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The map label for this gene is napA [H]

Identifier: 124486445

GI number: 124486445

Start: 1659536

End: 1660807

Strand: Reverse

Name: napA [H]

Synonym: Mlab_1633

Alternate gene names: 124486445

Gene position: 1660807-1659536 (Counterclockwise)

Preceding gene: 124486446

Following gene: 124486443

Centisome position: 92.01

GC content: 51.18

Gene sequence:

>1272_bases
ATGTTGGAAGAACTCATATCCACCATCGAATTTCAGATGAGTCTTCTGTTATTCGTTGCGCTGGGTGGTTATCTTCTCGC
TACACGGATCCACCAGTCCGCGGTCATCGGCGAGATCCTGGTAGGTCTGATCGTCGGACCAAGCGTTCTCGGACTCATTA
CTTATACGGATTTTGTCCAGAGTCTTGCGGGTCTTGGCGCAATCATTCTGCTGTTTGTCATAGGGTTTGAATTTGAGCTG
CGTGATATCACCAACTGGCGGTACATGGTAATTGCCCTCATCGGCGTTATCGTTCCGTGGGTCGGGGGCTACATCACCGC
GGTCTTCTTCGGCATGGACTTTTACAGCGCCATTTTCATTGGTACCGCGCTGACGGCAACGAGTATTGCGATCACGGCAA
ATGTTCTGCGGGAGATGGGCAAGCTCCATCAGCCGTTTGCGAAGGCCATCATCGGTGCTGCGGTCATCGACGATATCTTA
AGTTTGATCGTGCTTTCGATCTGTACCGATCTTGCCTCGACCGGCGAGCTTGTCCCTCTCGGAATCGGTTTAACCGTTAT
CAAAGCGTTCGGTTTCGTGATTATTGCTGCCGGTGTCGGTGTTAAAGTTATCCCGTATCTGATCACCAAGATGGATGAAA
CAAAGATCGCCCGGCAGTTCCCGGAGTTCGTGTTCATCTTTGCTATGATGATCGCATTCTTCTACGCAATGATGGCTGAA
ATGGTGGGGATCTCCGCTATTGTGGGGGCGTTCCTTGCGGGTGTCTGCGTGAACAGAGTCAGTCTGAAACATAGTATGGA
TATCAAACTCGGCGCCGAGTATCTGTATATCATCTTCGCGGCTATATTCTTCGTCTCGCTTGGTATCATCGCGGATCTGC
GGTATCTCACGCAGGACATGATCCTCTTTATCGCCATCCTGACTGTCGTCGCCGTCATCACGAAAGTTGTCGGCTGCGGT
CTCCCGGCGAAACTAACCGGGATGAGCTGGCGGGATGCGGCGGTGATCGGATTTGGTATGACTCCCCGCGGCGAGGTGGC
AATGATCGTTGGTCTTATCGCTTTGAATCATTTCGAAGAGATGGCAGCCTTGGCTGTGGATCCGACGGAGGCTGCACATC
TTCTCCAGCTTGGAAATGAGCTTTTCATCGCGATCGTGGTCGTGTCTCTTGTGACGACGATCATCGTTCCAATGATTTAT
CGGGGATTTTTCTTCAAGGGAGAAAAGCCCAAACCCCTTACATGTGAGCAGGAAAAGGAAATACAGGTTTAA

Upstream 100 bases:

>100_bases
TTATGTAATTACTGCCCGGCAAAACAGGATCCCGATTTTTGAAATCCGAAGGCATTAAGAGAAATTCTTTTTACTAGCAG
AACCTAAATTCAAGATACTT

Downstream 100 bases:

>100_bases
CTTCTTCTTTTTTTCGAACTGCCTGATTTTCTCACCGGGGGCAGACCTCTATTTGGAACCAGATCGCCGATCAGATCACG
TCTTCCTGCTTTCAAAAGCC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MLEELISTIEFQMSLLLFVALGGYLLATRIHQSAVIGEILVGLIVGPSVLGLITYTDFVQSLAGLGAIILLFVIGFEFEL
RDITNWRYMVIALIGVIVPWVGGYITAVFFGMDFYSAIFIGTALTATSIAITANVLREMGKLHQPFAKAIIGAAVIDDIL
SLIVLSICTDLASTGELVPLGIGLTVIKAFGFVIIAAGVGVKVIPYLITKMDETKIARQFPEFVFIFAMMIAFFYAMMAE
MVGISAIVGAFLAGVCVNRVSLKHSMDIKLGAEYLYIIFAAIFFVSLGIIADLRYLTQDMILFIAILTVVAVITKVVGCG
LPAKLTGMSWRDAAVIGFGMTPRGEVAMIVGLIALNHFEEMAALAVDPTEAAHLLQLGNELFIAIVVVSLVTTIIVPMIY
RGFFFKGEKPKPLTCEQEKEIQV

