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The map label for this gene is mutL

Identifier: 124485988

GI number: 124485988

Start: 1188725

End: 1190491

Strand: Reverse

Name: mutL

Synonym: Mlab_1168

Alternate gene names: 124485988

Gene position: 1190491-1188725 (Counterclockwise)

Preceding gene: 124485989

Following gene: 124485984

Centisome position: 65.96

GC content: 61.01

Gene sequence:

>1767_bases
ATGAGCCGGGTCAAAATCCTCGACGAGGAGACGATCAGCCACATCGCGGCGGGCGAAGTGGTCGAGCGTGCGGCGTCCGT
CGTGAAAGAGCTCGTCGAAAACGCCGTGGATGCGGACGCCCAAATCATCCGGATCGGCATATCGGCCGACAAAACCGGGA
TAACCAAAATCTCCGTCACGGACGACGGGATCGGGATGGACTTCGACGACGCTCTTCTGGCATTCCGCCAGCACGCAACA
AGCAAGATATCCCGCCCTGAGGATCTCGATGGGATCACCACGCTCGGGTTCCGCGGCGAGGCTCTTGCAAGCATCGCGGC
GATCTCGAAGGTGACCTTCACGACAAAGGAACGCGGCTCCCCTTCGCCCGAAGCGGCCCGCGTGGTGATCCACGGCGGCG
AGCTGATCTCTCACTCGGCTGTTGGTGCGCCGGAAGGAACGAGCGTTCTTATCGACGCTCTCTTTTACAACACTCCCGCC
CGGCGCAAGTTCCAGAAGTCCGTTCCAACGGAGTTGTCCCACGTCTACGACATGGTCGAGCGGATCGCCCTTTCGAACAG
GAACATCTCGTTTGTTCTGCTGTACAACGGCAAAGAGCGGTTCCAGACCTTTGGGACAGGCTCGTATCCGGACGTGATCG
CCGCGGTGTTCGGCTCCACCTTTTCCAAAGAGCTGACCCCGGTCTCCGGCAGTTTCGGGCCGGTGAAAATCGACGGCTGG
ATCACGCGTCCCGGCTCGGAGATGAAGACGACCCAGACGCGGTTTTATCTCTCGATAAACGGCCGGCAGGTGACGTCCCG
CCAGCTGCAGTGGGCGATCCGCGAAGGATACGGCACGCTTCTGCCAAAGGGCATGTACCCTGCGGCGTTTCTTGATATCG
TCCTCGATCCCCGGGACGTGGATGTGAACGTGCATCCGACAAAGCGGGAGGTCCGCCTCTCCCGCGAGAGGGAAGTGATG
CGGTGCGTTCAGGATGCGGTCTATACATCGCTGCATGAAGAGCGGGTCTTTTCCACCGCCCCCATGCCTACCCTCGCCCG
CGAGACTATCACGACCCTTCCGGTAGAGATCGTCGGCGAGCCGGTGCCTGTATATGCCGGGAAGCAGGAGATGCATGAGG
CAAGACAGGCCCCTCTCAAACAGACGGAGAAGCAGCTTCGGCGGACCGAGTCTGCGGATCTGCCGGAGACCGATCTGTTC
GTCCCGGAAGTCCTCGGGCAGATCGGGGACACCTACATTCTTGCGAAGAATGAATCCGGCGACCTTATCGTCGTGGATCA
GCATGCGGCCCACGAGCGGATCATGTACGATCAGCTGCTCGCCCGCTCCTCGTCAGCGGAGGCCGGGCAGGAACTGATCG
TCCCCCAGCCGATCACTCTCTCGAAAAAGGAGACCGCCGCCCTTCCCGATTTGCTGGATGTCCTCGCCGCCGCGGGATAC
CTTCTAGAACCGTTTGGAAAAGACGTCTGGATGGTCCGCTCCGTCCCCGTCGTCTCCTCAACGCTCGGCGACCCGGACAC
CATCCATGCGATCCTGGACGCGGCGCTGGACGGGGTGGGGAACACCGACGAGGTCCTTGATCGGGTGCTGAAGACCGCTG
CGTGCCGTGCTGTTGTGAAGGGGAACACGCCGCTGACGATCGAACAGATGCAGCGTCTCTTACGCCAGCTTATGGCGACA
AAATCCCCGTACACCTGCCCTCACGGTCGCCCTACGACGATCGTTCTCTCGAAATCGCGGTTGGCCGGGATGTTTCTGAG
AACATAA

Upstream 100 bases:

>100_bases
CCGCCGTCGAAGAGCGGATCCGCGACGCCGATCCGAACATGATGACCCCTATGCAGGCGCTTATGTTCATCAACGAACTC
AAGGCCCTGCTGGAGAAGAA

Downstream 100 bases:

>100_bases
TCCGATCAAAAATCGTTATTGATTTAAATAGGATTTACGAGGTGTTATCCTCAATCCAATTCGGGAAGGGAATTACAGGG
TGTGGAGACAAGAGATTATT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 588; Mature: 587

