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The map label for this gene is mutB [H]

Identifier: 124266207

GI number: 124266207

Start: 1077729

End: 1079888

Strand: Direct

Name: mutB [H]

Synonym: Mpe_A1014

Alternate gene names: 124266207

Gene position: 1077729-1079888 (Clockwise)

Preceding gene: 124266205

Following gene: 124266208

Centisome position: 26.65

GC content: 67.41

Gene sequence:

>2160_bases
ATGTCCGATCGCCCCGTACTTTCGCCCGAGGCCCTGGCGGCCTGGCACAAGGCCGCCGCGAAGTCGGCCCCCGGCGGCGA
CGTGTCGGCGCTGAACTGGGTCACGCCCGAAGGCATCACTGTGAAGCCGCTGTACACCGCGGCCGATCTGCAGGGTCTGC
CGCACACCGACACGCTGCCCGGGTTCGCGCCCTATCTGCGCGGTCCGCAGGCCACGATGTACGCGGTGCGGCCGTGGACC
ATCCGCCAGTACGCCGGCTTCTCCACCGCCGAGGAATCGAACGCCTTCTACCGCAAGGCGCTGGCCGCCGGCGGGCAGGG
CGTGAGCGTGGCCTTCGACCTGGCCACCCACCGCGGCTACGACAGCGACCACCCGCGCGTGACCGGCGACGTCGGCAAGG
CCGGCGTGGCGATCGACAGCGTGGAGGACATGAAGATCCTGTTCGACGGCATCCCGCTCGACAAGGTGTCGGTGTCGATG
ACCATGAACGGCGCGGTGCTGCCGGTGCTGGCCGGCTACATCGTCGCGGCCGAGGAGCAGGGCGTGCGCCAGGACCAGCT
GAGCGGGACCATCCAGAACGACATCCTCAAGGAGTTCATGGTCCGCAACACCTACATCTTCCCGCCCGAGCCGAGCATGC
GGGCCATCGGCGACATCATCGAGTACACGGCACAGAACATGCCGAAGTTCAACTCGATCTCGATCTCCGGCTACCACATG
CAGGAGGCCGGTGCGAACCAGGCGCTGGAGCTGGCCTTCACGCTGGCCGACGGCAAGGAGTACGTGCGCACCGCGCTCGC
CAAGGGCCTGAACGTCGACGAGTTCGCCGGCCGCCTGAGCTTCTTCTGGGCGATCGGCATGAACTTCTATCTCGAGATCG
CCAAGATGCGCGCCGCGCGCATGCTGTGGTGGAAGATCATGCAGGAGTTCGAGCCCAAGAACCCGAAGAGCCTGATGCTG
CGCACCCACTCGCAGACCTCGGGCTGGAGCCTGACCGAGCAGGACCCCTACAACAACGTGGTGCGCACCACCATCGAGGC
GATGGCGGCGGTGTTCGGCGGCACGCAGTCGCTGCACACCAATGCGCTCGACGAGGCGATCGCGCTGCCCACCGAGTTCA
GCTCGCGCATTGCGCGCAACACCCAGCTCATCATCCAGGAAGAGACGCACATCACCAACGTGGTCGACCCCTGGGCCGGC
AGCTACATGATGGAGAAGCTCACCCAGGACATGGCCGATGCCGCCTGGGCCATCATCGAGGAGGTCGAGGCGATGGGGGG
CATGACCAAGGCCGTGGACTCCGGCTGGGCCAAGCTCAAGATCGAGGCCAGCGCGGCCGAGAAGCAGGCCCGCATCGACT
CCGGCAAGGACGTGATCGTCGGCGTCAACAAGTACAAGCTCGACAAGGAAGACGTGGTCGACTTCCTCGACATCGACAAC
GTGAAGGTGCGCGACAGCCAGATCGAGCGGCTCAAGGCGATCCGTGCGCGCCGCGACGCACCTGCGGTGCAGGCGGCGCT
GGACGCGCTGACACAATGCGCCGAATCCGGCCAGGGCAACCTGCTCGACCTGAGCGTGAAGGCGATCCGCCTGCGCGCCA
CGGTCGGCGAGGTGTCCTCGGCGCTCGAGAAGGTCTGGGGGCGCCACCGCGCCGATACGCAGAAGGTGACCGGCGTGTAC
GCAGCTGCCTACGACTCGGCCGAAGGCTGGGAACAACTCAAGACCGAGATCGCGGCCTTCGCCGACGACCACGGCCGCCG
GCCGCGCGTGATGATCGCCAAGCTCGGCCAGGACGGCCACGACCGGGGCGCCAAGGTGGTGGCCACCGCCTTCGCCGACC
TCGGCTACGACGTCGACATGGGGCCGCTGTTCCAGACGCCCGACGAATGCGCGCGCCAGGCGATCGAGAACGACGTGCAC
GCGATCGGCGTGTCCACGCTGGCCGCCGGCCACAAGACGCTGGTGCCGGCCATCGTGGCCGAACTGAGGAAGCAGGGCGC
CGACGACATCATCGTGTTCGTCGGTGGCGTGATCCCGCGTCAGGACTACGACTTCCTCTACGAGGCCGGCGTCAAGGGCA
TCTACGGTCCCGGTACGCCGATCCCGGCCTCGGCGAAGGACGTGCTCGAGCAGATCAAGAAGGCCATCGCCGCGCCCTGA

