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The map label for this gene is gyaR [H]

Identifier: 124266166

GI number: 124266166

Start: 1036326

End: 1037291

Strand: Direct

Name: gyaR [H]

Synonym: Mpe_A0973

Alternate gene names: 124266166

Gene position: 1036326-1037291 (Clockwise)

Preceding gene: 124266165

Following gene: 124266167

Centisome position: 25.63

GC content: 75.78

Gene sequence:

>966_bases
ATGATGTCGACGAAGCCCCGCGTGCTGCAGATCGGCCGCCTGCTGCCCTGGCTGGAGGAGCGGCTGGCGGCCGCCCACGA
CCTGCACCGCCTGGCCGACGAGGCCGACCCGCAGGCCTTCCTGGCGGCGCGCGGCGCCGAGTTCGTGGGCCTGGTCACCT
CGGCCGGCGGCAGCGGCGCGGACGCGGCGCTGATCGACGCGCTGCCGTCGCTGCGCGTGATCTCGAGCTTCGGCGTGGGG
CTCGACAAGATCGACCTCGCGGCCGCCGCGCGGCGCGGCATCGCCGTGGGCTACACCCCCGACGTGCTGAACGACTGCGT
GGCCGATCTCGCGATGGCCCTGCTGCTCGACGTGGCACGCCGCACGCCCGAGGCCGACCGCTACGTGCGCGCCGGCCGCT
GGGGCGTGGCCGGCGCGCCGGCGTTCCCGCTCGGTCGCCGCGTCAGCGGCGCGCGGCTCGGCATCGTCGGGCTGGGCCGC
ATCGGTCGCACGATCGCGCGGCGCGCGCTCGGCTTCGACATGGCGATCCGCTACCACTCGCGCCGCCCGGTCGCCGACGC
GCCCTGGCCGCACGAACCGTCGCTGGTGGCGCTGGCCGAATGGGCCGACTTCCTGGTGGTCATTGCCGCCGGCGGTGCCG
GCACGCGCCACCTCGTGGACGGCGCGGTGCTCGGCGCGCTCGGCCCCGAAGGCTTCCTGGTCAACGTCTCGCGCGGCTCC
GTCGTCGACGAGGCGGCGCTGGTGCACGCTCTGGTCGAGCGGCGCATCGCCGGTGCGGCGCTCGACGTGTTCGAGCACGA
GCCACAGGTGCCGGCCGCACTGCGCGCGCTGGACAACGTGGTGCTGCTGCCGCACATCGCCAGCGCCACGCGCGAGACGC
GCCAGGCGATGGGCCAGCGCGTGCTGGACAACCTGGCGCTGTTCTTCGCCGAGGGCCGGCTGGTGACGGCCGCGCCGCTG
GACTGA

Upstream 100 bases:

>100_bases
CCGAGGTCTACACGATGACGCCGGCCGAGTTCGCCACCTTCTTCGAGCGCGAGCGCAAGAACTGGGCGAGCGTCGTCGCG
CAGGGCGGGGTGAAGATCGA

Downstream 100 bases:

>100_bases
TCGATCAACGAACGGACCCACGAACGCCGAGAGGATGAACATGAGACCCAACCGCCTGCGCGAGATCTGGAAGAGCGGCG
GCGCCGCCCTGAACGGCTGG

Product: putative D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MMSTKPRVLQIGRLLPWLEERLAAAHDLHRLADEADPQAFLAARGAEFVGLVTSAGGSGADAALIDALPSLRVISSFGVG
LDKIDLAAAARRGIAVGYTPDVLNDCVADLAMALLLDVARRTPEADRYVRAGRWGVAGAPAFPLGRRVSGARLGIVGLGR
IGRTIARRALGFDMAIRYHSRRPVADAPWPHEPSLVALAEWADFLVVIAAGGAGTRHLVDGAVLGALGPEGFLVNVSRGS
VVDEAALVHALVERRIAGAALDVFEHEPQVPAALRALDNVVLLPHIASATRETRQAMGQRVLDNLALFFAEGRLVTAAPL
D

Sequences:

>Translated_321_residues
MMSTKPRVLQIGRLLPWLEERLAAAHDLHRLADEADPQAFLAARGAEFVGLVTSAGGSGADAALIDALPSLRVISSFGVG
LDKIDLAAAARRGIAVGYTPDVLNDCVADLAMALLLDVARRTPEADRYVRAGRWGVAGAPAFPLGRRVSGARLGIVGLGR
IGRTIARRALGFDMAIRYHSRRPVADAPWPHEPSLVALAEWADFLVVIAAGGAGTRHLVDGAVLGALGPEGFLVNVSRGS
VVDEAALVHALVERRIAGAALDVFEHEPQVPAALRALDNVVLLPHIASATRETRQAMGQRVLDNLALFFAEGRLVTAAPL
D
>Mature_321_residues
MMSTKPRVLQIGRLLPWLEERLAAAHDLHRLADEADPQAFLAARGAEFVGLVTSAGGSGADAALIDALPSLRVISSFGVG
LDKIDLAAAARRGIAVGYTPDVLNDCVADLAMALLLDVARRTPEADRYVRAGRWGVAGAPAFPLGRRVSGARLGIVGLGR
IGRTIARRALGFDMAIRYHSRRPVADAPWPHEPSLVALAEWADFLVVIAAGGAGTRHLVDGAVLGALGPEGFLVNVSRGS
VVDEAALVHALVERRIAGAALDVFEHEPQVPAALRALDNVVLLPHIASATRETRQAMGQRVLDNLALFFAEGRLVTAAPL
D

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=252, Percent_Identity=38.8888888888889, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI23308577, Length=243, Percent_Identity=34.156378600823, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI61743967, Length=285, Percent_Identity=30.8771929824561, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI4557497, Length=285, Percent_Identity=30.8771929824561, Blast_Score=99, Evalue=4e-21,
Organism=Escherichia coli, GI87082289, Length=308, Percent_Identity=38.961038961039, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1789279, Length=290, Percent_Identity=30.6896551724138, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1787645, Length=296, Percent_Identity=25, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=244, Percent_Identity=29.5081967213115, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25147481, Length=282, Percent_Identity=27.6595744680851, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324055, Length=342, Percent_Identity=31.5789473684211, Blast_Score=139, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6320925, Length=260, Percent_Identity=28.8461538461538, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322116, Length=260, Percent_Identity=28.4615384615385, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321253, Length=212, Percent_Identity=29.7169811320755, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28571528, Length=266, Percent_Identity=37.9699248120301, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI45552429, Length=236, Percent_Identity=34.7457627118644, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24585514, Length=241, Percent_Identity=35.2697095435685, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28574282, Length=241, Percent_Identity=35.2697095435685, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28574284, Length=241, Percent_Identity=35.2697095435685, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI45551003, Length=242, Percent_Identity=35.1239669421488, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28574286, Length=242, Percent_Identity=33.4710743801653, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24585516, Length=251, Percent_Identity=32.6693227091633, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24646446, Length=241, Percent_Identity=31.9502074688797, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24646448, Length=241, Percent_Identity=31.9502074688797, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24646452, Length=241, Percent_Identity=31.9502074688797, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24646450, Length=241, Percent_Identity=31.9502074688797, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI62472511, Length=241, Percent_Identity=31.9502074688797, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19921140, Length=231, Percent_Identity=30.7359307359307, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 33837; Mature: 33837

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSTKPRVLQIGRLLPWLEERLAAAHDLHRLADEADPQAFLAARGAEFVGLVTSAGGSGA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHEEEEECCCCCCC
DAALIDALPSLRVISSFGVGLDKIDLAAAARRGIAVGYTPDVLNDCVADLAMALLLDVAR
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHH
RTPEADRYVRAGRWGVAGAPAFPLGRRVSGARLGIVGLGRIGRTIARRALGFDMAIRYHS
CCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHEEECC
RRPVADAPWPHEPSLVALAEWADFLVVIAAGGAGTRHLVDGAVLGALGPEGFLVNVSRGS
CCCCCCCCCCCCCCEEHHHHHHCEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCCCC
VVDEAALVHALVERRIAGAALDVFEHEPQVPAALRALDNVVLLPHIASATRETRQAMGQR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEEHHHHHHHHHHHHHHHHH
VLDNLALFFAEGRLVTAAPLD
HHHHHHHHHCCCCEEEECCCC
>Mature Secondary Structure
MMSTKPRVLQIGRLLPWLEERLAAAHDLHRLADEADPQAFLAARGAEFVGLVTSAGGSGA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHEEEEECCCCCCC
DAALIDALPSLRVISSFGVGLDKIDLAAAARRGIAVGYTPDVLNDCVADLAMALLLDVAR
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHH
RTPEADRYVRAGRWGVAGAPAFPLGRRVSGARLGIVGLGRIGRTIARRALGFDMAIRYHS
CCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHEEECC
RRPVADAPWPHEPSLVALAEWADFLVVIAAGGAGTRHLVDGAVLGALGPEGFLVNVSRGS
CCCCCCCCCCCCCCEEHHHHHHCEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCCCC
VVDEAALVHALVERRIAGAALDVFEHEPQVPAALRALDNVVLLPHIASATRETRQAMGQR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEEHHHHHHHHHHHHHHHHH
VLDNLALFFAEGRLVTAAPLD
HHHHHHHHHCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA