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The map label for this gene is sdhA

Identifier: 124484968

GI number: 124484968

Start: 126977

End: 128605

Strand: Reverse

Name: sdhA

Synonym: Mlab_0140

Alternate gene names: 124484968

Gene position: 128605-126977 (Counterclockwise)

Preceding gene: 124484969

Following gene: 124484967

Centisome position: 7.13

GC content: 54.76

Gene sequence:

>1629_bases
ATGGGCATCGAGAATACAAAAGACTGTCACGTACTTGTCATAGGGTCGGGCGGCGCCGGAATACGTGCCGCCGTTGAGGC
GGAAACGTTTGGCGAGACGATCATTGTCTCGAAAACGATCACCGGGAAAGGCGGGTGTACCGTCATGGCAGAAGGCGGAT
TCAATGCCGTATTGAATGAAGAAGATTCGATACAGACCCATTTCGAGGATACGATGAAGGGCGGGGCGTTTCTCAACGAT
GAATTACTCGTGCAGACACTCGCAAGCGAAGCCCCGAACAGGATCCGTGATCTTTTTTCCTGGGGGGCCGTCTTCGATCT
GAAAGAAGACAATACGATAGCTCAGCGGCCTTTCGGCGGACAGCGGTGTGCCAGAACCTGTTATGCGGGAGACCACACGG
GTCACGAGCTGGTGATGACCCTTCTCGAAAAACTCCGGGGTTCATCAGTCGAGATCGAAAATGAAGTGACGGTCCTTGAT
CTCCTTTCAGACGATGGAAAAGTAAACGGGGCGATCACGTGTGATCGGGAGGGAGAACTTGGGATCATTACGGCCGATGC
GGTGATCCTTGCGACCGGCGGGGCCGGCCAGGTCTACGACACGACGACCAACTCGACGGCCGGGACCGGAGACGGATACG
CTCTTGGCTACCGGGCCGGAGCACAGCTCATCGATATGGAACAGGTCCAATTCCACCCGACCGGAGCCGTAACTCCTTAC
GATTCACGCGGAAGGCTGATCACCGAAGCGGTGAGAGGAGAGGGAGGCATCCTGAAAAACGCACTCGGGGAACGGTTCAT
GGCGAAATATGATCCGGCACGTATGGAGCTTTCCACCCGCGATGTCGTGGCACGGGGAATTGCCACCGAAGTTCTCGAAG
GGCGGGGCACCTCCCATGGGGGTGTCTGGCTGGATGTCAGTCATCTTCCGCGTGAACAGATCGAAACACGCCTTCCGATC
ATGCTGAATCAGTTCCTGCAGTTCGGTGTGGATATCAGAAACGAACCGATGGAGGTCGCACCGACCGCCCACCATTTCAT
GGGCGGGATAAAGATAACGCCGGAAGCAAAAACAACGGTGCCTCATCTTTATGCAGCCGGAGAAGTAACCGGCGGTGTTC
ACGGAGGAAACCGTCTTGGAGGAAATGCTCTTGCCGATACGCAGGTGTTTGGGAGAAGGGCAGGCATCTCGGCAGGAAAA
ACAGAACGGACGGCAAGAAAAATCGACATGGATCAGATCAGAGCGGCTGAAAACAGACTGGAATCCTATTATGAAGGTAC
GGCGAAATCCGCCGATATCAGACGGGCCATGAAGATGATGATGTGGAACAATGTAGGGATCTACCGAAACGAACTCGACC
TGAGAGTTGCCGAAAGGGAGATCAAAAAACTGCAGAACACACAGCTGAAGATCGCTTCGCCCCGCGAACTTTCCGATGCC
GTGGTCACGGAAAATATGTTGCTTGTCGCCCAGCTCGTTATCGAAGGAGCACTCCTCCGAAGAGAGTCACGAGGGGCCCA
CACCCGGACCGATGTGAAGCAGAGCTGGACGAACGAGACATCGCCGTTCGGCCACACCTTCTTTGTCAAAGGCAAATCAG
GGATAGAAATTCTGGAGGATAGATTATGA

Upstream 100 bases:

>100_bases
TATACGACGCCGAACGGAGAGACGATTCTGGAAGCATAACCTTCCTTTTCCCCTGCTTTTATCCCCTCCCTCTTCCAATA
GATATAATTAAGGATTCGAA

Downstream 100 bases:

