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The map label for this gene is map [H]

Identifier: 124486087

GI number: 124486087

Start: 1294974

End: 1295849

Strand: Reverse

Name: map [H]

Synonym: Mlab_1267

Alternate gene names: 124486087

Gene position: 1295849-1294974 (Counterclockwise)

Preceding gene: 124486088

Following gene: 124486080

Centisome position: 71.79

GC content: 55.37

Gene sequence:

>876_bases
ATGAACGATAACGAACTGGATACCTACATTGAGGCGGGGCGAATCGCAAAAAACGTCCTGCACAAATGCGCCGCCGAAAT
AAAACCGGGTGTCGGCATGGCCGATATTTTCGACATGGTTTTGGATGAAATATCCTCGGCAGGCGTATCACCCTCCTTCC
CTCCCAATATTTCTTTGAATAACTGTGCGGCCCACGATACGGCCTCCCCTGACGAGGAACGGGTATTTGCCGAAGGGGAT
CTGATAAAACTGGATATTGGAACGCACATCGACGGATACATCGCAGACACCGCCGTCACGGTGGATCTCGGCGACCACGC
TTCCTTATGCGAGGCATCACGCGCTGCGCTTGACGCCGCGATCAATGTCGTTGCGCCGGAGGTTGTCGTCAGCGAGATCG
GCGCGGTCGTCGAAGAAACGATCACGTCATTTGGCTACAAGCCGATCATAAACTTAACAGGCCACGCACTTGCGCGCTAT
AGTCTCCACCACGGCCTCTCGATCCCGAACACGGGAAGATTCGGCAGCGCTGTTCTCAGAGAAGATATGGTTATTGCGAT
CGAACCCTTCGCATCGACCGGCTCGGGTCTGGTCCACGAGGCGCCGCGGGCCGAGATCTATCAGGTCGTCGGCAATGCTC
CGGTCAGATCACCCGCCGGCAGAAAAATCATGAAAAAGGCGGAAGAGATGCACGGTCTGCCGTTTGCCCGCCGCTGGCTG
AATGTTCCAAAGGCGGAACTTGCTCTGCCAACCCTCCTTCGTCAGGGAAATCTCTTCGTATATCACAGCTTATCGGACGT
GCCGGAGTCATTTGTTTCCCAATTCGAGCACACGGTCATCGTGACCGCAGACGGCGCTCTGGTAACAACGAGATAA

Upstream 100 bases:

>100_bases
CAGGGGATCGGCGGGGTCAGGCTCGAGGATATGGGTGTCGTAACAAGTGATGGATTTGACAGCTTTACGTGCTTTGAAGA
AAAATTAGTAGTATAGTATT

Downstream 100 bases:

>100_bases
AATAAGAAGAATCTCTCCACCTTTATTATATGTGGGAGTTACGCGGTGTGTAGTGGATCAAATTCGGGAAGGGTATGGCC
GAGTGTAGCTGAATGAGAAA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MNDNELDTYIEAGRIAKNVLHKCAAEIKPGVGMADIFDMVLDEISSAGVSPSFPPNISLNNCAAHDTASPDEERVFAEGD
LIKLDIGTHIDGYIADTAVTVDLGDHASLCEASRAALDAAINVVAPEVVVSEIGAVVEETITSFGYKPIINLTGHALARY
SLHHGLSIPNTGRFGSAVLREDMVIAIEPFASTGSGLVHEAPRAEIYQVVGNAPVRSPAGRKIMKKAEEMHGLPFARRWL
NVPKAELALPTLLRQGNLFVYHSLSDVPESFVSQFEHTVIVTADGALVTTR

Sequences:

>Translated_291_residues
MNDNELDTYIEAGRIAKNVLHKCAAEIKPGVGMADIFDMVLDEISSAGVSPSFPPNISLNNCAAHDTASPDEERVFAEGD
LIKLDIGTHIDGYIADTAVTVDLGDHASLCEASRAALDAAINVVAPEVVVSEIGAVVEETITSFGYKPIINLTGHALARY
SLHHGLSIPNTGRFGSAVLREDMVIAIEPFASTGSGLVHEAPRAEIYQVVGNAPVRSPAGRKIMKKAEEMHGLPFARRWL
NVPKAELALPTLLRQGNLFVYHSLSDVPESFVSQFEHTVIVTADGALVTTR
>Mature_291_residues
MNDNELDTYIEAGRIAKNVLHKCAAEIKPGVGMADIFDMVLDEISSAGVSPSFPPNISLNNCAAHDTASPDEERVFAEGD
LIKLDIGTHIDGYIADTAVTVDLGDHASLCEASRAALDAAINVVAPEVVVSEIGAVVEETITSFGYKPIINLTGHALARY
SLHHGLSIPNTGRFGSAVLREDMVIAIEPFASTGSGLVHEAPRAEIYQVVGNAPVRSPAGRKIMKKAEEMHGLPFARRWL
NVPKAELALPTLLRQGNLFVYHSLSDVPESFVSQFEHTVIVTADGALVTTR

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI5803092, Length=309, Percent_Identity=31.7152103559871, Blast_Score=144, Evalue=7e-35,
Organism=Homo sapiens, GI124494254, Length=260, Percent_Identity=25.3846153846154, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1786364, Length=197, Percent_Identity=25.3807106598985, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17544396, Length=310, Percent_Identity=30, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17542840, Length=320, Percent_Identity=26.875, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6319380, Length=317, Percent_Identity=30.5993690851735, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323273, Length=199, Percent_Identity=27.6381909547739, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137568, Length=311, Percent_Identity=29.903536977492, Blast_Score=130, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24658585, Length=259, Percent_Identity=25.4826254826255, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24583427, Length=208, Percent_Identity=27.4038461538462, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002468
- InterPro:   IPR018349
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 31133; Mature: 31133

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS01202 MAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDNELDTYIEAGRIAKNVLHKCAAEIKPGVGMADIFDMVLDEISSAGVSPSFPPNISLN
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC
NCAAHDTASPDEERVFAEGDLIKLDIGTHIDGYIADTAVTVDLGDHASLCEASRAALDAA
CCCCCCCCCCCHHEEEECCCEEEEECCCCCCCEEECEEEEEECCCCHHHHHHHHHHHHHH
INVVAPEVVVSEIGAVVEETITSFGYKPIINLTGHALARYSLHHGLSIPNTGRFGSAVLR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
EDMVIAIEPFASTGSGLVHEAPRAEIYQVVGNAPVRSPAGRKIMKKAEEMHGLPFARRWL
CCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHH
NVPKAELALPTLLRQGNLFVYHSLSDVPESFVSQFEHTVIVTADGALVTTR
CCCHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHCCEEEEEECCEEEECC
>Mature Secondary Structure
MNDNELDTYIEAGRIAKNVLHKCAAEIKPGVGMADIFDMVLDEISSAGVSPSFPPNISLN
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC
NCAAHDTASPDEERVFAEGDLIKLDIGTHIDGYIADTAVTVDLGDHASLCEASRAALDAA
CCCCCCCCCCCHHEEEECCCEEEEECCCCCCCEEECEEEEEECCCCHHHHHHHHHHHHHH
INVVAPEVVVSEIGAVVEETITSFGYKPIINLTGHALARYSLHHGLSIPNTGRFGSAVLR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
EDMVIAIEPFASTGSGLVHEAPRAEIYQVVGNAPVRSPAGRKIMKKAEEMHGLPFARRWL
CCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHH
NVPKAELALPTLLRQGNLFVYHSLSDVPESFVSQFEHTVIVTADGALVTTR
CCCHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHCCEEEEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]