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The map label for this gene is gntR [H]

Identifier: 124266161

GI number: 124266161

Start: 1030765

End: 1031808

Strand: Direct

Name: gntR [H]

Synonym: Mpe_A0968

Alternate gene names: 124266161

Gene position: 1030765-1031808 (Clockwise)

Preceding gene: 124266160

Following gene: 124266162

Centisome position: 25.49

GC content: 75.48

Gene sequence:

>1044_bases
ATGACAGCGCCCGACGCCACCGCGCCCCGCCGCTCGCGCCGCGGGGGCGGCATCACGCTCGGTGACGTGGCGCGCCTCGC
CGGGGTCTCGCCGATCACGGCCTCGCGCGCACTGAACACGCCGGACCAGGTGGCGCCCGACAAGCTGGCGCGCGTGCGCG
AGGCGGTGGCGCGCACCGGCTACGTGCCGAACCGGCTCGCCGGCGGCCTGGCCTCGGCACGCAGCCGGCTCGTCGCGGCC
GTCGTGCCCACGATCGCCGGGCCGGTGTTCATGGAGATGGTGCAGTCGCTGACCAGCGCGCTCGCCGACGCCGGCTACCA
GCTGATGCTGGGGCAGAGCGGCTACACCGAGTCGCGTGAGGACGCGCTGCTCGAGGCCATCATCGGCCGCCGGCCCGACG
GCATCGTGCTGACCGGCATCCTGCATTCGCCGGAGGGCCGGCGCCGCCTGCTGGCGAGCGGCATCCCGGTGGTCGAGACC
TGGGACCTCACGCCGACGCCGATCGACATGCTGGTCGGGTTCTCCCATGCGGAAGCGGCCGCCGCCGTGGCCCGCCACTT
GCACGCCAAGGGCCGGCGCCGCCCGGCACTGCTGAGCGCCGACGACGAGCGCGCACTGCGTCGCAACCGCGGCTTCGTCG
ACGAGGCCTTGCGCCTGGGCCTGGTGCGCGACGCGGCCGAGATCCCGGCGCTGCGCGTGCCGGCGCCCACCACGCTGGGC
AGCGGCCGCAGCGGCCTGGCACGCCTGCTGGCCGAGCGGCCCGAGGTCGATGCGGTGTTCTGCAGCTCCGACATGCTGGC
GCTGGGCGTGCTGGTCGAGGCCGCGGCGCGCGGCATCGCGGTCCCGCAGCAGCTGGCGGTGGTCGGCTTCGGCGACCTGG
GCTTCGCCGCCGATACCCAGCCGGCGCTGAGTACCGTGCGCATCGACGGCACCGGCATCGGCCAGCGCGCGGCGCGCTTC
ATCGTCGACCGCGCCGACGGCCGCACGGTGGGCGAGAAGATCGTCGACGTGGGCTTCCGCGTCATCGAGCGCGGCAGCAG
CTGA

Upstream 100 bases:

>100_bases
CACAAGCTGGCCGCCTGAGAGCCTGAAGCCCGTCCGCTCGCCGCGCCGGGCAGCGCGACGATGTGGATGGTAGCGGTGTC
ATCTCCACTACACTCGTGAG

Downstream 100 bases:

>100_bases
TCAGGGTTTTCACTTATCTGAGGTGGCTTGCAATCTCGAACGGTAGCGCTACCATTTTCAGACGATAGCGCTACCAGATG
GCGACCTCGCCGCACCAGGA

Product: LacI family transcription regulator

Products: NA

Alternate protein names: Gluconate utilization system GNT-I transcriptional repressor [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTAPDATAPRRSRRGGGITLGDVARLAGVSPITASRALNTPDQVAPDKLARVREAVARTGYVPNRLAGGLASARSRLVAA
VVPTIAGPVFMEMVQSLTSALADAGYQLMLGQSGYTESREDALLEAIIGRRPDGIVLTGILHSPEGRRRLLASGIPVVET
WDLTPTPIDMLVGFSHAEAAAAVARHLHAKGRRRPALLSADDERALRRNRGFVDEALRLGLVRDAAEIPALRVPAPTTLG
SGRSGLARLLAERPEVDAVFCSSDMLALGVLVEAAARGIAVPQQLAVVGFGDLGFAADTQPALSTVRIDGTGIGQRAARF
IVDRADGRTVGEKIVDVGFRVIERGSS

Sequences:

