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The map label for this gene is cadA [H]

Identifier: 125622979

GI number: 125622979

Start: 93484

End: 95265

Strand: Direct

Name: cadA [H]

Synonym: llmg_0100

Alternate gene names: 125622979

Gene position: 93484-95265 (Clockwise)

Preceding gene: 125622976

Following gene: 125622980

Centisome position: 3.7

GC content: 40.07

Gene sequence:

>1782_bases
ATGAAAAACTGGAAAAAACTGATTCTTGTTTTTGTCATCGCAGGCGTAGCATTGATTGCTTACTTTGGCTTTAATCAGCC
TTTTTTGGCGCGTCTAGTCGTCACAATTGCTGGGGGAGTTTTGGCTTTCTCAATGTTGATTGAAATGATCAAAACCCTAC
GAAGTGGCTCTTATGGTGTAGATTTATTAGCCATCACGGCCATTATTGCGACTTTACTGGTGGGAGAATATTGGGCTTCA
CTGATTATTATTCTCATGCTTGTTGGAGGAGAAAGTTTAGAGGATTATGCCAATGGCCGTGCTCACCGTGCCTTAGCAGC
TCTACTTGACAAGTCGCCTGAAATTGCACATGTACAAACAGGAGATAAGGTAGTTGATTTGCCACTGGACCATGTTGAGA
TTGGTAGTGTTTTATTGATTAGACCAATGGAAATTATTCCAATTGATGGGAAACTTCTATCGGAAGCTGTTGTGCTTGAT
GAGGCTTCACTGACTGGTGAAACAAAGCCTAATGAATTAGTCAGAGGCGACAATGTTCTTTCGGGTGCCATCAACGGTAA
CTCAAGCATTCAAATCGAAACAACGGTTGCTGCAGCGGATTCACAGTTTCAAAAAATCGTACAATTGGTTAAGGAAACGG
AAAAAACACCAGCTCAATTTGTGCGCTTAGCTGACCGTTATGCTGTTCCCTTTACAATTATTGCTTATATCATCGCAGCA
GTTGCTTATTTTATTTCGGGAGATCCAGTCCGAATTGCGGAAGTGTTAGTAGTGGCAAGTCCTTGTCCCTTAATTTTGGC
CGCGCCGATTGCTTTTGTTTCAGGAATGAGCCGCTCAAGTCAAAATGGGGCTTTAATCAAAAATGGGACCGTCATTGAAA
AATTAGCAAAAGCTCAAGAAATATTTTTAGATAAAACGGGAACCATTACTGAAGGAACAATCAAAGTTGACAGTATAAAG
CCAGTAAAATCAGGAAATGAAGCGGAACTTTTACAGTTAGTTTACACGGTTGAAAAATCAAGTGGTCACATTTTGGCCAA
AGCGGTTGTTGAATATGCAGAAACTAAAAAGATTGAACCTCTAAAATTAACTTCTTTAACTGAGGTCGCAGGCCTTGGAG
TAATTGGAGAGATTGATGGTGAAGAAATTAAAATTGGCCGTAGTTCATTTGCATTTGCGCCAGATAATCTAAATTATGAA
ACAGCTTTTTATGTCAGCAAATCTGGGAAATATATTGGAGCCGTCACTTTTTCAGATACTCTACGACCCGAAGCAAAAGC
AACAATTGCTCAGATGAGAAAAATTGGACTTGAAAACATCACAATGCTAACCGGTGATAACCAACTTGTTGCTGACAAAA
TTGCCAAAAGTGTGGGGATTGACAATGTCTATGCAGGACTGATGCCAGATGAAAAATTGAAGTTTATTCAAAATGCAACT
CATCGACCAGTTATTATGGTTGGAGATGGGGTTAATGATGCGCCAGCATTAGCAACAGCCGATATTGGAATTTCGATTGG
TGTAGGTTCAGGAACAGTTGCTAGTGAAGCAGCCGATATTGTTTTGCTGCAAAATGACCTTAGAAAGGTCACGACATCTA
TCGAAATTAGTCGTGACACTTTAAAGATTGCTAAACAAGCAGTCATGATTGGGATTGTCATTTGTATTATTCTAATGTTC
ATTGCTGCTTTAGGAGTGATTCCCGCAGTGATTGGAGCCTTGTTCCAAGAAATCATTGACGTTGTTTCCATTCTTTATGC
ACTTCGGGCACTTAGAGGTTAA

