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The map label for this gene is mhpE [C]

Identifier: 124485807

GI number: 124485807

Start: 988895

End: 989929

Strand: Reverse

Name: mhpE [C]

Synonym: Mlab_0987

Alternate gene names: 124485807

Gene position: 989929-988895 (Counterclockwise)

Preceding gene: 162319793

Following gene: 124485805

Centisome position: 54.84

GC content: 52.37

Gene sequence:

>1035_bases
ATGGAAATACTAGATACAACCATTAGGGACGGGGGATATGCAGTTGATTTCAACTTCTCCTGTTCAGACGTTAGAAACAT
CTCTTCCAAGCTGGAAGGGATGGGCATAGGATTGATCGAAATCGGACACGGGATGGGACTGAACGCCAGTTCTCCCAAAA
ACGGCATCGCCGCCCAGACCGACGAGGAATACATGCGTGCGGCCGGAGAGGTGCTGACGAAATCCAAATTCGGAATGTTC
TGCATTCCGGGCATCGCACGACTGGAGGATCTGCAGCTCGCCGTCGACTGCGGGGCCTCGTTTATCAGGGTCGGCATCAA
TGCGGATCAGATCCCGCTGACCGAACCGTACATCCGCGAAGCAAAAGACCTCGGCTTAACGGTGATGACGAACTACATGA
AGTCGTATGTTCTCACACCCGACGAGTTTGCGCAAAACGTCATGCTTTCAGAAAAATACGGGGCAGACTGCGTGTATATC
GTCGACTCGGCCGGGGGCATGTTCCCGGGCGAAATACAGGAATATTATGATACCATACGCGAATATTCCAGCATCCAGCT
CGGATTTCACGGGCACAACAATCTCGGACTCGCCGTTGCAAACAGCGTGTACTGTGCAAAGCTCGGATTCGATTTCATCG
ACTGCTCGCTGCAGGGGCTTGGACGAAGTTCCGGCAACGCCTGCACGGAAATGTTTCTCGCGATCCTTGAGAAAAACGGA
TACCGGACCGATGTGGATCTCGTGGAATTATTTTCGGCGGGATACGATCTTCTCCGGCCGATCACGAATAAAGACCTCAC
CGATCCGCTTGATTACGTCTGCGGATATGCCGGGTTCCACACCAGTTATCTCAATCAGATCAACACCTGCGCAGAAGAGT
TCGATGTGAATCCGTTCCGTCTGATCATCGAGTACTCGAAGTACGATCAGGCCAATATGGATTACGATAAACTCTGCAGC
ATGGCGATGACGATGCAGAAAAACTCCCGTCTGCGGCAGCTCGACCACCCGATCTGTCCAAACTGTGCAAGCTGA

Upstream 100 bases:

>100_bases
ACCAATTGATCAAAAAAGATGCGGAAATACCAAGGTATTCAGCATTGTGCTGTAACCATTTAAGGTACCGAGCCGATCAT
GCGTAACGGGAAAGGGATTC

Downstream 100 bases:

>100_bases
GTCTTGCCTGGACCACACCTCACAATTTTGAAAAAATTATTTTTCCTTCTCGATGAGAAGGACCCGCGCCGGTGCTCCGT
CGCTGTCTTTGATCTTCATC

Product: hypothetical protein

Products: NA

Alternate protein names: HOA 2; 4-hydroxy-2-keto-pentanoic acid aldolase 2; 4-hydroxy-2-oxopentanoate aldolase 2 [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MEILDTTIRDGGYAVDFNFSCSDVRNISSKLEGMGIGLIEIGHGMGLNASSPKNGIAAQTDEEYMRAAGEVLTKSKFGMF
CIPGIARLEDLQLAVDCGASFIRVGINADQIPLTEPYIREAKDLGLTVMTNYMKSYVLTPDEFAQNVMLSEKYGADCVYI
VDSAGGMFPGEIQEYYDTIREYSSIQLGFHGHNNLGLAVANSVYCAKLGFDFIDCSLQGLGRSSGNACTEMFLAILEKNG
YRTDVDLVELFSAGYDLLRPITNKDLTDPLDYVCGYAGFHTSYLNQINTCAEEFDVNPFRLIIEYSKYDQANMDYDKLCS
MAMTMQKNSRLRQLDHPICPNCAS

Sequences:

>Translated_344_residues
MEILDTTIRDGGYAVDFNFSCSDVRNISSKLEGMGIGLIEIGHGMGLNASSPKNGIAAQTDEEYMRAAGEVLTKSKFGMF
CIPGIARLEDLQLAVDCGASFIRVGINADQIPLTEPYIREAKDLGLTVMTNYMKSYVLTPDEFAQNVMLSEKYGADCVYI
VDSAGGMFPGEIQEYYDTIREYSSIQLGFHGHNNLGLAVANSVYCAKLGFDFIDCSLQGLGRSSGNACTEMFLAILEKNG
YRTDVDLVELFSAGYDLLRPITNKDLTDPLDYVCGYAGFHTSYLNQINTCAEEFDVNPFRLIIEYSKYDQANMDYDKLCS
MAMTMQKNSRLRQLDHPICPNCAS
>Mature_344_residues
MEILDTTIRDGGYAVDFNFSCSDVRNISSKLEGMGIGLIEIGHGMGLNASSPKNGIAAQTDEEYMRAAGEVLTKSKFGMF
CIPGIARLEDLQLAVDCGASFIRVGINADQIPLTEPYIREAKDLGLTVMTNYMKSYVLTPDEFAQNVMLSEKYGADCVYI
VDSAGGMFPGEIQEYYDTIREYSSIQLGFHGHNNLGLAVANSVYCAKLGFDFIDCSLQGLGRSSGNACTEMFLAILEKNG
YRTDVDLVELFSAGYDLLRPITNKDLTDPLDYVCGYAGFHTSYLNQINTCAEEFDVNPFRLIIEYSKYDQANMDYDKLCS
MAMTMQKNSRLRQLDHPICPNCAS

Specific function: Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4-hydroxy-2-oxovalerate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1786548, Length=330, Percent_Identity=33.030303030303, Blast_Score=192, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017629
- InterPro:   IPR013785
- InterPro:   IPR012425
- InterPro:   IPR000891
- ProDom:   PD005364 [H]

Pfam domain/function: PF07836 DmpG_comm; PF00682 HMGL-like [H]

EC number: =4.1.3.39 [H]

Molecular weight: Translated: 38036; Mature: 38036

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEILDTTIRDGGYAVDFNFSCSDVRNISSKLEGMGIGLIEIGHGMGLNASSPKNGIAAQT
CCCCCCHHCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCC
DEEYMRAAGEVLTKSKFGMFCIPGIARLEDLQLAVDCGASFIRVGINADQIPLTEPYIRE
HHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHH
AKDLGLTVMTNYMKSYVLTPDEFAQNVMLSEKYGADCVYIVDSAGGMFPGEIQEYYDTIR
HHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHH
EYSSIQLGFHGHNNLGLAVANSVYCAKLGFDFIDCSLQGLGRSSGNACTEMFLAILEKNG
HHCCEEEEECCCCCCCEEECCCEEEHHHCCHHEEHHHHHCCCCCCHHHHHHHHHHHHCCC
YRTDVDLVELFSAGYDLLRPITNKDLTDPLDYVCGYAGFHTSYLNQINTCAEEFDVNPFR
CCCCHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LIIEYSKYDQANMDYDKLCSMAMTMQKNSRLRQLDHPICPNCAS
EEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCC
>Mature Secondary Structure
MEILDTTIRDGGYAVDFNFSCSDVRNISSKLEGMGIGLIEIGHGMGLNASSPKNGIAAQT
CCCCCCHHCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCC
DEEYMRAAGEVLTKSKFGMFCIPGIARLEDLQLAVDCGASFIRVGINADQIPLTEPYIRE
HHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHH
AKDLGLTVMTNYMKSYVLTPDEFAQNVMLSEKYGADCVYIVDSAGGMFPGEIQEYYDTIR
HHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHH
EYSSIQLGFHGHNNLGLAVANSVYCAKLGFDFIDCSLQGLGRSSGNACTEMFLAILEKNG
HHCCEEEEECCCCCCCEEECCCEEEHHHCCHHEEHHHHHCCCCCCHHHHHHHHHHHHCCC
YRTDVDLVELFSAGYDLLRPITNKDLTDPLDYVCGYAGFHTSYLNQINTCAEEFDVNPFR
CCCCHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LIIEYSKYDQANMDYDKLCSMAMTMQKNSRLRQLDHPICPNCAS
EEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA