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The map label for this gene is napC [H]

Identifier: 125623191

GI number: 125623191

Start: 306738

End: 307928

Strand: Reverse

Name: napC [H]

Synonym: llmg_0320

Alternate gene names: 125623191

Gene position: 307928-306738 (Counterclockwise)

Preceding gene: 125623192

Following gene: 125623182

Centisome position: 12.17

GC content: 41.23

Gene sequence:

>1191_bases
ATGAACATCAATAAACACGCCCTCACTTTTGGGCTTATCACAACTTTTCTGACAGGACTTGGTTTTACACTCATTTCCCC
TGTTGTCCCATTTATGGTCGCTCCTTTTGCAAATGCTCATGACCAAGCATTCATCGTCTCTGCACTAATGGCCATTTATG
CACTCTGTACTTTCTTTGCCGCCCCCGCACTTGGCTCTTTATCAGACCGCTTTGGTCGCAAACCAATCTTACTAATTTCT
TTAGCTGGTTCTGCCTTGGGGTATCTGGTCTTTGGTTTAGCTGGCAGTCTTTGGGTGCTCTTTATCGGACGAATCATCGA
TGGCTTAACCGGTGGAAATATCGTGACACTTTTCGCTTATTTCGCCGATATTACTGATGAAGAAAATCGAACAAAAGTAT
TCGGATGGACAGCTGCTGCTGTTGGTGTTGGAACAATTTCTGGCCCAACCGTTGGTGGACTCCTAGCCCATTTTGGAAAT
TCAGTCCCCTTCTACTTTGGAGCAATCATCTCCCTTGCAAATCTTCTTTATGGTGCTTTTGTCATGGATGAAAGCCTTCC
TGAAAATAATCGCACAAGAAATTTTTCTCTTAAGCAGCTTAATCCATTCACCCAACTTTTTCAGCTCTTACGCATGAAAA
ATCTCAATCGTCTCCTCTTTGCCGGTATCTTACTTTGGTTGCCAAATGGTGCGCTCCAAGCTATTATCAGTCAGTTTTCA
CTTGATAGTTTTGCTTGGACACCTGTATTAATTGGTCTTGCCATTTCAATCATGGGTTTGATGGATATTTTAACTCAAAT
TTTCATCATGCCCAGACTTCTAAAATTAGCTAATGAAGATAAACTTATCCGTCTAGCAATAGTCTGCGAAATAATTGCTT
ACTTACTTTTCGCTCTTTCTGCTTTTTCTAAAATGTGGCCCCTCTTCATTCTGGCAATGTTTATCTTTGCTTTTGGAGAT
AGTATTTTCGGAACTGCCTTCAATGGCAAACTTTCAAAATCAGCGACTTCTTCTGAACAAGGTAAACTTCAAGGCGGAAG
TCAAGCTCTTCAAGCACTTACACGCGTTATCGGTCCTTTAATTGGTGGACAAATTTACATTAGTCTCGGACATTCTGCTC
CCGCCCTTATGGGATTTATCTTCCTTATTCTCGCTTTGATTGTTCTATCGAAAGCGAAATCAAACGAATAA

Upstream 100 bases:

>100_bases
TGTTGCCCTTGACCCTTTCTCCCACTTGCTAAAGCAATCGAAAAATAAAAAAGGTGCAAAGACCCTAGAACGAACTCACA
TCTTAATGGAGGTTCTCACT

Downstream 100 bases:

>100_bases
TTTATAAATAAAAAAACCACCTCTAAAAGGTGATTTTTATTTATAAATTACAATTTTTCAGCAATATCAGTAATTGCTTT
ATCAACTGCTGCTTTTTGGC

Product: multidrug-efflux transporter protein

Products: NA

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MNINKHALTFGLITTFLTGLGFTLISPVVPFMVAPFANAHDQAFIVSALMAIYALCTFFAAPALGSLSDRFGRKPILLIS
LAGSALGYLVFGLAGSLWVLFIGRIIDGLTGGNIVTLFAYFADITDEENRTKVFGWTAAAVGVGTISGPTVGGLLAHFGN
SVPFYFGAIISLANLLYGAFVMDESLPENNRTRNFSLKQLNPFTQLFQLLRMKNLNRLLFAGILLWLPNGALQAIISQFS
LDSFAWTPVLIGLAISIMGLMDILTQIFIMPRLLKLANEDKLIRLAIVCEIIAYLLFALSAFSKMWPLFILAMFIFAFGD
SIFGTAFNGKLSKSATSSEQGKLQGGSQALQALTRVIGPLIGGQIYISLGHSAPALMGFIFLILALIVLSKAKSNE

Sequences:

>Translated_396_residues
MNINKHALTFGLITTFLTGLGFTLISPVVPFMVAPFANAHDQAFIVSALMAIYALCTFFAAPALGSLSDRFGRKPILLIS
LAGSALGYLVFGLAGSLWVLFIGRIIDGLTGGNIVTLFAYFADITDEENRTKVFGWTAAAVGVGTISGPTVGGLLAHFGN
SVPFYFGAIISLANLLYGAFVMDESLPENNRTRNFSLKQLNPFTQLFQLLRMKNLNRLLFAGILLWLPNGALQAIISQFS
LDSFAWTPVLIGLAISIMGLMDILTQIFIMPRLLKLANEDKLIRLAIVCEIIAYLLFALSAFSKMWPLFILAMFIFAFGD
SIFGTAFNGKLSKSATSSEQGKLQGGSQALQALTRVIGPLIGGQIYISLGHSAPALMGFIFLILALIVLSKAKSNE
>Mature_396_residues
MNINKHALTFGLITTFLTGLGFTLISPVVPFMVAPFANAHDQAFIVSALMAIYALCTFFAAPALGSLSDRFGRKPILLIS
LAGSALGYLVFGLAGSLWVLFIGRIIDGLTGGNIVTLFAYFADITDEENRTKVFGWTAAAVGVGTISGPTVGGLLAHFGN
SVPFYFGAIISLANLLYGAFVMDESLPENNRTRNFSLKQLNPFTQLFQLLRMKNLNRLLFAGILLWLPNGALQAIISQFS
LDSFAWTPVLIGLAISIMGLMDILTQIFIMPRLLKLANEDKLIRLAIVCEIIAYLLFALSAFSKMWPLFILAMFIFAFGD
SIFGTAFNGKLSKSATSSEQGKLQGGSQALQALTRVIGPLIGGQIYISLGHSAPALMGFIFLILALIVLSKAKSNE

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=387, Percent_Identity=22.9974160206718, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI94721311, Length=325, Percent_Identity=25.8461538461538, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71996331, Length=373, Percent_Identity=22.7882037533512, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17551570, Length=364, Percent_Identity=23.9010989010989, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17738085, Length=366, Percent_Identity=23.7704918032787, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI21357569, Length=371, Percent_Identity=23.989218328841, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI161080926, Length=371, Percent_Identity=23.989218328841, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI161080924, Length=371, Percent_Identity=23.989218328841, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24656463, Length=371, Percent_Identity=23.989218328841, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24656468, Length=371, Percent_Identity=23.989218328841, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221513297, Length=209, Percent_Identity=25.8373205741627, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667557, Length=228, Percent_Identity=26.7543859649123, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24667561, Length=186, Percent_Identity=27.4193548387097, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42685; Mature: 42685

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNINKHALTFGLITTFLTGLGFTLISPVVPFMVAPFANAHDQAFIVSALMAIYALCTFFA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
APALGSLSDRFGRKPILLISLAGSALGYLVFGLAGSLWVLFIGRIIDGLTGGNIVTLFAY
HCCCCHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FADITDEENRTKVFGWTAAAVGVGTISGPTVGGLLAHFGNSVPFYFGAIISLANLLYGAF
HHHCCCCCCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
VMDESLPENNRTRNFSLKQLNPFTQLFQLLRMKNLNRLLFAGILLWLPNGALQAIISQFS
HHHCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHC
LDSFAWTPVLIGLAISIMGLMDILTQIFIMPRLLKLANEDKLIRLAIVCEIIAYLLFALS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AFSKMWPLFILAMFIFAFGDSIFGTAFNGKLSKSATSSEQGKLQGGSQALQALTRVIGPL
HHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
IGGQIYISLGHSAPALMGFIFLILALIVLSKAKSNE
HCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNINKHALTFGLITTFLTGLGFTLISPVVPFMVAPFANAHDQAFIVSALMAIYALCTFFA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
APALGSLSDRFGRKPILLISLAGSALGYLVFGLAGSLWVLFIGRIIDGLTGGNIVTLFAY
HCCCCHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FADITDEENRTKVFGWTAAAVGVGTISGPTVGGLLAHFGNSVPFYFGAIISLANLLYGAF
HHHCCCCCCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
VMDESLPENNRTRNFSLKQLNPFTQLFQLLRMKNLNRLLFAGILLWLPNGALQAIISQFS
HHHCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHC
LDSFAWTPVLIGLAISIMGLMDILTQIFIMPRLLKLANEDKLIRLAIVCEIIAYLLFALS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AFSKMWPLFILAMFIFAFGDSIFGTAFNGKLSKSATSSEQGKLQGGSQALQALTRVIGPL
HHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
IGGQIYISLGHSAPALMGFIFLILALIVLSKAKSNE
HCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]