Click here to switch to the map view.

The map label for this gene is dfx [H]

Identifier: 124485000

GI number: 124485000

Start: 159605

End: 159988

Strand: Reverse

Name: dfx [H]

Synonym: Mlab_0173

Alternate gene names: 124485000

Gene position: 159988-159605 (Counterclockwise)

Preceding gene: 124485001

Following gene: 124484999

Centisome position: 8.86

GC content: 50.78

Gene sequence:

>384_bases
ATGACACAGGCTAAAGAAATCTACAAATGTGCTATCTGCGGGAACACTGTCAGGGTCATCGGAAAAGGAAAAGGCCAGCT
CGTCTGCTGTGGCCAGCCGATGAATCTGCTTGAAGAAAACAGTACCGACGCCTCGCTCGAAAAACATGTTCCGGTTATTG
AAGAGGTCGCCGGAGGATACAAAGTAGCGGTCGGTTCAGCTCCCCACCCAATGCTCGATGAACACTACATCACCTGGGTC
GCTCTCAGAACCGATGACGGGATCGTTCACGAGAAGTTCCTTGTTCCGGGCGAAAAACCCGAGATGATCGTAAAGACCAC
TGCAAAGGCAGAGAAAGCCGGGGAATACTGTAACCAGCACGGACTCTGGGTCAAAAAAGTATAA

Upstream 100 bases:

>100_bases
ACTGGCGGATTCGATCGAAGAGCGTCATAAAACGCTCTGATTCTCTTTTTTTATTCCCCGATACGTACGTTTTTATTCAC
GTCTGACCTAAGATTCTACT

Downstream 100 bases:

>100_bases
CCGGTCTTACCATTCATTTTTTCCTGAAGACTGAATTCAGGCAACTACTATTATTATCAAACACCTAATTGTACTACAAA
TGGGGTATCTCAGGGAACTT

Product: DNA topoisomerase type IIA subunit B region 2 domain-containing protein

Products: NA

Alternate protein names: Dfx; Superoxide reductase; SOR [H]

Number of amino acids: Translated: 127; Mature: 126

Protein sequence:

>127_residues
MTQAKEIYKCAICGNTVRVIGKGKGQLVCCGQPMNLLEENSTDASLEKHVPVIEEVAGGYKVAVGSAPHPMLDEHYITWV
ALRTDDGIVHEKFLVPGEKPEMIVKTTAKAEKAGEYCNQHGLWVKKV

Sequences:

>Translated_127_residues
MTQAKEIYKCAICGNTVRVIGKGKGQLVCCGQPMNLLEENSTDASLEKHVPVIEEVAGGYKVAVGSAPHPMLDEHYITWV
ALRTDDGIVHEKFLVPGEKPEMIVKTTAKAEKAGEYCNQHGLWVKKV
>Mature_126_residues
TQAKEIYKCAICGNTVRVIGKGKGQLVCCGQPMNLLEENSTDASLEKHVPVIEEVAGGYKVAVGSAPHPMLDEHYITWVA
LRTDDGIVHEKFLVPGEKPEMIVKTTAKAEKAGEYCNQHGLWVKKV

Specific function: Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity [H]

COG id: COG2033

COG function: function code C; Desulfoferrodoxin

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the desulfoferrodoxin family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002742
- InterPro:   IPR004462
- InterPro:   IPR004793 [H]

Pfam domain/function: PF06397 Desulfoferrod_N; PF01880 Desulfoferrodox [H]

EC number: =1.15.1.2 [H]

Molecular weight: Translated: 13906; Mature: 13775

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAKEIYKCAICGNTVRVIGKGKGQLVCCGQPMNLLEENSTDASLEKHVPVIEEVAGGY
CCCHHHHEEEEECCCEEEEEECCCCCEEECCCCCHHHCCCCCCCCHHHCCCHHHHHCCCE
KVAVGSAPHPMLDEHYITWVALRTDDGIVHEKFLVPGEKPEMIVKTTAKAEKAGEYCNQH
EEEECCCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCEEEEECCCHHHHHHHHHHC
GLWVKKV
CEEEEEC
>Mature Secondary Structure 
TQAKEIYKCAICGNTVRVIGKGKGQLVCCGQPMNLLEENSTDASLEKHVPVIEEVAGGY
CCHHHHEEEEECCCEEEEEECCCCCEEECCCCCHHHCCCCCCCCHHHCCCHHHHHCCCE
KVAVGSAPHPMLDEHYITWVALRTDDGIVHEKFLVPGEKPEMIVKTTAKAEKAGEYCNQH
EEEECCCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCEEEEECCCHHHHHHHHHHC
GLWVKKV
CEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8955290; 10617593; 11305919 [H]