Upstream 100 bases:

>100_bases
TTCGCCGTCCAGCCCGGATTTCCGGAGTCTGGCGTGCGCCACGTGGCCTCGTGTCATGCCGCGGCGCCTCGCACACCGTT
CACCGCAGGAAAGATTCGCC

Downstream 100 bases:

>100_bases
TCCGATGGCTGCCGCCTCCGACCAGACGCTGATCGACGGCGTGCTCGGCCCGGCCGGGCCGGTGCAGCGCCGCGCCATCG
CCAAGACCATCACGCTGCTC

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 719; Mature: 718

Protein sequence:

>719_residues
MSDRPVLSPEALAAWHKAAAKSAPGGDVSALNWVTPEGITVKPLYTAADLQGLPHTDTLPGFAPYLRGPQATMYAVRPWT
IRQYAGFSTAEESNAFYRKALAAGGQGVSVAFDLATHRGYDSDHPRVTGDVGKAGVAIDSVEDMKILFDGIPLDKVSVSM
TMNGAVLPVLAGYIVAAEEQGVRQDQLSGTIQNDILKEFMVRNTYIFPPEPSMRAIGDIIEYTAQNMPKFNSISISGYHM
QEAGANQALELAFTLADGKEYVRTALAKGLNVDEFAGRLSFFWAIGMNFYLEIAKMRAARMLWWKIMQEFEPKNPKSLML
RTHSQTSGWSLTEQDPYNNVVRTTIEAMAAVFGGTQSLHTNALDEAIALPTEFSSRIARNTQLIIQEETHITNVVDPWAG
SYMMEKLTQDMADAAWAIIEEVEAMGGMTKAVDSGWAKLKIEASAAEKQARIDSGKDVIVGVNKYKLDKEDVVDFLDIDN
VKVRDSQIERLKAIRARRDAPAVQAALDALTQCAESGQGNLLDLSVKAIRLRATVGEVSSALEKVWGRHRADTQKVTGVY
AAAYDSAEGWEQLKTEIAAFADDHGRRPRVMIAKLGQDGHDRGAKVVATAFADLGYDVDMGPLFQTPDECARQAIENDVH
AIGVSTLAAGHKTLVPAIVAELRKQGADDIIVFVGGVIPRQDYDFLYEAGVKGIYGPGTPIPASAKDVLEQIKKAIAAP

Sequences:

>Translated_719_residues
MSDRPVLSPEALAAWHKAAAKSAPGGDVSALNWVTPEGITVKPLYTAADLQGLPHTDTLPGFAPYLRGPQATMYAVRPWT
IRQYAGFSTAEESNAFYRKALAAGGQGVSVAFDLATHRGYDSDHPRVTGDVGKAGVAIDSVEDMKILFDGIPLDKVSVSM
TMNGAVLPVLAGYIVAAEEQGVRQDQLSGTIQNDILKEFMVRNTYIFPPEPSMRAIGDIIEYTAQNMPKFNSISISGYHM
QEAGANQALELAFTLADGKEYVRTALAKGLNVDEFAGRLSFFWAIGMNFYLEIAKMRAARMLWWKIMQEFEPKNPKSLML
RTHSQTSGWSLTEQDPYNNVVRTTIEAMAAVFGGTQSLHTNALDEAIALPTEFSSRIARNTQLIIQEETHITNVVDPWAG
SYMMEKLTQDMADAAWAIIEEVEAMGGMTKAVDSGWAKLKIEASAAEKQARIDSGKDVIVGVNKYKLDKEDVVDFLDIDN
VKVRDSQIERLKAIRARRDAPAVQAALDALTQCAESGQGNLLDLSVKAIRLRATVGEVSSALEKVWGRHRADTQKVTGVY
AAAYDSAEGWEQLKTEIAAFADDHGRRPRVMIAKLGQDGHDRGAKVVATAFADLGYDVDMGPLFQTPDECARQAIENDVH
AIGVSTLAAGHKTLVPAIVAELRKQGADDIIVFVGGVIPRQDYDFLYEAGVKGIYGPGTPIPASAKDVLEQIKKAIAAP
>Mature_718_residues
SDRPVLSPEALAAWHKAAAKSAPGGDVSALNWVTPEGITVKPLYTAADLQGLPHTDTLPGFAPYLRGPQATMYAVRPWTI
RQYAGFSTAEESNAFYRKALAAGGQGVSVAFDLATHRGYDSDHPRVTGDVGKAGVAIDSVEDMKILFDGIPLDKVSVSMT
MNGAVLPVLAGYIVAAEEQGVRQDQLSGTIQNDILKEFMVRNTYIFPPEPSMRAIGDIIEYTAQNMPKFNSISISGYHMQ
EAGANQALELAFTLADGKEYVRTALAKGLNVDEFAGRLSFFWAIGMNFYLEIAKMRAARMLWWKIMQEFEPKNPKSLMLR
THSQTSGWSLTEQDPYNNVVRTTIEAMAAVFGGTQSLHTNALDEAIALPTEFSSRIARNTQLIIQEETHITNVVDPWAGS
YMMEKLTQDMADAAWAIIEEVEAMGGMTKAVDSGWAKLKIEASAAEKQARIDSGKDVIVGVNKYKLDKEDVVDFLDIDNV
KVRDSQIERLKAIRARRDAPAVQAALDALTQCAESGQGNLLDLSVKAIRLRATVGEVSSALEKVWGRHRADTQKVTGVYA
AAYDSAEGWEQLKTEIAAFADDHGRRPRVMIAKLGQDGHDRGAKVVATAFADLGYDVDMGPLFQTPDECARQAIENDVHA
IGVSTLAAGHKTLVPAIVAELRKQGADDIIVFVGGVIPRQDYDFLYEAGVKGIYGPGTPIPASAKDVLEQIKKAIAAP

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=711, Percent_Identity=64.5569620253165, Blast_Score=955, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=706, Percent_Identity=62.0396600566572, Blast_Score=879, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=701, Percent_Identity=64.1940085592011, Blast_Score=938, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 78125; Mature: 77993

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRPVLSPEALAAWHKAAAKSAPGGDVSALNWVTPEGITVKPLYTAADLQGLPHTDTLP
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEEEEEHHHCCCCCCCCCCC
GFAPYLRGPQATMYAVRPWTIRQYAGFSTAEESNAFYRKALAAGGQGVSVAFDLATHRGY
CCHHHHCCCCCEEEEECCEEEHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHCCCC
DSDHPRVTGDVGKAGVAIDSVEDMKILFDGIPLDKVSVSMTMNGAVLPVLAGYIVAAEEQ
CCCCCEEECCCCCCCEEECCHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHEEECCC
GVRQDQLSGTIQNDILKEFMVRNTYIFPPEPSMRAIGDIIEYTAQNMPKFNSISISGYHM
CCCHHHHCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECEEH
QEAGANQALELAFTLADGKEYVRTALAKGLNVDEFAGRLSFFWAIGMNFYLEIAKMRAAR
HHCCCCCEEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLWWKIMQEFEPKNPKSLMLRTHSQTSGWSLTEQDPYNNVVRTTIEAMAAVFGGTQSLHT
HHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHH
NALDEAIALPTEFSSRIARNTQLIIQEETHITNVVDPWAGSYMMEKLTQDMADAAWAIIE
HHHHHHHCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EVEAMGGMTKAVDSGWAKLKIEASAAEKQARIDSGKDVIVGVNKYKLDKEDVVDFLDIDN
HHHHHCCHHHHHCCCCEEEEEEHHHHHHHHHCCCCCEEEEECCHHCCCHHHHHHHHCCCC
VKVRDSQIERLKAIRARRDAPAVQAALDALTQCAESGQGNLLDLSVKAIRLRATVGEVSS
CEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEHHHHHHHHH
ALEKVWGRHRADTQKVTGVYAAAYDSAEGWEQLKTEIAAFADDHGRRPRVMIAKLGQDGH
HHHHHHCCCCCCHHHHHEEHEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
DRGAKVVATAFADLGYDVDMGPLFQTPDECARQAIENDVHAIGVSTLAAGHKTLVPAIVA
CCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHH
ELRKQGADDIIVFVGGVIPRQDYDFLYEAGVKGIYGPGTPIPASAKDVLEQIKKAIAAP
HHHHCCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDRPVLSPEALAAWHKAAAKSAPGGDVSALNWVTPEGITVKPLYTAADLQGLPHTDTLP
CCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEEEEEHHHCCCCCCCCCCC
GFAPYLRGPQATMYAVRPWTIRQYAGFSTAEESNAFYRKALAAGGQGVSVAFDLATHRGY
CCHHHHCCCCCEEEEECCEEEHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHCCCC
DSDHPRVTGDVGKAGVAIDSVEDMKILFDGIPLDKVSVSMTMNGAVLPVLAGYIVAAEEQ
CCCCCEEECCCCCCCEEECCHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHEEECCC
GVRQDQLSGTIQNDILKEFMVRNTYIFPPEPSMRAIGDIIEYTAQNMPKFNSISISGYHM
CCCHHHHCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECEEH
QEAGANQALELAFTLADGKEYVRTALAKGLNVDEFAGRLSFFWAIGMNFYLEIAKMRAAR
HHCCCCCEEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLWWKIMQEFEPKNPKSLMLRTHSQTSGWSLTEQDPYNNVVRTTIEAMAAVFGGTQSLHT
HHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHH
NALDEAIALPTEFSSRIARNTQLIIQEETHITNVVDPWAGSYMMEKLTQDMADAAWAIIE
HHHHHHHCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EVEAMGGMTKAVDSGWAKLKIEASAAEKQARIDSGKDVIVGVNKYKLDKEDVVDFLDIDN
HHHHHCCHHHHHCCCCEEEEEEHHHHHHHHHCCCCCEEEEECCHHCCCHHHHHHHHCCCC
VKVRDSQIERLKAIRARRDAPAVQAALDALTQCAESGQGNLLDLSVKAIRLRATVGEVSS
CEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEHHHHHHHHH
ALEKVWGRHRADTQKVTGVYAAAYDSAEGWEQLKTEIAAFADDHGRRPRVMIAKLGQDGH
HHHHHHCCCCCCHHHHHEEHEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
DRGAKVVATAFADLGYDVDMGPLFQTPDECARQAIENDVHAIGVSTLAAGHKTLVPAIVA
CCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHH
ELRKQGADDIIVFVGGVIPRQDYDFLYEAGVKGIYGPGTPIPASAKDVLEQIKKAIAAP
HHHHCCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8566763; 12949112 [H]