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The map label for this gene is relA [H]

Identifier: 125622992

GI number: 125622992

Start: 105797

End: 108019

Strand: Direct

Name: relA [H]

Synonym: llmg_0113

Alternate gene names: 125622992

Gene position: 105797-108019 (Clockwise)

Preceding gene: 125622991

Following gene: 125622994

Centisome position: 4.18

GC content: 39.09

Gene sequence:

>2223_bases
ATGCCTTCAGAACCAGTCTTAACCGGAGCAGAAGTTGTCAATATCTGCTCTGAATACATGAATGAAACTGACCTTTTACT
CGTAGAAAAAGCACTTGCCTGTGCTTCACTTGCCCATGCCGACCAATATCGTGCTTCTGGCGAAGCCTATTTTGTTCATC
CTACCCAAGTTGCAGGAATATTAGCCAAATTAAAACTGGATGCCGTTACCGTTTCCTGTGGTTTTTTGCATGATGTCGTT
GAAGATACTAATTTTACTCAGGGTGACCTGCAAGAATTATTTGGCGATGAAATTGCTGAAATAGTAGATGGTGTTACCAA
GTTAGGTAAAGTTGAGTATAAGTCACACGAAGAACAATTGGCAGAAAACCATCGGAAGATGCTAATGGCTATGTCCAAGG
ATATCCGTGTTATTTTGGTTAAACTGGCCGACCGTTTGCATAATATGCGTACGCTTAAACATCTTCGTCCAGATAAACAA
AAACGGATTTCACGTGAAACAATGGAAATCTATGCCCCCCTTGCTCATCGTTTAGGGATTGCCAGTATTAAGTGGGAATT
AGAAGATCTATCCTTCCGTTATCTTGAAGAAGCGGAATTTTATCGCATTCGTGGTCTTATGAATGAAAAACGGACTGCTC
GCGAAGCGCTCGTTACGGAAGTGATTGGAAAATTACAAGAACGTGTGGAAAAAGCAGGAGTGGATGCCGAAATTTATGGA
CGTCCGAAGCATATTTATTCTATTTATCGTAAAATGCACGATAAGAAAAAACGCTTTGATGAAATCTATGACTTGATTGC
TATTCGCTGTATCACTGAAACAACAAGCGATGTTTATACAACTTTGGGCTATATTCATGACCTCTGGAAGCCAATGCCAG
GACGTTTTAAAGATTATATTGCCAATCCGAAAGCCAATGGCTATCAATCTGTCCATACGACAGTTTATGGACCAAAAGGG
CCAATGGAATTCCAGATTAGAACGCGGGAAATGCACCAAATTGCGGAATATGGGGTTGCCGCTCACTGGGCTTACAAACA
AGGAATTAAATCAAAAGTTGATGTTCATGAAATCTCAGAAACATTGAATTGGATTCATGAATTAGTCGAATTGCGCGAAG
AAGCAGGCGACTCAGCCGAAGATTTTGTTAAAGCAGTTCAAGAAGATATCTTATCAGACAAGATTTATGTCTTTACTCCG
AATGGTGAAGTCCAAGAACTCCCTAGAGGCTCTGGTCCAATTGACTTTGCTTATGCGATTCACACTAAAGTTGGAGATCA
TGCGACGGGTGCTAAAGTAAATGGACGTATGAAACCTTTATCTGTTCAATTAAAAACAGGGGACCGAGTTGAAATTATTA
CCAGCTCAAGCTCTTTTGGACCAAGTCGTGACTGGATTAATTTAGTTAAAACCAATAAGGCTCGAAACAAAATTAAGCAA
TTCTTTAAAAACCAAGACAAAGAATTGTCGGTTAATAAAGGCCGTGAAATGTTGCAAGAAGCTTTGGAAGAAGCTGGCTT
TGTTCCAAATCAGTATTTAGATAAAAAACACCTTGATGAAGTTTTCAATAAGATTAGTTATCGCAATGCCGAAGCTTTGT
ACGCGGCAATTGGTTTTGGTGAACTTTCAGCAACAACGATTGCTAATCGTTTAACTGAAAATGAACGCCGTGAAGCTGAG
AGAGCTAAACAAAAAGCTGAAGCTGAAGAGCTGATGAAGGGTGAAGTTAAACGCGAATCAAGTAAAAATATCATGAAAAT
CCGCCACGATGGTGGTGTTAGCGTTTCTGGTATTGATAGTCTACTTGTTCGGATTGCCAAATGTTGTAATCCAGTTCCGG
GTGACCAGATTGTTGGATATATTACAAAAGGTCGAGGCGTTTCTGTTCACAGGGCGGATTGTCAAAATGTGCGCAGTATG
GAAGACTTTGAACAAAGACTTGTCGAAGTTGAATGGGATGATTCAGAGAACTTGGTCAAAGAATACGTTGCTAATATTGA
TGTCTATGGATTTAATCGTCCAGGATTGCTCAATGATGTGATGCAAGTTTTATCAAATTCGACTAAAAATTTGATTTCGA
TAAATGCTCAACCAACAAAAGATAAAAAAATGGCGAATATTCATATCGCTTTAGGGATTAAAAATTTATCAGATTTAACT
TTGATTGTTGATAAAATCAAAATGACTCCTGATGTTTATTCGGTAAAACGGACAAATGCCTAA

