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The map label for this gene is yfnC [H]

Identifier: 124485043

GI number: 124485043

Start: 205552

End: 206733

Strand: Reverse

Name: yfnC [H]

Synonym: Mlab_0216

Alternate gene names: 124485043

Gene position: 206733-205552 (Counterclockwise)

Preceding gene: 124485044

Following gene: 124485042

Centisome position: 11.45

GC content: 51.18

Gene sequence:

>1182_bases
ATGAACGATCTTACAAAACGCATTGCCGGTCTTGCCGCAGGTCACGGGGCAGCGGACTTTTACATCCCCGTGGTTCCGGC
TATCCTCCCGGCACTGATTCCGATATTTACCGAGCAGGGGATCACCTCCTATGCAATGGCAGGATGTCTGTTTACCCTCG
TCACGCTAACTATGGTAATATTCCAGCCATTGACCGGCTGGATGATCGATAAGGGTCGGTGGGTCCCGGGGATATCCTGG
TGTATTCTTATTACCGGCCTTGCCATCGCGGTATTCGGATTTACCCAGAATTACTGGGTGCTTCTCACCATGGCAGTGGT
TGCAGGAGCTGGAAATTCCATGTTCCATCCGAATGCCTACCAGCAGATCCATCAGTTCACCACCTCGGCAAATCGCGGAA
CGTTCCTTTCGCTCTTCTCGGTCGGTGGATCCTTTGGATACGGAGCGGCACCTCTCGTTACCGGAGCATTATTTGCATGG
GGAGGATTCCCGGCACTTATATGGCTCATTATTCCAGCAGTCATTGTGGCAGTTTTACTGAGGAAACACCAGCAGAAACC
GGCGTTCCTTCCACCGAAATCCGTGGATACAGAGACGGTAAAACCGAAATGGAGAAACGCCGTTTTTGTTCTCGGCATAA
GTTCACTTCGAACTTGGGTCTACTACGGATTTCTCGCCTTTGCCGCCGTCTATCTAACCACATATGCAGGAGTTGATTAC
CTTCTGGCGACTGGTGTTGTCAGCTGTATGATCTTTGCAGGAATGTTCGGCACCCTCATCGCCGGACCTCTATCCGACAA
GATCGGAAGAAAAGAGGTTATGTTCACGGCTTATATCGGAGCGACGGCTGCCTACTTCGGCATATTTCTCCTATCAGGAG
TTGGGTCGGTCATATCTCTCGTGATTGCCGGATTTTTCATGATGGCGACTGCCTCTGTTGAAATCGCAACAGTCCAGGAA
CTTATGCCGGGAAGTGTCGGACTTGCATCCGGAATCATAATCGGCATCCCCCAAGGGTTAGCAGCCGTGGCGATTATGGT
TATCGGCATTATGGCGGATGCCATAGGTATGCCGACAGCATTATTCTCGCAGGTATGGCTGATGGTTGCCGCCATCGTTC
TCTGCATTGCTCTCCCATATCCGCTGAAACTGCTTAACCGTACCCATAAACCTGTTGAATAA

Upstream 100 bases:

>100_bases
CAAAAACGGCAGCCATGCTGAATATTCCAAAACAATTCGCTTTCCACACAAAAGAACATCTGGAGATCCCGGTTGAGATC
ATCCGTTTAGAGAGAATATC

Downstream 100 bases:

>100_bases
CTCAGTTGGAATCCTCAACATCCCCTATTTTTTTAGAACAACGGCATATCTTGCTCCATTATCCGGCTGCAGCGTGTGTC
AACCCGCAAACGCTATTTAC

Product: hypothetical protein

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MNDLTKRIAGLAAGHGAADFYIPVVPAILPALIPIFTEQGITSYAMAGCLFTLVTLTMVIFQPLTGWMIDKGRWVPGISW
CILITGLAIAVFGFTQNYWVLLTMAVVAGAGNSMFHPNAYQQIHQFTTSANRGTFLSLFSVGGSFGYGAAPLVTGALFAW
GGFPALIWLIIPAVIVAVLLRKHQQKPAFLPPKSVDTETVKPKWRNAVFVLGISSLRTWVYYGFLAFAAVYLTTYAGVDY
LLATGVVSCMIFAGMFGTLIAGPLSDKIGRKEVMFTAYIGATAAYFGIFLLSGVGSVISLVIAGFFMMATASVEIATVQE
LMPGSVGLASGIIIGIPQGLAAVAIMVIGIMADAIGMPTALFSQVWLMVAAIVLCIALPYPLKLLNRTHKPVE

Sequences:

>Translated_393_residues
MNDLTKRIAGLAAGHGAADFYIPVVPAILPALIPIFTEQGITSYAMAGCLFTLVTLTMVIFQPLTGWMIDKGRWVPGISW
CILITGLAIAVFGFTQNYWVLLTMAVVAGAGNSMFHPNAYQQIHQFTTSANRGTFLSLFSVGGSFGYGAAPLVTGALFAW
GGFPALIWLIIPAVIVAVLLRKHQQKPAFLPPKSVDTETVKPKWRNAVFVLGISSLRTWVYYGFLAFAAVYLTTYAGVDY
LLATGVVSCMIFAGMFGTLIAGPLSDKIGRKEVMFTAYIGATAAYFGIFLLSGVGSVISLVIAGFFMMATASVEIATVQE
LMPGSVGLASGIIIGIPQGLAAVAIMVIGIMADAIGMPTALFSQVWLMVAAIVLCIALPYPLKLLNRTHKPVE
>Mature_393_residues
MNDLTKRIAGLAAGHGAADFYIPVVPAILPALIPIFTEQGITSYAMAGCLFTLVTLTMVIFQPLTGWMIDKGRWVPGISW
CILITGLAIAVFGFTQNYWVLLTMAVVAGAGNSMFHPNAYQQIHQFTTSANRGTFLSLFSVGGSFGYGAAPLVTGALFAW
GGFPALIWLIIPAVIVAVLLRKHQQKPAFLPPKSVDTETVKPKWRNAVFVLGISSLRTWVYYGFLAFAAVYLTTYAGVDY
LLATGVVSCMIFAGMFGTLIAGPLSDKIGRKEVMFTAYIGATAAYFGIFLLSGVGSVISLVIAGFFMMATASVEIATVQE
LMPGSVGLASGIIIGIPQGLAAVAIMVIGIMADAIGMPTALFSQVWLMVAAIVLCIALPYPLKLLNRTHKPVE

Specific function: Confers The Resistance Against Fosmidomycin. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=344, Percent_Identity=26.453488372093, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41795; Mature: 41795

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]