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The map label for this gene is rmlA [H]

Identifier: 125623083

GI number: 125623083

Start: 195461

End: 196330

Strand: Direct

Name: rmlA [H]

Synonym: llmg_0206

Alternate gene names: 125623083

Gene position: 195461-196330 (Clockwise)

Preceding gene: 125623082

Following gene: 125623084

Centisome position: 7.73

GC content: 37.7

Gene sequence:

>870_bases
ATGAAAGGGATTATTTTAGCGGGAGGGTCTGGAACACGACTTTACCCACTGACACGTGCTGCGTCAAAACAACTGATGCC
TATCTATGATAAACCAATGATTTATTATCCATTGTCAACTTTGATGTTGGCTGGAATTAAAGATATTTTGATTATTTCGA
CACCAACAGATACGCCACGTTTTAAAGAGCTCTTGCAAGATGGTTCAGAATTTGGTATCAATCTTCAATATGCTGTTCAA
CCTTCACCAGATGGCTTGGCTCAAGCCTTTATTATTGGAGAAGACTTTATCGGTGACGATTCAGTTGCGCTGATTTTGGG
AGATAACATTTATCACGGTCCTGGCATGTCTAAAATGCTTCAAAATGCAGCTGCAAAAGAAAAAGGTGCAACTGTTTTTG
GATATCATGTTCCAGATCCAGAACGTTTTGGTGTTGTTGAATTTGATAAAGATATGAATGCTGTTTCTATTGAAGAAAAA
CCAGAAGAACCTAAATCAAATTATGCGGTTACTGGTTTGTATTTCTATGATAACGATGTTATTGAAATTGCAAAAAGTAT
TGAACCTTCACCTCGTGGTGAACTTGAAATTACTGATGTGAATAAAGCCTATCTTGAACGTGGCGATTTGTCAGTTGAAT
TGATGGGACGTGGTTTTGCTTGGTTGGATACAGGAACACACGAATCTCTTCTTGAAGCTGCACAATATATTGAAACAGTT
CAACGGATGCAAAATATGCAAGTGGCAAACTTGGAAGAAATTGCTTATCGCATGGGTTATATCACAGAAGAGGATGTTCG
TACTTTGGCACAACCGCTTAAGAAAAATGAATACGGACAATATTTGCTTCGTTTGATTGGAGATAAATAA

Upstream 100 bases:

>100_bases
ATCAACCTTTTAAGCGCGAAATAGCCATAGAAGGTTGTGTATTGAGAAAGTTTTTGTGTTATAATGTATATTGATTAATT
ATGATTATGGAGGTCCTTTC

Downstream 100 bases:

>100_bases
TGACTGAGAATTTTTTCGGAAAAACACTTGCTAGTCGAGAAATTAGTCAAATTCCAGGAATGTTAGAATTTGATATTCCG
GTTCATGGTGATAATCGTGG

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MKGIILAGGSGTRLYPLTRAASKQLMPIYDKPMIYYPLSTLMLAGIKDILIISTPTDTPRFKELLQDGSEFGINLQYAVQ
PSPDGLAQAFIIGEDFIGDDSVALILGDNIYHGPGMSKMLQNAAAKEKGATVFGYHVPDPERFGVVEFDKDMNAVSIEEK
PEEPKSNYAVTGLYFYDNDVIEIAKSIEPSPRGELEITDVNKAYLERGDLSVELMGRGFAWLDTGTHESLLEAAQYIETV
QRMQNMQVANLEEIAYRMGYITEEDVRTLAQPLKKNEYGQYLLRLIGDK

Sequences:

>Translated_289_residues
MKGIILAGGSGTRLYPLTRAASKQLMPIYDKPMIYYPLSTLMLAGIKDILIISTPTDTPRFKELLQDGSEFGINLQYAVQ
PSPDGLAQAFIIGEDFIGDDSVALILGDNIYHGPGMSKMLQNAAAKEKGATVFGYHVPDPERFGVVEFDKDMNAVSIEEK
PEEPKSNYAVTGLYFYDNDVIEIAKSIEPSPRGELEITDVNKAYLERGDLSVELMGRGFAWLDTGTHESLLEAAQYIETV
QRMQNMQVANLEEIAYRMGYITEEDVRTLAQPLKKNEYGQYLLRLIGDK
>Mature_289_residues
MKGIILAGGSGTRLYPLTRAASKQLMPIYDKPMIYYPLSTLMLAGIKDILIISTPTDTPRFKELLQDGSEFGINLQYAVQ
PSPDGLAQAFIIGEDFIGDDSVALILGDNIYHGPGMSKMLQNAAAKEKGATVFGYHVPDPERFGVVEFDKDMNAVSIEEK
PEEPKSNYAVTGLYFYDNDVIEIAKSIEPSPRGELEITDVNKAYLERGDLSVELMGRGFAWLDTGTHESLLEAAQYIETV
QRMQNMQVANLEEIAYRMGYITEEDVRTLAQPLKKNEYGQYLLRLIGDK

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=253, Percent_Identity=24.5059288537549, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI11761619, Length=253, Percent_Identity=24.5059288537549, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1788351, Length=287, Percent_Identity=70.0348432055749, Blast_Score=429, Evalue=1e-121,
Organism=Escherichia coli, GI1790224, Length=286, Percent_Identity=65.3846153846154, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1787488, Length=244, Percent_Identity=25, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI133931050, Length=237, Percent_Identity=24.8945147679325, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=253, Percent_Identity=27.6679841897233, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355443, Length=249, Percent_Identity=24.4979919678715, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24644084, Length=249, Percent_Identity=24.4979919678715, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32178; Mature: 32178

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLYPLTRAASKQLMPIYDKPMIYYPLSTLMLAGIKDILIISTPTDTPR
CCCEEEECCCCCEEEEEHHHHCCCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCCHH
FKELLQDGSEFGINLQYAVQPSPDGLAQAFIIGEDFIGDDSVALILGDNIYHGPGMSKML
HHHHHHCCHHHCEEEEEEECCCCCCCEEEEEECCCCCCCCCEEEEECCCEECCCCHHHHH
QNAAAKEKGATVFGYHVPDPERFGVVEFDKDMNAVSIEEKPEEPKSNYAVTGLYFYDNDV
HHHHHHHCCCEEEEEECCCCCCCCEEEECCCCCEEECCCCCCCCCCCEEEEEEEEECCHH
IEIAKSIEPSPRGELEITDVNKAYLERGDLSVELMGRGFAWLDTGTHESLLEAAQYIETV
HHHHHHCCCCCCCCEEEEECCHHHHHCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHH
QRMQNMQVANLEEIAYRMGYITEEDVRTLAQPLKKNEYGQYLLRLIGDK
HHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKGIILAGGSGTRLYPLTRAASKQLMPIYDKPMIYYPLSTLMLAGIKDILIISTPTDTPR
CCCEEEECCCCCEEEEEHHHHCCCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCCHH
FKELLQDGSEFGINLQYAVQPSPDGLAQAFIIGEDFIGDDSVALILGDNIYHGPGMSKML
HHHHHHCCHHHCEEEEEEECCCCCCCEEEEEECCCCCCCCCEEEEECCCEECCCCHHHHH
QNAAAKEKGATVFGYHVPDPERFGVVEFDKDMNAVSIEEKPEEPKSNYAVTGLYFYDNDV
HHHHHHHCCCEEEEEECCCCCCCCEEEECCCCCEEECCCCCCCCCCCEEEEEEEEECCHH
IEIAKSIEPSPRGELEITDVNKAYLERGDLSVELMGRGFAWLDTGTHESLLEAAQYIETV
HHHHHHCCCCCCCCEEEEECCHHHHHCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHH
QRMQNMQVANLEEIAYRMGYITEEDVRTLAQPLKKNEYGQYLLRLIGDK
HHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186 [H]