Upstream 100 bases:

>100_bases
AAAGAATCAAAGCGGCGTAAGGAGAAGACATTCAGGTCGTAAAAACTCCAAACAAAGCAGGGCAATGTTCTAGGACAATT
AAATTTTTAAGGAGAAATGA

Downstream 100 bases:

>100_bases
ACTTGCAAAAAAAGTACTGATAAATTCGTCAGTACTTTTTATTTTTTAGCAGCTCAACTAGTAGGTTTTTTCATGACTTT
TTCATGATAAATTCTCGGTA

Product: cation-transporting ATPase

Products: NA

Alternate protein names: Zn(2+)-translocating P-type ATPase [H]

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MKNWKKLILVFVIAGVALIAYFGFNQPFLARLVVTIAGGVLAFSMLIEMIKTLRSGSYGVDLLAITAIIATLLVGEYWAS
LIIILMLVGGESLEDYANGRAHRALAALLDKSPEIAHVQTGDKVVDLPLDHVEIGSVLLIRPMEIIPIDGKLLSEAVVLD
EASLTGETKPNELVRGDNVLSGAINGNSSIQIETTVAAADSQFQKIVQLVKETEKTPAQFVRLADRYAVPFTIIAYIIAA
VAYFISGDPVRIAEVLVVASPCPLILAAPIAFVSGMSRSSQNGALIKNGTVIEKLAKAQEIFLDKTGTITEGTIKVDSIK
PVKSGNEAELLQLVYTVEKSSGHILAKAVVEYAETKKIEPLKLTSLTEVAGLGVIGEIDGEEIKIGRSSFAFAPDNLNYE
TAFYVSKSGKYIGAVTFSDTLRPEAKATIAQMRKIGLENITMLTGDNQLVADKIAKSVGIDNVYAGLMPDEKLKFIQNAT
HRPVIMVGDGVNDAPALATADIGISIGVGSGTVASEAADIVLLQNDLRKVTTSIEISRDTLKIAKQAVMIGIVICIILMF
IAALGVIPAVIGALFQEIIDVVSILYALRALRG

Sequences:

>Translated_593_residues
MKNWKKLILVFVIAGVALIAYFGFNQPFLARLVVTIAGGVLAFSMLIEMIKTLRSGSYGVDLLAITAIIATLLVGEYWAS
LIIILMLVGGESLEDYANGRAHRALAALLDKSPEIAHVQTGDKVVDLPLDHVEIGSVLLIRPMEIIPIDGKLLSEAVVLD
EASLTGETKPNELVRGDNVLSGAINGNSSIQIETTVAAADSQFQKIVQLVKETEKTPAQFVRLADRYAVPFTIIAYIIAA
VAYFISGDPVRIAEVLVVASPCPLILAAPIAFVSGMSRSSQNGALIKNGTVIEKLAKAQEIFLDKTGTITEGTIKVDSIK
PVKSGNEAELLQLVYTVEKSSGHILAKAVVEYAETKKIEPLKLTSLTEVAGLGVIGEIDGEEIKIGRSSFAFAPDNLNYE
TAFYVSKSGKYIGAVTFSDTLRPEAKATIAQMRKIGLENITMLTGDNQLVADKIAKSVGIDNVYAGLMPDEKLKFIQNAT
HRPVIMVGDGVNDAPALATADIGISIGVGSGTVASEAADIVLLQNDLRKVTTSIEISRDTLKIAKQAVMIGIVICIILMF
IAALGVIPAVIGALFQEIIDVVSILYALRALRG
>Mature_593_residues
MKNWKKLILVFVIAGVALIAYFGFNQPFLARLVVTIAGGVLAFSMLIEMIKTLRSGSYGVDLLAITAIIATLLVGEYWAS
LIIILMLVGGESLEDYANGRAHRALAALLDKSPEIAHVQTGDKVVDLPLDHVEIGSVLLIRPMEIIPIDGKLLSEAVVLD
EASLTGETKPNELVRGDNVLSGAINGNSSIQIETTVAAADSQFQKIVQLVKETEKTPAQFVRLADRYAVPFTIIAYIIAA
VAYFISGDPVRIAEVLVVASPCPLILAAPIAFVSGMSRSSQNGALIKNGTVIEKLAKAQEIFLDKTGTITEGTIKVDSIK
PVKSGNEAELLQLVYTVEKSSGHILAKAVVEYAETKKIEPLKLTSLTEVAGLGVIGEIDGEEIKIGRSSFAFAPDNLNYE
TAFYVSKSGKYIGAVTFSDTLRPEAKATIAQMRKIGLENITMLTGDNQLVADKIAKSVGIDNVYAGLMPDEKLKFIQNAT
HRPVIMVGDGVNDAPALATADIGISIGVGSGTVASEAADIVLLQNDLRKVTTSIEISRDTLKIAKQAVMIGIVICIILMF
IAALGVIPAVIGALFQEIIDVVSILYALRALRG