Protein sequence:

>588_residues
MSRVKILDEETISHIAAGEVVERAASVVKELVENAVDADAQIIRIGISADKTGITKISVTDDGIGMDFDDALLAFRQHAT
SKISRPEDLDGITTLGFRGEALASIAAISKVTFTTKERGSPSPEAARVVIHGGELISHSAVGAPEGTSVLIDALFYNTPA
RRKFQKSVPTELSHVYDMVERIALSNRNISFVLLYNGKERFQTFGTGSYPDVIAAVFGSTFSKELTPVSGSFGPVKIDGW
ITRPGSEMKTTQTRFYLSINGRQVTSRQLQWAIREGYGTLLPKGMYPAAFLDIVLDPRDVDVNVHPTKREVRLSREREVM
RCVQDAVYTSLHEERVFSTAPMPTLARETITTLPVEIVGEPVPVYAGKQEMHEARQAPLKQTEKQLRRTESADLPETDLF
VPEVLGQIGDTYILAKNESGDLIVVDQHAAHERIMYDQLLARSSSAEAGQELIVPQPITLSKKETAALPDLLDVLAAAGY
LLEPFGKDVWMVRSVPVVSSTLGDPDTIHAILDAALDGVGNTDEVLDRVLKTAACRAVVKGNTPLTIEQMQRLLRQLMAT
KSPYTCPHGRPTTIVLSKSRLAGMFLRT

Sequences:

>Translated_588_residues
MSRVKILDEETISHIAAGEVVERAASVVKELVENAVDADAQIIRIGISADKTGITKISVTDDGIGMDFDDALLAFRQHAT
SKISRPEDLDGITTLGFRGEALASIAAISKVTFTTKERGSPSPEAARVVIHGGELISHSAVGAPEGTSVLIDALFYNTPA
RRKFQKSVPTELSHVYDMVERIALSNRNISFVLLYNGKERFQTFGTGSYPDVIAAVFGSTFSKELTPVSGSFGPVKIDGW
ITRPGSEMKTTQTRFYLSINGRQVTSRQLQWAIREGYGTLLPKGMYPAAFLDIVLDPRDVDVNVHPTKREVRLSREREVM
RCVQDAVYTSLHEERVFSTAPMPTLARETITTLPVEIVGEPVPVYAGKQEMHEARQAPLKQTEKQLRRTESADLPETDLF
VPEVLGQIGDTYILAKNESGDLIVVDQHAAHERIMYDQLLARSSSAEAGQELIVPQPITLSKKETAALPDLLDVLAAAGY
LLEPFGKDVWMVRSVPVVSSTLGDPDTIHAILDAALDGVGNTDEVLDRVLKTAACRAVVKGNTPLTIEQMQRLLRQLMAT
KSPYTCPHGRPTTIVLSKSRLAGMFLRT
>Mature_587_residues
SRVKILDEETISHIAAGEVVERAASVVKELVENAVDADAQIIRIGISADKTGITKISVTDDGIGMDFDDALLAFRQHATS
KISRPEDLDGITTLGFRGEALASIAAISKVTFTTKERGSPSPEAARVVIHGGELISHSAVGAPEGTSVLIDALFYNTPAR
RKFQKSVPTELSHVYDMVERIALSNRNISFVLLYNGKERFQTFGTGSYPDVIAAVFGSTFSKELTPVSGSFGPVKIDGWI
TRPGSEMKTTQTRFYLSINGRQVTSRQLQWAIREGYGTLLPKGMYPAAFLDIVLDPRDVDVNVHPTKREVRLSREREVMR
CVQDAVYTSLHEERVFSTAPMPTLARETITTLPVEIVGEPVPVYAGKQEMHEARQAPLKQTEKQLRRTESADLPETDLFV
PEVLGQIGDTYILAKNESGDLIVVDQHAAHERIMYDQLLARSSSAEAGQELIVPQPITLSKKETAALPDLLDVLAAAGYL
LEPFGKDVWMVRSVPVVSSTLGDPDTIHAILDAALDGVGNTDEVLDRVLKTAACRAVVKGNTPLTIEQMQRLLRQLMATK
SPYTCPHGRPTTIVLSKSRLAGMFLRT

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=352, Percent_Identity=33.8068181818182, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI4505911, Length=339, Percent_Identity=27.7286135693215, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI189458898, Length=339, Percent_Identity=27.7286135693215, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI310128478, Length=347, Percent_Identity=29.6829971181556, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI4505913, Length=347, Percent_Identity=29.6829971181556, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI189458896, Length=333, Percent_Identity=28.5285285285285, Blast_Score=120, Evalue=5e-27,
Organism=Homo sapiens, GI263191589, Length=237, Percent_Identity=32.9113924050633, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI310128480, Length=298, Percent_Identity=28.8590604026846, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI91992162, Length=364, Percent_Identity=23.9010989010989, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI91992160, Length=364, Percent_Identity=23.9010989010989, Blast_Score=96, Evalue=9e-20,
Organism=Escherichia coli, GI1790612, Length=364, Percent_Identity=35.4395604395604, Blast_Score=213, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71991825, Length=322, Percent_Identity=32.2981366459627, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17562796, Length=360, Percent_Identity=28.0555555555556, Blast_Score=123, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6323819, Length=358, Percent_Identity=33.2402234636872, Blast_Score=180, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6324247, Length=352, Percent_Identity=28.4090909090909, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6325093, Length=297, Percent_Identity=26.9360269360269, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323063, Length=368, Percent_Identity=26.3586956521739, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17136968, Length=331, Percent_Identity=31.1178247734139, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI17136970, Length=363, Percent_Identity=25.6198347107438, Blast_Score=115, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_METLZ (A2SSN1)

Other databases:

- EMBL:   CP000559
- RefSeq:   YP_001030604.1
- ProteinModelPortal:   A2SSN1
- SMR:   A2SSN1
- STRING:   A2SSN1
- GeneID:   4795836
- GenomeReviews:   CP000559_GR
- KEGG:   mla:Mlab_1168
- eggNOG:   arNOG05147
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- PhylomeDB:   A2SSN1
- ProtClustDB:   PRK00095
- BioCyc:   MLAB410358:MLAB_1168-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 64331; Mature: 64200

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVKILDEETISHIAAGEVVERAASVVKELVENAVDADAQIIRIGISADKTGITKISVT
CCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEC
DDGIGMDFDDALLAFRQHATSKISRPEDLDGITTLGFRGEALASIAAISKVTFTTKERGS
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCHHHHHHHHHHHEEEEECCCCC
PSPEAARVVIHGGELISHSAVGAPEGTSVLIDALFYNTPARRKFQKSVPTELSHVYDMVE
CCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHH
RIALSNRNISFVLLYNGKERFQTFGTGSYPDVIAAVFGSTFSKELTPVSGSFGPVKIDGW
HHHHCCCCEEEEEEECCHHHHHHCCCCCCHHHHHHHHCCHHHCCCCCCCCCCCCEEEEEE
ITRPGSEMKTTQTRFYLSINGRQVTSRQLQWAIREGYGTLLPKGMYPAAFLDIVLDPRDV
EECCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCCHHCCCCCCCCHHHHHEEECCCCC
DVNVHPTKREVRLSREREVMRCVQDAVYTSLHEERVFSTAPMPTLARETITTLPVEIVGE
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHCCC
PVPVYAGKQEMHEARQAPLKQTEKQLRRTESADLPETDLFVPEVLGQIGDTYILAKNESG
CCCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEEECCCC
DLIVVDQHAAHERIMYDQLLARSSSAEAGQELIVPQPITLSKKETAALPDLLDVLAAAGY
CEEEECCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCH
LLEPFGKDVWMVRSVPVVSSTLGDPDTIHAILDAALDGVGNTDEVLDRVLKTAACRAVVK
HHHHCCCCEEEEECCCHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEC
GNTPLTIEQMQRLLRQLMATKSPYTCPHGRPTTIVLSKSRLAGMFLRT
CCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCHHCCHHHCC
>Mature Secondary Structure 
SRVKILDEETISHIAAGEVVERAASVVKELVENAVDADAQIIRIGISADKTGITKISVT
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEC
DDGIGMDFDDALLAFRQHATSKISRPEDLDGITTLGFRGEALASIAAISKVTFTTKERGS
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCHHHHHHHHHHHEEEEECCCCC
PSPEAARVVIHGGELISHSAVGAPEGTSVLIDALFYNTPARRKFQKSVPTELSHVYDMVE
CCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHH
RIALSNRNISFVLLYNGKERFQTFGTGSYPDVIAAVFGSTFSKELTPVSGSFGPVKIDGW
HHHHCCCCEEEEEEECCHHHHHHCCCCCCHHHHHHHHCCHHHCCCCCCCCCCCCEEEEEE
ITRPGSEMKTTQTRFYLSINGRQVTSRQLQWAIREGYGTLLPKGMYPAAFLDIVLDPRDV
EECCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCCHHCCCCCCCCHHHHHEEECCCCC
DVNVHPTKREVRLSREREVMRCVQDAVYTSLHEERVFSTAPMPTLARETITTLPVEIVGE
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHCCC
PVPVYAGKQEMHEARQAPLKQTEKQLRRTESADLPETDLFVPEVLGQIGDTYILAKNESG
CCCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEEECCCC
DLIVVDQHAAHERIMYDQLLARSSSAEAGQELIVPQPITLSKKETAALPDLLDVLAAAGY
CEEEECCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCH
LLEPFGKDVWMVRSVPVVSSTLGDPDTIHAILDAALDGVGNTDEVLDRVLKTAACRAVVK
HHHHCCCCEEEEECCCHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEC
GNTPLTIEQMQRLLRQLMATKSPYTCPHGRPTTIVLSKSRLAGMFLRT
CCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA