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The map label for this gene is gltA [H]

Identifier: 125623495

GI number: 125623495

Start: 628261

End: 629586

Strand: Direct

Name: gltA [H]

Synonym: llmg_0635

Alternate gene names: 125623495

Gene position: 628261-629586 (Clockwise)

Preceding gene: 125623494

Following gene: 125623496

Centisome position: 24.84

GC content: 32.35

Gene sequence:

>1326_bases
ATGAATTTAATGAATAAAGAAGAAAAAATGATTAAAAATTCACAAATTCCTAGTGAATTTTACAAAAAGTACAACGTTAA
AAAAGGTTTAAGAGATATTAATGGAAAAGGTGTTTTAGCAGGATTAACTAATATATCTGCGATCCATTCTTTTGATAAGG
AAGGGAATCAAATTCCTGGTGTCTTAGAATATCGAGCCTATAATATTAAAGATATCGTTAGTGACTTGAGAAGTAAAAAT
CGTTTTGGCTTTGAAGAGATGACCTACCTTTTATTATTTGGAGAGTTACCTTCGGCAAAGGAACTTCAAGAATTTCAAAT
TCTGTTAGCTAGCAAAAGAACTTTACCCGAGTTTTTTGTTCGCGAAACAATACTGACCAATCCTTCAAGTGATGTAATGA
ATTCTATGAGTCGCTGCCTACTTGCACTTGCTAGTTATGATAAAAAAGCTTCGGATATTTCAATTGAGAATGTCTTAGAG
CAGTCGTTAGCACTCATTGCAGATTTTCCTCTTCTTGCGATTTATAGTTATCAAGCTTATATTCATTATTTTAAGAAAGA
AAGTCTTTATATTCATTTCCCAGACCCTGAATTGACAACGGCCGAAAATATTTTGCGTATGCTACGACCAGATTGTCATT
ATTCAGATATGGAAGCAAAAGTATTAGACATTGCTCTAATTCTACACATGGAACATGGCGGAGGGAATAATTCGACATTT
ACGACTCATGTGGTTACTTCCAGTGGAACAGATACTTATGCTACGATAGCTGCTGCTCTTTCGAGTTTAAAAGGGCCAAA
ACATGGTGGAGCAAACATCAAAGCGGCAAAAATGCTAGAAAATATTAAAGAAAATATCTCTGATTACAATAATGATGAAG
AAATAAAAAAATATCTTCATCAAATATTAAATAAAGAAGTTTTTGATAAGCAAGGATTGATTTATGGCATTGGCCATGCA
ATCTATAGTGTGAGTGATCCACGTTTTGAGGTTTTTAAATCCTATGTTGAAAGTCTAGCAAAAGAAAAAGGATTAGAAGA
AGAATTTAAACTTTATGAAAAAGTTGCTTTCCTTGCTCCTAAAGTGATATCCGAAAATAGAAAAATTTATAAAACAATTT
GTCCAAATGTTGACTTTTATTCAGGCTTTGTCTATAAAATACTGGAAATCCCACAAGAATTATTTACTCCTTTATTTGCC
ATCGCTAGAATTGTAGGTTGGTTGGCTCATAGAATGGAAGAATTAATTAATATGAATAAAATTATAAGGCCTGCTTATGA
GAGTATTTTAGAGTCTAAAGCTTATACAAGATTGGAGGAAAGATGA

Upstream 100 bases:

>100_bases
TAGGATTTTTTATTTTCTAAAAAAAAGTAATTTTAATTTTCAGAAAATATATAATTTTCGGAATAAAAAGTGTATAATAA
TGAAATAGATGGAGGTATTT

Downstream 100 bases:

>100_bases
AAACTTTAAAAATTAATGATAAAGAGTATCACTATTTTGATATTAGTGAGACTGAGAGAATTGAAGACTTTCCATATAGT
TTAAGAGTTCTTTTGGAGAG

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MNLMNKEEKMIKNSQIPSEFYKKYNVKKGLRDINGKGVLAGLTNISAIHSFDKEGNQIPGVLEYRAYNIKDIVSDLRSKN
RFGFEEMTYLLLFGELPSAKELQEFQILLASKRTLPEFFVRETILTNPSSDVMNSMSRCLLALASYDKKASDISIENVLE
QSLALIADFPLLAIYSYQAYIHYFKKESLYIHFPDPELTTAENILRMLRPDCHYSDMEAKVLDIALILHMEHGGGNNSTF
TTHVVTSSGTDTYATIAAALSSLKGPKHGGANIKAAKMLENIKENISDYNNDEEIKKYLHQILNKEVFDKQGLIYGIGHA
IYSVSDPRFEVFKSYVESLAKEKGLEEEFKLYEKVAFLAPKVISENRKIYKTICPNVDFYSGFVYKILEIPQELFTPLFA
IARIVGWLAHRMEELINMNKIIRPAYESILESKAYTRLEER

Sequences:

>Translated_441_residues
MNLMNKEEKMIKNSQIPSEFYKKYNVKKGLRDINGKGVLAGLTNISAIHSFDKEGNQIPGVLEYRAYNIKDIVSDLRSKN
RFGFEEMTYLLLFGELPSAKELQEFQILLASKRTLPEFFVRETILTNPSSDVMNSMSRCLLALASYDKKASDISIENVLE
QSLALIADFPLLAIYSYQAYIHYFKKESLYIHFPDPELTTAENILRMLRPDCHYSDMEAKVLDIALILHMEHGGGNNSTF
TTHVVTSSGTDTYATIAAALSSLKGPKHGGANIKAAKMLENIKENISDYNNDEEIKKYLHQILNKEVFDKQGLIYGIGHA
IYSVSDPRFEVFKSYVESLAKEKGLEEEFKLYEKVAFLAPKVISENRKIYKTICPNVDFYSGFVYKILEIPQELFTPLFA
IARIVGWLAHRMEELINMNKIIRPAYESILESKAYTRLEER
>Mature_441_residues
MNLMNKEEKMIKNSQIPSEFYKKYNVKKGLRDINGKGVLAGLTNISAIHSFDKEGNQIPGVLEYRAYNIKDIVSDLRSKN
RFGFEEMTYLLLFGELPSAKELQEFQILLASKRTLPEFFVRETILTNPSSDVMNSMSRCLLALASYDKKASDISIENVLE
QSLALIADFPLLAIYSYQAYIHYFKKESLYIHFPDPELTTAENILRMLRPDCHYSDMEAKVLDIALILHMEHGGGNNSTF
TTHVVTSSGTDTYATIAAALSSLKGPKHGGANIKAAKMLENIKENISDYNNDEEIKKYLHQILNKEVFDKQGLIYGIGHA
IYSVSDPRFEVFKSYVESLAKEKGLEEEFKLYEKVAFLAPKVISENRKIYKTICPNVDFYSGFVYKILEIPQELFTPLFA
IARIVGWLAHRMEELINMNKIIRPAYESILESKAYTRLEER

Specific function: Catalyzes The Synthesis Of 2-Methylcitrate From Propionyl-CoA And Oxaloacetate. Also Catalyzes The Condensation Of Oxaloacetate With Acetyl-CoA But With A Lower Specificity. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=367, Percent_Identity=28.0653950953678, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1786527, Length=407, Percent_Identity=30.958230958231, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI1786939, Length=419, Percent_Identity=30.0715990453461, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17555174, Length=366, Percent_Identity=26.5027322404372, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319850, Length=378, Percent_Identity=29.1005291005291, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6325257, Length=366, Percent_Identity=29.2349726775956, Blast_Score=119, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6324328, Length=352, Percent_Identity=28.9772727272727, Blast_Score=113, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24640124, Length=339, Percent_Identity=29.7935103244838, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24640126, Length=338, Percent_Identity=29.2899408284024, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21356863, Length=453, Percent_Identity=25.8278145695364, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 50379; Mature: 50379

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLMNKEEKMIKNSQIPSEFYKKYNVKKGLRDINGKGVLAGLTNISAIHSFDKEGNQIPG
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCC
VLEYRAYNIKDIVSDLRSKNRFGFEEMTYLLLFGELPSAKELQEFQILLASKRTLPEFFV
CHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHH
RETILTNPSSDVMNSMSRCLLALASYDKKASDISIENVLEQSLALIADFPLLAIYSYQAY
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
IHYFKKESLYIHFPDPELTTAENILRMLRPDCHYSDMEAKVLDIALILHMEHGGGNNSTF
HHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHEEEEECCCCCCCEE
TTHVVTSSGTDTYATIAAALSSLKGPKHGGANIKAAKMLENIKENISDYNNDEEIKKYLH
EEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
QILNKEVFDKQGLIYGIGHAIYSVSDPRFEVFKSYVESLAKEKGLEEEFKLYEKVAFLAP
HHHCHHHHHCCCCEEEHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
KVISENRKIYKTICPNVDFYSGFVYKILEIPQELFTPLFAIARIVGWLAHRMEELINMNK
HHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIRPAYESILESKAYTRLEER
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLMNKEEKMIKNSQIPSEFYKKYNVKKGLRDINGKGVLAGLTNISAIHSFDKEGNQIPG
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCC
VLEYRAYNIKDIVSDLRSKNRFGFEEMTYLLLFGELPSAKELQEFQILLASKRTLPEFFV
CHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHH
RETILTNPSSDVMNSMSRCLLALASYDKKASDISIENVLEQSLALIADFPLLAIYSYQAY
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
IHYFKKESLYIHFPDPELTTAENILRMLRPDCHYSDMEAKVLDIALILHMEHGGGNNSTF
HHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHEEEEECCCCCCCEE
TTHVVTSSGTDTYATIAAALSSLKGPKHGGANIKAAKMLENIKENISDYNNDEEIKKYLH
EEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
QILNKEVFDKQGLIYGIGHAIYSVSDPRFEVFKSYVESLAKEKGLEEEFKLYEKVAFLAP
HHHCHHHHHCCCCEEEHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
KVISENRKIYKTICPNVDFYSGFVYKILEIPQELFTPLFAIARIVGWLAHRMEELINMNK
HHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIRPAYESILESKAYTRLEER
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]