>100_bases
AAGTAACCATCTCCCGTTTCGATCCGGCAACCGGAGAACCACCGAAATTTGTAGAGTATGATGTCAGTGTAAAAGATTCG
GCACGCGTACTCAATGTTTT

Product: succinate dehydrogenase flavoprotein subunit

Products: fumarate; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MGIENTKDCHVLVIGSGGAGIRAAVEAETFGETIIVSKTITGKGGCTVMAEGGFNAVLNEEDSIQTHFEDTMKGGAFLND
ELLVQTLASEAPNRIRDLFSWGAVFDLKEDNTIAQRPFGGQRCARTCYAGDHTGHELVMTLLEKLRGSSVEIENEVTVLD
LLSDDGKVNGAITCDREGELGIITADAVILATGGAGQVYDTTTNSTAGTGDGYALGYRAGAQLIDMEQVQFHPTGAVTPY
DSRGRLITEAVRGEGGILKNALGERFMAKYDPARMELSTRDVVARGIATEVLEGRGTSHGGVWLDVSHLPREQIETRLPI
MLNQFLQFGVDIRNEPMEVAPTAHHFMGGIKITPEAKTTVPHLYAAGEVTGGVHGGNRLGGNALADTQVFGRRAGISAGK
TERTARKIDMDQIRAAENRLESYYEGTAKSADIRRAMKMMMWNNVGIYRNELDLRVAEREIKKLQNTQLKIASPRELSDA
VVTENMLLVAQLVIEGALLRRESRGAHTRTDVKQSWTNETSPFGHTFFVKGKSGIEILEDRL

Sequences:

>Translated_542_residues
MGIENTKDCHVLVIGSGGAGIRAAVEAETFGETIIVSKTITGKGGCTVMAEGGFNAVLNEEDSIQTHFEDTMKGGAFLND
ELLVQTLASEAPNRIRDLFSWGAVFDLKEDNTIAQRPFGGQRCARTCYAGDHTGHELVMTLLEKLRGSSVEIENEVTVLD
LLSDDGKVNGAITCDREGELGIITADAVILATGGAGQVYDTTTNSTAGTGDGYALGYRAGAQLIDMEQVQFHPTGAVTPY
DSRGRLITEAVRGEGGILKNALGERFMAKYDPARMELSTRDVVARGIATEVLEGRGTSHGGVWLDVSHLPREQIETRLPI
MLNQFLQFGVDIRNEPMEVAPTAHHFMGGIKITPEAKTTVPHLYAAGEVTGGVHGGNRLGGNALADTQVFGRRAGISAGK
TERTARKIDMDQIRAAENRLESYYEGTAKSADIRRAMKMMMWNNVGIYRNELDLRVAEREIKKLQNTQLKIASPRELSDA
VVTENMLLVAQLVIEGALLRRESRGAHTRTDVKQSWTNETSPFGHTFFVKGKSGIEILEDRL
>Mature_541_residues
GIENTKDCHVLVIGSGGAGIRAAVEAETFGETIIVSKTITGKGGCTVMAEGGFNAVLNEEDSIQTHFEDTMKGGAFLNDE
LLVQTLASEAPNRIRDLFSWGAVFDLKEDNTIAQRPFGGQRCARTCYAGDHTGHELVMTLLEKLRGSSVEIENEVTVLDL
LSDDGKVNGAITCDREGELGIITADAVILATGGAGQVYDTTTNSTAGTGDGYALGYRAGAQLIDMEQVQFHPTGAVTPYD
SRGRLITEAVRGEGGILKNALGERFMAKYDPARMELSTRDVVARGIATEVLEGRGTSHGGVWLDVSHLPREQIETRLPIM
LNQFLQFGVDIRNEPMEVAPTAHHFMGGIKITPEAKTTVPHLYAAGEVTGGVHGGNRLGGNALADTQVFGRRAGISAGKT
ERTARKIDMDQIRAAENRLESYYEGTAKSADIRRAMKMMMWNNVGIYRNELDLRVAEREIKKLQNTQLKIASPRELSDAV
VTENMLLVAQLVIEGALLRRESRGAHTRTDVKQSWTNETSPFGHTFFVKGKSGIEILEDRL

Specific function: Catalyzes The Oxidation Of L-Aspartate To Iminoaspartate. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=503, Percent_Identity=37.5745526838966, Blast_Score=290, Evalue=2e-78,
Organism=Escherichia coli, GI1788928, Length=527, Percent_Identity=34.7248576850095, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1790597, Length=527, Percent_Identity=36.0531309297913, Blast_Score=262, Evalue=5e-71,
Organism=Escherichia coli, GI1786942, Length=525, Percent_Identity=36.1904761904762, Blast_Score=253, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17505833, Length=525, Percent_Identity=35.4285714285714, Blast_Score=271, Evalue=6e-73,
Organism=Caenorhabditis elegans, GI17550100, Length=525, Percent_Identity=36, Blast_Score=265, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI71986328, Length=283, Percent_Identity=30.0353356890459, Blast_Score=85, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6322701, Length=568, Percent_Identity=35.0352112676056, Blast_Score=266, Evalue=5e-72,
Organism=Saccharomyces cerevisiae, GI6322416, Length=568, Percent_Identity=35.9154929577465, Blast_Score=264, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6320788, Length=472, Percent_Identity=32.6271186440678, Blast_Score=154, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6322511, Length=480, Percent_Identity=28.75, Blast_Score=131, Evalue=3e-31,
Organism=Drosophila melanogaster, GI17137288, Length=533, Percent_Identity=36.0225140712946, Blast_Score=268, Evalue=6e-72,
Organism=Drosophila melanogaster, GI24655642, Length=533, Percent_Identity=36.0225140712946, Blast_Score=268, Evalue=6e-72,
Organism=Drosophila melanogaster, GI24655647, Length=533, Percent_Identity=36.0225140712946, Blast_Score=268, Evalue=6e-72,
Organism=Drosophila melanogaster, GI24663005, Length=526, Percent_Identity=34.9809885931559, Blast_Score=253, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: 1.3.99.1

