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The map label for this gene is pbuX [H]

Identifier: 125624164

GI number: 125624164

Start: 1318899

End: 1320203

Strand: Reverse

Name: pbuX [H]

Synonym: llmg_1345

Alternate gene names: 125624164

Gene position: 1320203-1318899 (Counterclockwise)

Preceding gene: 125624165

Following gene: 125624161

Centisome position: 52.19

GC content: 37.47

Gene sequence:

>1305_bases
ATGCCTCATAAAAATGAACAAAGCCAGGAGCAAAGTAACTCTAAATCTGCTGTCTTGGGACTCCAACATCTGTTGGCCAT
GTATTCCGGGTCAATTCTTGTCCCAATTATGATTGCTGGAGCTTTAAATTACTCGGCTACGCAATTAACTTATTTAATTT
CAGCAGATATTTTCATGTGTGGTTTGGCCACTTTATTGCAACTACAAATGCGTAAGTATTTTGGGATTGGTTTACCAGTA
GTCCTTGGGGTAGCCTTTCAATCTGTTGCTCCTTTGATTATTATTGGGCAAAGACATGGTTCAGGAGCTATGTTTGGTTC
ATTGATGGTTGCCGGAGTTTTCGTTATTTTGATTTCAGGAATTTTCTCTAAAATTCGCAAACTCTTTCCGCCAATTGTCA
CTGGTTCAGTAATTACAACAATCGGTTTAAGTCTTATTCCTGTGGCAATCGGAAATATGGGAAATAACGTTGAGAAGCCA
ACTATTCAAAGTTTAATTTTAGCTGTTTCTACTATTTTAATAATTTTACTCATTAATATTTTTACTACTGGATTTATTCG
TTCTATTGCGATATTGATTGGACTCATTGCAGGGACAATCATAGCAGCAAGTATGGGCTTGGTTGACTTTTCTGTTGTTT
CTCAAGCACCATGGGCACACCTTCCTCAACCTTTCTATTTCTCAGCACCGAAATTCTATCTGGCAGATTCCTTAATGATG
ATAATTATTGCTATCGTTTCATTGGTTGAATCAACTGGTGTTTATTTGGCTCTTGCCGACATCACTGGTGAAAATCTTGA
TGAAAAACGTTTACGTAATGGTTATCGTGCAGAAGGATTTGCTGTCTTTCTTGGAGGGATTTTCAATACCTTCCCTTACA
CAGGATTTTCACAAAACGTTGGTTTAGTGCAATTATCAGGAATTAAAACTCGTAAACCAATTTATTTTACTGCAGGATTT
TTAATTATTTTAGGACTTATCCCTAAATTTGCCGCTGTTGCACAACTTATTCCTACTCCCGTTCTTGGTGGAGCAATGTT
GATTATGTTTGGGATGGTCGCGACACAAGGGATTAGAATGTTAGCGAAAGTTGAATTTGAGGGTAATCAAAATCTTTTGA
TTGCCGCTGTTGCGATTGCGATGGGTGTCGGCTTTAACTCTACTAACCTGTTCACGGCTCTTCCAAGTTTCATTCAACCT
TTTGTTTCTAATGGGATTGTGATGAGTACTGTTTCAGCGATTATCTTGAATTTGGTATTTAACCATGGAAAAAAAGATGA
ATTAGCTGCTGATGAAGCAAAATAA

Upstream 100 bases:

>100_bases
TAAAGTAATCTTCGCCCCAGCGGACGATATCGCTTTCGATTAAAACTAAGCAATAAGCAATTAAAAAGAATAAAAAAAGA
AAAATTTAAGGAAAATCAAA

Downstream 100 bases:

>100_bases
AAAATAACCACCAAATGGTGGTTTTTTTATGTTATTTCAAATTTCTTTTAAATCGCGTTTAAATTTCTTTTCTGAGTAGA
CCTCGAGCGAACCGTCAGGC

Product: xanthine/uracil permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MPHKNEQSQEQSNSKSAVLGLQHLLAMYSGSILVPIMIAGALNYSATQLTYLISADIFMCGLATLLQLQMRKYFGIGLPV
VLGVAFQSVAPLIIIGQRHGSGAMFGSLMVAGVFVILISGIFSKIRKLFPPIVTGSVITTIGLSLIPVAIGNMGNNVEKP
TIQSLILAVSTILIILLINIFTTGFIRSIAILIGLIAGTIIAASMGLVDFSVVSQAPWAHLPQPFYFSAPKFYLADSLMM
IIIAIVSLVESTGVYLALADITGENLDEKRLRNGYRAEGFAVFLGGIFNTFPYTGFSQNVGLVQLSGIKTRKPIYFTAGF
LIILGLIPKFAAVAQLIPTPVLGGAMLIMFGMVATQGIRMLAKVEFEGNQNLLIAAVAIAMGVGFNSTNLFTALPSFIQP
FVSNGIVMSTVSAIILNLVFNHGKKDELAADEAK

Sequences:

>Translated_434_residues
MPHKNEQSQEQSNSKSAVLGLQHLLAMYSGSILVPIMIAGALNYSATQLTYLISADIFMCGLATLLQLQMRKYFGIGLPV
VLGVAFQSVAPLIIIGQRHGSGAMFGSLMVAGVFVILISGIFSKIRKLFPPIVTGSVITTIGLSLIPVAIGNMGNNVEKP
TIQSLILAVSTILIILLINIFTTGFIRSIAILIGLIAGTIIAASMGLVDFSVVSQAPWAHLPQPFYFSAPKFYLADSLMM
IIIAIVSLVESTGVYLALADITGENLDEKRLRNGYRAEGFAVFLGGIFNTFPYTGFSQNVGLVQLSGIKTRKPIYFTAGF
LIILGLIPKFAAVAQLIPTPVLGGAMLIMFGMVATQGIRMLAKVEFEGNQNLLIAAVAIAMGVGFNSTNLFTALPSFIQP
FVSNGIVMSTVSAIILNLVFNHGKKDELAADEAK
>Mature_433_residues
PHKNEQSQEQSNSKSAVLGLQHLLAMYSGSILVPIMIAGALNYSATQLTYLISADIFMCGLATLLQLQMRKYFGIGLPVV
LGVAFQSVAPLIIIGQRHGSGAMFGSLMVAGVFVILISGIFSKIRKLFPPIVTGSVITTIGLSLIPVAIGNMGNNVEKPT
IQSLILAVSTILIILLINIFTTGFIRSIAILIGLIAGTIIAASMGLVDFSVVSQAPWAHLPQPFYFSAPKFYLADSLMMI
IIAIVSLVESTGVYLALADITGENLDEKRLRNGYRAEGFAVFLGGIFNTFPYTGFSQNVGLVQLSGIKTRKPIYFTAGFL
IILGLIPKFAAVAQLIPTPVLGGAMLIMFGMVATQGIRMLAKVEFEGNQNLLIAAVAIAMGVGFNSTNLFTALPSFIQPF
VSNGIVMSTVSAIILNLVFNHGKKDELAADEAK

Specific function: Transport of xanthine in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=437, Percent_Identity=24.0274599542334, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI44680148, Length=186, Percent_Identity=29.0322580645161, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI40316845, Length=186, Percent_Identity=29.0322580645161, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI44680143, Length=175, Percent_Identity=26.8571428571429, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI87082181, Length=429, Percent_Identity=39.1608391608392, Blast_Score=281, Evalue=8e-77,
Organism=Escherichia coli, GI1790087, Length=430, Percent_Identity=32.7906976744186, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI87081818, Length=458, Percent_Identity=29.6943231441048, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1788843, Length=414, Percent_Identity=29.4685990338164, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI87082178, Length=441, Percent_Identity=28.7981859410431, Blast_Score=144, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17542262, Length=177, Percent_Identity=28.8135593220339, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17541904, Length=175, Percent_Identity=28, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17558856, Length=447, Percent_Identity=22.1476510067114, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356175, Length=447, Percent_Identity=25.503355704698, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 46225; Mature: 46094

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCCCC
>Mature Secondary Structure 
PHKNEQSQEQSNSKSAVLGLQHLLAMYSGSILVPIMIAGALNYSATQLTYLISADIFMC
CCCCCCHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GLATLLQLQMRKYFGIGLPVVLGVAFQSVAPLIIIGQRHGSGAMFGSLMVAGVFVILISG
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
IFSKIRKLFPPIVTGSVITTIGLSLIPVAIGNMGNNVEKPTIQSLILAVSTILIILLINI
HHHHHHHHCCCHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FTTGFIRSIAILIGLIAGTIIAASMGLVDFSVVSQAPWAHLPQPFYFSAPKFYLADSLMM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
IIIAIVSLVESTGVYLALADITGENLDEKRLRNGYRAEGFAVFLGGIFNTFPYTGFSQNV
HHHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
GLVQLSGIKTRKPIYFTAGFLIILGLIPKFAAVAQLIPTPVLGGAMLIMFGMVATQGIRM
CEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LAKVEFEGNQNLLIAAVAIAMGVGFNSTNLFTALPSFIQPFVSNGIVMSTVSAIILNLVF
HHEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
NHGKKDELAADEAK
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9098051; 9384377 [H]