>Translated_347_residues
MTAPDATAPRRSRRGGGITLGDVARLAGVSPITASRALNTPDQVAPDKLARVREAVARTGYVPNRLAGGLASARSRLVAA
VVPTIAGPVFMEMVQSLTSALADAGYQLMLGQSGYTESREDALLEAIIGRRPDGIVLTGILHSPEGRRRLLASGIPVVET
WDLTPTPIDMLVGFSHAEAAAAVARHLHAKGRRRPALLSADDERALRRNRGFVDEALRLGLVRDAAEIPALRVPAPTTLG
SGRSGLARLLAERPEVDAVFCSSDMLALGVLVEAAARGIAVPQQLAVVGFGDLGFAADTQPALSTVRIDGTGIGQRAARF
IVDRADGRTVGEKIVDVGFRVIERGSS
>Mature_346_residues
TAPDATAPRRSRRGGGITLGDVARLAGVSPITASRALNTPDQVAPDKLARVREAVARTGYVPNRLAGGLASARSRLVAAV
VPTIAGPVFMEMVQSLTSALADAGYQLMLGQSGYTESREDALLEAIIGRRPDGIVLTGILHSPEGRRRLLASGIPVVETW
DLTPTPIDMLVGFSHAEAAAAVARHLHAKGRRRPALLSADDERALRRNRGFVDEALRLGLVRDAAEIPALRVPAPTTLGS
GRSGLARLLAERPEVDAVFCSSDMLALGVLVEAAARGIAVPQQLAVVGFGDLGFAADTQPALSTVRIDGTGIGQRAARFI
VDRADGRTVGEKIVDVGFRVIERGSS

Specific function: Negative regulator for the gluconate utilization system GNT-I, the gntUKR operon [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI48994940, Length=328, Percent_Identity=32.3170731707317, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI1790715, Length=333, Percent_Identity=28.5285285285285, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1790369, Length=335, Percent_Identity=28.955223880597, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1790194, Length=334, Percent_Identity=26.3473053892216, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787948, Length=342, Percent_Identity=26.6081871345029, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788474, Length=302, Percent_Identity=27.8145695364238, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1789068, Length=324, Percent_Identity=27.1604938271605, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1789202, Length=292, Percent_Identity=27.3972602739726, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786540, Length=332, Percent_Identity=25, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787906, Length=287, Percent_Identity=24.390243902439, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36388; Mature: 36257

Theoretical pI: Translated: 10.62; Mature: 10.62

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPDATAPRRSRRGGGITLGDVARLAGVSPITASRALNTPDQVAPDKLARVREAVARTG
CCCCCCCCCCHHCCCCCCCHHHHHHHHCCCCCHHHHCCCCCHHCCHHHHHHHHHHHHHCC
YVPNRLAGGLASARSRLVAAVVPTIAGPVFMEMVQSLTSALADAGYQLMLGQSGYTESRE
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHH
DALLEAIIGRRPDGIVLTGILHSPEGRRRLLASGIPVVETWDLTPTPIDMLVGFSHAEAA
HHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHCCCCEEEECCCCCCCHHHHHCCCHHHHH
AAVARHLHAKGRRRPALLSADDERALRRNRGFVDEALRLGLVRDAAEIPALRVPAPTTLG
HHHHHHHHHCCCCCCCEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCC
SGRSGLARLLAERPEVDAVFCSSDMLALGVLVEAAARGIAVPQQLAVVGFGDLGFAADTQ
CCHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCHHEEEEECCCCCCCCCCC
PALSTVRIDGTGIGQRAARFIVDRADGRTVGEKIVDVGFRVIERGSS
CCCEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TAPDATAPRRSRRGGGITLGDVARLAGVSPITASRALNTPDQVAPDKLARVREAVARTG
CCCCCCCCCHHCCCCCCCHHHHHHHHCCCCCHHHHCCCCCHHCCHHHHHHHHHHHHHCC
YVPNRLAGGLASARSRLVAAVVPTIAGPVFMEMVQSLTSALADAGYQLMLGQSGYTESRE
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHH
DALLEAIIGRRPDGIVLTGILHSPEGRRRLLASGIPVVETWDLTPTPIDMLVGFSHAEAA
HHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHCCCCEEEECCCCCCCHHHHHCCCHHHHH
AAVARHLHAKGRRRPALLSADDERALRRNRGFVDEALRLGLVRDAAEIPALRVPAPTTLG
HHHHHHHHHCCCCCCCEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCC
SGRSGLARLLAERPEVDAVFCSSDMLALGVLVEAAARGIAVPQQLAVVGFGDLGFAADTQ
CCHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCHHEEEEECCCCCCCCCCC
PALSTVRIDGTGIGQRAARFIVDRADGRTVGEKIVDVGFRVIERGSS
CCCEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]