Upstream 100 bases:

>100_bases
TAACTTATAAAATTTGATGAGATAATACATTAATCCAATAAGGAGGAAAACTGGCCACCATTTTAAAGTTTATTTTTAAA
ATGGTCTAGTATATCAAGCT

Downstream 100 bases:

>100_bases
AAAAAGAGCTTGACTTAGTCAAGCTCTTTTATATTAGATTCTTTAATAATGTAGTTGGGACGTCTTTTAGTTTCCAGAAA
AATTTTAGCAATGTATTTAC

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: GTP pyrophosphokinase; (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; Stringent response-like protein; ppGpp synthase I; Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; Penta-phosphate guanosine-3'-pyrophosphohydrolase; (ppGpp)ase [H]

Number of amino acids: Translated: 740; Mature: 739

Protein sequence:

>740_residues
MPSEPVLTGAEVVNICSEYMNETDLLLVEKALACASLAHADQYRASGEAYFVHPTQVAGILAKLKLDAVTVSCGFLHDVV
EDTNFTQGDLQELFGDEIAEIVDGVTKLGKVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRLHNMRTLKHLRPDKQ
KRISRETMEIYAPLAHRLGIASIKWELEDLSFRYLEEAEFYRIRGLMNEKRTAREALVTEVIGKLQERVEKAGVDAEIYG
RPKHIYSIYRKMHDKKKRFDEIYDLIAIRCITETTSDVYTTLGYIHDLWKPMPGRFKDYIANPKANGYQSVHTTVYGPKG
PMEFQIRTREMHQIAEYGVAAHWAYKQGIKSKVDVHEISETLNWIHELVELREEAGDSAEDFVKAVQEDILSDKIYVFTP
NGEVQELPRGSGPIDFAYAIHTKVGDHATGAKVNGRMKPLSVQLKTGDRVEIITSSSSFGPSRDWINLVKTNKARNKIKQ
FFKNQDKELSVNKGREMLQEALEEAGFVPNQYLDKKHLDEVFNKISYRNAEALYAAIGFGELSATTIANRLTENERREAE
RAKQKAEAEELMKGEVKRESSKNIMKIRHDGGVSVSGIDSLLVRIAKCCNPVPGDQIVGYITKGRGVSVHRADCQNVRSM
EDFEQRLVEVEWDDSENLVKEYVANIDVYGFNRPGLLNDVMQVLSNSTKNLISINAQPTKDKKMANIHIALGIKNLSDLT
LIVDKIKMTPDVYSVKRTNA

Sequences:

>Translated_740_residues
MPSEPVLTGAEVVNICSEYMNETDLLLVEKALACASLAHADQYRASGEAYFVHPTQVAGILAKLKLDAVTVSCGFLHDVV
EDTNFTQGDLQELFGDEIAEIVDGVTKLGKVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRLHNMRTLKHLRPDKQ
KRISRETMEIYAPLAHRLGIASIKWELEDLSFRYLEEAEFYRIRGLMNEKRTAREALVTEVIGKLQERVEKAGVDAEIYG
RPKHIYSIYRKMHDKKKRFDEIYDLIAIRCITETTSDVYTTLGYIHDLWKPMPGRFKDYIANPKANGYQSVHTTVYGPKG
PMEFQIRTREMHQIAEYGVAAHWAYKQGIKSKVDVHEISETLNWIHELVELREEAGDSAEDFVKAVQEDILSDKIYVFTP
NGEVQELPRGSGPIDFAYAIHTKVGDHATGAKVNGRMKPLSVQLKTGDRVEIITSSSSFGPSRDWINLVKTNKARNKIKQ
FFKNQDKELSVNKGREMLQEALEEAGFVPNQYLDKKHLDEVFNKISYRNAEALYAAIGFGELSATTIANRLTENERREAE
RAKQKAEAEELMKGEVKRESSKNIMKIRHDGGVSVSGIDSLLVRIAKCCNPVPGDQIVGYITKGRGVSVHRADCQNVRSM
EDFEQRLVEVEWDDSENLVKEYVANIDVYGFNRPGLLNDVMQVLSNSTKNLISINAQPTKDKKMANIHIALGIKNLSDLT
LIVDKIKMTPDVYSVKRTNA
>Mature_739_residues
PSEPVLTGAEVVNICSEYMNETDLLLVEKALACASLAHADQYRASGEAYFVHPTQVAGILAKLKLDAVTVSCGFLHDVVE
DTNFTQGDLQELFGDEIAEIVDGVTKLGKVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRLHNMRTLKHLRPDKQK
RISRETMEIYAPLAHRLGIASIKWELEDLSFRYLEEAEFYRIRGLMNEKRTAREALVTEVIGKLQERVEKAGVDAEIYGR
PKHIYSIYRKMHDKKKRFDEIYDLIAIRCITETTSDVYTTLGYIHDLWKPMPGRFKDYIANPKANGYQSVHTTVYGPKGP
MEFQIRTREMHQIAEYGVAAHWAYKQGIKSKVDVHEISETLNWIHELVELREEAGDSAEDFVKAVQEDILSDKIYVFTPN
GEVQELPRGSGPIDFAYAIHTKVGDHATGAKVNGRMKPLSVQLKTGDRVEIITSSSSFGPSRDWINLVKTNKARNKIKQF
FKNQDKELSVNKGREMLQEALEEAGFVPNQYLDKKHLDEVFNKISYRNAEALYAAIGFGELSATTIANRLTENERREAER
AKQKAEAEELMKGEVKRESSKNIMKIRHDGGVSVSGIDSLLVRIAKCCNPVPGDQIVGYITKGRGVSVHRADCQNVRSME
DFEQRLVEVEWDDSENLVKEYVANIDVYGFNRPGLLNDVMQVLSNSTKNLISINAQPTKDKKMANIHIALGIKNLSDLTL
IVDKIKMTPDVYSVKRTNA

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the formation of pppGpp wh

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1790082, Length=725, Percent_Identity=39.8620689655172, Blast_Score=556, Evalue=1e-159,
Organism=Escherichia coli, GI1789147, Length=697, Percent_Identity=37.4461979913917, Blast_Score=493, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5; =3.1.7.2 [H]

Molecular weight: Translated: 83855; Mature: 83724

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSEPVLTGAEVVNICSEYMNETDLLLVEKALACASLAHADQYRASGEAYFVHPTQVAGI
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHH
LAKLKLDAVTVSCGFLHDVVEDTNFTQGDLQELFGDEIAEIVDGVTKLGKVEYKSHEEQL
HHHHHHHHEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
AENHRKMLMAMSKDIRVILVKLADRLHNMRTLKHLRPDKQKRISRETMEIYAPLAHRLGI
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
ASIKWELEDLSFRYLEEAEFYRIRGLMNEKRTAREALVTEVIGKLQERVEKAGVDAEIYG
HHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECC
RPKHIYSIYRKMHDKKKRFDEIYDLIAIRCITETTSDVYTTLGYIHDLWKPMPGRFKDYI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
ANPKANGYQSVHTTVYGPKGPMEFQIRTREMHQIAEYGVAAHWAYKQGIKSKVDVHEISE
CCCCCCCCCCEEEEEECCCCCCEEEEHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHH
TLNWIHELVELREEAGDSAEDFVKAVQEDILSDKIYVFTPNGEVQELPRGSGPIDFAYAI
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHCCCCCCCCEEEEEE
HTKVGDHATGAKVNGRMKPLSVQLKTGDRVEIITSSSSFGPSRDWINLVKTNKARNKIKQ
ECCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
FFKNQDKELSVNKGREMLQEALEEAGFVPNQYLDKKHLDEVFNKISYRNAEALYAAIGFG
HHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHCHHHHHHHHHHHHCCCHHHHHHHHCCC
ELSATTIANRLTENERREAERAKQKAEAEELMKGEVKRESSKNIMKIRHDGGVSVSGIDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHH
LLVRIAKCCNPVPGDQIVGYITKGRGVSVHRADCQNVRSMEDFEQRLVEVEWDDSENLVK
HHHHHHHHCCCCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHEEECCCCCHHHHH
EYVANIDVYGFNRPGLLNDVMQVLSNSTKNLISINAQPTKDKKMANIHIALGIKNLSDLT
HHHHCCEEEECCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEEEEEECCCHHHH
LIVDKIKMTPDVYSVKRTNA
HHHHHHHCCCCHHCCCCCCC
>Mature Secondary Structure 
PSEPVLTGAEVVNICSEYMNETDLLLVEKALACASLAHADQYRASGEAYFVHPTQVAGI
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHH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HHHHHHHCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8232196 [H]