Molecular weight: Translated: 58810; Mature: 58679

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIENTKDCHVLVIGSGGAGIRAAVEAETFGETIIVSKTITGKGGCTVMAEGGFNAVLNE
CCCCCCCCEEEEEEECCCCCCEEEEEHHHCCCEEEEEEEECCCCCEEEEECCCCCEECCC
EDSIQTHFEDTMKGGAFLNDELLVQTLASEAPNRIRDLFSWGAVFDLKEDNTIAQRPFGG
CCCHHHHHHHHHCCCCEECHHHHHHHHHHHCCHHHHHHHHCCCEEEECCCCCHHCCCCCH
QRCARTCYAGDHTGHELVMTLLEKLRGSSVEIENEVTVLDLLSDDGKVNGAITCDREGEL
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEECCCEEEEEEECCCCCCCEEEEECCCCCE
GIITADAVILATGGAGQVYDTTTNSTAGTGDGYALGYRAGAQLIDMEQVQFHPTGAVTPY
EEEEECEEEEEECCCCCEEECCCCCCCCCCCCEEEEECCCCCEEEHHHEEECCCCCCCCC
DSRGRLITEAVRGEGGILKNALGERFMAKYDPARMELSTRDVVARGIATEVLEGRGTSHG
CCCCCEEHHHHCCCCCHHHHHHHHHHHHHCCCHHEEECHHHHHHHHHHHHHHHCCCCCCC
GVWLDVSHLPREQIETRLPIMLNQFLQFGVDIRNEPMEVAPTAHHFMGGIKITPEAKTTV
CEEEECCCCCHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCEEECCCCCCCC
PHLYAAGEVTGGVHGGNRLGGNALADTQVFGRRAGISAGKTERTARKIDMDQIRAAENRL
CEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHH
ESYYEGTAKSADIRRAMKMMMWNNVGIYRNELDLRVAEREIKKLQNTQLKIASPRELSDA
HHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCEEEECCCCHHHHH
VVTENMLLVAQLVIEGALLRRESRGAHTRTDVKQSWTNETSPFGHTFFVKGKSGIEILED
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHC
RL
CC
>Mature Secondary Structure 
GIENTKDCHVLVIGSGGAGIRAAVEAETFGETIIVSKTITGKGGCTVMAEGGFNAVLNE
CCCCCCCEEEEEEECCCCCCEEEEEHHHCCCEEEEEEEECCCCCEEEEECCCCCEECCC
EDSIQTHFEDTMKGGAFLNDELLVQTLASEAPNRIRDLFSWGAVFDLKEDNTIAQRPFGG
CCCHHHHHHHHHCCCCEECHHHHHHHHHHHCCHHHHHHHHCCCEEEECCCCCHHCCCCCH
QRCARTCYAGDHTGHELVMTLLEKLRGSSVEIENEVTVLDLLSDDGKVNGAITCDREGEL
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEECCCEEEEEEECCCCCCCEEEEECCCCCE
GIITADAVILATGGAGQVYDTTTNSTAGTGDGYALGYRAGAQLIDMEQVQFHPTGAVTPY
EEEEECEEEEEECCCCCEEECCCCCCCCCCCCEEEEECCCCCEEEHHHEEECCCCCCCCC
DSRGRLITEAVRGEGGILKNALGERFMAKYDPARMELSTRDVVARGIATEVLEGRGTSHG
CCCCCEEHHHHCCCCCHHHHHHHHHHHHHCCCHHEEECHHHHHHHHHHHHHHHCCCCCCC
GVWLDVSHLPREQIETRLPIMLNQFLQFGVDIRNEPMEVAPTAHHFMGGIKITPEAKTTV
CEEEECCCCCHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCEEECCCCCCCC
PHLYAAGEVTGGVHGGNRLGGNALADTQVFGRRAGISAGKTERTARKIDMDQIRAAENRL
CEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHH
ESYYEGTAKSADIRRAMKMMMWNNVGIYRNELDLRVAEREIKKLQNTQLKIASPRELSDA
HHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCEEEECCCCHHHHH
VVTENMLLVAQLVIEGALLRRESRGAHTRTDVKQSWTNETSPFGHTFFVKGKSGIEILED
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHC
RL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: succinate; acceptor

Specific reaction: succinate + acceptor = fumarate + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]