Sequences:

>Translated_423_residues
MLEELISTIEFQMSLLLFVALGGYLLATRIHQSAVIGEILVGLIVGPSVLGLITYTDFVQSLAGLGAIILLFVIGFEFEL
RDITNWRYMVIALIGVIVPWVGGYITAVFFGMDFYSAIFIGTALTATSIAITANVLREMGKLHQPFAKAIIGAAVIDDIL
SLIVLSICTDLASTGELVPLGIGLTVIKAFGFVIIAAGVGVKVIPYLITKMDETKIARQFPEFVFIFAMMIAFFYAMMAE
MVGISAIVGAFLAGVCVNRVSLKHSMDIKLGAEYLYIIFAAIFFVSLGIIADLRYLTQDMILFIAILTVVAVITKVVGCG
LPAKLTGMSWRDAAVIGFGMTPRGEVAMIVGLIALNHFEEMAALAVDPTEAAHLLQLGNELFIAIVVVSLVTTIIVPMIY
RGFFFKGEKPKPLTCEQEKEIQV
>Mature_423_residues
MLEELISTIEFQMSLLLFVALGGYLLATRIHQSAVIGEILVGLIVGPSVLGLITYTDFVQSLAGLGAIILLFVIGFEFEL
RDITNWRYMVIALIGVIVPWVGGYITAVFFGMDFYSAIFIGTALTATSIAITANVLREMGKLHQPFAKAIIGAAVIDDIL
SLIVLSICTDLASTGELVPLGIGLTVIKAFGFVIIAAGVGVKVIPYLITKMDETKIARQFPEFVFIFAMMIAFFYAMMAE
MVGISAIVGAFLAGVCVNRVSLKHSMDIKLGAEYLYIIFAAIFFVSLGIIADLRYLTQDMILFIAILTVVAVITKVVGCG
LPAKLTGMSWRDAAVIGFGMTPRGEVAMIVGLIALNHFEEMAALAVDPTEAAHLLQLGNELFIAIVVVSLVTTIIVPMIY
RGFFFKGEKPKPLTCEQEKEIQV

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786685, Length=345, Percent_Identity=26.6666666666667, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1786232, Length=286, Percent_Identity=23.0769230769231, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322367, Length=377, Percent_Identity=24.6684350132626, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 45746; Mature: 45746

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEELISTIEFQMSLLLFVALGGYLLATRIHQSAVIGEILVGLIVGPSVLGLITYTDFVQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLAGLGAIILLFVIGFEFELRDITNWRYMVIALIGVIVPWVGGYITAVFFGMDFYSAIFI
HHHHHHHHHHHHHHCCCCEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTALTATSIAITANVLREMGKLHQPFAKAIIGAAVIDDILSLIVLSICTDLASTGELVPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
GIGLTVIKAFGFVIIAAGVGVKVIPYLITKMDETKIARQFPEFVFIFAMMIAFFYAMMAE
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVGISAIVGAFLAGVCVNRVSLKHSMDIKLGAEYLYIIFAAIFFVSLGIIADLRYLTQDM
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILFIAILTVVAVITKVVGCGLPAKLTGMSWRDAAVIGFGMTPRGEVAMIVGLIALNHFEE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHH
MAALAVDPTEAAHLLQLGNELFIAIVVVSLVTTIIVPMIYRGFFFKGEKPKPLTCEQEKE
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
IQV
CCC
>Mature Secondary Structure
MLEELISTIEFQMSLLLFVALGGYLLATRIHQSAVIGEILVGLIVGPSVLGLITYTDFVQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLAGLGAIILLFVIGFEFELRDITNWRYMVIALIGVIVPWVGGYITAVFFGMDFYSAIFI
HHHHHHHHHHHHHHCCCCEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTALTATSIAITANVLREMGKLHQPFAKAIIGAAVIDDILSLIVLSICTDLASTGELVPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
GIGLTVIKAFGFVIIAAGVGVKVIPYLITKMDETKIARQFPEFVFIFAMMIAFFYAMMAE
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVGISAIVGAFLAGVCVNRVSLKHSMDIKLGAEYLYIIFAAIFFVSLGIIADLRYLTQDM
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILFIAILTVVAVITKVVGCGLPAKLTGMSWRDAAVIGFGMTPRGEVAMIVGLIALNHFEE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHH
MAALAVDPTEAAHLLQLGNELFIAIVVVSLVTTIIVPMIYRGFFFKGEKPKPLTCEQEKE
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
IQV
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]