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The map label for this gene is fhs

Identifier: 124485829

GI number: 124485829

Start: 1009057

End: 1010739

Strand: Reverse

Name: fhs

Synonym: Mlab_1009

Alternate gene names: 124485829

Gene position: 1010739-1009057 (Counterclockwise)

Preceding gene: 124485830

Following gene: 124485828

Centisome position: 56.0

GC content: 51.4

Gene sequence:

>1683_bases
ATGGGGTGGAAATACTTGTTATCTGACATCGAAATTGCACAGCAGTGCAAAATGAAAAAAATCACTGAGATTGCCGCATC
TCTCGACATTACGCCGGATGAACTCGAACTCTACGGATCGTACAAAGCAAAACTTGCTGATTCACTGGAAAAACGTCTGG
CGGATAAACCAAACGGCAAACTGATCCTGGTGACGGCCATCAACCCGACGCCTGCCGGCGAGGGTAAGACCACGACAACA
GTCGGTCTTGGTCAGGCGATGCCCAAGATCGGTAAAAAGGCAGTCATTGCACTTCGCGAACCATCTCTAGGTCCCGTATT
CGGTGTTAAAGGCGGAGCTGCCGGCGGGGGATACTCGCAAGTCGTCCCGATGGAAGACATCAATCTCCACTTCACCGGAG
ATTTCCATGCGATTACCAGCGCAAACAACCTCTTGTGTGCTATGATCGACAATCATATCCAGCAGGGGAATGCGCTCGAC
ATTGATACCCGCCGTATCATCTTCAAGCGCTGTCTGGATATGAACGATCGTGCTCTTCGAAACATCATCATCGGGCTTGG
CGGTCAGACCAACGGCGTTCCGCGTGAGGATCACTTTATGATCACGGTCGCAAGCGAGGTAATGGCGATTCTCTGTCTTG
CAAATGATATCGACGACCTTAAAGAGCGTTTGGGGAATGTCATTTTTGGCTACAGCAGAAAAGGAACTCCTCTCTATGCC
CGTGATCTGAAGGCCGTCGGGGCTATGGCCGCCCTTCTCAAGGATGCCATCAAACCGAATCTTGTCCAGACGCTGGAAAA
CACCCCCTGTTTTATCCACGGCGGACCGTTTGCCAACATCGCACACGGCTGCAATTCGGTTCGTGCAACAAAACTTTCGC
TGAAGATGGCAGATTATGTCATCACGGAGGCGGGTTTCGGTTCTGATCTTGGTGCTGAAAAGTTCTTCGACATCAAATGC
CGGTATGCGGGCCTGACGCCGAATACTGTTGTTCTGGTGGCCACCGTTCGGGCACTGAAATACAATGGCGGTGTAAAGAA
AGAGGACACCACGATTCCAAACGTTGCTGCGCTCAAAGCAGGAATGGTCAATCTTGAGGCGCACATACAGAACCTCCAGA
CGTTTGGGGTTCCGGTTGTTGTGGCGATCAACCGGTTCTCTACCGATACGGACGAAGAACTTGCCGTGCTTAAAGAATTC
TGCACAGCGCAGGGAGCCGAGTTTGCAATCTCGGAAGTCTTTGCCAAAGGTGGGGAAGGTGGCGTTGAACTGGCGAAAAA
AGTCGTTGCCTCCTGCGAGAAGCCGCAGAAGTTCCAGTGTCTCTACGAACTGAATACACCGATAAAAGAGAAGATCAATG
CTCTCGCGACCCGGATATACGGAGCTGACGGGGTCGTTTACTCTCCTGCCGCCGATGCTGCAATCAAAGATATCGATGCT
CTTGGCAGAAGCAATCTGCCGATCTGTATGGCAAAGACCCAGTACTCGCTCTCCGATGATCCAAATAAACTCGGCAGACC
GAAGAACTTTGTTATTAACGCAGCAACGGTCAGGCTCTGTAATGGTGCCGGATTTATCGTTGTCGAGACCGGAGACATCA
TGACGCTCCCGGGACTGCCGGCTGTACCTGCAGCATGTTCGATCGACGTAAACAATGATGGATATATCTCCGGTCTCTTC
TGA

Upstream 100 bases:

>100_bases
TCTCATCTTAGTGTGGCAACTTAGATGCTTATATATAAGATAAGTTTAAGAGTAGTTAACAACATTTGGAGATAGCCCCT
CTGCTATCTCCTAAGGCTAC

Downstream 100 bases:

>100_bases
TTGACTGAAGGTTATACTCATCAGGACAATCCGCCCCAAAATTTCCTTTTTCTCTCCTATTGAAAATATATTTTATCTTG
ATCTGACCATTTTCCTGAAT

Product: formate-tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 560; Mature: 559

Protein sequence:

>560_residues
MGWKYLLSDIEIAQQCKMKKITEIAASLDITPDELELYGSYKAKLADSLEKRLADKPNGKLILVTAINPTPAGEGKTTTT
VGLGQAMPKIGKKAVIALREPSLGPVFGVKGGAAGGGYSQVVPMEDINLHFTGDFHAITSANNLLCAMIDNHIQQGNALD
IDTRRIIFKRCLDMNDRALRNIIIGLGGQTNGVPREDHFMITVASEVMAILCLANDIDDLKERLGNVIFGYSRKGTPLYA
RDLKAVGAMAALLKDAIKPNLVQTLENTPCFIHGGPFANIAHGCNSVRATKLSLKMADYVITEAGFGSDLGAEKFFDIKC
RYAGLTPNTVVLVATVRALKYNGGVKKEDTTIPNVAALKAGMVNLEAHIQNLQTFGVPVVVAINRFSTDTDEELAVLKEF
CTAQGAEFAISEVFAKGGEGGVELAKKVVASCEKPQKFQCLYELNTPIKEKINALATRIYGADGVVYSPAADAAIKDIDA
LGRSNLPICMAKTQYSLSDDPNKLGRPKNFVINAATVRLCNGAGFIVVETGDIMTLPGLPAVPAACSIDVNNDGYISGLF

Sequences:

>Translated_560_residues
MGWKYLLSDIEIAQQCKMKKITEIAASLDITPDELELYGSYKAKLADSLEKRLADKPNGKLILVTAINPTPAGEGKTTTT
VGLGQAMPKIGKKAVIALREPSLGPVFGVKGGAAGGGYSQVVPMEDINLHFTGDFHAITSANNLLCAMIDNHIQQGNALD
IDTRRIIFKRCLDMNDRALRNIIIGLGGQTNGVPREDHFMITVASEVMAILCLANDIDDLKERLGNVIFGYSRKGTPLYA
RDLKAVGAMAALLKDAIKPNLVQTLENTPCFIHGGPFANIAHGCNSVRATKLSLKMADYVITEAGFGSDLGAEKFFDIKC
RYAGLTPNTVVLVATVRALKYNGGVKKEDTTIPNVAALKAGMVNLEAHIQNLQTFGVPVVVAINRFSTDTDEELAVLKEF
CTAQGAEFAISEVFAKGGEGGVELAKKVVASCEKPQKFQCLYELNTPIKEKINALATRIYGADGVVYSPAADAAIKDIDA
LGRSNLPICMAKTQYSLSDDPNKLGRPKNFVINAATVRLCNGAGFIVVETGDIMTLPGLPAVPAACSIDVNNDGYISGLF
>Mature_559_residues
GWKYLLSDIEIAQQCKMKKITEIAASLDITPDELELYGSYKAKLADSLEKRLADKPNGKLILVTAINPTPAGEGKTTTTV
GLGQAMPKIGKKAVIALREPSLGPVFGVKGGAAGGGYSQVVPMEDINLHFTGDFHAITSANNLLCAMIDNHIQQGNALDI
DTRRIIFKRCLDMNDRALRNIIIGLGGQTNGVPREDHFMITVASEVMAILCLANDIDDLKERLGNVIFGYSRKGTPLYAR
DLKAVGAMAALLKDAIKPNLVQTLENTPCFIHGGPFANIAHGCNSVRATKLSLKMADYVITEAGFGSDLGAEKFFDIKCR
YAGLTPNTVVLVATVRALKYNGGVKKEDTTIPNVAALKAGMVNLEAHIQNLQTFGVPVVVAINRFSTDTDEELAVLKEFC
TAQGAEFAISEVFAKGGEGGVELAKKVVASCEKPQKFQCLYELNTPIKEKINALATRIYGADGVVYSPAADAAIKDIDAL
GRSNLPICMAKTQYSLSDDPNKLGRPKNFVINAATVRLCNGAGFIVVETGDIMTLPGLPAVPAACSIDVNNDGYISGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=618, Percent_Identity=43.6893203883495, Blast_Score=470, Evalue=1e-132,
Organism=Homo sapiens, GI36796743, Length=619, Percent_Identity=44.9111470113086, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI310124614, Length=80, Percent_Identity=45, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17568737, Length=624, Percent_Identity=42.1474358974359, Blast_Score=435, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17568739, Length=624, Percent_Identity=42.1474358974359, Blast_Score=435, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319558, Length=630, Percent_Identity=42.3809523809524, Blast_Score=452, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6321643, Length=625, Percent_Identity=43.52, Blast_Score=450, Evalue=1e-127,
Organism=Drosophila melanogaster, GI62472483, Length=619, Percent_Identity=42.4878836833603, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI45551871, Length=619, Percent_Identity=42.4878836833603, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24645718, Length=619, Percent_Identity=42.4878836833603, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI17137370, Length=619, Percent_Identity=42.4878836833603, Blast_Score=462, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_METLZ (A2SS72)

