCCCCCCCHHHHHHHHHCCCHHCCHHHHHH
KSQIEEEMFLGLRKKSGVLVEKFEAKFNCSFDKLYGEQITELIKQKLLYDDRERIHMTDK
HHHHHHHHHHHHHHCCCCHHEEHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHEEECCC
GFELGNNVFEKFLLDDVNF
CHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]