Specific function: Couples the hydrolysis of ATP with the transport of zinc into the cell [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=719, Percent_Identity=28.2336578581363, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI55743073, Length=513, Percent_Identity=30.2144249512671, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI115529486, Length=678, Percent_Identity=24.7787610619469, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI28373105, Length=200, Percent_Identity=31, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI28373103, Length=200, Percent_Identity=31, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI28373107, Length=200, Percent_Identity=31, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI28373115, Length=200, Percent_Identity=31, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI28373111, Length=200, Percent_Identity=31, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI28373109, Length=200, Percent_Identity=31, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI28373113, Length=200, Percent_Identity=31, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI27886529, Length=214, Percent_Identity=29.9065420560748, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI10835220, Length=214, Percent_Identity=29.9065420560748, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI310128958, Length=192, Percent_Identity=30.2083333333333, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1789879, Length=591, Percent_Identity=30.7952622673435, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI1786691, Length=534, Percent_Identity=31.6479400749064, Blast_Score=234, Evalue=9e-63,
Organism=Escherichia coli, GI1786914, Length=477, Percent_Identity=27.4633123689727, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI2367363, Length=555, Percent_Identity=22.8828828828829, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17556548, Length=158, Percent_Identity=39.2405063291139, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17554158, Length=218, Percent_Identity=28.4403669724771, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71988506, Length=218, Percent_Identity=28.4403669724771, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI193210130, Length=218, Percent_Identity=28.4403669724771, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71997262, Length=154, Percent_Identity=31.8181818181818, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71997269, Length=154, Percent_Identity=31.8181818181818, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71997275, Length=154, Percent_Identity=31.8181818181818, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17557486, Length=136, Percent_Identity=35.2941176470588, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=542, Percent_Identity=29.8892988929889, Blast_Score=189, Evalue=9e-49,
Organism=Saccharomyces cerevisiae, GI6319772, Length=628, Percent_Identity=25.9554140127389, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321271, Length=156, Percent_Identity=33.974358974359, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221329854, Length=395, Percent_Identity=28.1012658227848, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24668704, Length=154, Percent_Identity=31.1688311688312, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281366617, Length=154, Percent_Identity=31.1688311688312, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24668708, Length=154, Percent_Identity=31.1688311688312, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24668696, Length=154, Percent_Identity=30.5194805194805, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161085803, Length=154, Percent_Identity=30.5194805194805, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00702 Hydrolase [H]

EC number: =3.6.3.5 [H]