Other databases:

- EMBL:   CP000559
- RefSeq:   YP_001030445.1
- ProteinModelPortal:   A2SS72
- SMR:   A2SS72
- STRING:   A2SS72
- GeneID:   4794627
- GenomeReviews:   CP000559_GR
- KEGG:   mla:Mlab_1009
- eggNOG:   arNOG06240
- HOGENOM:   HBG677721
- OMA:   KMPGLPK
- PhylomeDB:   A2SS72
- BioCyc:   MLAB410358:MLAB_1009-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 59859; Mature: 59728

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGWKYLLSDIEIAQQCKMKKITEIAASLDITPDELELYGSYKAKLADSLEKRLADKPNGK
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCC
LILVTAINPTPAGEGKTTTTVGLGQAMPKIGKKAVIALREPSLGPVFGVKGGAAGGGYSQ
EEEEEEECCCCCCCCCCEEEEECHHHHHHCCCEEEEEEECCCCCCEEECCCCCCCCCCCE
VVPMEDINLHFTGDFHAITSANNLLCAMIDNHIQQGNALDIDTRRIIFKRCLDMNDRALR
ECCCCCCEEEEECCEEEECCCCCEEEEEHHHHHCCCCEECCHHHHHHHHHHCCCCHHHHH
NIIIGLGGQTNGVPREDHFMITVASEVMAILCLANDIDDLKERLGNVIFGYSRKGTPLYA
HEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCHHHHHHHHCCEEEECCCCCCCHHH
RDLKAVGAMAALLKDAIKPNLVQTLENTPCFIHGGPFANIAHGCNSVRATKLSLKMADYV
HHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEECCCHHHHHHCCCCCEEEEEEEEHHHHE
ITEAGFGSDLGAEKFFDIKCRYAGLTPNTVVLVATVRALKYNGGVKKEDTTIPNVAALKA
EECCCCCCCCCCCCEEEEEEEEECCCCCCEEEEEEEHHHHCCCCCCCCCCCCCCHHHHHH
GMVNLEAHIQNLQTFGVPVVVAINRFSTDTDEELAVLKEFCTAQGAEFAISEVFAKGGEG
CCEEHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
GVELAKKVVASCEKPQKFQCLYELNTPIKEKINALATRIYGADGVVYSPAADAAIKDIDA
HHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHH
LGRSNLPICMAKTQYSLSDDPNKLGRPKNFVINAATVRLCNGAGFIVVETGDIMTLPGLP
CCCCCCCEEEEECCCCCCCCHHHHCCCCCEEEEEEEEEEECCCCEEEEECCCEEECCCCC
AVPAACSIDVNNDGYISGLF
CCCCEEEEEECCCCEEEECC
>Mature Secondary Structure 
GWKYLLSDIEIAQQCKMKKITEIAASLDITPDELELYGSYKAKLADSLEKRLADKPNGK
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCC
LILVTAINPTPAGEGKTTTTVGLGQAMPKIGKKAVIALREPSLGPVFGVKGGAAGGGYSQ
EEEEEEECCCCCCCCCCEEEEECHHHHHHCCCEEEEEEECCCCCCEEECCCCCCCCCCCE
VVPMEDINLHFTGDFHAITSANNLLCAMIDNHIQQGNALDIDTRRIIFKRCLDMNDRALR
ECCCCCCEEEEECCEEEECCCCCEEEEEHHHHHCCCCEECCHHHHHHHHHHCCCCHHHHH
NIIIGLGGQTNGVPREDHFMITVASEVMAILCLANDIDDLKERLGNVIFGYSRKGTPLYA
HEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCHHHHHHHHCCEEEECCCCCCCHHH
RDLKAVGAMAALLKDAIKPNLVQTLENTPCFIHGGPFANIAHGCNSVRATKLSLKMADYV
HHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEECCCHHHHHHCCCCCEEEEEEEEHHHHE
ITEAGFGSDLGAEKFFDIKCRYAGLTPNTVVLVATVRALKYNGGVKKEDTTIPNVAALKA
EECCCCCCCCCCCCEEEEEEEEECCCCCCEEEEEEEHHHHCCCCCCCCCCCCCCHHHHHH
GMVNLEAHIQNLQTFGVPVVVAINRFSTDTDEELAVLKEFCTAQGAEFAISEVFAKGGEG
CCEEHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
GVELAKKVVASCEKPQKFQCLYELNTPIKEKINALATRIYGADGVVYSPAADAAIKDIDA
HHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHH
LGRSNLPICMAKTQYSLSDDPNKLGRPKNFVINAATVRLCNGAGFIVVETGDIMTLPGLP
CCCCCCCEEEEECCCCCCCCHHHHCCCCCEEEEEEEEEEECCCCEEEEECCCEEECCCCC
AVPAACSIDVNNDGYISGLF
CCCCEEEEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA