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The map label for this gene is paaK [H]

Identifier: 124266179

GI number: 124266179

Start: 1048299

End: 1049606

Strand: Direct

Name: paaK [H]

Synonym: Mpe_A0986

Alternate gene names: 124266179

Gene position: 1048299-1049606 (Clockwise)

Preceding gene: 124266178

Following gene: 124266180

Centisome position: 25.92

GC content: 69.11

Gene sequence:

>1308_bases
ATGCCCGTGAAACGCCCCGCCCCCGGCGACCTCGAGGCGATCGAGACCGCCAGCCGCGACGAGATCTCGGCGCTGCAGCT
GCAGCGCCTGCGTGCGACCCTGCGCCACGCCTACGACCGGGTGCCGCACTACCGGCGCGCGTTCGACGCCCAGGGCGTGC
ACCCCGACGACCTGAAGCAGCTCGCCGACCTCTCCAGGTTTCCGTTCACCGCCAAGAAGGATCTGCGCGACAACTACCCG
TTCGGCATGTTCGCGGTGCCGCGCGAGCAGGTGGCCCGCCTCCATGCGTCGTCCGGCACCACCGGCAAGCCGACGGTGGT
GGGCTACACGCTGAAGGACATCGACACCTGGGCCGAGCTGGTGGCACGCTCGATCCGCGCCTCCGGCGGGCGCCCGGGCG
ATCTCGTCCACGTGTCCTACGGCTACGGGCTGTTCACCGGCGGCCTCGGTGCGCACTACGGCGCCGAGCGGGTCGGCTGC
ACCGTCATCCCGATGTCGGGCGGACAGACCGAGAAGCAGGTGCAGCTGCTGTGCGACTTCCGGCCCGACATCATCATGGT
CACGCCCAGCTACATGCAGGTGATCATCGAGGAGTTCGTGCGCCAGGGCCTGGACCCGCGCGAGAGCTCGCTGAAGGTCG
GCATCTTCGGCGCCGAACCCTGGACCGAGGCGATGCGCCAGGAGATCGAGGGCCGGGCCGGCCTGGACGCGGTCGACATC
TACGGCCTGTCCGAGGTCATGGGCCCGGGCGTCGCCAACGAGTGCATCGAATCCAAGGACGGGCCGGTGATCTGGGAAGA
CCATTTCTACCCGGAGATCATCGACCCCGAGACCGGCGAGGTGCTGCCCGATGGCGCCGAGGGCGAACTGGTCTTCACCT
CGCTGACCAAGGAGGCGCTGCCCATCGTCCGCTACCGCACGCGCGACCTGACGCGGTTGCTGCCGCCGACAGCGCGTTCG
TTCCGCCGCATGAGCAAGATCGTCGGACGCAGCGACGACATGCTGATCATCCGCGGCGTCAACCTGTTCCCGACGCAGAT
CGAGGAGCTGGTGCTGCAGGAAGGCCCGCTGTCGGGGCAGTACCAGCTGGTGGTCACGCGCGAGGGCCTGCTCGACGAGG
TGGAGGTGCGCTGCGAGGTGCAGCCGGCGCATGCGGGGGTCGACCGCGTTGCCCTCGGTGCGCGGCTGCAGCAGCGCATC
AAGACGCTGATCGGCGTGAACACGACGGTCAGCGTCGGCCTGCCCGATTCGATCGAACGCACGCTGGTCGGCAAGGCCCG
CCGCGTGATCGACAGGCGACCCAAGTAA

Upstream 100 bases:

>100_bases
ACCAGCGCGGCGAATGCCTCGCGGTGTTCCGCGGCCGCTCCTACGCGATGCGCGGGAAGCCCGCGGTGGCGTCCGCCGGC
CGCTGAACGAGGAGACCGTC

Downstream 100 bases:

>100_bases
GGAACCCGCACCATGTACACGCAAGCCATGGACAGCGCGCCGAAGGACGAGCGCCCGGCGGTCCGCTCGGTCGAGGAGGC
GCGGCTCCAGCAGCGCTTCG

Product: phenylacetate-CoA ligase

Products: NA

Alternate protein names: Phenylacetyl-CoA ligase; PA-CoA ligase [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MPVKRPAPGDLEAIETASRDEISALQLQRLRATLRHAYDRVPHYRRAFDAQGVHPDDLKQLADLSRFPFTAKKDLRDNYP
FGMFAVPREQVARLHASSGTTGKPTVVGYTLKDIDTWAELVARSIRASGGRPGDLVHVSYGYGLFTGGLGAHYGAERVGC
TVIPMSGGQTEKQVQLLCDFRPDIIMVTPSYMQVIIEEFVRQGLDPRESSLKVGIFGAEPWTEAMRQEIEGRAGLDAVDI
YGLSEVMGPGVANECIESKDGPVIWEDHFYPEIIDPETGEVLPDGAEGELVFTSLTKEALPIVRYRTRDLTRLLPPTARS
FRRMSKIVGRSDDMLIIRGVNLFPTQIEELVLQEGPLSGQYQLVVTREGLLDEVEVRCEVQPAHAGVDRVALGARLQQRI
KTLIGVNTTVSVGLPDSIERTLVGKARRVIDRRPK

Sequences:

>Translated_435_residues
MPVKRPAPGDLEAIETASRDEISALQLQRLRATLRHAYDRVPHYRRAFDAQGVHPDDLKQLADLSRFPFTAKKDLRDNYP
FGMFAVPREQVARLHASSGTTGKPTVVGYTLKDIDTWAELVARSIRASGGRPGDLVHVSYGYGLFTGGLGAHYGAERVGC
TVIPMSGGQTEKQVQLLCDFRPDIIMVTPSYMQVIIEEFVRQGLDPRESSLKVGIFGAEPWTEAMRQEIEGRAGLDAVDI
YGLSEVMGPGVANECIESKDGPVIWEDHFYPEIIDPETGEVLPDGAEGELVFTSLTKEALPIVRYRTRDLTRLLPPTARS
FRRMSKIVGRSDDMLIIRGVNLFPTQIEELVLQEGPLSGQYQLVVTREGLLDEVEVRCEVQPAHAGVDRVALGARLQQRI
KTLIGVNTTVSVGLPDSIERTLVGKARRVIDRRPK
>Mature_434_residues
PVKRPAPGDLEAIETASRDEISALQLQRLRATLRHAYDRVPHYRRAFDAQGVHPDDLKQLADLSRFPFTAKKDLRDNYPF
GMFAVPREQVARLHASSGTTGKPTVVGYTLKDIDTWAELVARSIRASGGRPGDLVHVSYGYGLFTGGLGAHYGAERVGCT
VIPMSGGQTEKQVQLLCDFRPDIIMVTPSYMQVIIEEFVRQGLDPRESSLKVGIFGAEPWTEAMRQEIEGRAGLDAVDIY
GLSEVMGPGVANECIESKDGPVIWEDHFYPEIIDPETGEVLPDGAEGELVFTSLTKEALPIVRYRTRDLTRLLPPTARSF
RRMSKIVGRSDDMLIIRGVNLFPTQIEELVLQEGPLSGQYQLVVTREGLLDEVEVRCEVQPAHAGVDRVALGARLQQRIK
TLIGVNTTVSVGLPDSIERTLVGKARRVIDRRPK

Specific function: Catalyzes the activation of phenylacetic acid to phenylacetyl-CoA [H]

COG id: COG1541

COG function: function code H; Coenzyme F390 synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787664, Length=427, Percent_Identity=64.4028103044497, Blast_Score=558, Evalue=1e-160,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000873
- InterPro:   IPR011880 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.30 [H]

Molecular weight: Translated: 48194; Mature: 48063

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVKRPAPGDLEAIETASRDEISALQLQRLRATLRHAYDRVPHYRRAFDAQGVHPDDLKQ
CCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHH
LADLSRFPFTAKKDLRDNYPFGMFAVPREQVARLHASSGTTGKPTVVGYTLKDIDTWAEL
HHHHHHCCCCCHHHHCCCCCCCEEECCHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHH
VARSIRASGGRPGDLVHVSYGYGLFTGGLGAHYGAERVGCTVIPMSGGQTEKQVQLLCDF
HHHHHHHCCCCCCCEEEEEECCCHHCCCCCCCCCCHHCCEEEEECCCCCCHHHHHHHCCC
RPDIIMVTPSYMQVIIEEFVRQGLDPRESSLKVGIFGAEPWTEAMRQEIEGRAGLDAVDI
CCCEEEECHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCHHHH
YGLSEVMGPGVANECIESKDGPVIWEDHFYPEIIDPETGEVLPDGAEGELVFTSLTKEAL
CCHHHHHCCCHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHH
PIVRYRTRDLTRLLPPTARSFRRMSKIVGRSDDMLIIRGVNLFPTQIEELVLQEGPLSGQ
HHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCC
YQLVVTREGLLDEVEVRCEVQPAHAGVDRVALGARLQQRIKTLIGVNTTVSVGLPDSIER
EEEEEECCCCCCCEEEEEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHH
TLVGKARRVIDRRPK
HHHHHHHHHHCCCCC
>Mature Secondary Structure 
PVKRPAPGDLEAIETASRDEISALQLQRLRATLRHAYDRVPHYRRAFDAQGVHPDDLKQ
CCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHH
LADLSRFPFTAKKDLRDNYPFGMFAVPREQVARLHASSGTTGKPTVVGYTLKDIDTWAEL
HHHHHHCCCCCHHHHCCCCCCCEEECCHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHH
VARSIRASGGRPGDLVHVSYGYGLFTGGLGAHYGAERVGCTVIPMSGGQTEKQVQLLCDF
HHHHHHHCCCCCCCEEEEEECCCHHCCCCCCCCCCHHCCEEEEECCCCCCHHHHHHHCCC
RPDIIMVTPSYMQVIIEEFVRQGLDPRESSLKVGIFGAEPWTEAMRQEIEGRAGLDAVDI
CCCEEEECHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCHHHH
YGLSEVMGPGVANECIESKDGPVIWEDHFYPEIIDPETGEVLPDGAEGELVFTSLTKEAL
CCHHHHHCCCHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHH
PIVRYRTRDLTRLLPPTARSFRRMSKIVGRSDDMLIIRGVNLFPTQIEELVLQEGPLSGQ
HHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCC
YQLVVTREGLLDEVEVRCEVQPAHAGVDRVALGARLQQRIKTLIGVNTTVSVGLPDSIER
EEEEEECCCCCCCEEEEEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHH
TLVGKARRVIDRRPK
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9278503; 10766858 [H]