Molecular weight: Translated: 63181; Mature: 63181

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNWKKLILVFVIAGVALIAYFGFNQPFLARLVVTIAGGVLAFSMLIEMIKTLRSGSYGV
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DLLAITAIIATLLVGEYWASLIIILMLVGGESLEDYANGRAHRALAALLDKSPEIAHVQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHCCCCCEEEEEC
GDKVVDLPLDHVEIGSVLLIRPMEIIPIDGKLLSEAVVLDEASLTGETKPNELVRGDNVL
CCEEEECCCCCCCCCCEEEECCCEEEECCHHHHHHHHHEECCCCCCCCCCCHHHCCCCEE
SGAINGNSSIQIETTVAAADSQFQKIVQLVKETEKTPAQFVRLADRYAVPFTIIAYIIAA
EEEECCCCEEEEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHH
VAYFISGDPVRIAEVLVVASPCPLILAAPIAFVSGMSRSSQNGALIKNGTVIEKLAKAQE
HHHHHCCCCHHEEHHHEECCCCCHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHH
IFLDKTGTITEGTIKVDSIKPVKSGNEAELLQLVYTVEKSSGHILAKAVVEYAETKKIEP
HHHCCCCCEEECEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
LKLTSLTEVAGLGVIGEIDGEEIKIGRSSFAFAPDNLNYETAFYVSKSGKYIGAVTFSDT
EEECHHHHHHCCCEEECCCCCEEEECCCCCEECCCCCCCEEEEEEECCCCEEEEEEECCC
LRPEAKATIAQMRKIGLENITMLTGDNQLVADKIAKSVGIDNVYAGLMPDEKLKFIQNAT
CCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHCCC
HRPVIMVGDGVNDAPALATADIGISIGVGSGTVASEAADIVLLQNDLRKVTTSIEISRDT
CCCEEEECCCCCCCCCEEEECCCEEEECCCCCCHHCCCCEEEEHHHHHHHHHHHEECHHH
LKIAKQAVMIGIVICIILMFIAALGVIPAVIGALFQEIIDVVSILYALRALRG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNWKKLILVFVIAGVALIAYFGFNQPFLARLVVTIAGGVLAFSMLIEMIKTLRSGSYGV
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DLLAITAIIATLLVGEYWASLIIILMLVGGESLEDYANGRAHRALAALLDKSPEIAHVQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHCCCCCEEEEEC
GDKVVDLPLDHVEIGSVLLIRPMEIIPIDGKLLSEAVVLDEASLTGETKPNELVRGDNVL
CCEEEECCCCCCCCCCEEEECCCEEEECCHHHHHHHHHEECCCCCCCCCCCHHHCCCCEE
SGAINGNSSIQIETTVAAADSQFQKIVQLVKETEKTPAQFVRLADRYAVPFTIIAYIIAA
EEEECCCCEEEEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHH
VAYFISGDPVRIAEVLVVASPCPLILAAPIAFVSGMSRSSQNGALIKNGTVIEKLAKAQE
HHHHHCCCCHHEEHHHEECCCCCHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHH
IFLDKTGTITEGTIKVDSIKPVKSGNEAELLQLVYTVEKSSGHILAKAVVEYAETKKIEP
HHHCCCCCEEECEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
LKLTSLTEVAGLGVIGEIDGEEIKIGRSSFAFAPDNLNYETAFYVSKSGKYIGAVTFSDT
EEECHHHHHHCCCEEECCCCCEEEECCCCCEECCCCCCCEEEEEEECCCCEEEEEEECCC
LRPEAKATIAQMRKIGLENITMLTGDNQLVADKIAKSVGIDNVYAGLMPDEKLKFIQNAT
CCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHCCC
HRPVIMVGDGVNDAPALATADIGISIGVGSGTVASEAADIVLLQNDLRKVTTSIEISRDT
CCCEEEECCCCCCCCCEEEECCCEEEECCCCCCHHCCCCEEEEHHHHHHHHHHHEECHHH
LKIAKQAVMIGIVICIILMFIAALGVIPAVIGALFQEIIDVVSILYALRALRG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]