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The map label for this gene is clpP [H]

Identifier: 125623498

GI number: 125623498

Start: 633447

End: 634046

Strand: Reverse

Name: clpP [H]

Synonym: llmg_0638

Alternate gene names: 125623498

Gene position: 634046-633447 (Counterclockwise)

Preceding gene: 125623501

Following gene: 125623487

Centisome position: 25.07

GC content: 38.67

Gene sequence:

>600_bases
ATGGGTTATTTAGTACCTACCGTTATTGAACAATCAAGCCGTGGTGAACGTGCTTATGATATTTATTCACGACTTTTAAA
AGACCGCATTATCATGCTGACAGGACCTGTTGAAGATGGTATGGCAAATTCTATCATTGCCCAACTTCTTTTCTTGGATG
CACAAGATAATACTAAAGACATTTATCTCTATGTAAACACACCTGGTGGTTCTGTATCAGCTGGGCTCGCTATCGTGGAT
ACAATGAACTTTATCAAATCGGATGTCCAAACTATCGTTATGGGAATGGCTGCTTCTATGGGAACAATCATCGCCTCAAG
CGGTACTAAGGGTAAACGATTCATGTTACCAAATGCTGAATACCTCATTCACCAACCAATGGGTGGTGCAGGTCAAGGTA
CTCAACAAACTGATATGGCAATCGTCGCCGAACAACTTTTGAAAACACGTAAACGTTTGGAACAAATCCTTGCTGATAAT
TCTAATCGCTCACTTGAACAAATTCACAAAGATGCTGAACGTGACCATTGGATGGATGCCAAAGAAACTTTAGAATATGG
TTTCATTGATGAAATTATGGAAAATAATTCATTAAAATAA

Upstream 100 bases:

>100_bases
CCTTTTTTGACCAATGAGTTATAATATAGAAAAATAAACAATTGAACTTAATTTATTCCTAAATTAGGTCCATATCTTAT
TTATAAAGGAGATTTATTCT

Downstream 100 bases:

>100_bases
TACGCATGTAAATTAAAAAAGTCCTGATATAGGACTTTTTTTGTTATTGATAAAACATTTTAATAGTTTTTTATATATTG
AACCAAAGTATCAGTAAATT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MGYLVPTVIEQSSRGERAYDIYSRLLKDRIIMLTGPVEDGMANSIIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVD
TMNFIKSDVQTIVMGMAASMGTIIASSGTKGKRFMLPNAEYLIHQPMGGAGQGTQQTDMAIVAEQLLKTRKRLEQILADN
SNRSLEQIHKDAERDHWMDAKETLEYGFIDEIMENNSLK

Sequences:

>Translated_199_residues
MGYLVPTVIEQSSRGERAYDIYSRLLKDRIIMLTGPVEDGMANSIIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVD
TMNFIKSDVQTIVMGMAASMGTIIASSGTKGKRFMLPNAEYLIHQPMGGAGQGTQQTDMAIVAEQLLKTRKRLEQILADN
SNRSLEQIHKDAERDHWMDAKETLEYGFIDEIMENNSLK
>Mature_198_residues
GYLVPTVIEQSSRGERAYDIYSRLLKDRIIMLTGPVEDGMANSIIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDT
MNFIKSDVQTIVMGMAASMGTIIASSGTKGKRFMLPNAEYLIHQPMGGAGQGTQQTDMAIVAEQLLKTRKRLEQILADNS
NRSLEQIHKDAERDHWMDAKETLEYGFIDEIMENNSLK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=49.4736842105263, Blast_Score=202, Evalue=2e-52,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=56.701030927835, Blast_Score=236, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI17538017, Length=192, Percent_Identity=46.875, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI20129427, Length=192, Percent_Identity=46.875, Blast_Score=194, Evalue=4e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22053; Mature: 21921

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYLVPTVIEQSSRGERAYDIYSRLLKDRIIMLTGPVEDGMANSIIAQLLFLDAQDNTKD
CCCCCHHHHHCCCCCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCE
IYLYVNTPGGSVSAGLAIVDTMNFIKSDVQTIVMGMAASMGTIIASSGTKGKRFMLPNAE
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEECCCCC
YLIHQPMGGAGQGTQQTDMAIVAEQLLKTRKRLEQILADNSNRSLEQIHKDAERDHWMDA
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCH
KETLEYGFIDEIMENNSLK
HHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
GYLVPTVIEQSSRGERAYDIYSRLLKDRIIMLTGPVEDGMANSIIAQLLFLDAQDNTKD
CCCCHHHHHCCCCCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCE
IYLYVNTPGGSVSAGLAIVDTMNFIKSDVQTIVMGMAASMGTIIASSGTKGKRFMLPNAE
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEECCCCC
YLIHQPMGGAGQGTQQTDMAIVAEQLLKTRKRLEQILADNSNRSLEQIHKDAERDHWMDA
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCH
KETLEYGFIDEIMENNSLK
HHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]