BacMap

Definition	Methanocorpusculum labreanum Z chromosome, complete genome.
Accession	NC_008942
Length	1,804,962

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The map label for this gene is ppiA [C]

Identifier: 124486339

GI number: 124486339

Start: 1557248

End: 1557706

Strand: Reverse

Name: ppiA [C]

Synonym: Mlab_1524

Alternate gene names: 124486339

Gene position: 1557706-1557248 (Counterclockwise)

Preceding gene: 124486341

Following gene: 124486337

Centisome position: 86.3

GC content: 50.98

Gene sequence:

>459_bases
ATGACAGCACAGAAAGTACTTCTTTCCACCAATCACGGGGATATCGTCCTCGAACTCCGTGAGGATATGCCGGTGACCGC
CGGCAATTTTGCAAAGCTTGTTGCGGACGGATTCTATGACGGCGTCATCTTTCACCGAATCATTGACGGATTCATGATTC
AGGGCGGCGACCCGACCGGTACCGGCCGCGGAGGACCGGGCTACAAGATCCCCGATGAGTTCATGGCCGACAACAAAAAC
AACAAAGGCACGATCTCTATGGCAAATGCCGGACCAAATACCGGCGGCAGTCAGTTTTTCATCAACCTTGCAAACAACAA
CTACCTCGACAAAGCCCACCCGGCGTTCGGGAAAGTCATTGAGGGTATGGAGGTCGTTGAAAAACTCGGCAAGGTCAAGA
CGAACTACTCTGACAAACCCTTAGAAGATGTTGTGATCGTAAAAGCAACTCTTCTCTAA

Upstream 100 bases:

>100_bases
GAGTGTCGGAATGATCATGACATGGAACGGATTCTTCATTGGTGTCACTACGTTTGTCATGATACATGTTTATTATTTTT
GTCTGCGCACAACTAGATAC

Downstream 100 bases:

>100_bases
TCTTTTTTTATTGGACTTACGCGGTGTTAGTCTCGATTCAATTCAGGAGGGGTATCACTGGGTGTGGAGACAATAAATTA
TTTAACCGCGAATCTCCGCG

Product: hypothetical protein

Products: NA

Alternate protein names: Phosphatase; Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MTAQKVLLSTNHGDIVLELREDMPVTAGNFAKLVADGFYDGVIFHRIIDGFMIQGGDPTGTGRGGPGYKIPDEFMADNKN
NKGTISMANAGPNTGGSQFFINLANNNYLDKAHPAFGKVIEGMEVVEKLGKVKTNYSDKPLEDVVIVKATLL

Sequences:

>Translated_152_residues
MTAQKVLLSTNHGDIVLELREDMPVTAGNFAKLVADGFYDGVIFHRIIDGFMIQGGDPTGTGRGGPGYKIPDEFMADNKN
NKGTISMANAGPNTGGSQFFINLANNNYLDKAHPAFGKVIEGMEVVEKLGKVKTNYSDKPLEDVVIVKATLL
>Mature_151_residues
TAQKVLLSTNHGDIVLELREDMPVTAGNFAKLVADGFYDGVIFHRIIDGFMIQGGDPTGTGRGGPGYKIPDEFMADNKNN
KGTISMANAGPNTGGSQFFINLANNNYLDKAHPAFGKVIEGMEVVEKLGKVKTNYSDKPLEDVVIVKATLL

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=149, Percent_Identity=51.6778523489933, Blast_Score=143, Evalue=6e-35,
Organism=Homo sapiens, GI24308049, Length=155, Percent_Identity=46.4516129032258, Blast_Score=130, Evalue=4e-31,
Organism=Homo sapiens, GI19557636, Length=152, Percent_Identity=48.6842105263158, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI4758950, Length=131, Percent_Identity=49.618320610687, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI64276486, Length=123, Percent_Identity=46.3414634146341, Blast_Score=106, Evalue=8e-24,
Organism=Homo sapiens, GI20911035, Length=154, Percent_Identity=38.3116883116883, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI22547212, Length=153, Percent_Identity=45.0980392156863, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI7657473, Length=153, Percent_Identity=45.0980392156863, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI22547215, Length=153, Percent_Identity=45.0980392156863, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI5031987, Length=125, Percent_Identity=48.8, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI4505991, Length=134, Percent_Identity=45.5223880597015, Blast_Score=97, Evalue=4e-21,
Organism=Homo sapiens, GI256017253, Length=123, Percent_Identity=50.4065040650407, Blast_Score=96, Evalue=9e-21,
Organism=Homo sapiens, GI221139811, Length=123, Percent_Identity=50.4065040650407, Blast_Score=96, Evalue=9e-21,
Organism=Homo sapiens, GI256017251, Length=123, Percent_Identity=50.4065040650407, Blast_Score=96, Evalue=9e-21,
Organism=Homo sapiens, GI178057341, Length=121, Percent_Identity=47.9338842975207, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI10863927, Length=125, Percent_Identity=50.4, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI209417936, Length=125, Percent_Identity=48.8, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI30102944, Length=125, Percent_Identity=48.8, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI219842199, Length=125, Percent_Identity=48.8, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI42560244, Length=151, Percent_Identity=39.0728476821192, Blast_Score=91, Evalue=4e-19,
Organism=Homo sapiens, GI5174637, Length=143, Percent_Identity=41.958041958042, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI6631100, Length=156, Percent_Identity=37.1794871794872, Blast_Score=90, Evalue=7e-19,
Organism=Homo sapiens, GI5454154, Length=150, Percent_Identity=40, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI45439316, Length=127, Percent_Identity=44.8818897637795, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI310129267, Length=125, Percent_Identity=45.6, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI310120620, Length=125, Percent_Identity=45.6, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI303305009, Length=125, Percent_Identity=44.8, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI310110104, Length=125, Percent_Identity=44.8, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI310127646, Length=127, Percent_Identity=44.8818897637795, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI310114371, Length=127, Percent_Identity=44.8818897637795, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI310119221, Length=127, Percent_Identity=44.8818897637795, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI4826932, Length=153, Percent_Identity=41.1764705882353, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI169163387, Length=111, Percent_Identity=49.5495495495495, Blast_Score=84, Evalue=3e-17,
Organism=Homo sapiens, GI169164185, Length=111, Percent_Identity=49.5495495495495, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI169163623, Length=111, Percent_Identity=49.5495495495495, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI310132444, Length=125, Percent_Identity=45.6, Blast_Score=80, Evalue=7e-16,
Organism=Homo sapiens, GI310113152, Length=125, Percent_Identity=45.6, Blast_Score=80, Evalue=7e-16,
Organism=Homo sapiens, GI27735045, Length=158, Percent_Identity=35.4430379746835, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI150418007, Length=125, Percent_Identity=42.4, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI169214050, Length=125, Percent_Identity=43.2, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI239751853, Length=125, Percent_Identity=43.2, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI113428306, Length=125, Percent_Identity=43.2, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI310127745, Length=119, Percent_Identity=45.3781512605042, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI310119290, Length=119, Percent_Identity=45.3781512605042, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI310114540, Length=119, Percent_Identity=45.3781512605042, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI14277126, Length=96, Percent_Identity=45.8333333333333, Blast_Score=73, Evalue=1e-13,
Organism=Escherichia coli, GI1789763, Length=161, Percent_Identity=42.8571428571429, Blast_Score=106, Evalue=8e-25,
Organism=Escherichia coli, GI1786736, Length=164, Percent_Identity=39.6341463414634, Blast_Score=100, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17539496, Length=152, Percent_Identity=50.6578947368421, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71980594, Length=151, Percent_Identity=41.7218543046358, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71980590, Length=141, Percent_Identity=43.2624113475177, Blast_Score=113, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17532641, Length=153, Percent_Identity=41.1764705882353, Blast_Score=112, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17506311, Length=155, Percent_Identity=40.6451612903226, Blast_Score=106, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17559074, Length=155, Percent_Identity=43.8709677419355, Blast_Score=106, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17552780, Length=145, Percent_Identity=46.2068965517241, Blast_Score=102, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17539498, Length=145, Percent_Identity=48.2758620689655, Blast_Score=102, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17566266, Length=132, Percent_Identity=45.4545454545455, Blast_Score=97, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71997782, Length=126, Percent_Identity=42.8571428571429, Blast_Score=97, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17506307, Length=146, Percent_Identity=43.8356164383562, Blast_Score=96, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI32563659, Length=160, Percent_Identity=35.625, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17551284, Length=112, Percent_Identity=47.3214285714286, Blast_Score=93, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17532643, Length=153, Percent_Identity=39.8692810457516, Blast_Score=92, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17552782, Length=132, Percent_Identity=45.4545454545455, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17551282, Length=113, Percent_Identity=46.9026548672566, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17565860, Length=150, Percent_Identity=42, Blast_Score=89, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17552784, Length=148, Percent_Identity=37.8378378378378, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321848, Length=163, Percent_Identity=43.558282208589, Blast_Score=102, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6323562, Length=151, Percent_Identity=45.0331125827815, Blast_Score=95, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6320359, Length=125, Percent_Identity=47.2, Blast_Score=94, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6320510, Length=161, Percent_Identity=40.3726708074534, Blast_Score=93, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323246, Length=153, Percent_Identity=39.8692810457516, Blast_Score=84, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17986117, Length=151, Percent_Identity=49.6688741721854, Blast_Score=143, Evalue=5e-35,
Organism=Drosophila melanogaster, GI19922376, Length=146, Percent_Identity=44.5205479452055, Blast_Score=129, Evalue=7e-31,
Organism=Drosophila melanogaster, GI19922912, Length=154, Percent_Identity=46.7532467532467, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI45549139, Length=125, Percent_Identity=50.4, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24664125, Length=125, Percent_Identity=50.4, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21357783, Length=125, Percent_Identity=50.4, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24652460, Length=135, Percent_Identity=42.962962962963, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17647301, Length=148, Percent_Identity=44.5945945945946, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI20130249, Length=138, Percent_Identity=43.4782608695652, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24650807, Length=150, Percent_Identity=40.6666666666667, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17136360, Length=133, Percent_Identity=40.6015037593985, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21357249, Length=157, Percent_Identity=35.6687898089172, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI21355677, Length=160, Percent_Identity=34.375, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24586038, Length=154, Percent_Identity=37.012987012987, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24661775, Length=152, Percent_Identity=32.8947368421053, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21355237, Length=152, Percent_Identity=32.8947368421053, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24661771, Length=152, Percent_Identity=32.8947368421053, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR023214
- InterPro:   IPR013200
- InterPro:   IPR006379
- InterPro:   IPR000150
- InterPro:   IPR002130 [H]

Pfam domain/function: PF08282 Hydrolase_3; PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16347; Mature: 16216

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQKVLLSTNHGDIVLELREDMPVTAGNFAKLVADGFYDGVIFHRIIDGFMIQGGDPTG
CCCCEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCC
TGRGGPGYKIPDEFMADNKNNKGTISMANAGPNTGGSQFFINLANNNYLDKAHPAFGKVI
CCCCCCCCCCCHHHHCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHH
EGMEVVEKLGKVKTNYSDKPLEDVVIVKATLL
HHHHHHHHHHHHCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure 
TAQKVLLSTNHGDIVLELREDMPVTAGNFAKLVADGFYDGVIFHRIIDGFMIQGGDPTG
CCCEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCC
TGRGGPGYKIPDEFMADNKNNKGTISMANAGPNTGGSQFFINLANNNYLDKAHPAFGKVI
CCCCCCCCCCCHHHHCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHH
EGMEVVEKLGKVKTNYSDKPLEDVVIVKATLL
HHHHHHHHHHHHCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA