Click here to switch to the map view.

The map label for this gene is dys1 [H]

Identifier: 124484982

GI number: 124484982

Start: 139856

End: 140794

Strand: Reverse

Name: dys1 [H]

Synonym: Mlab_0154

Alternate gene names: 124484982

Gene position: 140794-139856 (Counterclockwise)

Preceding gene: 124484983

Following gene: 124484981

Centisome position: 7.8

GC content: 52.82

Gene sequence:

>939_bases
ATGCATAAACATTGTAGTACCCCGGTCAAGCAGTTTATCCCACGCGGCGACATGACCGTAAACGAACTGGTCTGTGAGAT
GGGGAAAGCAGGAGCGTACAACGGCGGAAGTCTTTTCCACGCTGTAGAAGTCTATGAAAAAATGCTTTCCGACCCCGACA
TGACCAAGTTTTTCGCTCTTTCGGGAGCGATGGTCCCGGCAGGGATGGGAGGGATCGTATCGACACTTATAGAAAAAGGC
CACATCGATGTGCTGACCTCGACGGGAGCAAACCTCACCCATGATGTAATCGAAGCGATCGGTTGTCATCACTACCACGG
CAAAGCTGAGTGCGATGACGTCGAGCTCAGAAATGACGAAGTAAATCGTATTTACGACGTCTTCCTGCCGAACGATGCAT
TCGAGGATCTGGAGGATTTCATTCAGGATATATACTGCGGACTTCCCGAAGAACCGATCACGATCAGCAATCTTCTGAAA
ACGATTGGCGAGGAGCTCGACACGGGAATTCTTGCAACGGCAGCAAAACACGATGTCCCGGTCTACTGCCCGGCGTTTCA
GGACTCGGTTCTGGGCCTCCAGTACTGGATGTTCTCCCAGTTCCACAAAAAGACGATCCTCGATGCGATCGGCGATATGC
ATGTCCTCCTCAATCAGGTGTTCAATGTGAAAAAGGCCGGGGCAGTTCTCGTTGGAGGAGGAGTCCCGAAGAACTTCACG
CTGCAGAGCATGCTGATGACGCCAAACGATTTCACGTATGTGATCCAGCTCACCGGAGACCGCCCCGACCTTGGCGGACT
TTCCGGAGCGACGCTGGACGAAGCAAAGTCCTGGGGTAAGATCGGCGAAGGAGGGACCGGCGTTACCGTGTACGGCGATG
CCACAATAACACTCCCCATCCTTGCAGCAGCAACGCTGGAACGTATGGAGAGAAAATAA

Upstream 100 bases:

>100_bases
TTGACTGCAGTTGAGATACAGCATTTTTATTTTTTTCATCGGCAAGACATACCTATATGGGTATACCCAACCAACCATAT
CCAGCATTAAGGTCACAATC

Downstream 100 bases:

>100_bases
ATGGCCGAACTTCTGCTCGCACTCGATGTAAAAGGTGCCGAAGAAGCGATCCGCGTATCCCGGGCTTGCGAAGGGGAACT
CGATGCGATAAAAATCGGTT

Product: putative deoxyhypusine synthase

Products: NA

Alternate protein names: DHS 1 [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MHKHCSTPVKQFIPRGDMTVNELVCEMGKAGAYNGGSLFHAVEVYEKMLSDPDMTKFFALSGAMVPAGMGGIVSTLIEKG
HIDVLTSTGANLTHDVIEAIGCHHYHGKAECDDVELRNDEVNRIYDVFLPNDAFEDLEDFIQDIYCGLPEEPITISNLLK
TIGEELDTGILATAAKHDVPVYCPAFQDSVLGLQYWMFSQFHKKTILDAIGDMHVLLNQVFNVKKAGAVLVGGGVPKNFT
LQSMLMTPNDFTYVIQLTGDRPDLGGLSGATLDEAKSWGKIGEGGTGVTVYGDATITLPILAAATLERMERK

Sequences:

>Translated_312_residues
MHKHCSTPVKQFIPRGDMTVNELVCEMGKAGAYNGGSLFHAVEVYEKMLSDPDMTKFFALSGAMVPAGMGGIVSTLIEKG
HIDVLTSTGANLTHDVIEAIGCHHYHGKAECDDVELRNDEVNRIYDVFLPNDAFEDLEDFIQDIYCGLPEEPITISNLLK
TIGEELDTGILATAAKHDVPVYCPAFQDSVLGLQYWMFSQFHKKTILDAIGDMHVLLNQVFNVKKAGAVLVGGGVPKNFT
LQSMLMTPNDFTYVIQLTGDRPDLGGLSGATLDEAKSWGKIGEGGTGVTVYGDATITLPILAAATLERMERK
>Mature_312_residues
MHKHCSTPVKQFIPRGDMTVNELVCEMGKAGAYNGGSLFHAVEVYEKMLSDPDMTKFFALSGAMVPAGMGGIVSTLIEKG
HIDVLTSTGANLTHDVIEAIGCHHYHGKAECDDVELRNDEVNRIYDVFLPNDAFEDLEDFIQDIYCGLPEEPITISNLLK
TIGEELDTGILATAAKHDVPVYCPAFQDSVLGLQYWMFSQFHKKTILDAIGDMHVLLNQVFNVKKAGAVLVGGGVPKNFT
LQSMLMTPNDFTYVIQLTGDRPDLGGLSGATLDEAKSWGKIGEGGTGVTVYGDATITLPILAAATLERMERK

Specific function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine

COG id: COG1899

COG function: function code O; Deoxyhypusine synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deoxyhypusine synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503325, Length=260, Percent_Identity=28.4615384615385, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17536927, Length=266, Percent_Identity=30.0751879699248, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321859, Length=278, Percent_Identity=25.5395683453237, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45550569, Length=262, Percent_Identity=28.2442748091603, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002773
- InterPro:   IPR022899 [H]

Pfam domain/function: PF01916 DS [H]

EC number: =2.5.1.46 [H]

Molecular weight: Translated: 33887; Mature: 33887

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKHCSTPVKQFIPRGDMTVNELVCEMGKAGAYNGGSLFHAVEVYEKMLSDPDMTKFFAL
CCCCCCCCHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
SGAMVPAGMGGIVSTLIEKGHIDVLTSTGANLTHDVIEAIGCHHYHGKAECDDVELRNDE
CCCCCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
VNRIYDVFLPNDAFEDLEDFIQDIYCGLPEEPITISNLLKTIGEELDTGILATAAKHDVP
HHHEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCC
VYCPAFQDSVLGLQYWMFSQFHKKTILDAIGDMHVLLNQVFNVKKAGAVLVGGGVPKNFT
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCEEEECCCCCCCCC
LQSMLMTPNDFTYVIQLTGDRPDLGGLSGATLDEAKSWGKIGEGGTGVTVYGDATITLPI
HHHEEECCCCEEEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCEEEECCCEEHHHH
LAAATLERMERK
HHHHHHHHHHCC
>Mature Secondary Structure
MHKHCSTPVKQFIPRGDMTVNELVCEMGKAGAYNGGSLFHAVEVYEKMLSDPDMTKFFAL
CCCCCCCCHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
SGAMVPAGMGGIVSTLIEKGHIDVLTSTGANLTHDVIEAIGCHHYHGKAECDDVELRNDE
CCCCCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
VNRIYDVFLPNDAFEDLEDFIQDIYCGLPEEPITISNLLKTIGEELDTGILATAAKHDVP
HHHEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCC
VYCPAFQDSVLGLQYWMFSQFHKKTILDAIGDMHVLLNQVFNVKKAGAVLVGGGVPKNFT
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCEEEECCCCCCCCC
LQSMLMTPNDFTYVIQLTGDRPDLGGLSGATLDEAKSWGKIGEGGTGVTVYGDATITLPI
HHHEEECCCCEEEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCEEEECCCEEHHHH
LAAATLERMERK
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]